Derek D. Smith, PhD
Derek D. Smith, PhD

Derek D. Smith, PhD

Associate Professor
School of Medicine

Academic Appointments

Department

  • Biomedical Sciences

Position

  • Associate Professor

Secondary Appointment

  • Graduate School

Education

  • Imperial College, University of London, BSc (Hons),10/80-6/83
  • University of Manchester Inst. of Science & Tech.,10/83-8/84
  • University of Edinburgh, Ph.D.,8/84-10/86
  • University of Arizona, 11/86-02/89

Publications and Presentations

Articles

  • Smith, D. D., Calcitonin Receptor Agents, Reference Module in Biomedical Sciences. Elsevier. 16-Mar-2017 doi:10.1016/B978-0-12-801238-3.96809-0, Reference Module in Biomedical Sciences, 2017
  • Smith D. D., AC187, Reference Module in Biomedical Sciences, Elsevier. 22-Jul-2016 doi:10.1016/B978-0-12-801238-3.92835-6, Reference Module in Biomedical Sciences, 2016
  • D. David Smith; Audrey T. Gallagher; Vincent M. Crowley; Wayne M. Gergens; Peter W. Abel; Martin Hulce ”An Efficient Synthesis of 4(5)-Benzyl-L-histidines Employing Caralytic Transfer Hydrogenolysis at Elevated Temperatures”, Synthesis, 46, 515-521, 2013
  • Synthesis of 4-arylmethyl-L-histidine analogues for structure-activity studies of position 10 of CGRP. D.D.Smith, M.Mao, H.Young, M.Hulce, Not Applicable, 2007
  • Pharmacological characterization of novel alpha-calcitonin gene-related peptide (CGRP) receptor peptide antagonists that are selective for human CGRP receptors. C.K. Taylor, D.D. Smith, M. Hulce, P.W. Abel, Not Applicable, 319, 2006
  • Vent J, Wyatt TA, Smith DD, Banerjee A, Luduena RF, Sisson JH, Hallworth R. Direct involvement of the isotype-specific C-terminus of beta tubulin in ciliary beating., J. Cell Science, 118, 4333-4341, 2005
  • Smith, DD, Abel, PW, AC187, Xpharm (web based), 2005
  • Taylor, CK, Abel, PW, Hulce, M, Smith, DD, Solvent eggects on coupling yields during repid solid-phase synthesis of CGRP(8-37) employing in situ neutralization, Journal of Peptide Research, 65, 84-89, 2005
  • Smith, DD, Abel, PW, Calcitonin Gene-Related Peptide, Xpharm (web based), 2004
  • Conlon, J.M., A. Sonnevend, C. Davidson, D.D. Smith, P.F. Nielsen The ascaphins: a family of antimicrobial, Biochem. Biophys. Res. Commun., 320 (1), 170-175, 2004
  • Reidelberger, R.D., A.C. Haver, U. Arnelo, D.D. Smith, C.S. Schaffert, J. Permert Amylin Receptor Blockade Stimulates Food Intake in Rats, American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 287, R568-R574, 2004
  • Smith, DD, S.Saha, G.Fang, C.Schaffert, D.J.J.Waugh, W.Zeng, G.Toth, M.Hulce, P.W.Abel. Modifications to the N-terminus but not the C-terminus of calcitonin gene-related peptide(8-37) produces antagonists with increased affinity, Journal of Medicinal Chemistry, 46, 2427-2435, 2003
  • Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand and reverse transcription-polymerase chain reaction. Boyd R. Rorabaugh, Margaret A. Scofield, D. David Smith, William B. Jeffries, Peter W. Abel, Journal of Pharmacology and Experimental Therapeutics, 299 (3), 1086-1094, 2001
  • Stratton, L.Pl; Kelly, R.M.; Rowe, J.; Shively, J.E.; Smith, D.D.; Carpenter, J.F.; Manning, M.C. Controlling deamidation rates in a model peptide: Effects of temperature, peptide concentration, and additives, Journal of Pharmaceutical Sciences, Volume 90, issue 12, 2141 to 2148, 2001
  • DD Smith, LA Bachle, DH Petzel ”Isolation and characterization of insulin from the Brockmann body of Dissostichus mawsoni, an Antarctic teleost.”, Proceedings of the European Peptide Symposium, 739-740, 2001
  • DD Smith, S Saha, DJJ Waugh, PW Abel ”Blocking the N-terminus of Calcitonin Gene-Related Peptide(8-37) produces high affinity antagonists., Proceedings of the European Peptide Symposium, 741-742, 2001
  • E Wren, S Guynn, K Karnaky, DD Smith, D Petzel ”The effects of Antarctic head extracts on short circuit current across the epithelium of the killifish”, MDIBL Bulletin, 39, 25, 2000
  • LA Bachle, DD Smith, D Petzel ”Isolation and characterization of insulin from the Brockmann body of Dissostichus mawsoni, an Antarctic teleost fish, J. Peptide Res., 56(1), 47 - 54, 2000
  • J. Pharmacol. Exp. Ther. 1999, 289, 1419-1426., Not Applicable, 1999
  • Proceedings of the 15th American Peptide Symposium, pp597-598., Not Applicable, 1999
  • Proceedings of the 15th American Peptide Symposium, pp416-417., Not Applicable, 1999

Publications

  • Taylor CK, Smith DD, Abel PW. Pharmacological characterization of novel high affinity CGRP receptor antagonists that are selective for human CGRP receptors., FASEB Journal, 20, A665, 2006
  • Taylor, CK, Smith, DD, Abel, PW, Pharmacological characterization of irreversible antagonists of calcitonin gene-related peptide receptors., FASEB Journal, 19, A105, 2005
  • Taylor, CK, Abel, PW, Smith, DD, Synthesis and pharmacological characterization of CGRP8-37 analogues containing N-terminal(bis(2-chloroethyl)-amino) and p-(fluorosulfonyl)- alkylating moeities., FASEB Journal, 18, A597, 2004
  • Rorabaugh, B.R.; Abel, P.W.; Smith, D.D.; Scofield, M.A. Putatuve CGRP2 receptors are identified as adrenomedullin receptors in SV40LT-SMC cells, FASEB Journal, Volume 16, Number 4, A576, 2002
  • Taylor, C.T.; Abel, P.W.; Smith, D.D. Synthesis and Pharmacological Characterization of a novel high affinity CGRP receptor antagonist, FASEB Journal, Volume 16, Number 4, A189, 2002
  • BR Rorabaugh, PW Abel, DD Smith, MA Scofield ”CGRP receptor signaling pathways in SK-N-MC and HEK293 cells”, FASEB Journal, A931, 2001
  • FASEB Journal & Gastroenterology, Not Applicable, 1999

Presentations

  • Eric Steele; D. David Smith "Preparation of 4(5)-benzyl-L-histidine methyl ester". Oral presentation at the 2017 Nebraska Academy of Sciences Annual Meeting, Nebraska Wesylean University, Lincoln, NE. April 21, 2017., 2017
  • Nick Mason; Martin Hulce; David Smith  "Synthesis of Truncated Calcitonin Gene-Related Peptide (8-11) by Fmoc coupling with Modified Hisitidne". Poster #31 presentation, 2017 St. Albert's Day Student Research Forum, Creighton University, Omaha, NE March 30, 2017., 2017
  • D. David Smith; Eric Steele; Paul Lievens; Martin R. Hulce "Preparation of 4(5)-benzyl-L-histidine methyl ester and its DiBoc derivative". Poster  #32 presentation 2017 St. Albert's Day Student Research Forum, Creighton University, Omaha, NE March 30, 2017., 2017
  • D. David Smith, Eric Steele, Paul Lievens, Martin R. Hulce "Preparation of 4(5)-benzyl-L-histidine methyl ester". Poster #380 presentation at the 51st Midwest Regional Meeting American Chemical Society, Kansas State University, Manhatten, KS. October 26-28, 2016., 2016
  • N.J. Mason; M.R. Hulce; D.D. Smith "Synthesis of trncated calcitonin gene-related peptide analogues by Fmoc coupling with modified histidines". Poster #191 presentation at the 51st Midwest Regional Meeting American Chemical Society, Kansas State University, Manhattan, KS. October 26-28, 2016., 2016
  • B.M. Cokington, K.P. Cokington, M. Hulce, R.T. Ishihara, D.D. Smith, E.M. Villa Sterically Directed Imidazole Side Chain Protection Strategies for Preparation of 4(5)-Benzyl-L-histidine Peptide Synthesis Reagents, poster presentation at St. Albert's Day/University Research Day, Creighton University, Omaha, NE April 14, 2015., 2015
  • I. Meerovich, A.K. Dash, D.D. Smith, M.Hulce Direct Solid Phase Peptide Synthesis on Chitosan Microparticles for Tumor Targeting, poster presentation at St. Albert's Day/University Research Day, Creighton University, Omaha, NE April 14, 2015, 2015
  • D.D. Smith, H. Roundtree, T. Simeone, K. Simeone Use of Reversed-Phase High Performance Liquid Chromatography to Measure Adenosine Amounts in Mouse Brain, poster presentation at the 2014 American Chemical Society Midwest Regional Meeting, University of Missouri, Columbia, MO November 12-15, 2014., 2014
  • B.M. Cokington, K.P. Cokington, R.T. Ishihara, M. Hulce, D.D. Smith, Sterically Directed Imidazole Side Chain Protection Strategies for Preparation of 4(5)-Benzyl-L-histidines Suitable for Solid Phase Peptide Synthesis, poster presentation at the 2014 American Chemical Society Midwest Regional Meeting, University of Missouri, Columbia, MO November 12-15, 2014, 2014
  • I. Meerovich, A.K. Dash, D.D. Smith, M. Hulce Direct Solid Phase Peptide Synthesis on Chitosan Microparticles for Tumor Targeting, poster presentation at 2014 AAPS Annual Meeting and Exposition, San Diego Convention Center, San Diego, CA November 2-6, 2014., 2014
  • D.D. Smith, C. Griggs, B. Mitchell, H. Mekada, M. Hulce Preparation of Protected Derivatives of 4(5)-Benzyl-L-Histidines, 2nd All University Research Fair, Creighton University, Omaha, NE September 25, 2014, 2014
  • D.D. Smith, C. Griggs, B. Mitchell, H. Mekada, M. Hulce Preparation of Protected Derivatives of 4(5)-Benzyl-L-Histidine, poster presentation at 248th Fall American Chemical Society National Meeting and Exposition, San Francisco, CA August 10-14, 2014, 2014
  • Benjamin Mitchell; D. David Smith; Martin Hulce "Preparation of Nalpha,Ntau-bis(t-butoxycarbonyl)-4(5)-benzyl-L-histidine Methyl Ester". Oral presentation, 124th Nebraska Academy of Sciences, Lincoln, NE April, 4, 2014., 2014
  • Connor Griggs; Martin Hulce; D. David Smith "Studies Towards the Synthesis of N-methyl-L-beta-hydroxvaline using the Schollkopf Chiral Auxiliary". Oral presentation, 124th nebraska Academy of Sciences, Lincoln NE April 4, 2014., 2014
  • Benjamin Mitchell; D. David Smith; Martin Hulce "Preparation of Nalpha,Ntau-bis(t-butoxycarbonyl)-4(5)-benzyl-L-histidine Methyl Ester". Poster presentation, 124th Nebraska Academy of Sciences, Lincoln, NE April, 1, 2014., 2014
  • Connor Griggs; Martin Hulce; D. David Smith "Studies Towards the Synthesis of N-methyl-L-beta-hydroxvaline using the Schollkopf Chiral Auxiliary". Poster presentation, 124th Nebraska Academy of Sciences, Lincoln NE April 4, 2014., 2014
  • The benzylation of histidyl residues during peptide synthesis, Invited speaker, Department of Chemistry weekly seminar, University of Nebraska Omaha, Omaha NE November 11, 2013., 2013
  • D. David Smith; Connor N. Griggs; Martin Hulce "Synthesis of N-Methyl-L-beta-hydroxyvaline Using The Schollkopf Chiral Auxiliary". Poster presentation, 48th Midwest Regional Meeting of the American Chemical Society, Springfield, MO October 16-19, 2013., 2013
  • Hideaki Mekada; Martin Hulce; D. David Smith "Synthesis of a 4(5)-L-histidinyl Peptide Using Fmoc-based Solid-phase Peptide Synthesis". Poster presentation, 48th Midwest Regional Meeting of the American Chemical Society, Springfield, MO October 16 - 19, 2013., 2013
  • Connor Griggs; Martin Hulce; D. David Smith "Studies Towards the Synthesis of N-methyl-L-beta-hydroxvaline using the Schollkopf Chiral Auxiliary". Oral presentation, 12th NE-INBRE Conference, Grand Island, NE August 4-6, 2013., 2013
  • Poster presentation at the 20th American Peptide Symposium in Montreal, Canada., 2007
  • Poster. Smith DD, Taylor CK, Abel PW, Hulce MR, Competitive and irreversible antagonists of CGRP. 30th National Medicinal Chemistry Symposium, Seattle, WA., 2006
  • Oral Presentation: Smith DD, Taylor CK, Abel PW, Hulce MR, Competitive and irreversible antagonists of calcitonin gene-related peptide. 116th Nebraska Academy of Sciences Meeting, Lincoln, NE., 2006
  • Poster Presentation: Taylor CK, Smith DD, Abel, PW. Pharmacological characterization of novel high affinity CGRP receptor antagonists that are selectice for human CGRP receptors. Experimental Biology, ASPET section, San Francisco, CA., 2006
  • Poster Presentation: Taylor CK, Smith DD, Abel, PW. Pharmacological characterization of novel high affinity CGRP receptor antagonists that are selectice for human CGRP receptors. Experimental Biology, Drug Discovery, Drug Development and Regulatory Affairs Young Investigator Section, San Francisco, CA., 2006
  • Oral Presentation: Taylor CK, Smith DD, Abel PW. Pharmacological characterization novel high affinity CGRP receptor antagonists that are selective for human CGRP receptors. 37th Midwest Student Biomedical Research Forum, Omaha, NE., 2006
  • Poster D31. Smith, DD, Taylor, CK, Abel, PW, Hulce, M Synthesis of Irreversible antagonists of CGRP receptors. National Organic Chemistry Symposium, 2005, Salt Lake City, UT., 2005
  • Poster. Taylor, CK, Smith, DD, Abel, PW Characterization of irreversible antagonists of calcitonin gene-related peptide receptors. Nebraska EpSCOR meeting, 2005, Omaha, NE., 2005
  • Taylor, CK, Smith, DD, Abel, PW Pharmacological Characterization of calcitonin gene-related peptide receptors. St. Albert's Day symposium, 2005, Omaha, NE., 2005
  • Poster. Taylor, CK, Smith, DD, Abel, PW, Pharmacological characterization of irreversible antagonists of calcitonin gene-related peptide receptors. Experimental Biology, 2005, San Diego, CA., 2005
  • Lecture. Taylor, CK, Abel, PW, Smith, DD, Synthesis and pharmacological characterization of novel irreversible antagonists of CGRP receptors. 36th Midwest Student Biomedical Research Conference, 2005, Omaha, NE., 2005
  • Poster. Taylor, CK, Abel, PW, Smith, DD, Synthesis and pharmacological characterization of novel irreversivle antagonists of CGRP receptors. Neuroscience meeting, 2004, Omaha, NE., 2004
  • Synthesis and Pharmacological Characterization of CGRP8-37 Analogues Containing N-"Terminal (bis(2- chloroethyl)-amino) and p-(fluorosulfonyl) Alkylating Moieties" poster presentation at Experimental Biology 2004 meeting in Washington DC, April 17-21, 2004., 2004
  • "SYNTHESIS OF PUTATIVE IRREVERSIBLE ANTAGONISTS OF CGRP RECEPTORS CONTAINING N-TERMINAL (BIS-(2-CHLOROETHYL)-AMINO) AND P-(FLUOROSULFONYL) GROUPS" Lecture presentation at the 114th Annual Meeting of the Nebraska Academy of Sciences, Nebraska Wesleyan University, Lincoln NE, 2004
  • "SYNTHESIS OF PUTATIVE IRREVERSIBLE ANTAGONISTS OF CGRP RECEPTORS CONTAINING N-TERMINAL (BIS-(2-CHLOROETHYL)-AMINO) AND P-(FLUOROSULFONYL) GROUPS" poster presentation at the Peptides, Chemistry & Biology of, Gordon Research conference, Ventura, CA February 15-20, 2004., 2004
  • Taylor CK, Abel PW, Smith DD, NMP is unsuitable as a solvent for the rapid solid phase synthesis of CGRP8-37 using in situ neutralization. Poster presentation at the American Peptide symposium, Boston ME. July 19-24, 2003., 2003
  • Taylor CK, Abel PW, Smith DD NMP is unsuitable as a solvent for the rapid solid phase synthesis of CGRP(837) using in situ neutralization. An oral presentation at the Nebraska Academy of Sciences, Nebraska Wesleyan University, Lincoln, NE., 2003
  • Taylor, C.K.; Abel, P.W.; Smith, D.D. Synthesis and pharmacological characterization of a novel high affinity CGRP receptor antagonist. Poster presentation at Experimental Biology 2002, New Orleans, LA April 20-24, 2002., 2002
  • Rorabaugh, B.R.; Abel, P.W.; Smith, D.D.; Scofield, M.A. Putative CGRP2 receptors are identified as adrenomedullin receptors in SV40LT-SMC cells. Poster presentation at Experimental Biology 2002, New Orleans, LA April 20-24, 2002., 2002
  • Use of Calcitonin Gene-Related Peptide (CGRP) antagonists to Characterize CGRP receptors, D. David Smith, Boyd R. Rorabaugh, Margaret A. Scofield, Peter W. Abel Poster Presentation at Gordon Research Conference, Chemistry & Biology of Peptides, Ventura Beach, CA February 17 - 22, 2002., 2002
  • "Development of CGRP antagonists and their use." Invited seminar speaker, Dept. of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO., 2002
  • "Benzylation of the Amino Terminus of the Peptide Antagonist CGRP(8-37) Leads to Formation of a Dibenzylated Byproduct" D. David Smith, Martin R. Hulce, David J.J. Waugh, Peter W. Abel, 36th Midwest Regional Meeting of the American Chemical Society, Lincoln, NE. 2001, 2001
  • Structural characterization of a dibenzylated-CGRP(8-37), a byproduct from n-alpha-benzylation of CGRP(8-37), 2nd International Peptide Symposium/ 17th American Peptide Symposium, San Diego, CA. Poster presentation., 2001
  • CGRP receptor signaling in SK-N-MC and HEK293 cells. 4th Nebraska Physiological Society meeting, Omaha, NE. Poster presentation., 2001
  • CGRP receptor signaling pathway in SK-N-MC and HEK293 cells, FASEB2001, Orlando, FL. Poster presentation, 2001
  • Pharmacological Comparison of Porcine CGRP receptors, Midwest Student Biomedical Research Forum, Omaha, NE. Poster presentation., 2001
  • Isolation and characterization of insulin from the Brockmann Body of dissostichus Mawsoni, an Antarctic teleost, 26th European Peptide Symposium, Montpellier, France. Poster presentation., 2000
  • Blocking the N-terminus of Calcitonin Gene-Related Peptide(8-37) produces high affinity antagonists. 26th European Peptide Symposium, Montpellier, Fance. Poster presentation, 2000
  • FASEB & Gastroenterology meetings, 1999
  • Rosehill Elementary School, Omaha., 1999

Awards and Honors

  • Intramural Research Award, 2014
  • PEPTIDE ANTAGONISTS OF CGRP SUPERFAMILY AND METHODS OF USE (Patent No: 6,756,205 B2), 2004
  • PEPTIDE ANTAGONISTS OF CGRP-RECEPTOR SUPERFAMILY AND METHOD OF USE (Patent No: 6268474), 2001
  • PEPTIDE ANTAGONISTS OF CGRP-RECEPTOR SUPERFAMILY AND METHODS OF USE. (Patent No: 09/813,345), 2001
  • The Welcome Trust, United Kingdom., 1999