Anthony E. Kincaid, PT, PhD
Anthony E. Kincaid, PT, PhD

Anthony E. Kincaid, PT, PhD

Professor
School of Pharmacy and Health Professions

Academic Appointments

Department

  • Pharmacy Sciences

Position

  • Professor

Secondary Appointment

  • School of Medicine

Teaching Activity

  • Cell Biology
  • Gross Anatomy
  • Histology
  • Neuroscience

Biography

Education

  • BS in Physical Therapy; California State University, Long Beach 1979
  • PhD in Anatomy and Cell Biology; University of Michigan 1991

Publications and Presentations

Articles

  • Bett, C., Lawrence, J., Kurt, T.D., Orru, C., Aguilar-Calvo, P., Kincaid, A.E., Surewicz, W.K., Caughey, B., Wu, C. and Sigurdson, C.J. (2017) Enhanced neuroinvasion by smaller soluble prions., Acta Neuropathologica Communications, 5 (32), doi: 10.1186/s40478-017-0430-z, 2017
  •  Shikiya, R.A., Langenfeld, K.A., Eckland, T.E., Trinh, J., Holec, S.A., Mathiason, C.K., Kincaid, A.E., Bartz, J.C. (2017) PrPSc formation and clearance as determinants of prion tropism.PrPSc formation and clearance as determinants of prion tropism., PLoS Pathogens, 13 (3), e1006298, 2017
  • Kincaid, A.E., Ayers, J.A. and Bartz, J.C. The specificity, size and frequency of spaces that characterize the mechanism of bulk transepithelial transport of prions in the nasal cavity of hamsters and mice., Journal of Virology, 90, 8293-8301, 2016
  • Langenfeld, K.A., Shikiya, R.A., Kincaid, A.E., and Bartz, J.C. Incongruity between prion conversion and incubation period following co-infection., Journal of Virology, 90, 5715-5723, 2016
  • Elder, A.M., Henderson, D.M., Nalls, A.V., Hoover, E.A., Kincaid, A.E., Bartz, J.C. and Mathiason, C.K. Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations., Journal of Virology, 89, 7421-7424, 2015
  • Clouse, M.D., Shikiya, R.A., Bartz, J.C and Kincaid, A.E. Nasal associated lymphoid tissue of the Syrian hamster expresses high levels of PrPC., PLoS One, 10, e0117935, 2015
  • Elder, A.M., Henderson, D.M., Nalls, A.V., Wilham, J.M., Caughey, B.W., Hoover, E.A., Kincaid, A.E., Bartz, J.C. and Mathiason, C.K. In vitro detection of prionemia in TSE-infected cervids and hamsters., PLoS One, 8, e80203, 2013
  • Kincaid, A.E., Hudson, K.F., Richey, M.W. and Bartz, J.C. Rapid transepithelial transport of prions following inhalation., Journal of Virology, 86, 12731-12740, 2012
  • Ayers, J.I., Schutt, C.R., Shikiya, R.A., Aguzzi, A., Kincaid, A.E., Bartz, J.C. The strain-encoded relationship between PrPSc replication, stability and processing in neurons is predictive of the incubation period of disease., PLoS Pathogens, 7 (3), e1001317, 2011
  • Shikiya, R. A., Ayers, J.I., Schutt, C.R., Kincaid, A.E., Bartz, J.C. Co-infecting prion strains compete for a limiting cellular resource., Journal of Virology, 84 (11), 5706-5714, 2010
  • Ayers, J. I., Kincaid, A. E. and Bartz, J. C. Prion strain targeting independent of strain-specific neuronal tropism., Journal of Virology, 83, 81-87, 2009
  • Kincaid, A. E. and Bartz, J. C. The nasal cavity is a route for prion infection in hamsters, Journal of Virology, 81, 4482-4491, 2007
  • Bartz, J.C., Kramer, M.L., Sheehan, M.H., Hutter, J.A.L., Ayers, J.I., Bessen, R.A. and Kincaid, A.E. Prion interference is due to a reduction in strain-specific PrPSc levels., Journal of Virology, 81 (2), 689-697, 2007
  • Shara, Michael, Kincaid, Anthony E., Limpach, Aimee L., Sandstrom, Robert, Barrett, Laura, Norton, Neil, Bramble, J. D., Yasmin, Taharat, Tran, Janet, Chatterjee, Archana, Bagchi, Manashi, Bagchi, Debasis Long-term safety evaluation of a novel oxygen-coordinated niacin-bound chromium (III) complex, Journal of inorganic biochemistry, 101, 1059-1069, 2007
  • Shara, M., Yasmin, T., Kincaid, A. E., Limpach, A. L., Bartz, J., Brenneman, K. A., Chatterjee, A., Bagchi, M., Stohs, S. J., Bagchi, D. Safety and toxicological evaluation of a novel niacin-bound chromium(III) complex, Journal of inorganic biochemistry, 99, 2161-2183, 2005
  • Marsh, R.F., Kincaid, A.E., Bessen, R.A. and Bartz, J.C. Interpsecies transmission of chronic wasting disease prions to squirrel monkeys., Journal of Virology, 79 (21), 13794-13796, 2005
  • Bartz, J.C., DeJoia, C, Tucker, T., Kincaid, A.E. and Bessen, R.A. Extraneural prion neuroinvasion without lymphoreticular system infection., Journal of Virology, 79 (18), 11858-11863, 2005
  • Robinson, B. S. and Kincaid, A. E. Repetitive motion in perception of tactile sensation in the fingers of string players, Perceptual and Motor Skills, 99, 1171-1183, 2004
  • Mulcahy, E.R., Bartz, J.C., Kincaid, A.E. and Bessen, R.A. Prion infection of skeletal muscle cells and papillae in the tongue., Journal of Virology, 78 (13), 6792-6798, 2004
  • Bartz, J.C., Kincaid, A.E. and Bessen, R.A. Rapid prion neuroinvasion following tongue infection., Journal of Virology, 77 (1), 583-591, 2003
  • Kincaid, A. E., Duncan, S. and Scott, S. A. Assessment of fine motor skill in musicians and nonmusicians: Differences in timing versus sequence accuracy in a bimanual fingering task, Perceptual and Motor Skills, 95, 245-257, 2002
  • Bartz, J.C., Kincaid, A.E. and Bessen, R.A. Retrograde transport of transmissible mink encephalopathy within descending motor tracts., Journal of Virology, 76 (11), 5759-5768, 2002
  • Kincaid, A. E. Spontaneous circling behavior and dopamine neuron loss in a genetically hypothyroid mouse, Neuroscience, 105, 891-898, 2001

Research and Scholarship

Research and Scholarship Interests

  • Pathogenesis of prion diseases; Drug delivery via nasal cavity.

Current Research Projects

  • Prion entry and spread following inhalation; prion neuroinvasion; the mechanisms of drug entry following inhalation into nasal cavity.

Grant Funding Received

  • Bulk paracellular transport of drug carriers in the nasal cavity
  • Mechanisms of prion strain selection
  • Characteristics of prion entry and neuroinvasion following nasal cavity infection
  • Prion strain selection in the central nervous system
  • Determination of prion transport via intranasal routes
  • Routes of prion neuroinvasion following oral infection
  • Prion strain targeting and competition in the central nervous system
  • The role of glial cells in prion disease

Awards and Honors

  • Educator of the Year: 1996, 1997, 1999, 2000, 2002, 2005, 2006, 2007, 2009, 2012, First year Physical Therapy students, 2012
  • Scholarly Achievement Award, School of Pharmacy and Health Professions Faculty, 2005
  • Robert F. Kennedy Excellence in Teaching Award, Creighton University Student's Union, 2000
  • Teacher of the Year, School of Pharmacy and Health Professions Faculty, 2000