James T. Fletcher, PhD
James T. Fletcher, PhD

James T. Fletcher, PhD

College of Arts and Sciences

Academic Appointments


  • Chemistry and Biochemistry


  • Professor

Publications and Presentations


  • Ru(II) coordination compounds of N-N bidentate chelators with 1,2,3-triazole and isoquinoline subunits: Synthesis, spectroscopy and antimicrobial properties, Polyhedron, 177, 114259, 2020
  • Antimicrobial 1,3,4-trisubstituted-1,2,3-triazolium salts, Bioorganic and Medicinal Chemistry Letters, 28, 3320-3323, 2018
  • Revisiting ring degenerate rearrangements of 1-substituted-4-imino-1,2,3-triazoles, Beilstein Journal of Organic Chemistry, 14, 2098-2105, 2018
  • Tandem synthesis of 4-formyl-1,2,3-triazoles, Tetrahedron Letters, 58, 4450-4454, 2017
  • Spermine detection via metal-mediated ethynylarene 'turn-on' fluorescence signaling, Sensors and Actuators B-Chemical, 207, 843-848, 2015
  • Silver-Mediated Synthesis of Indolizines via Oxidative C-H functionalization and 5- endo-dig cyclization, Tetrahedron Letters, 55, 6922-6924, 2014
  • 2-(1,2,3-Triazol-4-yl)pyridine-containing ethynylarenes as selective "turn-on" fluorescent chemosensors for Ni(II), Tetrahedron Letters, 55, 4612-4615, 2014
  • Evaluation of triazole-chelated lanthanides as chemically stabile bioimaging agents, Journal of Pharmaceutical Sciences, 102, 2589-2598, 2013
  • Dicarboxylated ethynylarenes as buffer-dependent chemosensors for Cd(II), Pb(II) and Zn(II), Tetrahedron Letters, 54, 5366-5369, 2013
  • Fast dye salts provide fast access to azidoarene synthons in multi-step one-pot tandem click transformations, Tetrahedron Letters, 52, 5512-5515, 2011
  • 1-Allyl- and 1-Benzyl-3-methyl-1,2,3-triazolium Salts via Tandem Click Transformations, Synthesis, 2010, 3339-3345, 2010
  • Benzodiazepine Synthesis and Rapid Toxicity Assay, Journal of Chemical Education, 87, 631-633, 2010
  • Fletcher, James T., Walz, Sara E., Keeney, Matthew E. Monosubstituted 1,2,3-triazoles from two-step one-pot deprotection/click additions of trimethylsilylacetylene, Tetrahedron Letters, 49, 7030-7032, 2008
  • Fletcher, James T., Bumgarner, Benjamin J., Engels, Nicole D., Skoglund, David A. Multidentate 1,2,3-Triazole-Containing Chelators from Tandem Deprotection, Organometallics, 27, 5430-5433, 2008
  • Fletcher, J. T., Finlay, J. A., Callow, M. E., Callow, J. A., Ghadiri, M. R. A combinatorial approach to the discovery of biocidal six-residue cyclic D,L-alpha-peptides against the bacteria methicillin-resistant Staphylococcus aureus (MRSA) and E. coli and the biofouling algae Ulva linza and Navicula perminuta., Chemistry, 13, 4008-4013, 2007

Research and Scholarship

Research and Scholarship Interests

  • Organic Synthesis and Coordination Chemistry

Current Research Projects

    • Triazole-containing multidentate chelators
    • Antimicrobial heterocycles
    • Tandem click reactions
    • Colorimetric and fluorimetric sensors

Grant Funding Received

  • Antimicrobial Properties of Click-Derived Triazole Compounds, Salts and Metal Complexes, National Institutes of Health, NE-INBRE Program, DRPP Grant
  • Development of 1,2,3-triazolium salts with antimicrobial properties, National Institutes of Health, NE-INBRE Program, DRPP Grant