Sandor Lovas, PhD

Sandor Lovas, PhD

Sandor Lovas, PhD

Professor
School of Medicine, Omaha Campus

Expertise/Specializations

  • Biophysical Chemistry
  • Computational Chemistry
  • Biochemistry
  • PeptideChemistry
  • Structural Bioinformatics, Structural Proteomics

Academic Appointments

Department

  • Biomedical Sciences

Position

  • Professor

Publications and Presentations

Articles

  • , 42(2), 232-242
  • , 11, 3267-3278
  • , 20(17), 4194; https://doi.org/10.3390/ijms20174194
  • , 20(6), 1261; doi:10.3390/ijms20061261
  • , https://doi.org/10.17952/35EPS.2018.202, 202-203
  • , 86(3), 279-300, doi: 10.1002/prot.25439
  • , 210286; doi: 10.1101/210286
  • , 85(6), 1024-1044, doi:10.1002/prot.25270,
  • , 23, 1061-1071
  • , 290, 24326-24339
  • , 104, 156-166
  • , 2:93, doi: 10.3389/fchem.2014.00093. PMID: 25368867, PMCID: PMC4201147.
  • , 104, 156-166
  • , 311, 25-35
  • , 117, 6175-6186
  • , 20, 3303-3313
  • , 19, 616-624. doi:10.2174/092986612800493968
  • , 18, 252-260, doi: 10.1002/psc.2393
  • , 125, 1039-1047. doi: 10.1242/jcs.097337
  • , 11, 90. doi:10.1186/1472-6750-11-90
  • , 50, 5154–5162. doi:10.1021/bi200147a
  • , 115, 4971-4981. doi: 10.1021/jp111076j

Research and Scholarship

Research and Scholarship Interests

  • Conformation-biological activity relationships in peptides/proteins including GnRH, gastrin, antibacterial peptides, amyloidogenic peptides and chlorotoxins. Structural characterization of prestin. Inhibtion of biological activity of 14-3-3e protein.  Description of solution structure of polypeptides by Molecular Dynamics simulations and ab initio quantum chemical calculations. Effects of weakly polar interactions on peptide/protein structures using the above theoretical methods and vibrational  and/or electronic circular dichroism spectroscopy.
     

Current Research Projects

  • Inhibition of biological function of 14-3-3 proteins
    Inhibition of skin cancer growth
    Mechanism of Amyloid beta aggregation

Grant Funding Received

  • NSF-EPSCoR Major Research Research Instrumentation Program: High-Performance Computing Cluster for Biomolecular Calculations
  • NSF-EPSCoR Major Research Research Instrumentation Program: High-Performance Computing Cluster for Biomolecular Calculations
  • LB595 Program; Project Title: Molecular Mechanisms and Novel Targets in Cancer. Project PI: Novel therapeutic targets for nonmelanoma skin cancer Dates: 7/1/14-6/30/19; Role: collaborator
  • NSF-EPSCoR Major Research Research Instrumentation Program, Project title: A high-throughput multi-user Biacore surface plasmon resonance system for studying biomolecular and biochemical interactions.

Awards and Honors

  • Hansen, L.A., Lovas, S., and Palermo, N.: 14-3-3 targeting peptides for cancer treatment” 100900144USU1, 2020
  • New Antitumor GnRH Analogs and Pharmaceutical Compositions Containing Them as Active Agents. Hungarian Patent 212661; C07K 7/06 A61K 33/08, 1994, Inventors: Mezo, I.; Lovas, S. et al., 2003
  • Biocidal Molecules, Macromolecular Targets and Methods of Production and Use. International Application PCT/US01/01812, 2006, Inventors: Otvos, L.; Thurin, M.; Rogers, M.; Lovas, S., 2001
  • NOVEL GnRH ANALOGUES WITH ANTITUMOR EFFECTS AND PHARMACEUTICAL COMPOSITIONS THEREOF. (PCT/US01/01812), 2000