Yaping Tu, PhD
Yaping Tu, PhD

Yaping Tu, PhD

Professor
School of Medicine

Academic Appointments

Department

  • Pharmacology

Position

  • Professor

Education

  • Wuhan University,B.S. Biochemistry,1983-1987
  • Institute of Biophysics,Ph.D.,1987-1992

Publications and Presentations

Books

  • 1. Tu, Y. Abel, P.W. and Piascik, M.T. (2010) Adrenergic Agonists. Pharmacology and Therapeutics for Dentistry. Sixth Edition, J.A. Yagiela, F.J. Dowd and E.A. Neidle, eds. pp. 91-105, Elsevier Mosby, Inc., Not Applicable, Sixth Edition, 2010
  • Tu, Y. Abel, P.W. and Piascik, M.T. (2010) Adrenergic Agonists. Pharmacology and Therapeutics for Dentistry. Sixth Edition, J.A. Yagiela, F.J. Dowd and E.A. Neidle, eds. Elsevier Mosby, Inc., Not Applicable, 91-105, 2010

Articles

  • Zhou T, Zhang B, Wei P, Du Y, Zhou H, Yu M, Yan L, Zhang W, Nie G, Chen C, Tu Y, Wei T. (2014) Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets., Biomaterials, 35, 9833-9843, 2014
  • Jiang H, Xie Y, Abel PW, Wolff DW, Toews ML, Panettieri Jr RA, Casale TB, Tu Y. RGS2 Repression Exacerbates Airway Hyperresponsiveness and Remodeling in Asthma, American Journal of Respiratory Cell Molecular Biology, 51, DOI: 10.1165/rcmb.2014-0319OC, 2014
  • Barrio-Real L, Benedetti LG, Engel N, Tu Y, Cho S, Sukumar S, Kazanietz MG. (2014) Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation., Breast Cancer Research, 16, 441, 2014
  • Zhou T, Yu M, Zhang B, Wang L, Wu X, Zhou H, Du Y, Hao J, Tu Y, Chen C,Wei T (2014) Inhibition of Cancer Cell Migration by Gold Nanorods: Molecular Mechanisms and Implications for Cancer Therapy., Advanced Functional Materials, 24, 6922–6932, 2014
  • 15. Zhao, J., Zhang, J., Yu, M., Xie, Y., Huang, Y., Wolff, D.W., Abel, P.W., Tu, Y. Mitochondrial dynamics regulates migration and invasion of breast cancer cells., Oncogene, 32, 4814-4824 , 2013
  • Xie Y, Abel PW, Kirui JK, Deng C, Sharma P, Wolff DW, Toews ML, Tu Y. (2013) Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion., Biochem Pharmacol, 85:, 1454-62, 2013
  • Xie, Y., Jiang, H., Nguyen, H., Jia, S., Berro, A., Panettieri, R.A., Wolff, D.W., Abel, P.W., Casale, T.B., and Tu, Y. (2012) Regulator of G-protein Signaling 2 is a key modulator of airway hyperresponsiveness., Journal of Allergy and Clinical Immunology, 130, 968-976 , 2012
  • Zhao K, Zhou H, Zhao X, Wolff DW, Tu Y, Liu H, Wei T, Yang F. (2012) Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis., J Lipid Res, 53:, 2102-14, 2012
  • Jiang H, Xie Y, Abel PW, Toews ML, Townley RG, Casale TB, Tu Y. (2012) Targeting phosphoinositide 3-kinase γ in airway smooth muscle cells to suppress interleukin-13-induced mouse airway hyperresponsiveness., Journal of Pharmacology and Experimental Therapeutics, 342, 305-11., 2012
  • Li X, Qiu L, Zhu P, Tao X, Imanaka T, Zhao J, Huang Y, Tu Y, Cao X. (2012) Epidermal growth factor-ferritin H-chain protein nanoparticles for tumor active targeting., Small, 8:, 2505-14, 2012
  • Sinha SH, Owens EA, Feng Y, Yang Y, Xie Y, Tu Y, Henary M, Zheng YG. (2012) Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents., Eur J Med Chem, 54:, 647-59, 2012
  • Veeramani S, Chou YW, Lin FC, Muniyan S, Lin FF, Kumar S, Xie Y, Lele SM, Tu Y, Lin MF. (2012) Reactive oxygen species induced by p66Shc longevity protein mediate nongenomic androgen action via tyrosine phosphorylation signaling to enhance tumorigenicity of prostate cancer cells., Free Radic Biol Med, 53:, 95-108, 2012
  • Wolff, D.W., Xie, Y., Deng, C., Gatalica, Z.., Yang, M., Wang, B., Wang, J., Lin, M.F., Abel, P.W., Tu, Y. (2012) Epigenetic repression of RGS2 promotes androgen-independent prostate cancer cell growth., Int. J. Cancer, 130, 1521-1531, 2012
  • Jiang, H., Xie, Y., Abel, P.W., Toews, M.L., Townley, R.G., Casale, T.B., and Tu, Y. (2012) Targeting phosphoinositide 3-kinase in airway smooth muscle cells to suppress interleukin-13-induced mouse airway hyperresponsiveness., Journal of Pharmacology and Experimental Therapeutics, 342, 305-311, 2012
  • Wong, C.Y., Wuriyanghan, H., Xie, Y., Lin, M.F., Abel, P.W. and Tu, Y. (2011) Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex1) gene expression in prostate cancer cells., J Biol Chem, 286, 25813-25822, 2011
  • 3. Wang J, Xie Y, Wolff DW, Abel PW and Tu Y. (2010) DHHC protein-dependent palmitoylation protects regulator of G-protein signaling 4 from proteasome degradation., FEBS Lett., 584, 4570-4574, 2010
  • 5. Jiang, H., Abel, P.W., Toews, M.L., Deng, C., Casale, T.B., Xie, Y., and Tu, Y. (2010) Phosphoinositide 3-kinase ¦Ã regulates airway smooth muscle contraction by modulating calcium oscillations., Journal of Pharmacology and Experimental Therapeutics, 334, 703-709, 2010
  • 6. Zhao, K., Zhao, X., Tu, Y., Miao,Q., Cao,X., Duan, W., Sun, Y., Wang, J., Wei, T., Yang, F. (2010) Lysosomal chymotrypsin B Potentiates apoptosis via cleavage of BID., Cellular and Molecular Life Sciences, 67, 2665-2678 , 2010
  • Chuang, T.D, Chen, S.J, Lin, F.F., Veeramani, S., Kumar S, Batra, S.K. Tu, Y. Lin MF (2010). Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth., J Biol Chem, 285, 2010
  • Kirui, J., Xie, Y., Wolff, D.W., Jiang, H., Abel, P.W. and Tu, Y. (2010) G¦Â¦Ã signaling promotes breast cancer cell migration and invasion, Journal of Pharmacology and Experimental Therapeutics, 333, 393-403. , 2010
  • Kang, L., Zhang, X., Xie, Y., Tu, Y., Wang, D., Liu, Z. and Wang. Z.Y. (2010) Involvement of Estrogen Receptor Variant ER-¦Á36, not GPR30, in Non-Genomic Estrogen Signaling., Molecular Endocrinology, 24, 709-721, 2010
  • Zhao, K., Zhao, X., Tu, Y., Miao,Q., Cao,X., Duan, W., Sun, Y., Wang, J., Wei, T., Yang, F. (2010) Lysosomal chymotrypsin B Potentiates apoptosis via cleavage of BID., Cellular and Molecular Life Sciences, 67, 2665-2678 , 2010
  • Xie, Y., Wolff, D.W., Wei, T., Wang, B., Deng, C., Kirui, J., Jiang, H., Qin, J., Abel, P.W. and Tu, Y. (2009) Breast cancer migration and invasion depends on proteasome degradation of regulator of G protein signaling 4 (RGS4)., Cancer Research, 69, 5743-5751, 2009
  • Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4, Cancer Research, 69, 5743-51, 2009
  • Upregulation of PIP3-dependent Rac exchanger 1 promote prostate cancer metastasis, Oncogene, 28, 1853-1863, 2009
  • Xie, Y., Wolff, D.W., Lin, M.F., and Tu, Y. Vasoactive intestinal peptide transactivates the androgen receptor through a PKA- dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells., Molecular Pharmacology, 72, 73-85, 2007
  • Cao X, Qin J, Xie Y, Khan O, Dowd F, Scofield M, Lin MF, Tu Y. Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells., Oncogene, 25, 3719-34, 2006
  • Khan OY, Fu G, Ismail A, Srinivasan S, Cao X, Tu Y, Lu S and Nawaz Z. Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland., Molecular Endocrinology, 20, 544-59, 2006
  • Tang W, Tu Y, Nayak SK, Woodson J, Jehl M and Ross EM. Gbetagamma inhibits Galpha GTPase-activating proteins by inhibition of Galpha-GTP binding during stimulation by receptor., J. Biol. Chem., 281, 4746-4753, 2006
  • Tu, Y. and Wilkie, T.M. (2004) Allosteric Regulation of RGS Domain GAP Activity, Methods Enzymol., 389, 89-105, 2004
  • Tu, Y., Nayak, S. K., Woodson, J. and Ross, E. M. Phosphorylation-Regulated Inhibition of the Gz GAP Activity of RGS Proteins by Synapsin Ia, Not Applicable, 278, 2003
  • Ouyang, Y.S. Tu, Y. and Yang, F.Y. (2003) The mutation in the N-terminal domain of RGS4 disrupts PA-conferred inhibitory effect on GAP activity, BioScience Reports, 23, 213-224, 2003

Publications

  • Breast Cancer Metastasis Depends on Proteasome Degradation of Regulator of G-protein Signaling 4, FASEB Journal, 23, 584.3, 2009
  • Histone deacetylases inhibit PIP3-dependent Rac exchange factor 1 (P-Rex1) expression in prostate cancer cells via SP1 binding site, FASEB Journal, 23, 585.6, 2009
  • Qin, J., Scofield, M.A., Dowd, F.J., Hoshino, M., Tu, Y. PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer cell migration., FASEB Journal, 21, 554.23, 2008
  • Xie, Y., Wolff, D.W., Lin, M.F., and Tu, Y. Vasoactive intestinal peptide transactivates the androgen receptor through a PKA-dependent extracellular signal-regulated kinase pathway in prostate cancer cells., FASEB Journal, 21, 569.13 , 2008

Presentations

  • The Bioscience Seminar, the Morsani College of Medicine, University of South Florida Topic: "Regulator of G Protein Signaling Proteins: Targets for Treatment of Asthma", 2015
  • The Nebraska Center for Cellular Signaling Month Meeting Topic: “Targeting the Androgen Receptor and TRAIL Pathways: A Novel Treatment Paradigm for Breast Cancer ”, 2015
  • The 4th International Symposium on Membrane Biology. Dali, China Topic: "Regulator of G Protein Signaling Proteins: Targets for Treatment of Asthma", 2014
  • American Asthma Foundation Annual Meeting-2014, 2014
  • Department of Pharmacology, Creighton University, 2014
  • Department of Chemistry, University of Nebraska at Omaha, NE, 2013
  • American Asthma Foundation Annual Meeting, San Francisco, CA, 2013
  • Experimental Biology-2013, Boston, 2013
  • Department of Urology, University of Kansas Medical Center, Kansas, KS, 2013
  • Annual Meeting of the American Academy of Allergy Asthma and Immunology, San Antonio, TX, 2013
  • The Nebraska Center for Cellular Signaling, Omaha, NE, 2013
  • Omaha VA Medical Center, Omaha, 2012
  • The 2nd International Symposium on Membrane Biology, Zhuhai, China, 2012
  • 2012-Annual Meeting of American Asthma Foundation, 2012
  • 2012 Experimental Biology, 2012
  • 2012-Creighton Faculty Club, 2012
  • Invited speaker, Creighton Cancer Research Symposium, 2011
  • Featured speaker, Nebraska Center for Cellular Signaling Symposium, 2011
  • Invited speaker, 7th Annual National Symposium on Prostate Cancer, 2011
  • Invited speaker, Innovative Minds in Prostate Cancer Today Conference, 2011
  • The 2nd International Symposium on Membrane Biology in China, 2010
  • Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 2010
  • Invited speaker, 2009 Nebraska Research and Innovation Conference. Omaha, 2009
  • Department of Pathology, Creighton University Medical Center, 2009
  • The 1st International Symposium on Membrane Biology, CHINA, 2009
  • GORDON RESEARCH CONFERENCE: PHOSPHORYLATION & G-PROTEIN MEDIATED SIGNALING, 2009
  • AACR 100th Annual Meeting 2009, 2009
  • "Dysregulation of G-Protein Signaling in Cancer" at State Key laboratory of Membrane Biology and Membrane Biotechnology, Chinese Academy of Sciences, 2009
  • Prostate Cancer Research Group, University of Nebraska Medical Center, 2008
  • "RGS proteins and cancer" at Peking University, China, 2008
  • "RGS2 and Prostate cancer progression" at National Center for Nanoscience and Technology, China, 2008
  • Experimental Biology Meeting-2008, 2008
  • 3rd RGS Protein Colloquium, 2008
  • Harry and Elsa Jiler-American Cancer Society Professors Meeting, 2007
  • Braman Family Breast Cancer Institute, 2007
  • The 2007 International Symposium on Biomembranes, Hubei, China, 2007
  • Department of Surgery at Evanston Northwestern Healthcare and the Department of Urology at Northwestern University Feinberg School of Medicine, 2007
  • The University of Minnesota Cancer Center, 2007
  • University of Nebraska Medical Center, 2007
  • Vasoactive intestinal peptide transactivates the androgen receptor, 2007
  • P-Rex1 promotes prostate cancer cell migration and invasion, 2007
  • 97th Annul Meeting of the American Association for Cancer Research, at the meeting in Washington, DC (April 1-5, 2006)., 2007
  • Role of RGS Proteins in Prostate Cancer, 2007
  • Molecular Studies of RGS2 in Prostate Cancer, 2006
  • University of Nebraska at Lincoln, 2006
  • Experimental Biology 2006 Meeting. in San Francisco (April 1-5), 2006
  • 97th Annul Meeting of the American Association for Cancer Research, at the meeting in Washington, DC (April 1-5, 2006)., 2006
  • American Heart Association Symposium(November 2005)at Dallas, TX, 2005
  • Modulation of RGS Proteins, 2004

Awards and Honors

  • Provisional-REGULATOR OF G-PROTEIN SIGNALLING 2 AND PROSTATE CANCER (Patent No: 60/881992), 2007