Christopher J. Destache, PharmD, FCCP
Christopher J. Destache, PharmD, FCCP

Christopher J. Destache, PharmD, FCCP

Professor
School of Pharmacy and Health Professions

Academic Appointments

Department

  • Pharmacy Practice

Position

  • Professor

Secondary Appointment

  • School of Medicine

Teaching Activity

  • HIV
  • Infectious Diseases

Biography

A more complete listing of scholarship, teaching, and research interests can be found on my Curriculum Vitae.  

Education

  • Creighton University 1978-1984
  • Creighton University School of Pharmacy,Pharm.D.,1980-84

Certifications

Antimicrobial Stewardship

Publications and Presentations

Books

  • Destache CJ. Brain as an HIV Sequestered Site: Use of Nanoparticles as a Therapeutic Option. Progress in Brain Research (Volume 180, Chapter 12). Elsevier Academic Press. 2010., Journal of Doctoral Nursing Practice, 2010
  • Gendelman HE, Destache CJ, Zelivyanskaya ML, et al. Neuroimaging and proteomic tracking of neurodegeneration in MPTP-treated mice. Parkinson’s Disease The Life Cycle of the Dopamine Neuron. Federoff HJ, Burke RE, Fahn S, Fiskum G. eds. Annuals of the New York Academy of Sciences. Vol 991 2002; pg 319-321., Journal of Doctoral Nursing Practice, 2002

Articles

  • Ahmad I, Zhao X, Parameswaran S, Destache CJ, Rodriguez-Sierra J, Ahmad H, Sorrentino J, Balasubramanian S. Direct differentiation of adult ocular progenitors into striatal dopaminergic neurons. International J Stem Cells 2015;8 http://dx.doi.org/10.15283/ijsc.2015.8.1.1., International Journal of Stem Cells, 2015;8 http://dx.doi.org/10.15283/ijsc.2015.8.1.1., 2015
  • Ahmad, I., Zhao, X., Parameswaran, S., Destache, C. J., Rodriguez-Sierra, J., Thoreson, W. B., Ahmad, H., Sorrentino, J., Balasubramanian, S. Direct differentiation of adult ocular progenitors into striatal dopaminergic neurons, International Journal of Stem Cells, 8, 106-114, 2015
  • Date, A. A., Shibata, A., Bruck, P., Destache, C. J. Development and validation of a simple and isocratic reversed-phase HPLC method for the determination of rilpivirine from tablets, nanoparticles and HeLa cell lysates, Biomedical Chromatography : BMC, 29, 709-715, 2015
  • Date, A. A., Shibata, A., Bruck, P., Destache, C. J. Development and validation of a simple and isocratic reversed-phase HPLC method for the determination of rilpivirine from tablets, nanoparticles and HeLa cell lysates, Biomedical Chromatography : BMC, 29, 709-715, 2015
  • Date, Abhijit A., Shibata, Annemarie, McMullen, Emily, La Bruzzo, Krista, Bruck, Patrick, Belshan, Michael, Zhou, You, Destache, Christopher J. Thermosensitive Gel Containing Cellulose Acetate Phthalate-Efavirenz Combination Nanoparticles for Prevention of HIV-1 Infection, Journal of Biomedical Nanotechnology, 11, 416-427, 2015
  • Date AD, Destache CJ. Natural polyphenols: Potential in the prevention of sexually transmitted viral infections. Drug Discovery Today 2015 Submitted., Drug Discovery Today, 2015
  • Narayanan MA, Haddad TM, Baskaran J, Reddy AK, Mansour G, Destache C, Mooss A, Wichman T, Morrow L, Suri R, Kalil AC, Vivekanandan R. Evidence of lower mortality in early surgical intervention for infective endocarditis: A meta-analysis. Br Med J Heart 2015 Submitted., British Medical Journal of the Heart, 2015
  • Li Q, Tso FY, Kang G, Fan W, Lu W, Li Y, Yuan Z, Destache CJ, Wood C. Early antiretroviral therapy prevents the establishment of HIV-1 infection in humanized-BLT mice. JAIDS 2015;69:519-527., J AIDS, 69, 519-527, 2015
  • Date AA, Shibata A, McMullen E, La Bruzzo K, Bruck P, Belshan M, Zhao Y, Destache CJ. Thermosensitive gel containing cellulose acetate phthalate-efavirenz nanoparticles for prevention of HIV-1 infection. J Biomed Nanotech 2015;11:416-427., Journal, 11, 416-427, 2015
  • Kovarova M, Council OD, Date AA, Long J, Nochii T, Belshan M, Shibata A, Vincent H, Baker CE, Thayer WO, Kraus G, Lachaud-Durand S, Williams P, Destache CJ, Garcia JV. Nanoformulations of rilpivirine for topical pericoital and systemic coital-independent administration efficiently prevent HIV transmission. PLoS Pathogen 2015; DOI:10.1371/journal.ppat 1005075., PLoS Pathogen, DOI:10.1371/journal.ppat 1005075., 2015
  • Mandal S, Zhou Y, Shibata A, Destache CJ. Confocal fluorescence microscopy: an ultra-sensitive tool used to evaluate intracellular antiretroviral nano-drug delivery in HeLa cells. AIP Advances. 2015;8 http://dx.doi.org/10.1063/1.4926584 PMCID:4499042, AIP Advances, http://dx.doi.org/10.1063/1.4926584 PMCID:4499042, 2015
  • Au T, Destache CJ, Vivekanandan R. Hepatitis C: Looking toward interferon-sparing regimens. J Am Pharm Assoc 2015:e72-86. http://dx.doi.org/10.1331/JAPhA.2015.15508., Journal of American Pharmacists Association, 2015:e72-86. http://dx.doi.org/10.1331/JAPhA.2015.15508. , 2015
  • Destache CJ, Mandal S, Kang G, Zhe Y, Li Q. Combination antiretroviral nanoparticles as a sustained treatment modality in humanized mice. (In Preparation)., Journal of Doctoral Nursing Practice, 2015
  • Destache CJ, Mandal S, Date AA, Zhe Y, Kang G, Lu W, Shibata A, Bruck P, Zhao Y, Fletcher CV, Li Q. Topical application of tenofovir DF nanoparticles prevents HIV-1 vaginal transmission in humanized-BLT mice. (In Preparation)., Journal of Doctoral Nursing Practice, 2015
  • Destache, C. J. Aminoglycoside-induced nephrotoxicity--a focus on monitoring: a review of literature, Journal of Pharmacy Practice, 27, 562-566, 2014
  • Hermsen, Elizabeth D., McDaneld, Patrick M., Eiland, Edward H., Destache, Christopher J., Lusardi, Katherine, Estrada, Sandy J., Mercier, Renée-Claude, DePestel, Daryl D., Lamp, Kenneth C., Anderson, Evette, Chung, Thomas J., McKinnon, Peggy S. Breaking Down the Barriers: Challenges With Development and Implementation of an Industry-Sponsored Antimicrobial Stewardship Data Collection and Analysis Tool, Clinical Infectious Diseases, 59, S179-S184, 2014
  • DePestel, Daryl D., Eiland, Edward H., Lusardi, Katherine, Destache, Christopher J., Mercier, Renée-Claude, McDaneld, Patrick M., Lamp, Kenneth C., Chung, Thomas J., Hermsen, Elizabeth D. Assessing Appropriateness of Antimicrobial Therapy: In the Eye of the Interpreter, Clinical Infectious Diseases, 59, S154-S161, 2014
  • Dull, Ryan B., Friedman, Stacey K., Risoldi, Zara M., Rice, Eric C., Starlin, Richard C., Destache, Christopher J. Antimicrobial Treatment of Asymptomatic Bacteriuria in Noncatheterized Adults: A Systematic Review, Pharmacotherapy, 34, 941-960, 2014
  • DePestel DD, Eiland E III, Lusardi K, Destache CJ, Claude-Mercier R, McDaneld, P Lamp KC, Chung TJ, Hermsen ED. Assessing appropriateness of antimicrobial therapy: In the eye of the interpreter. Clin Infect Dis 2014 2014;59(Suppl 3):S154-S161., Clinical Infectious Diseases, 59 (Suppl) 3), S154-S161, 2014
  • Hermsen ED, McDaneld P, Eiland E III, Destache CJ, Lusardi K, Estrada S, Mercier R-C, DePestel D Lamp K, Anderson E, Chung T, McKinnon P. Breaking down the barriers: challenges with development and implementation of an industry-sponsored antimicrobial stewardship data collection and analysis tool. Clin Infect Dis 2014 2014;59(Suppl 3): S179-S184., Clinical Infectious Diseases, 59 (Suppl 3), S179-S184, 2014
  • Date AA, Shibata A, Bruck P, Destache CJ. Development and validation of a simple isocratic reverse-phase HPLC method for the determination of rilpivirine from tablets, nanoparticles, and cell lysates. Biomed Chromatog 2014 DOI 10.1002/bmc.3346., Biomedical Chromatography : BMC, 2014
  • Destache CJ. Aminoglycoside-induced nephrotoxicity – A focus on monitoring: A review of the literature. doi: 10/1177/0897190014546102 http://jpp.sagepub.com/cgi/reprint/27/6/562.pdf?ijkey=eF7FbvzIRHukQoO&keytype=finite, Journal of Pharmacy Practice, 2014
  • Dull RB, Friedman SK, Risoldi AM, Destache CJ. A systemic review of antimicrobial use for asymptomatic bacteriuria in non-catheterized adults. Pharmacother 2014; doi: 10/1002/phar.1437., Pharmacotherapy, 2014
  • Date, Abhijit A., Destache, Christopher J. A review of nanotechnological approaches for the prophylaxis of HIV/AIDS, Biomaterials, 34, 6202-6228, 2013
  • Shibata A, McMullen E, Pham A, Belshan MA, Sanford B, Zhao Y, Goede M, Date A, Destache CJ. Polymeric nanoparticles containing combination antiretroviral drugs for HIV-1 treatment. AIDS Res Hum Retroviruses 2013;29(5):746-754. PMC3636590, AIDS Research in Human Retroviruses, 29(5), 746-754, 2013
  • Knaak E, Cavalieri SM, Elsasser GN, Gonitzke A, Preheim LC, Destache CJ. Does antibiotic de-escalation for nosocomial pneumonia impact intensive care unit length of stay? Inf Dis Clin Pract 2013;21:172-176., Infectious Disease in Clinical Practice, 21, 172-176, 2013
  • Date A and Destache CJ. Potential of nanotechnology to improve prophylaxis for HIV/AIDS. Biomaterials 2013. http://dx.doi.org/10.1016/j.biomaterials.2013.05.012 PMC482205., Biomaterials, 2013
  • Davis, Estella M., Stang, Jenna, Foral, Pamela A., Baker, Thomas M., Destache, Chris Factors associated with early readmission of cardiothoracic surgical patients, Pharmacotherapy, 32, E109-E109, 2012
  • Date, Abhijit A., Shibata, Annemarie, Goede, Michael, Sanford, Bridget, Bruzzo, Krista L., Belshan, Michel, Destache, Christopher J. Development and evaluation of a thermosensitive vaginal gel containing raltegravir? +? efavirenz loaded nanoparticles for HIV prophylaxis, Antiviral Research, 96, 430-436, 2012
  • Date AA, Shibata A, Goede M, Sanford B, La Bruzzo K, Belshan M, Destache CJ. Development and evaluation of a thermosensitive vaginal gel containing raltegravir + efavirenz loaded nanoparticles for HIV prophylaxis. Antiviral Res 2012;96(3):430-436. PMC3513487, Antiviral Research, 96(3), 430-436, 2012
  • Teply R, Goodman M, Destache CJ. Lopinavir-ritonavir: A review for 2011. Clinical Medicine Insights 2011;3:93-102., Clinical Medicine Insights: Cardiology, 3, 93-102, 2011
  • Destache, C. J., Belgum, T., Goede, M., Shibata, A., Belshan, M. A. Antiretroviral release from poly(DL-lactide-co-glycolide) nanoparticles in mice, Journal of Antimicrobial Chemotherapy, 65, 2183-2187, 2010
  • Destache, C. J., Goede, M., Belgum, T. Antiretroviral nanoparticles: An extended drug delivery modality. Spotlight article, Therapeutic Delivery, 1, 383-386, 2010
  • Packard, Kathleen A., Lenz, Thomas L., Destache, Christopher J. Teaching Heart Failure Treatment Guidelines and Assessing Heart Failure Therapy, American Journal of Pharmaceutical Education, 74, 103-103, 2010
  • Elsasser, Gary N., Kavan, Michael G., Westerman, Gary H., Destache, Christopher J., Sexson, Emily, Turner, Paul D. A Survey of Pharmacy Students' Experiences With Gambling, American Journal of Pharmaceutical Education, 74, 26-26, 2010
  • Packard, K. A., Lenz, T. L., Destache, C. J. A tool to teach heart failure treatment guidelines and to assess heart failure therapy in a pharmacy cardiology rotation, American Journal of Pharmaceutical Education, 74, 1-7, 2010
  • Destache CJ, Goede M, Belgum T. Antiretroviral nanoparticles: An extended drug delivery modality. Spotlight article. Therapeutic Delivery. 2010;1:383-386., Therapeutic Delivery, 1, 383-386, 2010
  • Destache CJ, Goede M, Belgum T, Shibata A, Belshan MA. Pharmacokinetics of antiretroviral release from PLGA nanoparticles in mice. J Antimicrob Chemother 2010;65:2183-2187. PMC2941676, Journal of Antimicrobial Chemotherapy, 65, 2183-2187, 2010
  • Packard KA, Lenz TL, Destache CJ. Teaching heart failure treatment guidelines and assessing heart failure therapy. Am J Pharm Educ 2010;74:Article 103. PMC2933012, American Journal of Pharmaceutical Education, 74, Article 103, 2010
  • Elsasser GN, Kavan M, Westerman GH, Destache CJ, Sexson E, Turner PD. Pharmacy student experiences with gambling. Am J Pharm Educ 2010;74:Article 18. PMC2856415, American Journal of Pharmaceutical Education, 74, Article 18, 2010
  • Zhao, Min, Destache, Christopher J., Ohia, Sunny E., Opere, Catherine A. Role of Prostanoid Production and Receptors in the Regulation of Retinal Endogenous Amino Acid Neurotransmitters by 8-Isoprostaglandin E-2, Ex Vivo, Neurochemical Research, 34, 2170-2180, 2009
  • Nystrom, K. K., Foral, P. A., Christensen, C. M., Destache, C. J., Davis, Estella M. Rotation Students' Perceptions of Clinical Workload Documentation Using a Personal Digital Assistant, Hospital Pharmacy, 44, 968, 2009
  • Stading, J. A., Hermann, J., Walters, R., Destache, C. J., Chock, A. Impact of pharmacist intervention on diabetes patients in an ambulatory setting., Diabetes Spectrum, 22, 241-246, 2009
  • Davis, Estella M., Bebee, Anne, Crawford, LeaAnne, Destache, Chris Nurse Satisfaction Using Insulin Pens in Hospitalized Patients, Diabetes Educator, 35, 799-809, 2009
  • Dou, H., Grotepas, C. B., McMillan, J. M., Destache, C. J., Chaubal, M., Werling, J., Kipp, J., Rabinow, B., Gendelman, H. E. Macrophage delivery of nanoformulated antiretroviral drug to the brain in a murine model of neuroAIDS, Journal of Immunology, 183, 661-669, 2009
  • Elsasser, G. N., Hoie, E. B., Destache, C., Monaghan, M. S. Availability of internet download lecture audio files on class attendance and examination performance, International Journal of Instructional Technology and Distance Learning, 6, Article 3, 2009
  • Destache, C. J., Belgum, T., Christensen, K., Shibata, A., Sharma, A., Dash, A. Combination antiretroviral drugs in PLGA nanoparticle for HIV-1, BMC infectious diseases, 9, 198, 2009
  • Skrabal, M. Z., Jones, R. M., Nemire, R. E., Boyle, C. J., Assemi, M., Kahaleh, A. A., Soltis, D. A., Allen, R. E., Hritcko, P. M., O'Sullivan, T. A., Destache, C. J. National survey of volunteer pharmacy preceptors, American Journal of Pharmaceutical Education, 72, 112, 2008
  • Davis, Estella M., Christensen, Carla M., Nystrom, Kelly K., Foral, Pamela A., Destache, Chris Patient satisfaction and costs associated with insulin administered by pen device or syringe during hospitalization, American Journal of Health-System Pharmacy, 65, 1347-1357, 2008
  • Dou, H. Y., Morehead, J., Destache, C. J., Kingsley, J. D., Shlyakhtenko, L., Zhou, Y., Chaubal, M., Werling, J., Kipp, J., Rabinow, B. E., Gendelman, H. E. Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human nomocyte-derived macrophages, Virology, 358, 148-158, 2007
  • Elsasser, G. N., Goodman, M. D., Destache, C. J., Frey, D. R., Hadi, Z. Preprinted Risk Assessment and Prophylaxis Order Form for Venous Thromboembolism, American Journal of Health-System Pharmacy, 64, 1294, 2007
  • Dou, H., Destache, C. J., Morehead, J. R., Mosley, R. L., Boska, M. D., Kingsley, J., Gorantla, S., Poluektova, L., Nelson, J. A., Chaubal, M., Werling, J., Kipp, J., Rabinow, B. E., Gendelman, H. E. Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery, Blood, 108, 2827-2835, 2006
  • Elsasser, G. N., Hoie, E. B., Destache, C. J., Monagahan, M. S. Effect of Lecture Audio Files on Class Attendance and Examination Performance, American Journal of Pharmaceutical Education, 70, Article 65, 2006
  • Enose, Y., Destache, C. J., Mack, A. L., Anderson, J. R., Ullrich, F., Ciborowski, P. S., Gendelman, H. E. Proteomic fingerprints distinguish microglia, bone marrow, and spleen macrophage populations, Glia, 51, 161-172, 2005
  • Benner, E. J., Mosley, R. L., Destache, C. J., Lewis, T. B., Jackson-Lewis, V., Gorantla, S., Nemachek, C., Green, S. R., Przedborski, S., Gendelman, H. E. Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease, Proceedings of the National Academy of Sciences of the United States of America, 101, 9435-9440, 2004
  • Gendelman, H. E., Destache, C. J., Zelivyanskaya, M. L., Nelson, J. A., Boska, M. D., Biskup, T. M., McCarthy, M. K., Carlson, K. A., Nemechek, C., Benner, E. J., Mosley, R. L. Neuroimaging and proteomic tracking of neurodegeneration in MPTP-Treated mice, Parkinson's Disease: the Life Cycle of the Dopamine Neuron, 991, 319-321, 2003
  • Chock, A., Gong, V., Destache, C. J. Antibacterials and acute exacerbation of chronic bronchitis - Issues for formulary decision makers, Disease Management and Health Outcomes, 10, 333-336, 2002
  • Destache, CJ Optimizing economic outcomes in acute exacerbations of chronic bronchitis, Pharmacotherapy, 22, 12S-17S, 2002
  • Faulkner, M. A., Hilleman, D. E., Destache, C. J., Mooss, A. N. Potential influence of timing of low-density lipoprotein cholesterol evaluation in patients with acute coronary syndrome, Pharmacotherapy, 21, 1055-1060, 2001
  • Destache, C. J., Pakiz, C. B., Larsen, C., Owens, H., Dash, A. K. Cerebrospinal fluid penetration and pharmacokinetics of levofloxacin in an experimental rabbit meningitis model, Journal of Antimicrobial Chemotherapy, 47, 611-615, 2001
  • Streetman, D. S., Nafziger, A. N., Destache, C. J., Bertino, J. S. Individualized pharmacokinetic monitoring results in less aminoglycoside-associated nephrotoxicity and fewer associated costs, Pharmacotherapy, 21, 443-451, 2001

Publications

  • Hoie E, Le S, Destache C. Use of fluconazole as prophylaxis for invasive Candida infections in preterm infants: a retrospective chart review. 2015 Global Conference on Clinical Pharmacy. San Francisco, CA Oct 17-21, 2015. Accepted., Journal of Doctoral Nursing Practice, 2015
  • Narayanan MA, Mansour G, Haddad T, Destache C, Vivekanandan R. Is there enough evidence for early surgery in infective endocarditis? A meta-analysis. 2015 American Thoracic Society Annual Meeting, Denver, CO May 15-20, 2015., Journal of Doctoral Nursing Practice, 2015
  • Foral P, Anthone J, Horne J, Dobronski L, Syed J, Destache C, Vivekanandan R, Preheim L, Gorby G, Bittner M. Incorporating interprofessional practice education and motivational interviewing techniques in antimicrobial stewardship programs at two academic medical centers. (Abstract #P-428) 2015 IDWeek San Diego, CA., Infectious Diseases, 2015
  • Kaye KS, Destache C, Guevil DJ. Ceftaroline fosamil for the treatment of Gram-positive endocarditis CAPTURE study experience. 2015 Interscience Conference of Antimicrobial Agents and Chemotherapy. (Abstract #L-345) San Diego, CA., Journal of Doctoral Nursing Practice, Abstract #L-345, 2015
  • 15. Davis EM, Stang J, Foral PA, Baker TM, Destache C. Factors associated with early readmission of cardiothoracic surgical patients. American College of Clinical Pharmacy. Abstract 26438. Virtual Poster Symposium ACCP May 22-24, 2012., Journal of Doctoral Nursing Practice, 2015
  • Li Q, Tso FY, Kang G, Lu W, Li Y, Fan W, Destache CJ, Wood C. Early antiretroviral therapy prevents the establishment of HIV-1 infection in humanized-BLT mice. (#396) 2014 Conference on Retroviruses and Opportunistic Infections. Boston, MA. Mar 3-6, 2014. Presented as a poster., Journal of Doctoral Nursing Practice, 2014
  • Date AA, Shibata A, Bruck P Rezich M, Madson C, Belshan M, Destache C. Polymeric nanoparticles of tenofovir disoproxil furmarate for HIV prophylaxis. (Abstract #T3100) 2014 American Association of Pharmaceutical Scientists Annual Meeting. San Diego, CA. Presented as a poster., Journal of Doctoral Nursing Practice, 2014
  • Destache CJ, Date AA, Zhe Y, Kang G, Lu W, Tso FY, Wood C, Li Q. Topical application of tenofovir DF nanoparticles prevents HIV-1 vaginal transmission in humanized-BLT mice. (Abstract #109) 2014 American College of Clinical Pharmacy Annual Meeting. San Antonio, TX. Presented as a poster., Journal of Doctoral Nursing Practice, Abstract #109, 2014
  • Kaye K, Destache C, Cole P, Jandourek A, Friedland HD. Gram-positive infective endocarditis treated with ceftaroline fosamil: CAPTURE study experience. (Abstract #L-1735) 2014 Interscience Conference of Antimicrobial Agents and Chemotherapy. Washington DC. Presented as a poster., Journal of Doctoral Nursing Practice, 2014
  • Destache CJ, Date AA, Zhe Y, Kang G, Lu W, Tso FY, Wood C, Li Q. Topical application of tenofovir DF nanoparticles prevents HIV-1 vaginal transmission in humanized-BLT mice. (#H-997) 2014 Interscience Conference of Antimicrobial Agents and Chemotherapy. Washington DC. Presented as a poster., Journal of Doctoral Nursing Practice, 2014
  • Anthone J, Vivekanandan R, Mindru C, Ali K, Ali M, Horowitz E, Bittner M, Gorby G, Destache C, Preheim L. Impact of an antimicrobial stewardship program (ASP) on antimicrobial usage and incidence of Clostridium difficile infections (CDI) at an academic teaching hospital. Abstract 41546 IDWeek San Francisco, CA Oct 2-5, 2013., Journal of Doctoral Nursing Practice, 2013
  • J. Long, C. Destache, M. Swanson, A. Date, J.V. Garcia. Thermosensitive gel delivery of rilpivirine nanoparticles (RPV NPs) prevents vaginal HIV-1 acquisition. Abstract MOPE141 International AIDS Society Meeting, Kuala Lumpur, Malaysia, June 30-July 3, 2013., Journal of Doctoral Nursing Practice, 2013
  • Rajca A, Li Q, Belshan M, Date A, Destache C. Thermosensitive vaginal gel containing PLGA-NRTI conjugate nanoparticles for HIV prophylaxis. Abstract T5.862. 2013 Nanotech Conference. Washington DC. May 12-16, 2013. Presented as a poster., Journal of Doctoral Nursing Practice, Vol. 46, 2013
  • 13. Cernik B, Foral P, Hrdy M, Destache C. Evaluating the appropriateness of an antimicrobial intravenous to oral conversion protocol compared to antimicrobial stewardship recommendations in a veterans affairs health care system. International Pharmaceutical Abstracts 2012. ASHP Midyear Clinical Meeting 46 (Dec). P3-157, Journal of Doctoral Nursing Practice, 46(Dec), P3-157, 2012
  • Date A, Shibata A, Goede M, Sanford B, DeBoer J, Belshan M, Destache CJ. Thermosensitive gel containing raltegravir + efavirenz loaded nanoparticles for HIV prophylaxis. Abstract 2737. 2012 American Association of Pharmaceutical Scientists Annual Meeting Chicago, IL., Journal of Doctoral Nursing Practice, 2012
  • 17. Mohapatra S, Kadajji VG, Goede M, Destache CJ, Dash AK. Combination antiretroviral vaginal gels for prophylactic treatment of HIV-1. American Association of Pharmaceutical Scientists Annual Meeting, New Orleans, LA. November 2011., Journal of Doctoral Nursing Practice, 2011
  • Elsasser GN, Lorhan PS, Destache CJ. Identifying an optimal dose of vancomycin in morbidly obese patients. (Abstract 134). American College of Clinical Pharmacy Annual Meeting, Pittsburgh, PA October 2011., Journal of Doctoral Nursing Practice, 2011
  • 18. Destache CJ, Knaak E, Elsasser GN, Cavalieri SM, Preheim LC. Antibiotic De-Escalation for ICU Pneumonia: What is the impact? (Abstract K-1454) 51st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL September 2011., Journal of Doctoral Nursing Practice, 2011
  • 19. Destache CJ, Goede M, McMullen E, Pham A, Shibata A. Sub-cellular fractionation and confocal microscopy for nanoparticle antiretroviral drugs for HIV-infected cell lines. (Abstract 129) Protection from HIV: Targeted Intervention Strategies. A Keystone Conference. Whistler, British Columbia. Mar 20-25, 2011. Presented as a poster, Journal of Doctoral Nursing Practice, 2011
  • Davis WM, Foral PA, Baker TM, Herdzina AM, Destache C, Hardy KM. Identification of factors associated with early readmission of cardiothoracic surgical patients in a community hospital. Abstract 32 American College of Clinical Pharmacy 31st Annual Meeting, Austin, TX October 17-21, 2010., Journal of Doctoral Nursing Practice, 2010
  • Packard KA, Lenz TL, Destache CJ. A tool to teach heart failure guidelines and assess therapy in a cardiology rotation. American Association of Colleges of Pharmacy Annual Meeting, Seattle, WA. July 11-12, 2010., Journal of Doctoral Nursing Practice, 2010

Presentations

  • Rapid Viral Respiratory Pathogen Identification. MEDS symposium. Omaha, NE, 2014
  • Antiretroviral nanoparticles for HIV infection. Presented at the 2014 ACCP Annual Meeting, Austin, TX October 14, 2014., 2014
  • HIV Treatment Up-date and Treatment of Hepatitis C. Alaska Pharmacists Association annual meeting., 2014
  • Topical tenofovir nanoparticle application prevents HIV-1 vaginal transmission in humanized-BLT mice. Nebraska Center for Virology Annual retreat, Nebraska City, NE, 2014
  • Evaluation of nanomedicine for HIV treatment and prevention. Distinguished Lecture Series. Texas Tech Center of Excellence in Infectious Diseases, Texas Tech University Health Sciences Center, El Paso, TX, 2014
  • Cerebrospinal fluid penetration and pharmacokinetics of anti-infective agents. Presented at the 2013 AAPS Annual Meeting and Exposition, San Antonio, TX, 2013
  • Development of a nanoparticle-based thermosensitive vaginal gel for HIV prevention. 47th American Chemical Society Regional Meeting. Omaha, NE, 2012
  • In vivo levels of ritonavir, lopinavir, efavirenz over time after intraperitoneal injection of antiretroviral PLGA nanoparticle. Part of the Great 8 abstracts presented at the 30th American College of Clinical Pharmacy meeting. Anaheim, CA, 2009

Research and Scholarship

Research and Scholarship Interests

  • Pharmacology, nanomedicine, HIV

Current Research Projects

  • HIV

Grant Funding Received

  • R01AI117740-01 02/01/2015 – 01/30/2019 NIH/NIAID Title: Long-acting antiretroviral nanoparticles for HIV prophylaxis. The goal for this project is to evaluate several antiretroviral drugs incorporated into a nanoparticle formulation for HIV prevention in a Hu-BLT mouse model.
  • Acute bacterial skin and skin structure infection (abSSSI) practice pattern assessment (DUR000501). Durata Therapeutics. Funded. 2014-2015.
  • Evaluation of nanomedicines in the treatment of HIV. National Institute of Allergy & Infectious Diseases (NIAID) $434,988 2014-2016.
  • Use of thermosensitive gel-based tenofovir nanoparticles in a humanized BLT mouse model for HIV prevention. Nebraska Center for Virology Award $50,000/year. 2013-2015. Funded.
  • Combination antiretroviral nanoparticles for treatment in a humanized mouse model of HIV. Nebraska Smoking Tax Fund (LB692) sponsored by Creighton University. $74,850 2013-2014 Funded.
  • R56AI095115-01 09/01/2011-08/30/2013 NIH/NIAID Title: Once monthly antiretroviral nanoparticles for HIV-1 treatment. The goal of this project was to evaluate antiretroviral drugs incorporated into a nanoparticle formulation for HIV treatment in a Hu-BLT mouse model
  • Efficacy of combination antiretroviral nanoparticles in a mouse model of HIV-1. Clinical and Translational Research Grant Program, Creighton University $37,500 2011-2012 Funded
  • Clinical Assessment Program and Teflaro Utilization Registry (CAPTURE). A multicenter, retrospective cohort study to characterize the use of Teflaro in the treatment of patients with acute bacterial skin and skin structure infection or community-acquired pneumonia. Cerexa, Inc. Funded. 2012-2015.
  • 3R15AI076039-01A1S1 01/03/2010-01/02/2011 NIH/NIAID Title: Pharmacology of Antiretroviral Nanoparticle Micelles The goal of this project was to investigate the use of a hollow-fiber system to evaluate the pharmacokinetics of antiretroviral nanoparticles.
  • 1R15AI076039-01A1 09/01/2008-08/30/2010 NIH/NIAID Title: Pharmacology of Antiretroviral Nanoparticle Micelles. The goal of this project was to determine the physical-chemical properties and pharmacokinetics of antiretroviral nanoparticles in mice.
  • Combined nanofabrications for antiretroviral prophylaxis. Dr. Annemarie Shibata co-principle investigator. President’s Faculty Research Fund. Creighton University $15,000 2012-2013.
  • 1R15 AI118550-01 Shibata A (PI) 04/01/2015-03/30/2017 NIH/NIAID Title: Integrase inhibitor combination nanomicrobicide for prevention of HIV infection. The goal of this project is to evaluate dolutegravir+cellulose acetate phalate for HIV prevention as a vaginal gel.
  • Determination of the Efficacy of Nanoparticle driven Antiretroviral Drug Delivery Systems using Cellular Model Systems. Annemarie Shibata, Ph. D., principle investigator. $10,000 CU President’s Faculty Research Fund. 2011-2012. Funded
  • Clinical and economic impact associated with agents used for treatment of suspected or documented infections due to methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, and Pseudomonas aeruginosa. Cubist Pharmaceuticals, Inc. Funded. 2012-2013.
  • Warfarin Dosing: Pharmacogenetic Algorithm Compared to Pharmacist Dosing. Angie Goeser, Pharm. D. principle investigator. American College of Clinical Pharmacy Foundation. $20,000 2006-2007. 20% effort. CU Internal Funding $4,000