Lynne M. Dieckman, MS, PhD

Department

• Chemistry and Biochemistry

Position

• Associate Professor

Articles

• , 293 (29), 11271-11282
• , 13(3), e0193333
• , 055900
• , 11(6), e0157023
• , 30, 85-108
• , 52 (33), 5611-5619
• , 12 (5), 367-376
• , 62, 281-299
• , 49 (34), 7344-7350

Research and Scholarship Interests

• 
  Research in the Dieckman lab focuses on the mechanisms by which errors in DNA replication and repair and chromatin organization lead to genome instability and disease.  Specifically, our main goal is to characterize the interactions of key factors that are essential for the interplay between genomic and epigenetic stability.  Two of these factors include the proteins PCNA (the processivity factor that stimulates DNA polymerases during DNA replication and repair) and CAF-1 (the main histone chaperone that is necessary for packaging DNA into nucleosomes following replication and repair).  The interaction between PCNA and CAF-1 is crucial for proper DNA synthesis, assembly of nucleosomes, and preservation of epigenetic marks.  Students will learn biochemical techniques used in modern biomedical research in order to determine the mechanistic basis of the network of interactions between CAF-1, PCNA, DNA, and other factors during replication-dependent nucleosome assembly and to work towards an understanding of proper DNA maintenance.

Grant Funding Received

• Dr. George F. Haddix President’s Faculty Research Fund, Creighton University
• National Institutes of Health INBRE Program, DRPP
• National Science Foundation Nebraska EPSCoR FIRST Award