Patrice A. Watson, PhD
Patrice A. Watson, PhD

Patrice A. Watson, PhD

Adjunct Associate Professor
School of Medicine

Academic Appointments


  • Medicine


  • Adjunct Associate Professor

Publications and Presentations


  • Roy HK, Turzhitsky V, Kim Y, Goldberg MJ, Watson P, Rogers JD, Gomes AJ, Kromine A, Brand RE, Jameel M, Bogovejic A, Pradhan P, Backman V. Association between rectal optical signatures and colonic neoplasia: Potential applications for screening, Cancer Research, 69, 4476-4483, 2009
  • Drescher KM, Sharma P, Watson P, Gatalica Z, Thibodeau SN, Lynch HT. Lymphocyte recruitment into the tumor site is altered in patients with MSI-H colon cancer, Familial Cancer, Published Online, 2009
  • Watson P, Vasen HFA, Mecklin J-P, Bernstein I, Aarnio M, Järvinen HJ, Myrhøj T, Sunde L, Wijnen JT, Lynch HT. The risk of extra-colonic, extra-endometrial cancer in the lynch syndrome, International Journal of Cancer, 123, 444-449, 2008
  • Lynch HT, Ferrara K, Barlogie B, Coleman EA, Lynch JF, Weisenburger D, Sanger W, Watson P, Nipper H, Witt V, Thomé S. Familial myeloma, New England Journal of Medicine, 359, 152-157, 2008
  • Majewski T, Lee S, Jeong J, Yoon D-S, Kram A, Kim M-S, Tuziak T, Bondaruk J, Lee S, Park W-S, Tang KS, Chung W, ShenL, Ahmed SS, Johnston DA, Grossman HB, Dinney CP, Zhou J-H, Harris RA, Snyder C, Filipek S, Narod SA, Watson P, Lynch HT, Gazdar A, Bar-Eli M, Wu XF, McConkey DJ, Baggerly K, Issa J-P, Benedict WF, Scherer SE and Czerniak B. Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy, Lab Invest, 88, 694-721, 2008
  • Chao EC, Velasquez JL, Witherspoon MS, Rozek LS, Peel D, Ng P, Gruber SB, Watson P, Rennert G, Anton-Culver H, Lynch H, Lipkin SM. Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR)., Hum Mutat, 29(6), 852-860, 2008
  • Aoun, P., G.Zhou, W.C.Chan, C.Page, K.Neth, D.Pickering, W.Sanger, B.Quinn-Laquer, P.Watson, J.F.Lynch, H.T.Lynch, and D.D.Weisenburger. Familial B-cell chronic lymphocytic leukemia: Analysis of cytogenetic abnormalities, immunophenotypic profiles, and immunoglobulin heavy chain gene usage., American Journal of Clinical Pathology, 127(1), 31-38, 2007
  • Chen,S., W.Wang, S.Lee, K.Nafa, J.Lee, K.Romans, P.Watson, S.B.Gruber, D.Euhus, K.W.Kinzler, J.Jass, S.Gallinger, N.M.Lindor, G.Casey, N.Ellis, F.M.Giardiello, K.Offit, G.Parmigiani, for the Colon Cancer Family Registry. Prediction of germline mutations and cancer risk in the Lynch syndrome., JAMA: Journal of the American Medical Association, 296(12), 1479-1487, 2006
  • Brand,R.M., D.D.Jones, H.T.Lynch, R.E.Brand, P.Watson, R.Ashwathnayaran, H.K.Roy. Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking., World Journal of Gastroenterology, 12(28), 4485-4491, 2006
  • Douglas,J.A., S.B.Gruber, K.A.Meister, J.Bonner, P.Watson, A.J.Krush, H.T.Lynch. History and molecular genetics of Lynch syndrome in Family G: a century later. In: JAMA (journal)., Not Applicable, 294(17), 2195-2202, 2005
  • Watson,P., B. Riley. The tumor spectrum in the Lynch syndrome, Familial Cancer, 4(3), 245-248, 2005
  • Chen,S., P. Watson, G. Parmigiani. Accuracy of MSI testing in predicting germline mutations of MSH2 and MLH1: a case study in Bayesian meta-analysis of diagnostic tests without a gold standard., Biostatistics, 6(3), 450-464, 2005
  • Tinley St, Houfek J, Watson P, Wenzel L, Clark MB, Coughlin S, Lynch HT. Screening adherence in BRCA1/2 families is associated with primary physicians' behavior., American Journal of Medical Genetics, 125A, 5-11, 2004
  • Watson P, Narod SA, Fodde R, Wagner A, Lynch JF, Tinley ST, Snyder CL, Coronel SA, Riley B, Kinarsky Y, Lynch HT. Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer., American Journal of Medical Genetics, 40(8), 591-596, 2003
  • Wagner A, Barrows A, Wijnen JT, van der Klift H, Franken PF, Verkuijlen P, Nakagawa H, Geugien M, Jaghmohan-Changur S, Breukel C, Meijers-Heijboer H, Morreau H, van Puijenbroek M, Burn J, Coronel S, Kinarski Y, Okimoto R, Watson P, Lynch JF, de la Chapelle A, Lynch HT, Fodde R. Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: High mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene., American Journal of Human Genetics, 72, 1088 - 1100, 2003
  • Marsh RE, Perdue CL, Watson P, Mittal SK, Awad ZT, Tomonaga T, Shiino Y, Filipi CJ. Is analysis of lower esophageal sphincter vector volumes of value in diagnosing gastroesophageal reflux disease?, World Journal of Gastroenterology, 9, 174 - 178, 2003
  • Lynch HT, Weisenburger DD, Quinn-Laquer B, Watson P, Lynch JF, Sanger WG. Hereditary chronic lymphocytic leukemia: An Extended family study and literature review., Am J Medical Genet, 115, 113 - 117, 2002
  • Berry DA, Iversen ES, Gudbjartsson DF, Hiller EH, Garber JE, Peshkin BN, Parmigiani G. BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other breast cancer susceptibility genes., J Clinical Oncology, 20, 2701 - 2712, 2002
  • Watson P, Bützow R, Lynch HT, Mecklin J-P, Järvinen HJ, Vasen HFA, Madlensky L, Fidalgo P, Bernstein I, and the International Collaborative Group on HNPCC (ICG-HNPCC). The Clinical Features of Ovarian Cancer in Hereditary Nonpolyposis Colorectal Cancer., Gynecologic Oncology, 82, 223-228, 2001
  • Wilcox CW, Wilwerding TM, Watson P, Morris JT. Use of electrosurgery and lasers in the presence of dental implants., International Journal of Oral & Maxillofacial Implants, 16, 578-582, 2001
  • Watson P, Lynch HT. Cancer risk in mismatch repair gene mutation carriers., Familial Cancer, 1, 57-60, 2001
  • Casey MJ, Bewtra C, Hoehne LL, Tatpati AD, Lynch HT, Watson P. Histology of prophylactically removed ovaries from BRCA1 and BRCA2 mutation carriers compared with noncarriers in hereditary breast ovarian cancer syndrome kindreds., Gynecologic Oncology, 78, 278-287, 2000


  • Common extracolonic and extraendometrial cancers in the Lynch syndrome: incidence, heterogeneity, and screening., 2007
  • "The risk of small bowel cancer in the Lynch syndrome". Presented at: International Society for Gastrointestinal Hereditary Tumors Conference, Yokohama, Japan., 2007
  • "Ovarian cancer and the Lynch syndrome". Presented at: Consensus Conference on Endometrial Cancer in the Lynch Syndrome, MD Anderson Cancer Center, Houston TX., 2007