Creighton is known for the opportunities it provides students to conduct valuable research. Here’s a snapshot of two dental students’ research project that was published in Scientific Reports.

Title of Research

In Silico Design of a Multivalent Vaccine against Candida Albicans

Student Researchers

Blake LaTendresse, second-year dental student, Overland Park, Kansas; and Laramie Lindgren, second-year dental student, Wahoo, Nebraska

Faculty Mentors

Shikha Tarang, PhD, assistant professor of oral biology; and Sonia Rocha-Sanchez, PhD, associate dean of dental research

What It Means

Dental students Blake LaTendresse and Laramie Lindgren assisted on groundbreaking research that identifies and recommends a vaccine to better protect against Candida albicans, a deadly fungal infection. Known as “oral-thrush,” Candida albicans overgrowth is not uncommon in patients wearing dentures. Candidemia is associated with high morbidity and mortality, and is one of the most common systemic fungal infections. Specific triggers such as a compromised immune system, poor diet and stress can cause Candida to become virulent, resulting in life-threatening blood infections. The vaccine aims to elicit robust, long-lasting immunity; further research on the project will continue in the dental school.