Timothy A. Simeone, PhD
Timothy A. Simeone, PhD

Timothy A. Simeone, PhD

Associate Professor
School of Medicine

Academic Appointments

Department

  • Pharmacology

Position

  • Associate Professor

Education

  • Boston University,B.A.,1992-1997
  • University of Utah,Ph.D.,1997-2002

Publications and Presentations

Articles

  • Kim DY, Simeone KA, Simeone TA, Pandya JD, Wilke JC, Ahn Y, Geddes JW, Sullivan PG, Rho JM.2. Ketone bodies mediate antiseizure effects through mitochondrial permeability transition., Annals of Neurology, doi: 10.1002/ana.24424, 2015
  • Simeone TA, Matthews SA, Samson KK, Simeone KA. In vivo ketogenic diet treatment attenuates pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices from epileptic Kv1.1alpha knockout mice., Epilepsia, 55(5), e44-49, 2014
  • Simeone KA, Matthews SA, Samson KK, Simeone TA. Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures., Experimental Neurology, 251, 84-90, 2014
  • Simeone TA, Simeone KA, Samson KK, Kim DY, Rho JM (2013) Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices., Neurobiology of Disease, 54, 68-81, 2013
  • Simeone TA, Wilcox KS, White HS. cAMP-dependent protein kinase A activity modulates topiramate potentiation of GABAA receptors, Epilepsy Research, 9, 176-179, 2011
  • Simeone TA, Wilcox KS, White HS. Topirmate modulation of β1- and β3-homomeric GABAA receptors., Pharmacological Research, 64:1, 44-52, 2011
  • Simeone TA, Wilcox KS, White HS cAMP-dependent protein kinase A activity modulates topiramate potentiation of GABAA receptors, Epilepsy Research, doi:10.1016/j.eplepsyres.2011.05.009, 2011
  • Simeone TA, Wilcox KS, White HS Topirmate modulation of beta1- and beta3-homomeric GABAA receptors., Pharmacology Research, 64(1), 44-52, 2011
  • Simeone KA, Sabesan S, Kim do Y, Kerrigan JF, Rho JM, Simeone TA L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue., Epilepsia, 52(3), 531-540, 2011
  • Simeone TA. Mechanisms of Antiepileptic Drug Action. In: Epilepsy: Mechanisms, Models, and Translational Perspectives, Rho JM (Ed.), Sankar R (Ed.), Stafstrom CE (Ed.). CRC Press, Taylor & Francis Group LLC., Not Applicable, 123-141, 2010
  • T.A. Simeone and J.M. Rho. Antiepileptic Drug Mechanisms. P.A. Schwartzkroin (ed.), Oxford:Academic Press, Not Applicable, 1, 59-66, 2009
  • Simeone, T.A., Wilcox, K.S., White, H.S. gamma-aminobutyric acid type A receptor beta-subunit specific modulation by topiramate, felbamate, pentobarbitone, and loreclezole. Submitted to British Journal of Pharmacology.
  • Simeone, K.A., Kim, D.Y., Rho, J.M., Kerrigan, J.F., Simeone, T.A. L-type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue. Submitted to Experimental Neurology.
  • Simeone, T.A., Wilcox, K.S., White, H.S. cAMP-dependent protein kinase activity modulates topiramate potentiation of alpha2beta3gamma2S GABAA receptors. Submitted to British Journal of Pharmacology.
  • Simeone TA, Matthews SA, Samson KK, Simeone KA. Regulation of brain PPARγ2 mediates ketogenic diet anti-seizure efficacy. Submitted to Neurobiology of Disease.
  • Roundtree HM, Simeone TA, Samson KK, Simeone KA. Dual orexin receptor antagonism restores NREM rhythms and reduces seizures in Kcna1-null mice, a model of epilepsy with comorbid sleep disorder symptoms. Submitted to Sleep.

Publications

  • Simeone TA. Carbamazepine inhibition of sharp wave-ripple complexes is associated with synapse specific effects on neurotransmission and short-term plasticity., 64th Annual Meeting of the American Epilepsy Society, 2010
  • Simeone KA, Rho JM, Samson K, Simeone TA. Pathologic Mitochondria and Refractory Epilepsy: Carbamazepine (CBZ) Directly Modulates Mitochondrial Function in Wild-Type and Epileptic Mice., 64th Annual Meeting of the American Epilepsy Society, 2010

Presentations

  • 3. Iyer S, Matthews SA, Samson KK, Simeone KA, Simeone TA. Antiseizure Effects Of Ketogenic Diet Are Mediated Via Regulation Of Brain PPAR-gamma, A Nutritionally Responsive Transcription Factor. ADD Program Symposium, Park City, UT, May, 2015., 2015
  • 1. Roundtree HM, Matthews SA, Johnson CC, Simeone TA, Simeone KA. Effects of Dual Orexin Receptor Antagonism on Sleep and Seizures in the Kcna1-null Model of Epilepsy. ADD Program Symposium, Park City, UT, May, 2015., 2015
  • 2. Deodhar M, Aggarwal A, Simeone TA, Simeone KA. Preliminary evidence of adaptive immune cell infiltration into the brain of a genetic model of chronic epilepsy. ADD Program Symposium, Park City, UT, May, 2015., 2015
  • 2015 Creighton University School of Medicine, Omaha, NE. Department of Biomedical Sciences. Research Rounds Seminar Series. Title: The role of brain PPARs in the anti-seizure efficacy ketogenic diet., 2015
  • 2015 Creighton University School of Medicine, Omaha, NE. Department of Pharmacology. Research Rounds Seminar Series. Title: Optogenetic Use in Epilepsy: examples from the literature., 2015
  • Neuroscience Journal Club. On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy., 2015
  • Simeone TA, Matthews SA, Samson KK, Simeone KA. Brain PPARgamma mediates ketogenic diet anti-seizure efficacy. American Epilepsy Society, Seattle, WA, 2014., 2014
  • 2014 American Epilepsy Society annual meeting, Seattle, WA. Ketogenic Diet Special Interest Group. Title: Is the ketogenic diet a disease modifying therapy for Epilepsy? The basic science perspective., 2014
  • 2014 Society for Neuroscience annual meeting, Washington D.C. Nanosymposium. Title: Brain PPARgamma contributes to the anti-seizure efficacy of the ketogenic diet., 2014
  • Simeone KA, Roundtree HM, Samson KK, Simeone TA. Consequences of seizure propagation to the sleep regulating lateral hypothalamus. Society for Neuroscience, Washington D.C., 2014., 2014
  • 2014 University of Nebraska Medical Center, Omaha, NE. Department of Neurological Sciences. Current and Future Directions for Translational Epilepsy Research Seminar Series. Title: PPARgamma involvement in Ketogenic Diet Therapy for Refractory Epilepsy., 2014
  • “Seizure Propagation to the Lateral Hypothalamus and Sleep-Wake Triggers” Oregon Health Science University, Portland, OR, 2014
  • “Mechanisms of Hippocampal Network Hyperexcitability in Kv1.1alpha Knockout Mice” Department of Pharmacology Research Rounds, Creighton University, Omaha, NE, 2014
  • Samson KK, Simeone KA, Rho JM, Simeone TA. Effects of Ketogenic Diet and Constituents on Pathologic Sharp Waves and High Frequency Oscillations. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Simeone KA, Stephanie A. Matthews SA, Samson KK, Simeone TA. A Novel Mitochondria-targeted Anticonvulsant Treatment. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Roundtree HM, Samson KK, Simeone TA, Simeone KA. Evidence of Pathology in the Lateral Hypothalamus: A Connection Between Sleep Disorder and Epilepsy in the Kv1.1 Knock-Out Mouse. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Ranade NP, Samson KK, Simeone KA, Simeone TA. Anticonvulsant Effects of Pioglitazone on High Potassium Seizure-Like Events in in vitro Hippocampal Slices. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Simeone TA. Carbamazepine inhibition of sharp wave-ripple complexes is associated with synapse specific effects on neurotransmission and short-term plasticity. Creighton University, The Faculty Club Research at Center Stage, October, 2012., 2012
  • “High Frequency Oscillations and Epilepsy: the State of Our Knowledge” Neurology Grand Rounds, CME credit, Creighton University School of Medicine, Omaha, NE, March 2012, 2012
  • Simeone TA, Simeone KA, Samson KK, Rho JM. Loss of Kv1.1 Alpha Subunit Alters Hippocampal Sharp Wave-Ripple Complexes and Promotes the Emergence of Pathologic Fast Ripples. American Epilepsy Society, Baltimore, MD., 2011
  • 2. Simeone KA, Roundtree HM, Samson KK, Simeone TA. Pathologic Hypocretin Circuitry: A Novel Mechanism of Sleep Disorders Associated with Epilepsy in Kv1.1 Knock-Out Mice. American Epilepsy Society, Baltimore, MD., 2011
  • Normal Emergent Properties Hijacked by an Epileptic Brain. St. Albert's Day, Creighton University School of Medicine, 2011
  • 1. Simeone TA. Carbamazepine inhibition of sharp wave-ripple complexes is associated with synapse specific effects on neurotransmission and short-term plasticity. American Epilepsy Society, San Antonio, TX, 2010
  • UNL Department of Biochemistry & Redox Biology Center. “Epilepsy and Emergent Properties of Neuronal Networks”., 2010
  • Normal Emergent Properties Hijacked by an Epileptic Brain. Faculty Club, Creighton University School of Medicine, 2010
  • “Epilepsy: dysregulation of emergent properties of neuronal networks.” Dept of Pharmacology, UNMC, Omaha, NE, 2010
  • “Epilepsy: Dysregulation of Emergent Properties of Neuronal Networks,” presented to the Molecular & Cellular Biology Faculty Research Group, 2009

Awards and Honors

  • Intramural Research Award, 2014