Sandor Lovas, PhD
Sandor Lovas, PhD

Sandor Lovas, PhD

Professor
School of Medicine

Expertise/Specializations

  • Biophysical Chemistry
  • Computational Chemistry
  • Biochemistry
  • PeptideChemistry
  • Structural Bioinformatics, Structural Proteomics

Academic Appointments

Department

  • Biomedical Sciences

Position

  • Professor

Education

  • Jozsef Attila University, Szeged, Hungary, M.Sc.,1977-82
  • Jozsef Attila University, Szeged, Hungary, Ph.D.,1985

Publications and Presentations

Articles

  • Charles R. Watts, Andrew Gregory, Cole Frisbie, Sándor Lovas. Effects of Force Fields on the Conformational and Dynamic Properties of Amyloid β(1-40) Dimer Explored by Replica Exchange Molecular Dynamics Simulations, bioRxiv, 210286; doi: 10.1101/210286, 2017
  • Charles R. Watts, Andrew J. Gregory, Cole P. Frisbie, and Sándor Lovas.  Structural Properties of Amyloid b(1-40) Dimer Explored by Replica Exchange Molecular Dynamics Simulations.
     doi:10.1002/prot.25270, PMID: 28241387, Proteins: Structure, Function and Genetics, 85(6), 1024-1044, 2017
  • Knappe, D.; Goldbach, T.; Hatfield, M.P.D.; Palermo, N.Y.; Weinert, S.; Sträter, N.; Hoffmann, R. and Lovas, S. Proline-rich Antimicrobial Peptides Optimized for Binding to Escherichia coli Chaperone DnaK. doi: 10.2174/0929866523666160719124712, PMID:274499., Protein and Peptide Letters, 23, 1061-1071, 2016
  • Lovas, S.; He, D.Z.Z.; Liu, H.; Tang, J.; Pecka, J.L.; Hatfield M.P.ED. and Beisel, K.W. Anion-pi Interaction is the Mechanism for the Voltage-Dependent Response of Prestin, the Motor Protein of Cochlear Outer Hair Cells. doi: 10.1074/jbc.M115.649962, PMID: 26283790, Journal of Biological Chemistry, 290, 24326-24339, 2015
  • Otvos, L. Jr.; Kovalszky, I.; Olah, J.; Coroniti, R.; Knappe, D.; Nollmann, F.I.; Hoffmann, R.; Wade, J.D.; Lovas, S. and Surmacz, E. Optimization of Adiponectin-derived Peptides for Inhibition of Cancer Cell Growth and Signaling. doi:10.1002/bip.22627., Biopolymers: Peptide Sci., 104, 156-166, 2015
  • Otvos, J. Jr.; Knappe, D.; Hoffmann, R.; Kovalszky, I.; Olah, J.; Hewitson, T.D.; Stawikowska, R.; Stawikowski, M.; Cudic, P.; Lin, F.; Wade, J.D.; Surmacz E. and Lovas, S. Development of Second Generation Peptides Modulating Cellular Adiponectin Receptor Responses., Frontiers in Chemistry, 2:93, doi: 10.3389/fchem.2014.00093. PMID: 25368867, PMCID: PMC4201147., 2014
  • Otvos, L. Jr.; Kovalszky, I.; Olah, J.; Coroniti, R.; Knappe, D.; Nollmann, F.I.; Hoffmann, R.; Wade, J.D.; Lovas, S. and Surmacz, E. Optimization of Adiponectin-derived Peptides for Inhibition of Cancer Cell Growth and Signaling. doi: 10.1002/bip.22627., Biopolymers: Peptide Sci., 104, 156-166, 2014
  • He, D.Z.Z.; Lovas, S.; Ai, Y.; Li, Y.; Beisel, K.W. Prestin at Year 14: Progress and Prospect. Hearing Res. doi: 10.1016/j.heares.2013.12.002., PMID: 24361298., 311, 25-35, 2014
  • Lovas, S.; Zhang, Y.; Yu, J.; Lyubchenko, Y.L. Molecular Mechanism of Misfolding and Aggregation of Ab(13-23). doi: 10.1021/jp402938p. PMID: 23642026; PMCID: PMC3695694, J. Phys. Chem. B, 117, 6175-6186, 2013
  • Hatfield, M.P.D.; Lovas, S. Conformational Sampling Techniques. Curr. Pharm. Des. doi:10.2174/13816128113199990603, PMID: 23947647, Current Pharmaceutical Design, 20, 3303-3313, 2013
  • Hatfield, M.P.D.; Lovas, S. Role of Hsp70 in cancer growth and survival., Protein and Peptide Letters, 19, 616-624. doi:10.2174/092986612800493968, 2012
  • Palermo, N.Y.; Thomas, P.; Murphy, R.F. and Lovas, S. Hexapeptide Fragment of Carcinoembryonic Antigen which Acts as an Agonist of Heterogeneous Ribonucleoprotein M., J Pept Sci, 18, 252-260, doi: 10.1002/psc.2393, 2012
  • Tan, X.; Pecka, J.L.; Tang, J.; Lovas, S.; Beisel, K.W.; He, D.Z.Z. A motif of eleven amino acids is a structural adaptation that facilitates motor capability of eutherian prestin., J. Cell Sci., 125, 1039-1047. doi: 10.1242/jcs.097337, 2012
  • Otvos, L., Jr.; Haspinger, E.; La Russa, F.; Maspero, Maspero, F.; Graziano, P.; M.; Kovalszky, I.; Lovas, S.; Nama, K.; Hoffmann, R.; Knappe, D.; Cassone, M.; Wade, J. and Surmacz, E. Design and Development of a Peptide-based Adiponectin Receptor Agonist for Cancer Treatment., BMC Biotechnology, 11, 90. doi:10.1186/1472-6750-11-90, 2011
  • Kim, B-H.; Palermo, N.Y.; Lovas, S.; Zaikova, Z.; Keana, J.F.W. and Lyubchenko, Y.L. Single molecule AFM force spectroscopy study of Aβ-40 interactions., Biochemistry, 50, 5154–5162. doi:10.1021/bi200147a, 2011
  • Hatfield, M.P.D.; Murphy, R.F.; Lovas, S. The CLN025 Decapeptide Retains a b-Hairpin Conformation in Urea and Guanidium Chloride., J Phys Chem B, 115, 4971-4981. doi: 10.1021/jp111076j, 2011

Research and Scholarship

Research and Scholarship Interests

  • Conformation-biological activity relationships in peptides/proteins including GnRH, gastrin, antibacterial peptides, amyloidogenic peptides and chlorotoxins. Structural characterization of prestin. Inhibtion of biological activity of 14-3-3e protein.  Description of solution structure of polypeptides by Molecular Dynamics simulations and ab initio quantum chemical calculations. Effects of weakly polar interactions on peptide/protein structures using the above theoretical methods and vibrational  and/ro electronic circular dichroism spectroscopy.
     

Current Research Projects

  • Amyloid beta
    14-3-3
    Prestin

Grant Funding Received

  • High-Performance Computing Cluster for Biomolecular Calculations
  • High-Performance Computing Cluster for Biomolecular Calculations

Awards and Honors

  • New Antitumor GnRH Analogs and Pharmaceutical Compositions Containing Them as Active Agents. Hungarian Patent 212661; C07K 7/06 A61K 33/08, 1994, Inventors: Mezo, I.; Lovas, S. et al., 2003
  • Biocidal Molecules, Macromolecular Targets and Methods of Production and Use. International Application PCT/US01/01812, 2006, Inventors: Otvos, L.; Thurin, M.; Rogers, M.; Lovas, S., 2001
  • NOVEL GnRH ANALOGUES WITH ANTITUMOR EFFECTS AND PHARMACEUTICAL COMPOSITIONS THEREOF. (PCT/US01/01812), 2000