Robert B. Mackin, PhD
Robert B. Mackin, PhD

Robert B. Mackin, PhD

Associate Professor
School of Medicine

Academic Appointments

Department

  • Biomedical Sciences

Position

  • Associate Professor

Education

  • Carleton College, B.A., 1978-82
  • Emory University, Ph.D., 1982-87
  • Salk Institute, Post-doctoral fellow, 1987-1989
  • Max Planck Institute, Post-doctoral fellow, 1989-1991

Publications and Presentations

Articles

  • Alternative preparation of inclusion bodies excludes interfering non-protein contaminants and improves the yield of recombinant proinsulin., MethodsX, 1, 108-117, 2014
  • An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design., Journal of Biological Chemistry, 285, 10806-10821, 2010
  • Solution structure of proinsulin: connecting domain flexibility and prohormone processing., Journal of Biological Chemistry, 285, 7847-7851, 2010
  • Crystal structure of a "nonfoldable" insulin: impaired folding efficiency despite native activity., Journal of Biological Chemistry, 284, 35259-35272, 2009
  • Total error profiling of a proinsulin time resolved fluorescence immunoassay., Journal of Chromatography B, 877, 2403-2406, 2009
  • Synthetic small molecule prohormone convertase 2 inhibitors., Molecular Pharmacology, 75, 617-625, 2009
  • Disruption of a receptor-mediated mechanism for intracellular sorting of proinsulin in familial hyperproinsulinemia., Molecular Endocrinology, 17, 1856-1867, 2003
  • Expression, purification, and PC1-mediated processing of human proglucagon, glicentin, and major proglucagon fragment., Protein Expression and Purification, 28, 15-24, 2003
  • Expression, purification and PC1-mediated processing of (H10D, P28K, and K29P)-human proinsulin., Protein Expression and Purification, 27, 210-219, 2003
  • Streamlined procedure for the production of normal and altered versions of recombinant human proinsulin., Protein Expression and Purification, 15, 308-313, 1999

Presentations

  • Poster at Gordon Research Conference, 2016
  • Poster at American Society for Biochemistry and Molecular Biology, 2016
  • Poster at American Society for Biochemistry and Molecular Biology, 2015
  • Poster at American Society for Biochemistry and Molecular Biology, 2014
  • Poster at American Society for Biochemistry and Molecular Biology, 2013
  • Poster at American Society for Biochemistry and Molecular Biology, 2012
  • Poster at American Diabetes Association, 2011
  • Poster at American Diabetes Association, 2010
  • Poster at American Diabetes Association, 2009
  • Poster at American Diabetes Association, 2009
  • Poster at Endocrine Society, 2009
  • Poster at Midwest Islet Club, 2009
  • Poster at Endocrine Society, 2008
  • Poster at Endocrine Society, 2007
  • Seminar - Carleton College Biology Department, 2006
  • Poster at Gordon Research Conference, 2006
  • Poster at American Society for Biochemistry and Molecular Biology, 2006
  • Oral Presentation at Midwest Student Biomedical Research Forum, 2006
  • Poster at Midwest Student Biomedical Research Forum, 2006
  • Poster at Endocrine Society, 2005
  • Seminar to Dept. of Biomedical Sciences, 2005
  • Poster at Gordon Research Conference, 2004
  • Poster at Endocrine Society, 2004
  • Invited talk at the American Society for Biochemistry and Molecular Biology/International Union for Biochemistry and Molecular Biology, Boston, MA, 2004
  • Poster at Midwest Student Biomedical Research Forum, 2004
  • Poster at Endocrine Society, 2003
  • Poster at Endocrine Society, 2003
  • Oral Presentation at Midwest Student Biomedical Research Forum, 2003
  • Poster at American Society for Cell Biology, 2002
  • Department seminar, Department of Physiology, University of Nebraska Medical Center, 2002
  • Poster at Gordon Research Conference, 2002
  • Poster at Endocrine Society, 2002
  • Department seminar, Department of Pharmacology, University of Nebraska Medical Center, 2002
  • Poster at Endocrine Society, 2001
  • Poster at Midwest Student Biomedical Research Forum, 2001
  • Poster at Symposium on Cell Biology and Pathophysiology of Peptide Hormone Processing, 2000
  • Poster at Gordon Research Conference, 2000
  • Poster at Endocrine Society, 2000
  • Poster at American Diabetes Association, 1999
  • Poster at Midwest Student Biomedical Research Forum, 1999

Research and Scholarship

Research and Scholarship Interests

  • Biosynthesis of polypeptide hormones.

Awards and Honors

  • Basic Science Teaching Award, Creighton University School of Medicine, 2016
  • Dedicated Teacher Award, Creighton University School of Medicine, 2016
  • Golden Apple Award, Class of 2014, Creighton University School of Medicine, 2011
  • Golden Apple Award, Class of 2012, Creighton University School of Medicine, 2009
  • Golden Apple Award, Class of 2008, Creighton University School of Medicine, 2005
  • Poster Award, Gordon Research Conference "Hormonal and Neural Peptide Biosynthesis", 2002
  • Golden Apple Award, Class of 2005, Creighton University School of Medicine, 2002
  • Young Investigator Award, Creighton University School of Medicine, 2000