Gajanan Shelkar, PhD

Department

Pharmacology and Neuroscience

Position

Resident Assistant Professor

Articles

• Neurobiology of Disease
  Gawande DY, Shelkar G, Narasimhan K, Dravid SM GluN2D subunit-containing NMDA receptors regulate reticular thalamic neuron function and seizure susceptibility
  181, p. 106117 2023
• Biological Psychiatry
  Gawande DY, Narasimhan K, Shelkar G, Pavuluri R, Stessman HA, Dravid SM GluN2D subunit in parvalbumin interneurons regulates prefrontal cortex inhibitory circuit, transcriptomics and cognitive flexibility relevant to schizophrenia. 2023
• Science Advances
  Shelkar GP, Gandhi PJ, Liu J, Dravid SM Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus
  8(29), p. eabo6574 2022
• Pharmacological Research
  Gawande DY, Narsimhan K, Bhatt J, Pavuluri R, Shelkar GP, Dravid SM Glutamate delta 1 receptor regulates autophagy mechanisms and affects excitatory synapse maturation in the somatosensory cortex.
  178, p. 106144 2022
• International Journal of Neuropsychopharmacology
  Shelkar GP, Liu J, Dravid SM Astrocytic NMDA receptors in the basolateral amygdala contribute to facilitation of fear extinction
  24(11), p. 907-919 2021
• Cells
  Gandhi PJ, Gawande DY, Shelkar GP, Gakare SG, Kiritoshi T, Ji G, Misra B, Pavuluri R, Liu J, Neugebauer V, Dravid SM Dysfunction of glutamate delta-1 receptor-cerebellin 1 trans-synaptic signaling in the central amygdala in chronic pain
  10(10), p. 2644 2021
• Molecular Neurobiology
  Gawande DY*, Shelkar GP*, Liu J*, , Ayala A, Pavuluri R, Choi D, Smith Y, Dravid SM Glutamate Delta-1 receptor regulates inhibitory neurotransmission in the nucleus accumbens core and anxiety-like behaviors.
  58(10), p. 4787-4801 2021
• Neurobiology of Disease
  Liu J*, Shelkar GP*, Sarode LP, Zhao F, Clausen RP, Ugale RR, Dravid SM Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model
  150, p. 105254 2021
• Journal of Comparative Neurology
  Hoover AH, Pavuluri R, Shelkar GP, Dravid SM, Smith Y, Villalba RM Ultrastructural localization of Glutamate Delta 1 (GluD1) receptor immunoreactivity in the mouse and monkey striatum
  529(7), p. 1703-1718 2020
• Neurobiology of Disease
  Liu J, Shelkar GP, Gandhi PJ, Gawande DY, Hoover A, Villalba RM, Pavuluri R, Smith Y, Dravid SM Striatal glutamate delta-1 receptor regulates behavioral flexibility and thalamostriatal connectivity
  137, p. 104746 2020
• Molecular Pharmacology
  Liu J*, Shelkar GP*, Zhao F, Clausen RP, Dravid SM Modulation of burst firing of neurons in nucleus reticularis of the thalamus by GluN2C-containing NMDA receptors
  96(2), p. 193-203 2019
• Scientific Reports
  Shelkar GP, Pavuluri R, Gandhi PJ, Ravikrishnan A, Gawande DY, Liu J, Stairs DJ, Ugale RR, Dravid SM Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes
  9(1), p. 7572 2019
• Translational Psychiatry
  Liu J, Gandhi PJ, Pavuluri R, Shelkar GP, Dravid SM Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens
  8(1), p. 219 2018
• Neuroscience
  Ravikrishnan A, Gandhi PJ, Shelkar GP, Liu J, Pavuluri R, Dravid SM Region-specific expression of NMDA receptor GluN2C subunit in parvalbumin-positive neurons and astrocytes: analysis of GluN2C expression using a novel reporter model
  380, p. 49-62 2018

Presentations

• Presented research work: Shelkar GP, Gandhi PJ, Jinxu Liu, Shashank M Dravid. (2022). Astrocytic GluN2C-containing NMDA receptors in the nucleus accumbens regulates cocaine-induced behavior and plasticity. "Neuroscience 2022, Society for Neuroscience conference", San Diego, CA, USA. 2022
• Presented research work: Shelkar GP, Jinxu Liu, Shashank M Dravid. (2021). Astrocytic GluN2C-containing NMDA receptors in the basolateral amygdala facilitate fear extinction. "Neuroscience 2021, Society for Neuroscience conference", Chicago, IL, USA. 2021
• Presented research work: Shelkar GP, Jinxu Liu, F. Zhao, Ratnamala Pavuluri, Pauravi Gandhi, R. Clausen, Shashank M Dravid. (2019). Role of GluN2C subunit in nucleus reticularis of the thalamus in MK-801 induced schizophrenia like condition in mice. "Neuroscience 2019, Society for Neuroscience conference", Chicago, IL, USA. 2019
• Presented research work: Shelkar GP, Ratnamala Pavuluri, Jinxu Liu, Pauravi Gandhi, Shashank M Dravid. (2018). Differential role of NMDA receptors GluN2C and GluN2D subunits in cocaine addiction. "Neuroscience 2018, Society for Neuroscience conference", San Diego, CA, USA. 2018

Awards

• 2021 Trainee Professional Development Award (TPDA)
  Neuroscience 2021, Society for Neuroscience conference", Chicago, IL, USA.
• Molecular Pharmacology Highlighted Trainee Author for the August 2019
  https://www.aspet.org/aspet/news/news/2019/07/17/molecular-pharmacology-highlighted-trainee-author-august-2019
  Molecular Pharmacology journal: American Society for Pharmacology and Experimental Therapeutics (ASPET)