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Shashank Dravid, PhD

Professor

Pharmacology & Neuroscience

Shashank Dravid

Contact

School of Medicine
Pharmacology and Neuroscience
Neuroscience (Master of Science)
Graduate School
CRISS III - Criss 3

Shashank Dravid, PhD

Professor

Pharmacology & Neuroscience

Dr. Dravid’s laboratory focuses on studies of NMDA and other glutamate receptors using electrophysiological and genetic tools to improve our understanding of neuropsychiatric and neurological disorders.

Research Focus

Glutamate is the major excitatory neurotransmitter in the central nervous system. The family of glutamate receptors play a critical role in synaptic plasticity and learning and memory. We are interested in understanding the roles of glutamate receptors and in particular N-methyl-D-aspartate (NMDA) and glutamate delta receptors in the central nervous system. The eventual goal is apply this undestanding to develop therpeuatics to treat severe neuropsychiatric and neurological disorders. 

Department

Pharmacology and Neuroscience

Position

Professor

Articles

  • Molecular Pharmacology
    Modulation of burst firing of neurons in nucleus reticularis of the thalamus by GluN2C-containing NMDA receptors. Liu J, Shelkar GP, Zhao F, Clausen RP, Dravid SM.
    96 (2), p. 193-203 2019
  • Scientific Reports
    Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes. Shelkar GP, Pavuluri R, Gandhi PJ, Ravikrishnan A, Gawande DY, Liu J, Stairs DJ, Ugale RR, Dravid SM
    20;9(1), p. 7572 2019
  • Epilepsia
    A mouse model of seizures in anti-N-methyl-d-aspartate receptor encephalitis. Taraschenko O, Fox HS, Pittock SJ, Zekeridou A, Gafurova M, Eldridge E, Liu J, Dravid SM, Dingledine R.
    60(3), p. 452-463 2019
  • Neurochemical Research
    In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons. Alsaad HA, DeKorver NW, Mao Z, Dravid SM, Arikkath J, Monaghan DT.
    44(1), p. 61-77 2019
  • Translational Psychiatry
    Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens.Liu J, Gandhi PJ, Pavuluri R, Shelkar GP, Dravid SM.
    12;8(1), p. 219 2018
  • Neuroscience
    Region-specific Expression of NMDA Receptor GluN2C Subunit in Parvalbumin-Positive Neurons and Astrocytes: Analysis of GluN2C Expression using a Novel Reporter Model. Ravikrishnan A, Gandhi PJ, Shelkar GP, Liu J, Pavuluri R, Dravid SM.
    380, p. 49-62 2018
  • Nature Neuroscience
    Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior. Jung EM, Moffat JJ, Liu J, Dravid SM, Gurumurthy CB, Kim WY.
    20(12), p. 1694-1707 2017
  • Neuropharmacology
    Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives.Sapkota K, Irvine MW, Fang G, Burnell ES, Bannister N, Volianskis A, Culley GR, Dravid SM, Collingridge GL, Jane DE, Monaghan DT.
    125, p. 64-79 2017
  • Scientific Reports
    A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors.Chopra DA, Sapkota K, Irvine MW, Fang G, Jane DE, Monaghan DT, Dravid SM.
    7(1), p. 6933 2017
  • Stem Cells
    Generation of Functional Human Retinal Ganglion Cells with Target Specificity from Pluripotent Stem Cells by Chemically Defined Recapitulation of Developmental Mechanism. Teotia P, Chopra DA, Dravid SM, Van Hook MJ, Qiu F, Morrison J, Rizzino A, Ahmad I.
    35(3), p. 572-585 2017
  • Scientific Reports
    The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function. Gupta SC, Ravikrishnan A, Liu J, Mao Z, Pavuluri R, Hillman BG, Gandhi PJ, Stairs DJ, Li M, Ugale RR, Monaghan DT, Dravid SM.
    6, p. 38321 2016
  • British Journal of Pharmacology
    Interactions of nitric oxide with α2 -adrenoceptors within the locus coeruleus underlie the facilitation of inhibitory avoidance memory by agmatine. Shelkar GP, Gakare SG, Chakraborty S, Dravid SM, Ugale RR.
    173(17), p. 2589-99 2016
  • Molecular Pharmacology
    Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus. Suryavanshi PS, Gupta SC, Yadav R, Kesherwani V, Liu J, Dravid SM.
    90(2), p. 96-105 2016
  • Journal of neuroscience : the official journal of the Society for Neuroscience
    Essential Roles for ARID1B in Dendritic Arborization and Spine Morphology of Developing Pyramidal Neurons. Ka M, Chopra DA, Dravid SM, Kim WY.
    36(9), p. 2723-42 2016
  • Molecular Pharmacology
    Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors. Kristensen AS, Hansen KB, Naur P, Olsen L, Kurtkaya NL, Dravid SM, Kvist T, Yi F, Pøhlsgaard J, Clausen RP, Gajhede M, Kastrup JS, Traynelis SF.
    89(2), p. 253-62 2016
  • Molecular Pharmacology
    Bidirectional Effect of Pregnenolone Sulfate on GluN1/GluN2A N-Methyl-D-Aspartate Receptor Gating Depending on Extracellular Calcium and Intracellular Milieu. Chopra DA, Monaghan DT, Dravid SM 
    88(4), p. 650-9 2015
  • Neuropharmacology
    Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity. Gupta SC, Yadav R, Pavuluri R, Morley BJ, Stairs DJ, Dravid SM
    2015 Jun;93, p. 274-84 2015
  • Stem Cells
    Continuous non-cell autonomous reprogramming to generate retinal ganglion cells for glaucomatous neuropathy Parameswaran S, Dravid SM, Teotia P, Krishnamoorthy RR, Qiu F, Toris C, Morrison J, Ahmad I
    Jun;33(6), p. 1743-58 2015
  • Molecular Brain
    Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors Park H, Han KS, Seo J, Lee J, Dravid SM, Woo J, Chun H, Cho S, Bae JY, An H, Koh W, Yoon BE, Berlinguer-Palmini R, Mannaioni G, Traynelis SF, Bae YC, Choi SY, Lee CJ.
    Feb 3;8:7 2015
  • Frontiers in Cellular Neuroscience
    Spatially selective photoconductive stimulation of live neurons. Campbell J, Singh D, Hollett G, Dravid SM, Sailor MJ, Arikkath J.
    8:142, p. doi: 10.3389/fncel.2014.00142. 2014
  • British Journal of Pharmacology
    GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice. Suryavanshi PS, Ugale RR, Yilmazer-Hanke D, Stairs DJ, Dravid SM
    171(3), p. 799-809 2014
  • European Journal of Neuroscience
    Effect of D-cycloserine in conjunction with fear extinction training on extracellular signal-regulated kinase activation in the medial prefrontal cortex and amygdala in rat. Gupta SC, Hillman BG, Prakash A, Ugale RR, Stairs DJ, Dravid SM.
    37(11), p. 1811-22 2013
  • PLoS One
    Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning Yadav R, Hillman BG, Gupta SC, Suryavanshi P, Bhatt JM, Pavuluri R, Stairs DJ, Dravid SM
    8(4), p. e60785 2013
  • Molecular Pharmacology
    Effect of ifenprodil on GluN1/GluN2B N-methyl-D-aspartate receptor gating. Bhatt JM, Prakash A, Suryavanshi PS, Dravid SM
    83(1), p. 9-21 2013
  • PLoS One
    Yadav R, Gupta SC, Hillman BG, Bhatt JM, Stairs DJ, Dravid SM Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors
    7(3):e32969 2012
  • Molecular Pharmacology
    Opioid receptor inhibition of calcium oscillations in spinal cord neurons. Kelamangalath L, Dravid SM, George J, Aldrich JV, Murray TF.
    79:6, p. 1061-71 2011
  • Neurobiology of Learning and Memory
    Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory Hillman BG, Gupta SC, Stairs DJ, Buonanno A, Dravid SM
    95:4, p. 404-14 2011
  • Brain Res
    Mutations in the transmembrane domain M3 generate spontaneously open orphan glutamate delta 1 receptor Yadav R, Rimerman R, Scofield MA, Dravid SM
    1382, p. 1-8 2011
  • Journal of Pharmacology and Experimental Therapeutics
    Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels. Jabba SV, Prakash A, Dravid SM, Gerwick WH, Murray TF.
    332(3), p. 698-709 2010
  • Journal of Neuroscience
    Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors. Dravid SM, Burger PB, Prakash A, Geballe MT, Yadav R, Le P, Vellano K, Snyder JP, Traynelis SF.
    30(7), p. 2741-54 2010
  • Journal of Neuroscience
    George J, Dravid SM, Prakash A, Xie J, Peterson J, Jabba SV, Baden DG, Murray TF. Title: Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons.
    29 (10), p. 3288-301 2009
  • Journal of Physiology
    Dravid SM, Prakash A, Traynelis SF. Title: Activation of recombinant NR1/NR2C NMDA receptors.
    486 (18), p. 4425-39 2008
  • Proceedings of the National Academy of Sciences
    Naur P, Hansen KB, Kristensen AS, Dravid SM, Pickering DS, Olsen L, Vestergaard B, Egebjerg J, Gajhede M, Traynelis SF, Kastrup JS. ”Ionotropic glutamate-like receptor delta2 binds D-serine and glycine.”
    104(35), p. 14116-21 2007
  • Journal of Physiology
    Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block. Dravid SM, Erreger K, Yuan H, Nicholson K, Le P, Lyuboslavsky P, Almonte A, Murray E, Mosely C, Barber J, French A, Balster R, Murray TF, Traynelis SF.
    581(Pt 1), p. 107-28 2007
  • Journal of Neuroscience
    Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog. Erreger K, Geballe MT, Dravid SM, Snyder JP, Wyllie DJ, Traynelis SF.
    25(34), p. 7858-66 2005
  • Journal of Biological Chemistry
    Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3. Yuan H, Erreger K, Dravid SM, Traynelis SF.
    280(33), p. 29708-16 2005
  • Journal of Physiology
    Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signaling profiles. Erreger K, Dravid SM, Banke TG, Wyllie DJ, Traynelis SF.
    563(2), p. 345-58 2005
  • Brain Res
    Brevetoxin augments NMDA receptor signaling in murine neocortical neurons. Dravid SM, Baden DG, Murray TF.
    1031(1), p. 30-8 2005
  • Journal of Neuroscience
    Protons trap NR1/NR2B NMDA receptors in a nonconducting state. Banke TG, Dravid SM, Traynelis SF.
    25(1), p. 42-51 2005
  • Journal of Neurochemistry
    Brevetoxin activation of voltage-gated sodium channels regulates Ca dynamics and ERK1/2 phosphorylation in murine neocortical neurons. Dravid SM, Baden DG, Murray TF.
    89(3), p. 739-49 2004
  • Brain Res
    Spontaneous synchronized calcium oscillations in neocortical neurons in the presence of physiological [Mg(2+)]: involvement of AMPA/kainate and metabotropic glutamate receptors Dravid SM, Murray TF.
    1006(1), p. 8-17 2004
  • Neuroscience Letters
    Fluorescent detection of Ca2+-permeable AMPA/kainate receptor activation in murine neocortical neurons Dravid SM, Murray TF.
    35(3), p. 145-8 2003

Presentations

  • Society for Neuroscience Annual Meeting. Poster presentation. Ultrastructural localization of glutamate delta-1 subunit in the mouse striatum. Hoover A., Villalba R. M., Pare J-F., Liu J., Gandhi P.J, Shelkar G. P., Pavuluri R., Dravid S. M., Smith Y. Prog No. 034.02/B30. SFN 2019 online 2019
  • Society for Neuroscience Annual Meeting. Poster presentation. Role of GluN2C subunit in nucleus reticularis of the thalamus in schizophrenia-like phenotypes in mice. Shelkar G. P., Liu J., Zhao F., Pavuluri R., Clausen R. P., Dravid S. M. Prog No. 087.20/AA16. SFN 2019 online 2019
  • Soceity for Neuroscience Annual Meeting. Poster presentation. Effect of region-specific deletion of glutamate delta 1 receptors on cognitive flexibility in mice. Gawnade D. Y., Shelkar G. P., Pavuluri R., Dravid S. M. Prog No. 034.04/B32. SFN 2019 online 2019
  • Society for Neuroscience Annual Meeting. Poster presentation. Expression of GluN2C subunit in parvalbumin positive neurons and astrocytes: Relevance to schizophrenia. Gandhi P. J., Shelkar G. P., Pavuluri R., Liu J., Dravid S. M. Prog No. 370.17/D22. SFN 2018 online 2018
  • Society for Neuroscience Annual Meeting. Poster presentation. Glutamate delta-1 subunit regulates cocaine-induced plasticity in the nucleus accumbens. Liu J., Gandhi P.J, Pavuluri R., Shelkar G. P., Dravid S. M. Prog No. 161.14/AAA25. SFN 2018 online. 2018
  • Society for Neuroscience Annual Meeting. Poster presentation.Deletion of Neurexin 1 binding glutamate delta-1 subunit produces cortico-striatal dysfunction: relevance to autism. Liu J., Dravid S. M. (2016) Prog No. 121.10/D17. SFN 2016 online. 2016
  • Society for Neuroscience Annual Meeting. Poster presentation. Differential role of NMDA receptors GluN2C and GluN2D subunits in cocaine addiction. Shelkar G. P., Pavuluri R., Liu J., Gandhi P. J., Dravid S. M. Prog No. 419.20/GGG10. SFN 2018 online. 2016
  • Cortico-limbic circuit dysfunction in NMDA receptor hypofunction model of schizophrenia. Prog No. 227.11/I3. SFN 2015 online.Ravikrishnan A., Gupta S. C., Hillman B. G., Dravid S. M.  2015
  • Society for Neuroscience Annual Meeting. Poster presentation. Novel mechanisms of pregnenolone sulfate modulation of GluN1/GluN2A NMDA receptor gating. Prog No. 383.08/A87. SFN 2015 online.   2015
  • Poster presentation Title: Gating effects of a novel allosteric modulator at GluN1/GluN2A NMDA receptors Chopra D. A., Irvine M. W., Jane D. E., Monaghan D. T., Dravid S. M.FASEB J, April 2015; 29, 933.3 2015
  • Society for Neuroscience Annual meeting. Poster presentation Title: The NMDA receptor GluN2C subunit regulates behavioral and cellular phenotypes relevant to schizophrenia 2. Ravikrishnan A., Hillman B. G., Gupta S. C., Pavuluri R., Stairs D. J., Dravid S. M 2014
  • Society for Neuroscience Annual meeting. Poster presentation Title: Glutamate delta-1 receptor regulates dendritic spine morphology and density in cortico-limbic circuit *S. C. GUPTA1, P. S. SURYAVANSHI1, B. J. MORLEY2, S. M. DRAVID1; 2013
  • Society for Neuroscience Annual meeting. Poster presentation Title: Voltage-gated sodium channel activator enhancement of immature cerebrocortical neuron development requires both the N-methyl-D-aspartate receptor 2B (GluN2B) and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) *S. MEHROTRA, S. M. DRAVID, T. F. MURRAY 2013
  • Society for Neuroscience Annual meeting. Poster presentation Title: Best1-mediated astrocytic glutamate lowers the threshold of synaptic plasticity *J. LEE1, H. PARK1, K.-S. HAN1, J. SEO2, S. M. DRAVID3, J. WOO1, H. CHUN1, S. CHO2, T. KIM1, H. AN1, B.-E. YOON1,4, R. BERLINGUER-PALMINI5, G. MANNAIONI6, S. F. TRAYNELIS7, S. CHOI2, C. LEE1; 2013
  • Targeting the NMDA receptor hypofunction hypothesis of schizophrenia: Emerging clues from genetic models and drug discovery efforts Winter Conference on Brain Research Panel Chair 2013
  • Protease activated receptor regulates migration and invasion of glioblastoma via transactivation of EGFR. Gupta S.C., Bandyopadyay B., Prakash A., Yadav R. and Dravid S.M. Society for Neuroscience 2012 2012
  • Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficits in contextual fear conditioning. Suryavanshi P.S., Yadav R., Hillman B.G., Gupta S.C., Stairs D.J. and Dravid S.M. Society for Neuroscience 2012 2012
  • INBRE 'Ionotropic glutamate receptors: Therapeutic potential in neuropsychiatric disorders' 2012
  • Hillman B.G., Stairs D.J. and Dravid S.M. (2012) Role of GluN2C-containing receptors in rodent schizophrenia-like phenotypes. FASEB J, March 29, 26:1045.5 2012
  • Ugale R.R., Hillman B.G., Gupta S.C., Suryavanshi P., Stairs D.J. and Dravid S.M. (2012) Role of NMDA receptor subtype in regulation of central amygdala. FASEB J, March 29, 26:lb574. 2012
  • Dravid S.M., Mannioni G., Lee J., Wahl P., Lee C.J. and Traynelis S.F. (2012). Protease activated receptor-1 (PAR1) control of glutamate time course in the synaptic cleft. FASEB J, March 29, 26:lb577. 2012
  • Society for Neuroscience Annual meeting. Poster presentation. Gupta S.C., Hillman B.G., Prakash A., Stairs D.J. and Dravid S.M. (2011). D-cycloserine potentiates fear extinction-induced ERK activation in prefrontal cortex and lateral nucleus of central amygdala. Prog No. 762.17. SFN 2011 online. 2011
  • Society for Neuroscience Annual meeting. Poster presentation. Murray T.F., Kelamangalath L., George J., Dravid S.M. and Aldrich J.V. (2011). Kappa-opioid receptor inhibition of calcium oscillations in spinal cord neurons. Prog No. 341.24. SFN 2011 online. 2011
  • Hillman B.G., Gupta S.C., Suryavanshi P.S., Stairs D.J. and Dravid S.M. (2011). Regulation of inhibitory tone in the central amygdala by NMDA receptor GluN2C subunit. Gordon Research Conferences. Amygdala in health and disease. 2011
  • Adopting the orphan glutamate delta-1 receptor at Indian Institute of Sciences, Bangalore 2011
  • The orphan glutamate delta-1 receptor: potential role in central nervous system and mental disorders NIMHANS, Bangalore, India 2011
  • Society for Neuroscience Annual meeting. Poster presentation. Ablation of nr2c receptor models negative symptoms of schizophrenia B. HILLMAN1, S. GUPTA1, D. STAIRS2, S. DRAVID1 2010
  • Society for Neuroscience Annual meeting. Poster presentation. Effects of Ifenprodil on NR1/NR2B NMDA receptor gating J. M. BHATT1, A. PRAKASH1, *S. DRAVID2; 2010
  • Society for Neuroscience Annual meeting. Poster presentation. Kappa opioid receptor regulation of spontaneous calcium oscillations in embryonic spinal cord neurons L. KELAMANGALATH1, S. DRAVID1, J. ALDRICH2, T. F. MURRAY 2010
  • Society for Neuroscience Annual meeting. Poster presentation. Functional study of ionotropic glutamate delta-1 receptor R. YADAV, M. SCOFIELD, R. A. RIMERMAN, S. M. DRAVID 2010
  • Society for Neuroscience Annual meeting. Poster presentation. Structure-function study of ionotropic glutamate delta-1 receptor. R. YADAV, M. ROENFELD, M. SCOFIELD, S. DRAVID 2009
  • Society for Neuroscience Annual meeting. Poster presentation. Acquisition of fear and extinction in an NR2C knock-out B. HILLMAN, S. DRAVID 2009
  • Tuesday Night Neuroscience 'Adopting the orphan glutamate delta receptor.' 2008
  • Society for Neuroscience Annual meeting. Poster presentation S. M. DRAVID, M. T. GEBALLE, J. P. SNYDER, S. F. TRAYNELIS Residue at dimer interface of NR1/NR2C ligand binding domain control the relative efficacy of D-cycloserine 2007
  • Society for Neuroscience Annual Meeting. Poster presentation. Differential role of GluD1 in synapse maintenance. Gandhi P.J, Liu J., Shelkar G. P., Pavuluri R., Dravid S. M. Prog No. 034.03/B31. SFN 2019 online