Mark J . Holmberg, MD, PhD

Department

Medicine

Position

Professor

Articles

• Cardiovasc Hematol Disord Drug Targets
  , Latif A, Lateef N, Razzaq F, Kapoor V, Ahsan MJ, Ashfaq, Iftikhar A, Anwer F, Holmberg M, William P. Fundamentals of Light Chain Cardiac Amyloidosis: A Focused review. Cardiovasc Hematol Disord Drug Targets 2020 Nov; 20(4):274-283. 2020
• Circulation
  Haddad M, Abuzaid A,Narayanan M, Holmberg M. Recurrent Spontaneous Coronary Artery Dissection Treated Medically. Circ 2014;I30:A20381  2018
• Journal of American College of Cardiology
  , Jhand A, Kabach A, Smer A, Holmberg M. Unusual Source of Bacteremia in a Patient with Prosthetic Valve and Implantable Defibrillator. Journal of the American College of Cardiology 71 (11 Supplement), A2278. March 2018
  aa, p. A2278 2018
• Criminology and Criminal Justice: Theory, Research Methods and Statistics
  Vallabhajosyula S, Sundaragiri PR, Kanmanthareddy A, Ahmed AA. Mahfood Haddad T, Rayes HA, Khan AN, Buaisha HM, Pershwitz GE, McCann DA, Holmberg MJ, Morrow LE. Influence of left ventricular hypertrophy on in-hospital outcomes in acute exacerbation of chronic obstructive pulmonary disease. COPD. 2016;13(6):712-717. PMID: 273798  2016
• COPD
  Vallabhajosyula S, Sundaragiri PR, Kanmanthareddy A, Ahmed AA. Mahfood Haddad T, Rayes HA, Khan AN, Buaisha HM, Pershwitz GE, McCann DA, Holmberg MJ, Morrow LE. Influence of left ventricular hypertrophy on in-hospital outcomes in acute exacerbation of chronic obstructive pulmonary disease. COPD. 2016;13(6):712-717. PMID: 27379826 
  13;6, p. 712-17 2016
• Journal of Cardiovascular Surgery
  Smer A, Alla V, Chandraprakasam S, Abuzaid A, Saurav A, Holmberg J. Saphenous venous graft pseudoaneurysm: a review of the literature. J Card Surg. 2015 Jan;30(1):70-3
  30;1, p. 70-3 2015
• JACC
  Chandraprakasam S, Saurav A, Patel N, Sirineni G, Holmberg M, Nair C, Biddle W, Hunter C. RUPTURED SINUS OF VALSALVA ANEURYSM WITH SPONTANEOUS CLOSURE OF PERIMEMBRANOUS VENTRICULAR SEPTAL DEFECT: DIFFICULT DIAGNOSIS AND DISCREPANCIES IN MULTI-MODALITY IMAGING. J Am Coll Cardiol. 2014 4/1;63(12, Supplement):A614. 
  2014 4/1;63(12, Supplement):A614. 2014
• Journal of Heart Valve Disease
  Deshmukh A, Schima SM, White MD, Arouni AJ, Holmberg MJ. Right-Heart Failure and Hypotension after Arteriovenous Graft Placement in a Patient with Idiopathic Tricuspid Annular Dilatation. J Heart Valve Dis. 2012 MAY;21(3):406-7. 
  21:3, p. 406-7 2012
• American Heart Asso
  Shen X, Li H, Holmberg MJ, Cloutier D, Aryana A,Rovang K, Hee T, Mooss AN, Mohiuddin SM. Correlation between QRS Duration and Various Echocardiographic Parameters in Patinets scheduled to receive the Biventricular Pacemaker. Submitted to AHA 2005 2005
• American Heart Asso
  Holmberg MJ, Shen X, Li H, Lakkireddy DJ, Cloutier D, Rovang K, Hee T, Mooss AN, Mohiuddin SM. Anticoagulation on Thromboembolism in Atrial Fibrillation Patients with and without left Atrial Thrombi Documented by Transesophageal Echocardiography. Submitted to AHA 2005 2005
• Chest
  Shen X, Li H, Hee T, Lakkireddy DJ, Holmberg MJ, Cloutier D, Rovang K, Mooss AN, Mohiuddin SM. Does mitral regurgitation provide protection against the formation of left atrial thrombus and embolic cerebral vascular accident in patients with atrial fibrillation? Submitted to Chest 2005 2005
• Chest
  Shen X, Li H, Lakkireddy DJ, Thambidorai S, Cloutier D, Holmberg MJ, Mooss AN, Mohiuddin SM. Does the aortic atherosclerotic plaques severity correlate with embolic events? Submitted to Chest 2005 2005
• Echocardiography
  Shen X , Holmberg MJ, Sype J, Hunter C, Mooss AN, Mohiuddin SM.Real-time three-dimensional echocardiography in diagnosis of right ventricular pseudoaneurysm after pacemaker implantation. Echocardiography 2005 in press 2005
• Clinical Cardiology
  Shen X, Li H, Holmberg MJ, Lakkireddy DJ, Cloutier D, Rovang K, Hee T, Mooss AN, Mohiuddin SM. Left atrial thrombus in patients with atrial fibrillation: the benefit of anticoagulation and the implication of clot persistence. Submitted to Clinical Coardiology 2005 2005
• Chest
  Holmberg MJ, Shen X, Li H, Lakkireddy DJ, Cloutier D, Rovang K, Hee T, Mooss AN, Mohiuddin SM. Thromboembolism in atrial fibrillation patients with and without left atrial thrombi documented by transesophageal echocardiography. Submitted to Chest 2005 2005
• American Journal of Cardiology
  Shen X, Li H, Rovang KS, Hee TT, Holmberg MJ, Mooss AN, Mohiuddin SM. Transesophageal Echocardiography Before Cardioversion of Recurrent Atrial Fibrillation: Does Absence of Previous Atrial Thrombi Preclude the Need of a Repeat Test? Am Heart J 2003;146:741-755
  146, p. 741-755 2003
• Circulation
  Lakkireddy DJ, Shen XD, Li H, Holmberg MJ, Cloutier D, Rovang K, Hee T, Mooss AN, Mohiuddin SM. Prognosis of Patients with Persistent Atrial Thrombus and Atrial Fibrillation on Anticoagulation. Circulation 2003 2003
• American Journal of Cardiology
  Prevention of Intra-Atrial Thrombi in Atrial Fibrillation. Patients with subtherapeutic International Normalized Ratios while Taking Conventional Anticoagulation. Shen XD, Li H, Rovang K, Hee T, Holmberg MJ, Mooss AN, Mohiuddin SM.
  90 (6), p. 660-662 2002
• Journal of Heart Failure
  Holmberg MJ, Abdul-Aziz S, Shen XD, Price C, Li HG, Johnson TC, Mooss, AN, Mohiuddin SM. A novel approach to improve accuracy of measurement of left ventricular function in patienbts with suboptimal echocardiogram images.
  7(1) 2002
• J Heart Disease
  Shen X, Holmberg MJ, Johnson T, Mooss AN, Mohiuddin S: Measurement of left ventricular volume by echocardiographic automated border detection in models with contrast micro-bubbles 2001
• Pharmacotherapy
  Benzocaine-Induced Methemoglobinemia during an outpatient procedure.
  20, p. 735-738 2000
• Not Applicable
  Correlation of Intensity of AS Murmur... 1999

Publications

• American College of Cardiology
  , Ismayl M, Radaideh Q, Abusnina W, Salah A, Aboeta A, Holmberg M. A Rare Case of Acute Limb Ischemia From Embolization of LV Pseudoaneurysm Thrombus. (In Press for ACC 2022) 2022
• Circulation
  Fluoroquinolones and the Risk of Aortopathy: A Systematic Review and Meta-Analysis Azka Latif  Muhammad Junaid Ahsan  Saad Ullah Malik  Noman Lateef  Vikas Kapoor  Muhammad Fazeel Anwar  Mohsin M Mirza Mark J Holmberg Originally published11 Nov 2019Circulation. 2019;140:A15936 
  140, p. A15936 2019
• Circulation
  Impact of Extent of Coronary Revascularization on Mortality After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-AnalysisMuhammad Junaid Ahsan  Noman Lateef  Saad Ullah Malik Muhammad Fazeel Anwar  Hafiz Muhammad Z Zubair  Azka Latif Mohsin M Mirza  Mark J Holmberg Originally published11 Nov 2019Circulation. 2019;140:A15926 
  140, p. A15926 2019
• JACC
  Gangi RP, Akinapelli A, Koneru S, Matta A, Vallabhajosyula S, Bellamkonda P, Alla V, Mooss A, Nair C, Holmberg M, Sugimoto J. IMPACT OF MITRAL ANNULAR CALCIFICATION ON OUTCOMES OF AORTIC VALVE SURGERY. J Am Coll Cardiol. 2014 4/1;63(12, Supplement):A2010. 
  63:12, p. A2010 2014
• JACC
  Lavu M, Holmberg M. ADDISON'S DISEASE PRESENTING AS ‘STEMI’. J Am Coll Cardiol. 2014 4/1;63(12, Supplement):A657
  63;12, p. A657 2014
• JACC
  Kaushik M, Saurav A, Smer A, Alla VM, Khan S, Madan R, Holmberg MJ, Mohiuddin, S.  Epicardial Adipose Tissue as Assessed by Echocardiography and Incident Cardiac Disease. J Am Coll Cardiol. 2012 MAR 27;59(13):E1159
  59;13, p. E1159 2012
• ACC Current Journal Review
  Shen X, Li H, Nair CK, Holmberg MJ, Lakkireddy D, Cloutier D, Rovang K, Hee TT, Mooss AN, Mohiuddin SM. Different implications of left atrial thrombus detected by transesophageal echocardiography in atrial fibrillation patients with and without warfarin therapy. ACC (Accepted) 2006. 2006
• Journal of Cardiovascular Ultrasound & Allied Techniques
  21. Xuedon Shen, M.D., Holmberg, MJ, John Sype, M.D., Claire Hunter, M.D., Aryan N. Mooss, M.D., and Syed M. Mohiuddin, M.D.;”Real-Time Three-Dimensional Echocardiography in Diagnosis of Right Ventricular Pseudoaneurysm after Pacemaker Implantation”; Echocardiography A Journal of Cardiovascular Ultrasound and Allied Techniques, Volume 23, Number 3, pp 240-243, March 2006
  23 #3, p. 240-243 2006
• J American College of Cardiology
  19. Shen XD, Li HU, Holmberg MJ, Reddy M, Kusler M, Almeida N, Cloutier D, Rovang K, Hee T, Mooss A, Mohiuddin SM. Outcome in Heart Failure in Narrow QRS Patients With and Without Left Ventricular Dyssynchrony. J Am Coll Cardiol 2006; 47(4): 99A.
  47 (4), p. 99A 2006
• J American College of Cardiology
  Shen XD, Li HU, Nair C, Holmberg MJ, Cloutier D, Rovang K, Hee T, Mooss A, Mohiuddin SM. Warfarin Therapy Initiated Before Transesophageal Echocardiography Detected Left Atrial Thrombus is More Beneficial than When Started After. J Am Coll Cardiol 2006; 47(4): 152A.
  47 (4), p. 152A 2006
• Journal of American Echo Society
  Shen XD, Li HU, Lakkireddy DJ, Holmberg MJ, Cloutier D, Rovang K, Hee T., Moss A, Mohiuddin SM. The Impact of Anticoagulation on Cerebrovascular Accidents in Patients with Atrial Fibrillation and Left Atrial Thrombi Documented by Transesophageal Echocardiography. J. Am Soc Echocardiog 2005;18 (5):561
  18, p. 561 2005
• Journal of American Echo Society
  Thambidorai S, Shen X, Nair CK, Li H, Lakkireddy DJ, Cloutier D, Holmberg MJ, Mooss AN, Mohiuddin SM. The incidenceof Embolic Stroke in Patients with Left Atrial Thrombus and/or Thoracic Aortic Plaques Assessed by Transesophageal Ehocardiography. J Am Soc Echocardiogr 2005;18(5):565
  18, p. 565 2005
• Circulation
  Repeat Transesophageal Echocardiography before Cardioversion of Recurrent atrial fibrillation. Is it Necessary in Undercoagulated Patients who had no Previous Atrial Thrombi? Shen XD, Li HG, Rovang KS, Hee T, Holmberg MJ, Mooss AN, Mohiuddin SM. 2002
• Circulation
  Automatead Echocardiographic Determination of Left Ventricular Function in Patients with Suboptimal Endocardial Visualization. Holmberg MJ, AbdulAziz S, Shen XD, Price C, Li HG, Johnson TC, Del Core M, Mooss AN, Mohiuddin SM, Porter TR. 2002
• Circulation
  Contrast Echocardiography Enhances Automated Border Detection Evaluation of Left Ventricular Function as compared to Manual Tracing. Holmberg MJ, AbdulAziz S, Shen XD, Price C, Li HG, Johnson TC, Del Core M, Mooss AN, Mohiuddin SM 2002
• J American College of Cardiology
  Shen X, Li H, Rovang K, Hee T, Holmberg JM, Mohiuddin SM. Transesophageal echocardiography before cardioversion of atrial fibrillation: Is it needed for patients receiving conventional antocoagulation but having sibtherapeutic INR?
  39, p. 376 A 2002
• Not Applicable
  Peripheral Endothelial Function: Is There a Gender Difference? in Oct '99 Chest 1999
• Not Applicable
  Does Ausculatory Grade of AS Murmur... in Journal of American Society of Echocardiography Jul '99 1999
• Smer A, Alla V, Chandraprakasam S, Abuzaid A,Saurav A, Holmberg J. Saphenous venous graft pseudoaneurysm: A review of the literature. J Card Surg 2015; 30(1):70-73. 

Editing and Reviews

• Holmberg, MJ (contributing editor) Koster  N.. Cardiovascular Imaging Review, Expert Consult-Online and Print. Philadelphia, PA: Elsevier July 2011 

General

• Vallabhajosyula S,Sundaragiri PR, Bellamkonda P, Holmberg MJ. Coronary arteriovenous fistula with coexisting atrial septal defect. BMJ Case Rep. 2014 May 5;2014. 
• Deshmukh A, Schima SM, White MD, Arouni AJ, Holmberg MJ. Right-heart Failure and Hypotension after Arteriovenous Graft Placement in a Patient with Idiopathic Tricuspid Annular Dilatation. J Heart Valve Dis. 2012; 21(3):406-407
• Kaushik M, Saurav A, Smer A, Alla, VM, Khan S, Madan R, Holmberg MJ, Mohiuddin S. Epicardial adipose tissue as assessed by echocardiography and incident cardiac disease. J Am Coll Cardiol. 2012; 59(13):E1159-E1159. 
• Shen X, Nair, CK, Aronow W, Holmberg MJ, Reddy M, Anand K, Hee T, Chen A, Fang X, Maciejewski S, Esterbrooks D.  A New Baseline Scoring System May Help to Predict Response to Cardiac Resynchronization Therapy.  Arch Med Sci. 2011; 7(4):  627-633

Presentations

• Stable Chest Pain Evaluation in the Office, Dept of Medicine Grand Rounds, 5/21/21 2021
• Impact of Extent of Coronary Revascularization on Mortality After Transcatheter Aortic Valve Replacement: A Slystematic Review and Meta-Analysis. Ahsan, J., Holmberg, M. American Heart Association Conference, Philadelphia, PA. 2019
• Fluoroquinolones and the Risk of Aortopathy: A Systematic Review and Meta-Analysis. Latif, A., Holmberg, M. American Heart Association Conference, Philadelphia, PA. 2019
• CU School of MedicineCardiology Grand Rounds"The Left Atrium: Function and Dysfunction" 2018
• “A Bridge Too Far?” presented at the Department of Medicine Grand Rounds 2015
• A True View of the Heart: 3-D Echocardiography, Creighton University Medical Center 07/07/2005. 2005
• Tricuspid Regurgitation, Cardiology Grand Rounds, Creighton University Medical Center 2005
• 16. Contrast Echocardiography Enhance Automated Border Detection Evaluation of Left Ventricular Function as Compared to Manual Tracing. AHA, Chicago, IL. 2003
• Holmberg MJ, AbdulAziz S, Shen XD, PRice C, Li HG, Johnson TC, DelCore M, Mooss AN, Mohiuddin SM, Porter TR. Automated Echocardiographic Determination of Left Ventricular Function in Patients with Suboptimal Endicardial Visualization. Presented at American Heart Association Scientific Session 2002, Chicago IL 2002
• Shen XD, Li HG, Rovang KS, Hee T, Holmberg MJ, Mooss AN, Mohiuddin SM. Repeat Transesophageal Echocardiography before Cardioversion of Recurrent atrial fibrillation. Is it Necessary in Undercoagulated Patients who had no Previous Atrial Thrombi? Presented at American Heart Association Scientific Session 2002 2002
• Holmberg MJ, AbdulAziz S, Shen XD, Price C, Li HG, Johnson TC, DelCore M, Mooss AN, Mohiuddin SM. Contrast Echocardiography Enhances Automated Border Detection Evaluation of Left ventricular Function as compared to Manual Tracing. Presented at American Heart Association Scientific Session 2002, Chicago IL 2002
• Holmberg MJ. Stress echocardiography. Presented at American Association of Cardiovascular and Pulmonary Rehabilitation, 17th Annual Meeting, Charlotte, NC 2002
• Holmberg MJ, AbdulAziz S, Shen XD, Price C, Li HG, Johnson TC, Mooss AN, Mohiuddin SM. A novel approach to Improve Accuracy of Measurement of Left Ventricular Function in Patients with Suboptimal Echocardiogram Images. Presented at the 8th World Congress on Heart Failure-Mechanisms and Management, Washington DC 2002
• Management of Heart Failure. American Association of Cardiovascular and Pulmonary Rehabilitation Annual Meeting. Tampa, FL 2000
• Peripheral Endothelial Function: Is There a Gender Difference? Am. College of Chest Physicians, Chicago, IL Nov '99 1999

Other

• EMPEROR-PRESERVED: A Phase III Randomized, Double-Blind Trial to Evaluate Efficacy and Safety of Once Daily Empagliflozin 10 mg Compared to Placebo, in Patients with Chronic Heart Failure with Preserved Ejection Fraction (Boehringer Ingelheim), 6/27/2017 – 5/28/21, Sub-investigator