Catherine A. Opere, BPharm, MBA, PhD
Catherine A. Opere, BPharm, MBA, PhD

Catherine A. Opere, BPharm, MBA, PhD

Professor
School of Pharmacy and Health Professions

Academic Appointments

Department

  • Pharmacy Sciences

Position

  • Professor

Secondary Appointment

  • School of Medicine

Teaching Activity

  • Pharmacology (OT, POTD, PT and PharmD); Health conditions (OT); Ocular pharmacology and therapeutics (PharmD); Academic Rotation (PharmD); Research rotation and Directed Independent Research (PharmD; Grad Student)

Education

  • University of Nairobi,B. Pharm.,1978-1983
  • Creighton University,M.B.A.,1990-1992
  • Creighton University,Ph.D.,1992-1997

Publications and Presentations

Books

  • Opere, C. A., Ohia, S. E., Kulkarni, M., Njie-Mbye, Y. F. Role of Neurotransitters in obesity regulation, Obesity: Epidemiology, Pathophysiology, and Prevention, 113-124, 2013
  • Njie-Mbye YF, Barrett A, Kulkarni M, Opere CA, Ohia SE. Ocular Health. Bagchi D, Rahman I, eds. Inflammation, Advancing Age and Nutrition: Research, Science and Interventions, 1st ed. Elsevier. Imprint: Academic Press; ISBN: 9780123978035; 2013; http://store.elsevier.com/9780123978073., Elsevier, 1st Ed., 2013
  • Ohia, S. E., Opere, C. A., Kulkarni, M., Njie-Mbye, Y. F. Role of Neurotransmitters in obesity regulation., Phytochemicals for Obesity Treatment: Pathophysiology and Weight Management, 113-124, 2012
  • Njie-Mbye YF, Anjanette F, Zhao M, Ohia SE, Opere CA. Oxidative stress in ocular tissues: pathophysiological and pharmacological implications. In: Catala A eds. Lipid peroxidation: biological implications. Research Signpost Transworld Research Network, 2011., Research Signpost Transworld Research Network, 2011
  • Opere CA, Zhao M, Njie-Mbye YF, Ohia SE. Biological consequences of lipid peroxidation of long chain polyunsaturated fatty acids in ocular tissues: role of the isoprostanes and neuroprostanes. In: Catala A eds. Lipid peroxidation: biological implications. Research Signpost Transworld Research Network, 2011. ISBN: 978-81-7895-527-8., Research Signpost Transworld Research Network, 2011

Articles

  • J Ocul Pharmacol Ther., 33(2), 91-97, 2017
  • Kulkarni-Chitnis, M., Njie-Mbye, Y. F., Mitchell, L., Robinson, J., Whiteman, M., Wood, M. E., Opere, C. A., Ohia, S. E. Inhibitory action of novel hydrogen sulfide donors on bovine isolated posterior ciliary arteries, Experimental eye research, 134, 73-79, 2015
  • Jamil, J., Bankhele, P., Salvi, A., Mannix, J. E., Oger, C., Guy, A., Galano, J. M., Durand, T., Njie-Mbye, Y. F., Ohia, S. E., Opere, C. A. Role of the non-enzymatic metabolite of eicosapentaenoic acid, 5-epi-5-F3t-isoprostane in the regulation of [ (3)H]D-aspartate release in isolated bovine retina, Neurochemical research, 39, 2360-2369, 2014
  • Ali, H., Opere, C., Singh, S. In Vitro-Controlled Release Delivery System for Hydrogen Sulfide Donor, AAPS PharmSciTech, 15, 910-919, 2014
  • Chitnis, Madhura K., Njie-Mbye, Ya F., Opere, Catherine A., Wood, Mark E., Whiteman, Matthew, Ohia, Sunny E. Pharmacological actions of the slow release hydrogen sulfide donor GYY4137 on phenylephrine-induced tone in isolated bovine ciliary artery, Experimental eye research, 2014
  • Ya, Fatou N., Kulkarni-Chitnis, Madhura, Opere, Catherine A., Barrett, Aaron, Ohia, Sunny E., Passi, Alberto, Gasull, Xavier Lipid peroxidation: pathophysiological and pharmacological implications in the eye, Frontiers in Physiology, 4, 1-10, 2013
  • Galano, Jean-Marie, Mas, Emilie, Barden, Anne, Mori, Trevor A., Signorini, Cinzia, De Felice, Claudio, Barrett, Aaron, Opere, Catherine, Pinot, Edith, Schwedhelm, Edzard, Benndorf, Ralf, Roy, J?r?me, Le Guennec, Jean-Yves, Oger, Camille, Durand, Thierry Isoprostanes and Neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans, Prostaglandins & other lipid mediators, 107, 95-102, 2013
  • Njie-Mbye, Y. F., Kulkarni, M., Opere, C.A., Ohia, S. E. Mechanism of action of hydrogen sulfide on cyclic AMP formation in rat retinal pigment epithelial cells, Experimental eye research, 98, 16-22, 2012
  • Njie-Mbye, Y. F., Opere, C. A., Ohia, S. E., Chitnis, M. Hydrogen sulfide: role in ion channel and transporter modulation in the eye, Frontiers in Physiology, 3, 1-9, 2012
  • Njie-Mbye, Ya F., Chitnis, Madhura, Opere, Catherine, Ohia, Sunny P41 Hydrogen sulfide: Endogenous production and regulatory role in ocular tissues, Nitric Oxide, 27, S30, 2012
  • Opere CA, O’Brien KK, Shea JL. “Understanding diabetic retinopathy.” US Pharmacist, April, 2011. Role: contribution to preparation of manuscript., U.S. Pharmacist, 2011
  • Jamil, J., Wright, A., Harrison, N., Kegey, E., Flowers, A. F., Flyod, N. J., Kotera, C., Guy, A., Galano, J. M., Durand, T., Njie-Mbye, Y. F., Ohia, S. E., Opere, C. A. Regulation of [(3)H]D-Aspartate Release by the 5-F(2t)-Isoprostane and Its 5-Epimer in Isolated Bovine Retina, Neurochemical research, 37, 574-582, 2011
  • Kulkarni, Madhura, Njie-Mbye, Ya, Okpobiri, Ikechukwu, Zhao, Min, Opere, Catherine A., Ohia, Sunny Endogenous Production of Hydrogen Sulfide in Isolated Bovine Eye, Neurochemical research, 36, 1540-1545, 2011
  • Ohia, Sunny E., Opere, Catherine A., Monjok, Emmanuel M., Kouamou, Ghislaine, Leday, Angela M., Njie-Mbye, Ya Role of Hydrogen Sulfide Production in Inhibitory Action of L-Cysteine on Isolated Porcine Irides, Current eye research, 35, 402-407, 2010
  • Njie-Mbye, Ya, Bongmba, Odelia Y. N., Onyema, Chinwe C., Chitnis, Abhishek, Kulkarni, Madhura, Opere, Catherine A., LeDay, Angela M., Ohia, Sunny E. Effect of Hydrogen Sulfide on Cyclic AMP Production in Isolated Bovine and Porcine Neural Retinae, Neurochemical research, 35, 487-494, 2010
  • Kotera C, Opere CA. Practolol. xPharm (On-line pharmacology information service of Elsevier), eds: F. Dowd, 2010; http://www.mdl.com/products/knowledge/xpharm/index.jsp., Elsevier, 2010
  • Kotera C, Opere CA. Mannitol. xPharm (On-line pharmacology information service of Elsevier), eds: F. Dowd, 2010; http://www.mdl.com/products/knowledge/xpharm/index.jsp., Elsevier, 2010
  • Zhao, Min, Destache, Christopher J., Ohia, Sunny E., Opere, Catherine A. Role of Prostanoid Production and Receptors in the Regulation of Retinal Endogenous Amino Acid Neurotransmitters by 8-Isoprostaglandin E-2, Ex Vivo, Neurochemical research, 34, 2170-2180, 2009
  • Monjok, E. M., Kulkarni, K. H., Njie, Y. F., Ohia, S. E., Opere, Catherine A. Regulation of [(3)h] d: -aspartate release from mammalian isolated retinae by hydrogen sulfide, Neurochemical research, 34, 1962-1968, 2009
  • Kulkarni, Kaustubh H., Monjok, Emmanuel M., Zeyssig, Robert, Kouamou, Ghislaine, Bongmba, Odelia N., Opere, Catherine A., Njie, Ya F., Ohia, Sunny E. Effect of Hydrogen Sulfide on Sympathetic Neurotransmission and Catecholamine Levels in Isolated Porcine Iris-Ciliary Body, Neurochemical research, 34, 400-406, 2009
  • Opere, Catherine A. Aquaporin 2, xPharm, 2009
  • Opere, Catherine A. Aquaporin family, xPharm, 2009
  • Monjok, Emmanuel M., Kulkarni, Kaustubh H., Kouamou, Ghislaine, Mckoy, Marshalyn, Opere, Catherine A., Bongmba, Odelia N., Njie, Ya F., Ohia, Sunny E. Inhibitory action of hydrogen sulfide on muscarinic receptor-induced contraction of isolated porcine irides, Experimental eye research, 87, 612-616, 2008
  • Opere, C. A., Ford, K., Zhao, M., Ohia, S. E. Regulation of neurotransmitter release from ocular tissues by isoprostanes, Methods and findings in experimental and clinical pharmacology, 30, 697-701, 2008
  • Min Zhao, Opere, Catherine A. Prejunctional Inhibitory Effects of Isoprostanes on Dopaminergic Neurotransmission in Bovine Retinae, In vitro, Neurochemical research, 33, 37-42, 2008
  • Opere, D., Opere, Catherine A. Aquaporin 1, xPharm, 2008
  • Opere, C. A. Procainamide, xPharm, 2007
  • Opere, C. A., Zheng, W. D., Zhao, M., Lee, J. S., Kulkarni, K. H., Ohia, S. E. Inhibition of potassium- and ischemia-evoked [H-3] D-aspartate release from isolated bovine retina by cannabinoids, Current eye research, 31, 645-653, 2006
  • Kulkarni, K. H., Opere, C. A., Leday, A. M., Shara, M. A., Ohia, S. E. Regulation of norepinephrine release from isolated bovine irides by histamine, Neurochemical research, 31, 891-897, 2006
  • Ohia, S. E., Opere, C. A., LeDay, A. M. Pharmacological consequences of oxidative stress in ocular tissues, Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 579, 22-36, 2005
  • Opere, C. A., Zheng, W. D., Huang, J. F., Adewale, A., Kruglet, M., Ohia, S. E. Dual effect of isoprostanes on the release of [H-3]D-aspartate from isolated bovine retinae: Role of arachidonic acid metabolites, Neurochemical research, 30, 129-137, 2005
  • LeDay, A. M., Kulkarni, K. H., Opere, C. A., Ohia, S. E. Arachidonic acid metabolites and peroxide-induced inhibition of [H-3]D-aspartate release from bovine isolated retinae, Current eye research, 28, 367-372, 2004
  • LeDay, A. M., Awe, S. O., Kulkarni, K., Harris, L. C., Opere, C., Dash, A., Ohia, S. E. Effect of peroxides on [H-3]D-aspartate release from bovine isolated retinae, Neurochemical research, 29, 811-818, 2004
  • Ohia, S. E., Awe, S. O., Opere, C. A., LeDay, A. M., Harris, L. C., Kulkarni, K., Sharif, N. A. Glucose-deprivation-induced [H-3]D-aspartate release from isolated bovine and human retinae, Journal of Ocular Pharmacology and Therapeutics, 19, 599-609, 2003
  • Harris, L. C., Awe, S. O., Opere, C. A., Leday, A. M., Ohia, S. E., Sharif, N. A. Pharmacology of serotonin receptors modulating electrically-induced [H-3]-norepinephrine release from isolated mammalian iris-ciliary bodies, Journal of Ocular Pharmacology and Therapeutics, 18, 339-348, 2002
  • Harris, L. C., Olubusayo, S., Opere, C. A., Leday, A. M., Ohia, S. E., Sharif, N. A. [H-3]-serotonin release from bovine iris-ciliary body: Pharmacology of prejunctional serotonin (5-HT7) autoreceptors, Experimental eye research, 73, 59-67, 2001
  • Opere, C. A., Awe, S. O., Harris, L. C., LeDay, A. M., Ohia, S. E. Potentiation of sympathetic neurotransmission in bovine isolated irides by isoprostanes, Free radical research, 35, 257-264, 2001
  • Ohia, S. E., Awe, S. O., Opere, C. A., LeDay, A. M., Harris, L. C., Sharif, N. A. Hypoxia-induced [H-3]D-aspartate release from isolated bovine retina: modulation by calcium-channel blockers and glutamatergic agonists and antagonists, Current eye research, 23, 386-393, 2001
  • Matutte, B., Awe, S. O., Ameh, F. A., Leday, A. M., Rice, J. C., Opere, C. A., Ohia, S. E. Role of catalase in pre- and postjunctional responses of mammalian irides to hydrogen peroxide, Journal of Ocular Pharmacology and Therapeutics, 16, 429-438, 2000
  • Ohia, S. E., Opere, C. A., Awe, S. O., Adams, L., Sharif, N. A. Human, bovine, and rabbit retinal glutamate-induced [H-3]D-aspartate release: Role in excitotoxicity, Neurochemical research, 25, 853-860, 2000
  • Graham, J., Awe, S. O., LeDay, A. M., Rice, J. C., Ramos, G., Harris, L. C., Opere, C. A., Ohia, S. E. Effect of inhibition of cyclooxygenase on pre- and postjunctional actions of peroxides in the iris-ciliary body, Neurochemical research, 25, 519-525, 2000
  • Awe, S. O., Opere, C. A., Harris, L. C., Uketui, A. J., Ohia, S. E. Effect of isoprostanes on sympathetic neurotransmission in the human isolated iris-ciliary body, Neurochemical research, 25, 491-496, 2000

Presentations

  • Opere CA, Bankhele P, Salvi A, Jamil J, Munt D, Njie-Mbye YF, Chitnis M, Ohia SE. “Comparative inhibition of neurotransmission by N-acetylcysteine and L-cysteine in bovine isolated retina.” Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, abstract #1886, Orlando, FL May 4-8, 2014., 2014
  • Njie-Mbye YF, Robinson J, Ezeudu C, Mitchell L, Chitnis MK, Opere CA, Ohia SE. “Effect of hydrogen sulfide releasing compounds on aqueous humor dynamics.” Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, abstract #2890, Orlando, FL May 4-8, 2014., 2014
  • Ohia SE, Chitnis MK, Njie-Mbye YF, Robinson J, Ezeudu C, Mitchell L, Opere CA, Whiteman M. “Effect of novel hydrogen sulfide donors (AP67 and AP72) on isolated bovine ciliary artery.” Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, abstract #4348, Orlando, FL May 4-8, 2014., 2014
  • Chitnis MK, Belford R, Robinson J, Mitchell L, Njie-Mbye YF, Opere CA, Ohia SE. “Interaction between hydrogen sulfide and nitric oxide in isolated bovine retina.” Presented at the: Experimental Biology meeting, abstract #1060.2, San Diego, CA April 26-30, 2014., 2014
  • Robinson J, Ezeudu C, Mitchell L, Chitnis MK, Opere CA, Ohia SE, Njie-Mbye YF. “Involvement of KATP channels in hydrogen sulfide-induced increase in aqueous humor outflow.” Presented at the: Experimental Biology meeting, abstract #1060.3, San Diego, CA April 26-30, 2014., 2014
  • Opere CA, Bankhele P, Salvi A, Jamil J, Munt D, Njie Mbye YF, Chitnis M, Ohia SE. “Comparative pharmacological actions of N-acetylcysteine and L-cysteine on excitatory neurotransmission in isolated bovine retina.” Presented at the: Experimental Biology meeting, abstract #1060.4, San Diego, CA April 26-30, 2014., 2014
  • Opere CA, Salvi A, Bankhele P, Jamil J, Njie-Mbye YF, Kulkarni K, Ohia SE. “Inhibitory action of hydrogen sulfide donor, ACS 67 on sympathetic neurotransmitter release in isolated bovine iris-ciliary bodies.” Presented at the: ISER symposium, abstract #15, Sarasota, Fl, Sept 29-Oct 2, 2013., 2013
  • Njie-Mbye YF, Robinson J, Kulkarni M, Opere CA, Ohia SE. “Hydrogen sulfide and aqueous humor outflow.” Presented at the: ISER symposium, Abstract #4, Sarasota, Fl, Sept 29-Oct 2, 2013., 2013
  • Jamil J, Kegey E, Flowers AF, Flyod NJ, Salvi A, Bankhele P, Guy A, Galano JM, Durand T, Njie-Mbye YF, Kulkarni M, Ohia SE, Opere CA. “Further studies on the role of arachidonic acid metabolites in the regulation of potassium-induced [3H]D-aspartate release from isolated bovine retinae by 5-epi-5-F3t-isoprostane.” Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting. ID: 1616232; abstract #6315; Seattle, WA, May 5-9, 2013., 2013
  • Bankhele P, Jamal J, Salvi A, Njie Mbye YF, Kulkarni M, Ohia SE, Opere CA. “Further studies on the inhibition of [3H]D-aspartate release by hydrogen sulfide donors in isolated bovine retina.” Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, Abstract #6325, Seattle, WA, May 5-9, 2013., 2013
  • Salvi A, Bankhele P, Jamal J, Njie Mbye YF, Kulkarni M, Ohia SE, Opere CA. “Regulation of mammalian sympathetic neurotransmitter release and intraocular pressure by hydrogen sulfide donor, GYY 4137.” Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, ID: 1615348; abstract #1976, Seattle, WA, May 5-9, 2013., 2013
  • Njie-Mbye YF, Robinson J, Okpobiri A, Kulkarni M, Opere CA, Ohia SE. “Effect of NaHS, a fast-releasing hydrogen sulfide donor on aqueous humor outflow in porcine trabecular meshwork.” Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, ID 1616794; abstract #3563; Seattle, WA, May 5-9, 2013., 2013
  • Ohia SE, Okpobiri A, Njie-Mbye YF, Robinson J, Kulkarni M, Opere CA. “Pharmacological actions of L-cysteine on isolated bovine ciliary muscles.” Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, ID 1616651, abstract #787; Seattle, WA, May 5-9, 2013., 2013
  • Opere CA, Jamil J, Salvi A, Bankhele P, Flowers AF, Floyd N, Durand T, Galano JM, Guy A, Oger C, Njie-Mbye YF, Kulkarni K, Ohia SE. “Regulation of potassium-induced [3H]D-aspartate release from isolated bovine retina by 5-epi-5-F3t-isoprostane: Role of prostanoid receptors.” Presented at the: Experimental Biology meeting, Abstract #7268, Boston, MA April 20-24, 2013., 2013
  • Robinson J, Njie-Mbye YF, Okpobiri A, Kulkarni M, Opere CA, Ohia SE. “Hydrogen sulfide increases aqueous humor outflow in porcine trabecular meshwork.” Presented at the: Experimental Biology meeting, Abstract #5025, Boston, MA April 20-24, 2013., 2013
  • Okpobiri A, Njie-Mbye YF, Robinson J, Kulkarni M, Opere CA, Ohia SE. “Effect of hydrogen sulfide on isolated bovine ocular smooth muscle.” Presented at the: Experimental Biology meeting, Abstract #5534, Boston, MA April 20-24, 2013., 2013
  • Salvi A, Bankhele P, Jamal J, Njie-Mbye YF, Kulkarni M, Ohia SE, Opere CA. “Regulation of mammalian sympathetic neurotransmitter release and intraocular pressure by hydrogen sulfide donor, GYY 4137.” Presented at the: Creighton University St. Albert’s Day, Abstract #81, Harper Center, Creighton University, Omaha, NE, Mar 26, 2013., 2013
  • Bankhele P, Jamil J, Salvi A, Opere CA. “Further studies on the Inhibition of [3H]D-aspartate release by hydrogen sulfide donors in isolated bovine retina.” Presented at the: Creighton University St. Albert’s Day, Abstract #83, Harper Center, Creighton University, Omaha, NE, Mar 26, 2013., 2013
  • Opere CA, Flowers A, Floyd N, Kegey E, Jamil J, Durand T, Galano JM, Guy A, Oger C, Njie-Mbye YF, Ohia SE. “Enhancement of excitatory neurotransmitter release by metabolites of long chain polyunsaturated fatty acids in bovine retina, in vitro.” Presented at the: Fourth European Workshop on Lipid Mediators, Pasteur Institute - Paris, September 27-28, 2012., 2012
  • Opere CA, Jamil J, Salvi A, Bankhele P, Njie-Mbye YF, Kulkarni M, Ohia SE. “Inhibition of [3H]D-aspartate release by hydrogen sulfide in isolated bovine retina.” Presented at the: Second International Conference on H2S Biology and Medicine, Abstract #P110, Atlanta, Georgia, Sept 20-22, 2012., 2012
  • Njie-Mbye YF, Kulkarni M, Opere CA, Ohia SE. “Hydrogen Sulfide: Endogenous Production and Regulatory Role in Ocular Tissues.” Presented at the: Second International Conference on H2S Biology and Medicine, Abstract #P41, Atlanta, Georgia, Sept 20-22, 2012., 2012
  • Opere CA, Flowers A, Jamil J, Kegey E, Floyd N, Salvi A, Bankhele A, Durand T, Galano JM, Guy A, Oger C. “Regulation of excitatory neurotransmitter release by metabolites of long chain polyunsaturated fatty acids in bovine retina, in vitro.” Presented at the: Frontiers in Lipid Biology, American Society of Biochemistry and Molecular Biology (ASMB); International Conference on the Bioscience of Lipids (ICBL) and The Canadian Lipoprotein Conference (CLC), Abstract # 2374, Banff Alberta, Canada, September 5-8, 2012., 2012
  • Chitnis MK, Njie-Mbye YF, Opere CA, Ohia SE. “Hydrogen sulfide-induced increase in cyclic AMP production in RPE-J cells: Role of prostanoids, adenyl cyclase and KATP channels.” Presented at the: ISER meeting, Berlin, Germany, July 21-25, 2012. Abstract #P061, 2012
  • Opere CA, Flowers A, Floyd N, Kegey E, Jamil J, Durand T, Galano JM, Guy A, Oger C, Njie-Mbye YF, Ohia SE. “Role of prostanoid receptors in the excitatory effect of neuroprostanes on potassium induced [3H]D-aspartate release in isolated bovine retina.” Presented at the : 19ème journée IRPF de Chimie Sorèze, France, 15 Juin 2012., 2012
  • Kulkarni M, Njie-Mbye YF, Opere CA, Whiteman M, Ohia SE. “Effect of slow releasing hydrogen sulfide donor GYY4137 on isolated bovine ciliary artery.” Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, Abstracts March 26, 2012 53:6866. May 6-9, 2012, Ft. Lauderdale, Fl., 2012
  • Opere CA, Flowers AF, Floyd N, Kegey E, Jamil J, Durand T, Galano JM, Guy A, Oger C, Njie-Mbye YF, Ohia SE. “Role of prostanoid receptors in the excitatory effect of neuroprostanes on potassium induced [3H]D-aspartate release in isolated bovine retina.” Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, Abstracts March 26, 2012 53:5386. May 6-9, 2012, Ft. Lauderdale, Fl., 2012
  • Flowers AF, Floyd N, Kegey E, Jamil J, Durand T, Galano JM, Guy A, Njie-Mbye YF, Kulkarni K, Ohia SE, Opere CA. “Regulation of K+-induced [3H]D-aspartate release by synthetic neuroprostanes in isolated bovine retina.” Presented at the: The Experimental Biology meeting, Journal. 2012;26:843.4., 2012
  • Stroud DD, Kulkarni M, Njie-Mbye YF, Opere CA, Ohia SE. “Pharmacological actions of L-cysteine on isolated bovine irides.” Presented at the: The Experimental Biology meeting, Journal. 2012;26:1049.4, 2012
  • Kegey E, Jamil JM, Harrison NC, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE, Opere CA. “Role of prostanoid receptors in the inhibitory effect of 5-F2t-IsoP and its 5-epimer on potassium-induced [3H]D-aspartate release in isolated bovine retina.” Presented at the: 8Th GERLI Lipidomics Meeting, Bioactive Lipids, Membranes and Bioactive lipids, Lyon, October, 25-28-2011., 2011
  • Ali H, Opere CA, Singh S. “An easy to use, safe, and efficient spectrophotometric method for the determination of hydrogen sulfide released from its analogues.” Presented at the: American Association of Pharmaceutical Scientists, October, 23-27, 2011. Walter E. Washington Convention Center, Washington, D.C., 2011
  • Ali H, Opere CA, Singh S. “Phase-sensitive smart polymer-based sustained release delivery system for hydrogen sulfide analogue.” Presented at the: Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, October, 23-27, 2011. Walter E. Washington Convention Center, Washington, D.C., 2011
  • Kegey E, Jamil JM, Harrison NC, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE, Opere CA. “Role of prostanoid receptors in the inhibitory effect of 5-F2t-IsoP and its 5-epimer on potassium-induced [3H]D-aspartate release in isolated bovine retina.” Presented at the: 2nd International conference on Enviromental Stressors in Biology and Medicine Siena, 5-7 October 2011, 2011
  • Kulkarni M, Njie-Mbye YF, Okpobiri I, Zhao M, Opere CA, Ohia SE. “Regulation of endogenous hydrogen sulfide production in isolated bovine retina by carbon monoxide and nitric oxide.” Program/poster 5669/A581, May 5, 2011, Ft. Lauderdale, Fl., 2011
  • Zhao M, Taylor M, Njie-Mbye YF, Kulkarni M, Opere CA, Ohia SE. “Hydrogen sulfide-induced relaxation of isolated bovine ciliary artery.” Program/poster 2658/A139, May 3, 2011, Ft. Lauderdale, Fl., 2011
  • Opere CA, Njie-Mbye YF, Jamil J, Durand T, Galano JM, Guy A, Kulkarni M, Zhao M, Ohia SE. “Regulation of cyclic AMP production in rat RPE-J cells by the synthetic neuroprostane,” BA-12high. Program/poster 2067/D1074, May 2, 2011, Ft. Lauderdale, Fl., 2011
  • Opere CA, Jamil JM, Wright A, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE. “Neuroprostanes inhibit [3H]D-aspartate release in bovine retina, in vitro.” Presented at the: Journées CHEVREUL 2011, "LIPIDS & BRAIN 2" Paris 28-30 March 2011., 2011
  • Kegey E, Jamil J, Harrison N, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE, Opere CA. “Role of prostanoid receptors in the inhibitory effect of synthetic isoprostanes on potassium-induced [3H]D-aspartate release in isolated bovine retina .” Presented at the: Experimental Biology Meeting, March 17, 2011 25:799.4, 2011
  • Opere CA, Jamil JM, Wright A, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE. “Neuroprostanes inhibit [3H]D-aspartate release in bovine retina, in vitro.” Presented at the: 7th GERLI Lipodomic Meeting: Lipids in all States, 3-6 October, Anglet-Biarritz, France, 2010., 2010
  • Opere CA, Jamil JM, Wright A, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE. “Neuroprostanes inhibit [3H]D-aspartate release in bovine retina, in vitro.” Presented at the: Third European Workshop on Lipid Mediators, Pasteur Institute - Paris, June 3-4, 2010, 2010
  • Ohia SE, Kulkarni M, Njie-Mbye YF, Jackson D, Zhao M, Opere CA. “Measurement of hydrogen sulfide concentration in isolated bovine eyes.” Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, May 2-6, 2010 Abstract #3305/D786., 2010
  • Njie-Mbye YF, Kulkarni M, Jackson D, Zhao M, Opere CA, Ohia SE. “Mechanism of action of hydrogen sulfide on cyclic AMP formation in RPE-J cells.” Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, May 2-6, 2010, Abstract # 3315/D796., 2010
  • Opere CA, Jamil JM, Wright A, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE. “Regulation of [3H]D-aspartate release by neuroprostanes in bovine retina, in vitro.” Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, May 2-6, 2010, Abstract # 3315/D796., 2010
  • Opere CA, Jamil J, Wright A, Njie-Mbye YF, Ohia SE. “Peroxide-induced production of metabolites of polyunsaturated fatty acids in bovine retina, in vitro.” Presented at the: Experimental Biology Meeting, April 6, 2010 24:971.2, 2010
  • Njie-Mbye YF, Kulkarni M, Opere CA, Ohia SE. “Hydrogen sulfide stimulates cyclic AMP formation in mammalian retina through the adenylyl cyclase pathway.” Presented at the: Experimental Biology Meeting, April 6, 2010 24:962.2, 2010

Research and Scholarship

Research and Scholarship Interests

  • Oxidative stress (OS) is an underlying pathology in retinal neurodegenerative diseases such as age-related macular degeneration, diabetic retinopathy and glaucoma (Dreyer EB. J. Glaucoma. 7(1):62-67). These ocular retinopathies account for a large number of cases of blindness and visual impairment among the elderly in the US, warranting research into potential therapeutic options to prevent visual impairment (Vision Problems in the U.S. Prevalence of Adult Vision Impairment and Age-Related Eye Disease in America. Prevent Blindness America. http://www.visionproblemsus.org/introduction.html). My research focus is directed towards identifying the underlying mechanisms by which OS interacts with pharmacological receptors in ocular tissues, with the aim of revealing potential pharmacological targets that can be manipulated for therapeutic interventions. My specific areas of interests include studies on the regulation of uveal sympathetic and retinal excitatory neurotransmission by OS and OS-metabolites of long chain polyunsaturated fatty acids (PUFAs).  Other areas of study include the regulation of retinal ganglion cells and neural tissue survival by OS-PUFA metabolites; regulation of neurotransmitter release, intraocular pressure and aqueous humor dynamics by hydrogen sulfide donors; development of innovative, slow release hydrogen sulfide donor formulations that can achieve sustainable concentrations in the anterior and posterior segments of the eye for management of glaucoma and other retinopathies; identification and characterization of subtypes of prejunctional (autoreceptors and heteroreceptors) receptors in the mammalian anterior uvea and retina. Receptors of interest include those for glutamate, histamine, prostanoids and cannabinoids.
     

Awards and Honors

  • Faculty/Student FASEB/MARC Travel Award, FASEB/MARC, 2014
  • Faculty/Student FASEB/MARC Travel Award, FASEB/MARC, 2013
  • Faculty/Student FASEB/MARC Travel Award, FASEB/MARC, 2013
  • Faculty/Student FASEB/MARC Travel Award, FASEB/MARC, 2012
  • Faculty/Student FASEB/MARC Travel Award, FASEB/MARC, 2011
  • Summer Research Opportunity Award, Office of MARC, 2011
  • Faculty/Student FASEB/MARC Travel Award, FASEB/MARC, 2011
  • Faculty/Student FASEB/MARC Travel Award, FASEB/MARC, 2010
  • Faculty/Student FASEB/MARC Travel Award, FASEB/MARC, 2010
  • Summer Research Opportunity Award, Office of MARC, 2010
  • SPAHP Summer Research Award, SPAHP Summer Research Award , 2010
  • Faculty/Student FASEB/MARC Travel Award, FASEB/MARC, 2010
  • “Use of hydrogen sulfide in the therapy of glaucoma and related diseases” Co-Inventors: Ohia SE and Opere CA. Discovered the potential application of hydrogen sulfide in treatment of glaucoma. Contributors: Guilin Zhan, M.D., Emmanuel Monjok, M.D. and Kau, 2006