Somnath Singh, BPharm, MPharm, PhD

Department

• Pharmacy Sciences

Position

• Professor

• MPS 602: Analytical Aspects of Pharmaceutical Sciences Research, 2 credits, required
• MPS 617: Advanced Pharmaceutics, 3 Credits, required
• MPS 633: Research Methods, 1-3 credits
• MPS 691 - Pharmaceutical Science Seminar
• MPS 692 - Directed Independent Study, 1-5 credits
• MPS 693 - Directed Independent Research, 1-5 credits
• MPS 797 - Master's Directed Independent Research, 1-4 credits
• MPS 799 - Master's Thesis, 1-4 credits
• PHA 300: Pharmacogenomics in Disease Management, 2 credits, elective
• PHA 317: Pharmaceutics I: Physicochemical Principles of Drugs, 3 credits; required course
• PHA 535: Academic Advance Pharmacy Practice Experience
• PHA 551: Research Advance Pharmacy Practice Experience

Biography of Somnath Singh Associate Professor, Department of Pharmacy Sciences, Creighton University, 2500 California St., Omaha, NE, 68178 Phone: 402-850-7207 (Mobile), 402-280-3548 (Work), 402-827-9710 (Home); Fax: 402-280-1883 E-mail: ssingh@creighton.edu EDUCATION 1. Ph. D., Pharmaceutics, Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USA [2000-03]. i. Thesis: Smart polymer based controlled release drug delivery system for peptide and protein. ii. Relevant Courses: Principle of polymer synthesis, Advanced pharmaceutics, Recombinant DNA technology (laboratory course), Animal cell culture technique (laboratory course), Biochemistry (proteins – purification, structure, function, and stability, receptor mediated signal transduction, metabolic pathways, protein synthesis and its regulation), Quantitative drug design, Pharmacokinetic, and Statistical methods of experimental design. 2. Master of Pharmacy, Pharmaceutical Chemistry, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221005, INDIA (1991-93). i. Thesis: Synthesis and antibacterial activity of some N-Mannich bases of Isatin-3- (4’- cyclohexyl-3’-thiosemicarbazone) derivatives. ii. Relevant Courses: Advanced pharmaceutical analysis, Biostatistics and Spectroscopy, Pharmaceutical Chemistry. 3. Bachelor of Pharmacy, Department of Pharmacy, Muzaffarpur Institute of Technology, Muzaffarpur 842003, INDIA (1986-90). i. Relevant Courses: Pharmaceutics, biopharmaceutics and pharmacokinetics, advanced organic chemistry, chemistry of natural products, synthetic organic chemistry, medicinal chemistry, pharmacology, pharmacognosy, pharmaceutical analysis, Human anatomy and physiology, and mathematics. PROFESSIONAL EXPERIENCE Research Experience Nov. 1999- July, 2003: Research Associate, Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USA. (i) Worked on a Department of Defense, USA project entitled “Percutaneous Absorption, Skin Biophysics, and Dermatotoxicity from JP-8” [Nov. 1999 – April 2003]. (ii) Carried out transport of drugs in vitro through porcine skin using Franz diffusion cell and in vivo in weanling pig. (iii) Investigated biophysical changes in stratum corneum, microscopic and macroscopic barrier perturbation in vitro and in vivo. (iv) Studied microscopic alterations in skin by toxicants by light microscopy and changes at cellular level (Langerhans cell, stratum basale) by electron microscopy. Experience and training in managing multiple projects and meeting aggressive deadlines. (i) Synthesis and characterization of thermosensitive polymers. (ii) Investigating biocompatibility of biomaterials in vitro using fibroblast cell lines. (iii) Preparation and characterization of PLGA microspheres. (iv) Iontophoretic transdermal, microspheres, and smart polymer based controlled drug delivery systems. (v) Synthesis of medicinal compounds as I worked on a research project entitled “Synthesis and antibacterial activity of some N-Mannich bases of Isatin-3- (4’- cyclohexyl-3’-thiosemicarbazone) derivatives” during master of pharmacy program. (vi) Trouble shooting equipment and processes during laboratory operations. Proven team person, working on a highly collaborative Ph.D. thesis project involving personnel and equipment support from five different research laboratories on campus. Teaching Experience (a) Worked as Assistant Professor at Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad, UP – 201204, INDIA [Feb. 22, 1993 to July 07, 1997. (b) Worked as Assistant Professor at Dept. of Pharmaceutical Sciences, Guru Jambheshwar University, Hisar, Haryana – 125001, INDIA {July 08, 1997 - Oct. 29, 1999}. (c) Assistant Professor (Pharmaceutics), Pharmacy Sciences, Creighton University, Omaha, NE 68178 (2003-2010) (d) Associate Professor (Pharmaceutics), Pharmacy Sciences, Creighton University, Omaha, NE 68178 (2010-present) PROFESSIONAL SKILLS Pharmaceutical analysis (i) Chromatography (HPLC, TLC, GPC), liquid scintillation counter, differential scanning calorimeter (DSC), Spectrophotometer (FTIR, UV- VIS), Microscopy (Optical microscopy, Transmission electron microscopy, Scanning electron microscopy, fluorescence microscopy), Lyophilizer, Infra-red thermometer, gel electrophoresis, PAGE, dot blot techniques, autoradiogram, and PCR. (ii) Preparative ultracentifugation (differential and density gradient methods), Radio-immuno assay of leuprolide acetate, protein determination by colorimetric method, dialysis. Animal cell culture technique Asceptic technique of cell line handling, Spliting/subculture and maintenance of cell line, Plating efficiency, Cellular bioassay for cytokines, Cell toxicity assay, Plaque and Microtiter assays, Somaic cell fusion, Mycoplasma detection using PCR Animal experiment (i) Skin irritation studies on awake, unanesthesized rabbits. (ii) Injection and blood sampling techniques in rabbits. Computer literacy Computer literacy: Data analysis software (Microcal Origin, PSI plot), Statistical software (Minitab, SAS); Online databases such as Medline, Pubmed and Current Contents. WORKSHOPS/SHORT COURSE ATTENDED 1. Radiation Safety Short Course “Laboratory Use of Radioactive Material” Jan. 25, 2000. 2. Biotechnology as a business. AAPS, Annual Meeting and exposition, Denver, Colorado, Oct. 21, 2000. AWARD 1. Educator of the Year by pharmacy campus class of 2017 announced on March 29, 2014. 2. Educator of the Year by pharmacy distance class of 2016 announced on Feb. 18, 2014. 3. Educator of the Year by pharmacy campus class of 2014 announced on April 1, 2011. 4. Educator of the Year by pharmacy distance class of 2012 announced on April 1, 2009. 5. School of Pharmacy and Health Professions Faculty Research Development Grant, 2005 for project entitled: Polymer-based in situ gel forming controlled release drug delivery system for peptide and protein, funded amount $15,000.00. 6. Research fellowship from University Grant Commission (UGC), India, 1991-93. Grants submitted: Grants funded: 1. Shed snake skin as a model membrane for assessing percutaneous absorption of drugs in humans, Health Future Foundation Faculty Development Grant, $20,000.00, 7/1/2005-6/30/2007. 2. Effect of polymer-protein interaction on burst release and conformational stability of proteins in a smart polymer-based sustained release formulation, Health Future Foundation Faculty Development Grant, $20,000.00, 7/1/2008-6/30/2009. 3. Investigation of effect of chemical skin penetration enhancers on stability and biological activity of protein-based therapeutics, Health Future Foundation Faculty Development Grant, $10,000.00, 12/1/2006-6/30/2008. Grants not funded: 1. A Sustained Release Delivery System of Hydrogen Sulfide for the Potential Treatment of Parkinson’s Disease. The Dr. George F. Haddix President’s Faculty Research Fund, Creighton University, $15,000, March 1, 2015-Feb. 29, 2016, Role: PI 2. Novel in situ gel forming ocular delivery system for hydrogen sulfide. R15-NIH, $296,610, 4/1/2015-3/30/2018, Role: Co-PI 3. Exploring Potential of Hydrogen Sulfide in Synucleinopathies. LB692 - NE Tobacco Settlement Biomedical Research Development New Initiative Grant. $72,000, 7/1/2014-6/30/2016, Role: PI 4. Investigating the potential role of H2S gas in geriatric disorders, President’s Faculty Research Fund, $5,000.00, 2/1/2014-1/31/2015. Role: PI 5. Novel ocular delivery system for hydrogen sulfide analogs, President’s Faculty Research Fund, $5,000.00, 2/1/2013-1/31/2014. Role: PI 6. Novel sustained release delivery system for exenatidePresident’s Faculty Research Fund, $15,000.00, 2/1/2013-1/31/2014. Role: PI 7. Ocular Delivery of Hydrogen Sulfide, NIH, $ 248,121.00, 7/1/2012-6/30/2014. Role: Co-PI 8. Polymer-protein interactions in a sustained release formulations, Health Future Foundation Faculty Development Grant, $20,000.00, 7/1/2012-6/30/2013. Role: PI 9. Subconjunctival delivery of novel hydrogen sulfide donor for reduction of intraocular pressure, President’s Faculty Research Fund, $5,000.00, 2/1/2012-1/31/2013. 10. Sustained release delivery of hydrogen sulfide and its ocular activity, LB692 Nebraska Tobacco Settlement Biomedical Research New Initiative Grant, $ 73,630, 7/1/2011-6/30/2012. 11. Reducing burst release in controlled release delivery systems for proteins, NIH, $ 150,000.00, 12/1/2009-11/30/2011. 12. Dendrimers as carrier for drugs targeted to tumors, LB692-New Initiatives Research, $100,000.00, 7/1/2009- 6/30/2010. 13. Role of end groups in sustained release drug delivery system for proteins, Health Future Foundation, $ 20,000.00, 7/1/2008- 6/30/2010. 14. Navigating transport of chemicals through snake skins with multiphoton fluorescence lifetime imaging, The American Association of College of Pharmacy, 2008-2009 New Investigator program for Pharmacy Faculty, $ 10,000.00, 1/1/2009-12/31/2009. 15. In situ gel forming smart polymer-based sustained release delivery system of levodopa for potential use in Parkinson's disease. Health Future Foundation, $ 20,000.00, 7/1/2007- 6/30/2009. 16. Effect of polymer end groups on release profile, conformational stability, and biological activity of proteins incorporated in a phase-sensitive smart polymer–based controlled release drug delivery system, The American Association of Colleges of Pharmacy (AACP), $ 10,000.00, 1/1/2007-12/31/2007. 17. Dendrimer-based nanoparticles as carriers of anti-cancer drugs to tumor cells, Health Future Foundation, $ 20,000.00, 7/1/2006- 6/30/2007. 18. In situ gel forming smart polymer-based sustained release formulations of levodopa for use in Parkinson's disease, The American Association of Colleges of Pharmacy, $15,000.00, 1/1/2006-12/31/2006. BOOK/ BOOK CHAPTER 1. Alekha K. Dash, Somnath Singh, and Justin Tolman (2013). Pharmaceutics: Basic Principles and Application to Pharmacy Practice. Elsevier, New York. 2. Jatin Khurana, Somnath Singh, and Alekha K. Dash (2010). Multiple Emulsions: An Overview and Pharmaceutical Applications. In: Colloids in Drug Delivery, Surfactant Science series, 148, 177-202, CRC Press, Taylor & Francis Group, New York. 3. Babu Medi, Somnath Singh, and Jagdish Singh, 2004. Assessing Efficacy of Penetration Enhancers, In: Dermal Absorption Models in Toxicology and Pharmacology, Jim E Riviere (Ed.), Taylor and Francis, New York, USA. 4. Shitut, N. R., Rastogi, S. K., Singh, S., Kang, F., and Singh, J., 2004. Rectal and Vaginal Routes of drug Delivery, In: Theory and Practice of Contemporary Pharmaceutics, Ghosh, T. K. and Jasti, B. R.(Eds.), Taylor and Francis, New York, USA. 5. Arya, P., Mittal, R., and Singh, S., 1999. A Text Book of Medicinal Chemistry: Drug Action and Synthesis. Piyush Publication, P B No. 8076, B – 161, Part – 1, Gujrawala Town, Delhi – 110 033, INDIA REVIEW 1. Singh, SK., 2015. Development of Zolmitriptan loaded PLGA/poloxamer nanoparticles for migraine using quality by design approach. International Journal of Biological Macromolecules. Manuscript Number: IJBIOMAC-D-15-02104. 2. Redmond, K.A. and Ryan, R.O., 2007. All-trans-retinoic acid nanodisks. International Journal of Pharmaceutics (manuscript # IJP-D-06-01243). 3. Medina, M. and Kumar, V., 2006. Influence of degree of polymerization on tableting properties of cellulose I and cellulose II powders. International Journal of Pharmaceutics (manuscript # IJP-D-06-00549). 4. Prietoa, M.J., Bacigalupeb, D. Pardinic, O., Amalvy, J.I., Venturini, C., Morilla, M.J., Romero, E.L., 2006. Nanomolar cationic dendrimeric sulfadiazine as potential antitoxoplasmic agent International Journal of Pharmaceutics (manuscript # IJP-D-06-00121). 5. Leon, C., Taylor, R., Bartlett, K.H., Wasan, K.M., 2005. Effect of Heat-Treatment on Fungizone-Induced Cytotoxicity within Human Kidney Proximal Tubular (HK-2) Cells and Aspergillus Fumigatus; the role of Phospholipases. International Journal of Pharmaceutics (manuscript # KU-2357). 6. Chilcott, R.P., Dalton, C.H., Hill, I., Davison, C.M., Blohm, K.L., Clarkson, E.D., Hamilton, M.G. 2004. In vivo skin absorption and distribution of the nerve agent VX (O-ethyl-S-[2(diisopropylamino)ethyl] methylphosphonothioate) in the domestic white pig. Human and Experimental Toxicology (manuscript # MP3227/04). 7. Jiangfeng Su and Kadriye Ciftci, 2004. Formulation of novel PLGA-histone-p53 microparticles for breast cancer gene therapy. International Journal of Pharmaceutics (manuscript # KU-2194). 8. Yuxin Wang, Archna Desai, and Naushad M. Khan Ghilzai, 2004. Influence of hydroxypropyl-beta-cyclodextrin on in vitro diffusion studies of hydrocortisone acetate. Drug Development and Industrial Pharmacy (manuscript # UT2004-64-1). 9. Takahashi, K., Sakano, H., Numata, N. Kuroda, S., and Mizuno, N. 2002. Effect of fatty acid diesters on permeation of anti-inflammatory drugs through rat skin. Drug Development and Industrial Pharmacy (manuscript # UT2002-51). 10. Funke, A., Gunther, C., Muller, R., and Lipp, R. 2002. Development of matrix patches for transdermal delivery of a highly lipophilic antiestrogen. Drug Development and Industrial Pharmacy (manuscript # UT2002-165). 11. Vermani, K., Garg, S., and Zaneveld, L. 2001. “Evaluation of bioadhesion and retention characteristics of polymers in vaginal environment. Drug Development and Industrial Pharmacy (manuscript # UT2001-135). 12. Christy, M., Bellantone, R., Taft, D., and Plakogiannia, F. 2001. In vitro evaluation of the release of albuterol sulfate from poymer gels: Effect of fatty acids on drug transport across biological membranes. Drug Development and Industrial Pharmacy (manuscript # UT2001-201). PROFESSIONAL MEMBERSHIPS 1. American Association of Pharmaceutical Scientists (AAPS), member # 142615 2. Controlled Release society (CRS), USA, member # 11387 3. American Association of College of Pharmacy (AACP), member # 69250 4. National Geographic Society, member # 4173376106 CITATIONS (1) Chilcott, R.P., Dalton, C.H., Hill, I., Davison, C.M., Blohm, K.L., Clarkson, E.D., Hamilton, M.G. 2005. In vivo skin absorption and distribution of the nerve agent VX (O-ethyl-S-[2(diisopropylamino)ethyl] methylphosphonothioate) in the domestic white pig. Human and Experimental Toxicology (manuscript # MP3227/04) cited Singh, S., Zhao, K., and Singh, J. (2002). In vitro permeability and binding of hydrocarbons in pig ear and human abdominal skin. Drug and Chemical Toxicology, 25, 83-92. (2) H. Ali, C. A. Opere, and S. Singh (2014). In vitro controlled release delivery system for hydrogen sulfide donor. AAPS PharmSciTech.2014 Aug;15(4):910-9. doi: 10.1208/s12249-014-0117-8. Epub 2014 Apr 24. PubMed PMID: 24760470; PubMed Central PMCID: PMC4113624: Citation: 1. Jianbo Guo, Junwei Wang, Chenchen Cai, Jinghua Xu, Hongdan Yu, Hui Xu and Tang Xing. The Anti-Melanoma Efficiency of the Intratumoral Injection of Cucurbitacin-Loaded Sustained Release Carriers: In Situ-Forming Implants. AAPS PharmSciTech, 2015, DOI: 10.1208/s12249-015-0292-2. 2. T. Spencer Bailey and Michael D. Pluth. Series: Methods in Enzymology, Year: 2015, DOI: 10.1016/bs.mie.2014.11.012 (3) Fogueri, L.R., Singh, S. Smart polymers for controlled delivery of proteins and peptides: A review of patents. Recent Patents on Drug Delivery and Formulation volume 3, issue 1, year 2009, pp. 40 - 48 has been cited in: 1. Choonara, B.F., Choonara, Y.E., Kumar, P., Bijukumar, D., du Toit, L.C., Pillay, V. A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules. Biotechnology Advances. volume 32, issue 7, year 2014, pp. 1269 - 1282 PUBLICATIONS IN PEER-REVIEWED JOURNALS (1) H. Ali, C. A. Opere, and S. Singh (2014). In vitro controlled release delivery system for hydrogen sulfide donor. AAPS PharmSciTech.2014 Aug;15(4):910-9. doi: 10.1208/s12249-014-0117-8. Epub 2014 Apr 24. PubMed PMID: 24760470; PubMed Central PMCID: PMC4113624 (2) and Somnath Singh (2012). Investigation of effects of terpene skin penetration enhancers on stability and biological activity of lysozyme. AAPS Pharm Sci Tech Aug., 2012, DOI: 10.1208/s12249-012-9840-1. (3) Nihal S. Mulla and Somnath Singh (2011). Dendrimers in Drug Delivery, Pharmstudent, XXV, 11-17. (4) Somnath Singh and Alekha Dash (2009). Paclitaxel in Cancer Treatment: Perspectives and Prospects of its Delivery Challenges, Critical Reviews in Therapeutic Drug Carrier Systems, 26, 333-76. (5) Laxmi R. Fogueri and Somnath Singh (2009). Smart Polymers for Controlled Delivery of Proteins and Peptides: A Review of Patents. Recent Patents on Drug Delivery & Formulation, 3, 40-48. (6) Somnath Singh, Saurabh Jauhari, and Alekha Dash (2009). Paclitaxel. Profiles of Drug Substances, Excipients, and Related Methodology, 34, 1-33. (7) Somnath Singh and Alekha Dash (2008). Radioprotectants: basic concepts, current status and future directions. Drugs of the Future, 33(8): 681-689. (8) Somnath Singh and Alekha Dash (2008). Creatine Monohydrate. Profiles of Drug Substances, Excipients, and Related Methodology, 34, 299-340. (9) Singh, S and Singh, J. (2007). Phase-sensitive polymer-based controlled delivery systems of leuprolide acetate: In vitro release, biocompatibility, and in vivo absorption in rabbits. International Journal of Pharmaceutics, 328, 42-48. (10) Sumit Chhabra, Vishal Sachdeva, and Somnath Singh (2007). Influence of end groups on in vitro release and biological activity of lysozyme from a phase-sensitive smart polymer-based in situ gel forming controlled release drug delivery system. International Journal of Pharmaceutics, 342, 72-77. (11) Somnath Singh and Jagdish Singh, (2007). Thermosensitive polymers: Synthesis, characterization, and delivery of proteins. International Journal of Pharmaceutics, 341, 68-77. (12) D.N. Mishra, S.K. Singh, S.G. Vijaya Kumar and S. Singh (2006). Teaching strategies for better pharmaceutical education. Indian Journal of Technical Education, Vol 29, No-1, Jan-March, 18-23. (13) Singh, S. (2005). An Overview of Transdermal Drug Delivery. Drug Delivery Report, Autumn/Winter, 2005, 35-38. (14) Singh, S and Singh, J. (2004). Controlled release, conformational stability, and biological activity of lysozyme from phase sensitive smart polymer based delivery systems. International Journal of Pharmaceutics, 271, 189-196. (15) Singh, S. and Singh, J. (2004). Dermal toxicity and microscopic alterations by of JP-8 jet fuel components in vivo in rabbits. Environmental Toxicology and Pharmacology, 16, 153-161. (16) Singh, S and Singh, J. (2003). Effect of polyols on the conformational stability and biological activity of a model protein lysozyme. AAPS Pharm Sci Tech 4 (3) Article 43. (17) Singh, S and Singh, J. (2003). Percutaneous Absorption, Biophysical, and Macroscopic Barrier Properties of skin exposed to major components of JP-8 Jet Fuel. Environmental Toxicology and Pharmacology, 14, 77-85. (18) Singh, S., Zhao, K., and Singh, J. (2003). In vivo percutaneous absorption, skin barrier perturbation, and irritation from JP-8 jet fuel components. Drug and Chemical Toxicology, 26, 135-146. (19) Singh, S., Zhao, K., and Singh, J. (2002). In vitro permeability and binding of hydrocarbons in pig ear and human abdominal skin. Drug and Chemical Toxicology, 25, 83-92. (20) Singh, S and Singh, J. (2001). Dermal Toxicity: Effect of Jet Propellant-8 Fuel Exposure on the Biophysical, Macroscopic and Microscopic Properties of Porcine Skin. Environmental Toxicology and Pharmacology, 10, 123-131. (21) Singh, S. and Singh, J. (2001). Effect of JP-8 Jet fuel on the Ultrastructure of the Skin. Journal of Toxicology – Cutaneous and Ocular Toxicology, 20, 11-21. (22) Zhao, K., Singh, S., and Singh, J. (2001). Effect of menthone on the in vitro absorption of tamoxifen and skin reversibility. International Journal of Pharmaceutics, 219, 177-181. (23) Singh, J., Rastogi, S. K., Singh, S., and Bhatia, J. S. (2000). Quantification of Leuprolide Acetate by High Performance Liquid Chromatography. J. Liq. Chrom. & Rel. Technol., 23, 3023-3031. (24) Pathak D.P, Singh S., Sharma, S., and Singh, D. K. (2000). Gene Therapy: Perspectives and Prospective. The Eastern pharmacist, 43(508), 21-26. (25) Singh, S., Mishra, D. N., Singh, S. K., Kumar, U., Pathak, D., and Pathak, K. (1998). Enzyme Inhibitors as Target for Drug Design. Eastern Pharmacist, XLI, 486, 31-36, 1998. (26) Panot, V., Pathak, K., Pathak, D., and Singh, S. (1996). Borderline Substances: A Review. IDMA Bulletin, XXVII, 10, 298-302. PEER-REVIEWED ABSTRACTS/ PAPERS/ POSTERS PRESENTED AT INTERNATIONAL/ NATIONAL MEETING (1) Somnath Singh (2015). A Quantitative and Peer-Reviewed Approach for Assessment of Students’ Oral Presentations. 2015 University Assessment Symposium, Skutt Student Center Ballroom, Creighton University, Omaha, NE, Feb. 20, 2015. (2) Anthony J. Rangel, Somnath Singh, Catherine A. Opere (2015). In Vitro Release of H2S from ACS67, Measured with UV-Visible Spectrophotometry. 2015 Annual Biomedical Research Conference for Minority Students (ABRCMS). November 11 – 14, Washington State Convention Center in Seattle, WA. (3) Patil, A., Dash, A., and Singh, S. Development and validation of a simple HPLC method for quantification of hydrogen sulfide in aqueous samples. Annual Meeting and Exposition, Association of Pharmaceutical Scientists, Oct. 24-29, 2015, Orlando, FL. (4) Somnath Singh (2014). Teaching as Service to God. "All Things Ignatian" Celebrates: One Creighton: Bridging to a Greater Future, 3:00 – 5:30 pm, Monday, February 3, 2014, Harper Center Ahmanson Ballroom. (5) L. R. Fogueri and S. Singh (2014). Smart Polymers for Controlled Release Delivery System for Proteins: Effect of molecular size of protein, polymer composition, and its end groups, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, November 02-06, 2014, San Diego Convention Center, San Diego, California. (6) N. Mulla, S. Singh (2014). Formulation development and evaluation of nanoparticles for sustained delivery of levodopa- dendrimer conjugate for treatment of Parkinson’s disease. 41st Annual Meeting of the Controlled Release Society, July 13-16, 2014, Chicago, IL. (7) H. Ali, C. Opere, S. Singh (2013). Effect of sonication parameters on in vitro release of a model hydrogen sulfide donor from a sustained release formulation. Annual Meeting and Exposition, Association of Pharmaceutical Scientists, Nov. 10-14, 2013, San Antonio, TX. (8) H. Ali, C. Opere, S. Singh (2012). Effect of polymer composition, concentration, and end groups on in vitro release of a model hydrogen sulfide donor from a sustained release formulation. Annual Meeting and Exposition, Association of Pharmaceutical Scientists, October 14-18, 2012, Walter E. McCormick Place, Chicago. (9) Seher A. Khan and Somnath Singh (2012). Professionalism in evaluating oral presentations. Annual Meeting and Seminars, American Association of College of Pharmacy, July 14-18, 2011, Kissimmee, Florida. (10) Seher A. Khan and Somnath Singh (2012). Pre-pharmacy requirements towards successful completion of a basic pharmaceutics course. Annual Meeting and Seminars, American Association of College of Pharmacy, July 14-18, 2011, Kissimmee, Florida. (11) N. Mulla, S. Singh (2011). Effect of dendrimer-levodopa conjugated nanoparticles on fibrillation of alpha synuclein. Annual Meeting and Exposition, Association of Pharmaceutical Scientists, October 23-27, 2011, Walter E. Washington Convention Center, Washington, D.C. (12) H. Ali, C. Opere, S. Singh (2011). An easy to use, safe, and efficient spectrophotometric method for the determination of hydrogen sulfide released from its analogues. Annual Meeting and Exposition, Association of Pharmaceutical Scientists, October 23-27, 2011, Walter E. Washington Convention Center, Washington, D.C. (13) H. Ali, C. Opere, S. Singh (2011). Phase-sensitive smart polymer-based sustained release delivery system for hydrogen sulfide analogue, Annual Meeting and Exposition, Association of Pharmaceutical Scientists, October 23-27, 2011, Walter E. Washington Convention Center, Washington, D.C. (14) Seher A. Khan and Somnath Singh (2011). Methodologies and strategies for teaching a course on basic pharmaceutics. Annual Meeting and Seminars, American Association of College of Pharmacy, July 09-13, 2011, San Antonio, Texas. (15) Seher A. Khan and Somnath Singh (2011). Importance of a course to enhance pharmacy students' readiness against biological/chemical disasters. Annual Meeting and Seminars, American Association of College of Pharmacy, July 09-13, 2011, San Antonio, Texas. (16) H. Ali, L. R. Fogueri, and S. Singh (2010). Snake skins as a model for predicting percutaneous absorption in humans, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, November 11-16, 2010, Ernest N. Morial Convention Center, New Orleans, Louisiana. (17) N. S. Mulla, J. T. Aaltonen, L. R. Fogueri, and S. Singh (2010). A controlled release delivery system of follicle stimulating hormone for inducing superovulation in tigers, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, November 11-16, 2010, Ernest N. Morial Convention Center, New Orleans, Louisiana. (18) S. Singh and N. S. Mulla (2010). Evaluation of alpha synuclein fibrillation a potential model for determining therapeutic effectiveness of anti Parkinson drug, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, November 11-16, 2010, Ernest N. Morial Convention Center, New Orleans, Louisiana. (19) J. T. Aaltonen, S. Singh, L. R. Fogueri, N. S. Mulla, and N. M. Loskutoff (2010). In vitro development of a less invasive hormone delivery system to superovulate tigers, 36th Annual Conference of the International Embryo Transfer Society (IETS), Jan. 9-12, 2010, Sheraton Cordoba Hotel, Cordoba, Argentina. (20) S. Singh and L. R. Fogueri (2010). Investigation of the role of polymer–protein interaction on the release profile of protein from a smart polymer delivery system, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, November 11-16, 2010, Ernest N. Morial Convention Center, New Orleans, Louisiana. (21) L. R. Fogueri and S. Singh (2009). Reducing burst and rate of release of lysozyme from a smart polymer-based controlled release drug delivery system, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, November 07-11, 2009, Los Angeles Convention Center, Los Angeles, California. (22) L. R. Fogueri, S. Singh, and S. Grothen (2009).The effects of Bisphenol A and di-isononyl phthalate on conformational stability and activity of lysozyme., Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, November 07-11, 2009, Los Angeles Convention Center, Los Angeles, California. (23) Gary N. Elsasser, Kelly Nystrom, Victor Padron, Alicia Vanden Bosch, and Somnath Singh (2009). Use of Web-Enabled Proprietary Software to Disseminate Admission Application Files. Annual Meeting and Seminars, American Association of College of Pharmacy, July 18-22, 2008, Westin Boston Waterfront, Boston, Massachusetts (24) L.R. Fogueria, Heather Jensen-Smith, and S. Singh (2008). Biophysical investigation of snake skins by confocal microscope, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, November 16-20, 2008, Georgia World Congress Center, Atlanta, Georgia. (25) L.R. Fogueri and S. Singh (2008). Inter-species differences in snakes for percutaneous absorption of model compounds, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, November 16-20, 2008, Georgia World Congress Center, Atlanta, Georgia. (26) L.R. Fogueria and S. Singh. Investigation of effects of terpene skin penetration enhancers on stability and biological activity of lysozyme, Annual Meeting and Seminars, American Association of College of Pharmacy, July 19-23, 2008, Sheraton Chicago Hotel & Towers, Chicago, Illinois (27) Charlene A. Fajardo and Somnath Singh (2007). Biophysical measurements, transepidermal water loss, and moisture contents of skins from different snake species, Annual Meeting and Seminars, American Association of College of Pharmacy, July 19-18, 2007, Disney’s Yacht and Beach Club in Lake Buena Vista, Florida. (28) Beth A Muszynski, Somnath Singh, and Stephen M Gross (2007). Tri-block biodegradable polymers for drug delivery applications, Undergraduate Research Poster Sessions at the 233rd ACS national meeting, March 25-29, 2007, Chicago. (29) Alvin Samuels and Somnath Singh (2006). The effect of cigarette smoke exposure on the conformational stability and biological activity of a model protein, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Oct. 29-Nov. 02, 2006, San Antonio, Texas. (30) Sumit Chhabra and Somnath Singh (2006). Effect of end groups on polymer-based in situ gel forming controlled release drug delivery system for protein, American Association of Pharmaceutical Scientists, Oct. 29-Nov. 02, 2006, San Antonio, Texas. (31) S. Singh, D. C. Webster, and J. Singh (2005). Suppression of testosterone level in vivo in rabbits by smart polymer-based controlled release formulations of leuprolide acetate. Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Nov. 6-10, 2005, Nashville, Tennessee. (32) S. Singh, D. C. Webster, and J. Singh (2005). Smart polymer-based controlled release formulations of leuprolide acetate for suppression of testosterone level in vivo in rabbits. Engebretson Symposium on Drug Discovery and Development, (33) S. Singh (2005). Evaluating the Outcome of Teaching PHA 315 Physical Pharmacy to Web-based Pharm.D. Students. The Virtual Frontier: Developing and Delivering Health Science Education from a Distance, June 20-23, 2005, Omaha, Nebraska. (34) S. Singh, T.R. Gustad, and J. Singh (2004). Biocompatibility and biodegradability of smart polymer based in situ gel forming controlled release drug delivery systems. Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Nov. 7-11, 2004, Baltimore, Maryland. (35) S. Singh and J. Singh (2004). In Vitro Release of Leuprolide Acetate from In Situ Gel Forming and Biocompatible Controlled Release Formulations. 31st Annual Meeting and Exposition of the Controlled Release Society, June 12-16, 2004, Honolulu, Hawaii. (36) S. Singh, D.C. Webster, and J. Singh (2004). Controlled release of protein and peptide from in situ gel forming thermosensitive polymers. Engebretson Symposium on Drug Discovery and Development, Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, ND, May 10-12, 2004. (37) J. Singh and S. Singh (2003). Controlled release of a model protein lysozyme from biocompatible and thermosensitive smart polymer formulations. Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Oct. 26-30, 2003, Salt Lake City, Utah. (38) S. Singh and J. Singh (2003). Biocompatible and in situ gel forming phase sensitive smart polymer formulations for controlled release of proteins in biologically active form. Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Oct. 26-30, 2003, Salt Lake City, Utah. (39) S. Singh and J. Singh (2003). Smart polymer based controlled release formulation of model protein bromelain. 30th Annual Meeting and Exposition of the Controlled Release Society, July 19-23, 2003, Glasgow, Scotland. (40) S. Singh and J. Singh (2002). Evaluation of preservatives for protein formulations by differential scanning calorimeter using a model protein lysozyme, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Nov. 9-14, 2002, Toronto, Canada. (41) J. Singh and S. Singh (2002). In situ gel forming polymer as controlled drug delivery system for a model protein lysozyme, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Nov. 9-14, 2002, Toronto, Canada. (42) S. Singh and J. Singh (2002). Skin barrier perturbation, irritation, and microscopic alterations in vivo in rabbit from JP-8 jet fuel, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Nov. 9-14, 2002, Toronto, Canada. (43) N. Shitut, S. Singh, and J. Singh (2002). Preparation, characterization and targeting of 5-fluorouracil loaded PLGA microspheres suitable for passive targeting to the lungs, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Nov. 9-14, 2002, Toronto, Canada. (44) S. Singh and J. Singh (2002). Evaluation of stabilizers against destabilization of a model protein lysozyme due to oxidation by hydrogen peroxide, 29th Annual Meeting of the Controlled Release Society, July 20-25, 2002, Seoul, Korea. (45) S. Singh and J. Singh (2001). Percutaneous absorption and binding to stratum corneum of model aliphatic and aromatic components of JP-8 jet fuel. Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Oct. 21-25, 2001, Denver, Colorado. (46) J. Singh and S. Singh (2001). Effect of polyols on deamidation of a model protein lysozyme. Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Oct. 21-25, 2001, Denver, Colorado. (47) S. Singh and J. Singh (2001). Polyols stabilize lysozyme against destabilization due to salting out by sodium chloride. Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Oct. 21-25, 2001, Denver, Colorado. (48) S. Singh and J. Singh (2001). Percutaneous absorption of model aliphatic and aromatic solutes, 28th International Symposium on Controlled Release of Bioactive Materials, June 24-27, 2001, San Diego, USA. (49) J. Singh and S. Singh (2001). Percutaneous absorption, biophysical, macroscopic and microscopic barrier perturbation from six major components of JP-8 jet fuel. AFOSR JP-8 jet fuel toxicology conference, January 10-12, 2001, The University of Arizona, Tucson, Arizona. (50) S. Singh and J. Singh (2001). Effect of Aliphatic Constituents of JP-8 on Skin Lipid and Protein Biophysics, and In Vitro Transepidermal Water Loss. Pharmaceutical Congress of Americas, March 24 –29, 2001, Orlando, Florida. (51) J. Singh and S. Singh (2001). Effect of Naphthalene on Biophysical, Macroscopic and Microscopic properties of Skin. Pharmaceutical Congress of Americas, March 24 –29, 2001, Orlando, Florida. (52) S. Singh, K. Zhao, and J. Singh (2000). Pig skin as Model for Humans to Study In Vitro Percutaneous Absorption of Chemicals, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Oct. 29-Nov. 2, 2000, Indianapolis, IN. (53) S. Singh and J. Singh (2000). Ultrastructural Changes in Porcine Skin due to JP-8 Exposure, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Oct. 29-Nov. 2, Indianapolis, IN. (54) J. Singh and S. Singh (2000). Effect of JP-8 on the Biophysical, Macroscopic Properties of the Skin, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Oct. 29-Nov. 2, 2000, Indianapolis, IN. (55) J. Singh, K. Zhao, and S. Singh (2000). Barrier Function and Irritation from Chemicals in vivo in Weanlings Pigs, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Oct. 29-Nov. 2, 2000, Indianapolis, IN. (56) S. K. Rastogi, S. Singh, and J. Singh (2000). Iontophoretic Transport of Polar, Non-ionic and Ionic Solutes. Engebretson Symposium on Drug Discovery and Development, Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, May 18-19, 2000. (57) V. Soumyalata, B. Venkatalakshmi, Y. Kumar, S. Singh, and D. Pathak (1996). Free radical scavenging effect of Shilajit from different geographical locales, Oral presentation, 48th Indian Pharmaceutical Congress, Dec. 25-27, 1996, Chennai, India. (58) S. Singh, S. K. Singh, D. N. Mishra, R. P. Gupta, and G. Nath (1995). Synthesis and antibacterial activity of some N-Mannich bases of Isatin-3- (4’- cyclohexyl-3’-thiosemicarbazone) derivatives, Poster Presentation, International Seminar on “Recent Trends in Pharmaceutical Sciences”, Feb. 18-20, 1995 Ootacamund, Tamilnadu, INDIA. (59) S. K. Singh, S. Singh, D. N. Mishra, D. C. Bhatt, and A. K. Srivastava (1995). Preparation and evaluation of ethyl cellulose microcapsules of Verapamil Hydrochloride”, Poster Presentation, International Seminar on “Recent Trends in Pharmaceutical Sciences” Feb. 18-20, 1995 Ootacamund, Tamilnadu, INDIA. (60) S. K. Singh, S. Singh, D. N. Mishra, D. C. Bhatt, and A. K. Srivastava (1995). Sustained release formulation of Verapamil hydrochloride, Poster Presentation, International Seminar on “Recent Trends in Pharmaceutical Sciences” Feb. 18-20, 1995 Ootacamund, Tamilnadu, INDIA. (61) D. N. Mishra, S. K. Singh, S. Singh, P. K. Sharma, and J. K. Pandit (1995). Fast release dosage form of Frusemide, Poster Presentation, International Seminar on “Recent Trends in Pharmaceutical Sciences” Feb. 18-20, 1995 Ootacamund, Tamilnadu, INDIA.

Books

• , 177-202

Articles

• , 20, 250
• , 1, 01-09
• , 1 & 2, 114-123
• , 1 & 1, 25-28
• , 6, 2291-2302
• , 15, 910-919
• , 13, 1084-1090
• , XXV, 11-17
• , 34, 1-33
• , 34, 299-340
• , 3, 40-48
• , 26, 333-372
• , 33, 681-689
• , 342, 72-77
• , 341, 68-77
• , 328, 42-48

Presentations

Research and Scholarship Interests

• Skin irritation, dermatotoxicity, percutaneous absorption, protein formulation and stability, controlled release drug delivery system, smart polymer

Current Research Projects

• Controlled release delivery system for hydrogen sulfide donor.

Grant Funding Received

• Shed snake skin as a model membrane for assessing percutaneous absorption of drugs in humans, Health Future Foundation Faculty Development Grant, $20,000.00, 7/1/2005-6/30/2007.
• Effect of polymer-protein interaction on burst release and conformational stability of proteins in a smart polymer-based sustained release formulation, Health Future Foundation Faculty Development Grant, $20,000.00, 7/1/2008-6/30/2009.
• Investigation of effect of chemical skin penetration enhancers on stability and biological activity of protein-based therapeutics, Health Future Foundation Faculty Development Grant, $10,000.00, 12/1/2006-6/30/2008.
• Acquisition of a state of the art gel permeation chromatography system Funding Source: U.S. Department of Defense Role: Co-PI (PI: Dr. Stephen Gross, Department of Chemistry, Creighton University)
• 5. Title: Polymer-based in situ gel forming controlled release drug delivery system for peptide and protein. Funding Source: HFF (Faculty Development Research Grant)

• Educator of the Year, Pharmacy distance class of 2019, 2016
• Educator of the Year (2014), Pharmacy campus class of 2017, 2014
• Educator of the Year (2014), Pharmacy distance class of 2016, 2014
• Educator of the Year (2011), Pharmacy campus class of 2014, 2011
• Educator of the Year (2009), Pharmacy distance class of 2012, 2009