Benjamin M. Brandsen, PhD
Benjamin M. Brandsen, PhD

Benjamin M. Brandsen, PhD

Assistant Professor
College of Arts and Sciences

Academic Appointments

Department

  • Chemistry and Biochemistry

Position

  • Assistant Professor

Teaching Activity

  • CHM 322: Organic Chemistry Laboratory I
  • CHM 371: Biochemistry of Metabolism

Biography

Ben Brandsen is an Assistant Professor in the Chemistry Department at Creighton University. He earned the B.S. in Biochemistry from Calvin College in 2010, and the Ph.D. in Chemistry from the University of Illinois at Urbana-Champaign in 2016. He was an NIH postdoctoral fellow in the Department of Genome Sciences at the University of Washington before coming to Creighton in 2019.

Publications and Presentations

General

  • Yao, T.; Przybyla, J. J.; Yeh, P.; Woodard, A. M.; Nilsson, H. J.; Brandsen, B. M.; Silverman, S. K. “DNAzymes for Amine and Peptide Lysine Acylation”, Org. Biomol. Chem. 2021, 19, 171-181., Organic & Biomolecular Chemistry, 2021
  • Brandsen, B. M.; Mattheisen, J. M.; Noel, T.; Fields, S. A biosensor strategy for E. coli based on ligand-dependent stabilization, ACS Synth. Biol. 2018, 7, 19901999., ACS Synthetic Biology, 2018
  • Lee, Y.; Klauser, P. J.; Brandsen, B. M.; Zhou, C.; Li, X.; Silverman, S. K. "DNA-Catalyzed DNA Cleavage by a Radical Pathway with Well-Defined Products", J. Am. Chem. Soc. 2017, 139, 255261., Journal of the American Chemical Society, 2017
  • Hesser, A. R.; Brandsen, B. M.; Walsh, S. M.; Wang, P.; Silverman, S. K. DNA-Catalyzed Glycosylation Using Aryl Glycoside Donors, Chem. Commun. 2016, 52, 92599262., Chemical Communications, 2016
  • Zhou, C.; Avins, J. L.; Klauser, P. C.; Brandsen, B. M.; Lee, Y.; Silverman, S. K. DNA-Catalyzed Amide Hydrolysis, J. Am. Chem. Soc. 2016, 138, 21062109., Journal of the American Chemical Society, 2016
  • Brandsen, B. M.; Velez, T. E.; Sachdeva, A.; Ibrahim, N. A.; Silverman, S. K. “DNA-Catalyzed Lysine Side Chain Modification”, Angew. Chem. Int. Ed. 2014, 53, 9045–9050., Angewandte Chemie International Edition, 2014
  • Brandsen, B. M.; Hesser, A. R.; Castner, M. A.; Chandra, M.; Silverman, S. K. “DNA-Catalyzed Hydrolysis of Esters and Aromatic Amides”, J. Am. Chem. Soc. 2013, 135, 16014–16017., Journal of the American Chemical Society, 2013
  • Tasker, S. Z.; Brandsen, B. M.; Ryu, K. A.; Snapper, G. S.; Staples, R. J.; DeKock, R. L.; Anderson, C. E. “Synthesis of a New Class of b-Iodo N-Alkenyl 2-Pyridones”, Org. Lett. 2011, 13, 6224–6227., Organic Letters, 2011
  • DeKock, R. L. Brandsen, B. M.; Strikwerda, J. R. Theoretical Study of Formation of Ion Pairs in (NH3HCl)(H2O)6 and (NH3HF)(H2O)6, Theor. Chem. Acc. 2011, 130, 871-881., Theoretical Chemistry Accounts, 2011
  • DeKock, R. L.; Schipper, L. A.; Dykhouse, S. C.; Heeringa, L. P.; Brandsen, B. M., Ion Pairs or Neutral Molecule Adducts? Cooperativity in Hydrogen Bonding, J. Chem. Educ. 2009, 86, 1459 1464., Journal of Chemical Education, 2009

Presentations

  • Woodward, T. J.; Hills, E. M.; Fields, S.; Brandsen, B. M.* "The Antibiotic Activity of the Lasso Peptide Klebsidin and its Variants." Nebraska Academy of Sciences Annual Meeting, April 23-24, 2021., 2021
  • Johnson, K. S.; Hills, E. H.; Brandsen. B. M.* "Production of highly diverse lasso peptides from a single biosynthetic pathway." Nebraska Academy of Sciences Annual Meeting, April 23-24, 2021., 2021
  • McCollum, C. M.; Manse, A. M.; Brandsen, B. M.* "An Engineered Biosensor for the Herbicide Dicamba." Nebraska Academy of Sciences Annual Meeting, April 23-24, 2021., 2021
  • McCollum, C. M.; Manse, A. M.; Brandsen, B. M.* "An Engineered Biosensor for the Herbicide Dicamba." University Research Week, Creighton University, April 19-22, 2021., 2021
  • Johnson, K. S.; Hills, E. H.; Brandsen. B. M.* "Production of highly diverse lasso peptides from a single biosynthetic pathway." University Research Week, Creighton University, April 19-22, 2021., 2021
  • Woodward, T. J.; Hills, E. M.; Fields, S.; Brandsen, B. M.* "The Antibiotic Activity of the Lasso Peptide Klebsidin and its Variants." University Research Week, Creighton University, April 19-22, 2021., 2021

Research and Scholarship

Grant Funding Received

  • Evolving Highly Active Lasso Peptides (Nebraska-INBRE DRPP, $102,000 direct, $148,410 total, 05/01/20 – 04/30/23, P.I. Ben Brandsen)