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News & Highlights

News & Highlights

Neuroscience undergraduate and mentee of Dr. Jian Zuo, Madeleine Urbanek, is the first author of the following paper that has been accepted for publication in the journal Scientific Reports: "Genetic predisposition to tinnitus in the UK Biobank population".

Dr. Jian Zuo received 1-year NE LB606 DHHS Stem Cell Research Grant Award for a project titled “Cochlear Stem Cells for Hearing Restoration.”

Dr. Brian North received 1-year NE LB606 DHHS Stem Cell Research Grant Award for a project titled "Targeting SIRT2 in Glioblastoma Cancer Stem Cells.”

Dr. Tejbeer Kaur and team lab published an article titled “Innate Immunity to Spiral Ganglion Neuron Loss: A Neuroprotective Role of Fractalkine Signaling in Injured Cochlea” in the journal of Frontiers in Cellular Neuroscience. DOI: https://doi.org/10.3389/fncel.2021.694292.

MD/PhD graduate student, Justin Rudd (in Dr. Laura Hansen's lab), was awarded Best Graduate/Professional Student Platform Presentation in Basic Sciences during University Research Week.

Dr. Laura Hansen is the recipient of the 2021 Dr. Robert Heaney Graduate Research Mentor Award presented by the University Research Council during University Research Week.

Dr. Peter Steyger is the recipient of the 2021 University Research Award (Health Sciences) presented by the University Research Council during University Research Week.

Dr. Jian Zuo received a 2-Year Department of Defense (DOD) Award for a project titled "Pre-clinical and clinical therapeutics for noise-induced hearing loss."

Neuroscience undergraduate and mentee of Dr. Jian Zuo, Madeleine Urbanek, has been awarded the prestigious Clare Boothe Luce Summer Fellowship and Academic Scholarship.

Dr. David He co-authored research work titled “Transcription co-factor LBH is necessary for the survival of cochlear hair cells” in the Journal of Cell Science. DOI: 10.1242/jcs.254458

Dr. David He co-authored research work titled “SCN11A gene deletion causes sensorineural hearing loss by impairing the ribbon synapses and auditory nerves” in the journal of BMC Neuroscience. DOI: https://doi.org/10.1186/s12868-021-00613-8

Dr. Garrett Soukup received an award from the LB692 Nebraska Tobacco Settlement Biomedical Research Development fund for the purchase of research equipment.

Neuroscience undergraduate and mentee of Dr. Jian Zuo, Madeleine Urbanek, has been awarded the prestigious Goldwater scholarship for her research in the hearing field.

Creighton’s Translational Hearing Center, which was established in 2019, has been awarded a $10.8 million grant, payable over five years and competitively renewable up to 15 years, by the NIH-affiliated Centers of Biomedical Research Excellence (COBRE). Read the Full Story in the News Center

Dr. Tejbeer Kaur received NIH/NIGMS COBRE funding for 3 years to study the Contribution of Macrophages and Fractalkine Towards Degeneration and Repair of Cochlear Synapses.

Dr. Ken Kramer received the Teaching for Tomorrow Award in February from the Creighton University Students Union.

Dr. Sandor Lovas co-authored research work titled "DksA-dependent regulation of RpoS contributes to Borrelia burgdorferi tick-borne transmission and mammalian infectivity" in the journal of PlosPathogens. DOI: 10.1371/journal.ppat.1009072.

Dr. Tejbeer Kaur served as Chair at the Young Investigator Symposium titled "Role of Immune cells in auditory system development, pathology and regeneration” at the ARO 44th MidWinter Meeting.

Dr. Tejbeer Kaur presented at the ARO 44th MidWinter Meeting with her talk titled "Macrophages facilitate repair of damaged ribbon synapses after acoustic trauma" and poster titled "Fate mapping reveals slow turnover of adult cochlear macrophages in steady state and distinguishes resident from recruited monocyte-derived macrophages following acoustic trauma.

Dr. Tejbeer Kaur co-authored research work titled “Dynamic patterns of YAP1 expression and cellular localization in the developing and injured utricle” in the journal of Scientific Reports.

Dr. Brian North received a 2-year NIH R03 award for his project titled "Characterizing upstream regulators of glucosylceramide metabolism for Parkinson's disease and Lewy Body Dementia."

MD/PhD graduate student, Jonathan Fleegel, in Dr. Jian Zuo lab has been awarded an NIH F30 predoctoral fellowship for project titled, “Repurposing momelotinib for the prevention of aminoglycoside-induced ototoxicity."

Dr. Marisa Zallocchi co-authored research work titled "BRAF inhibition protects against hearing loss in mice" in the journal of Sci. Adv. DOI: 10.1126/sciadv.abd0561.

Dr. David He received a subaward from OHSU for the project titled "Hair Bundle Structure and Dynamics."

Dr. Laura Hansen has been invited to serve as a standing member for the NIH Special Emphasis Panel (SEP) on Musculoskeletal, Orthopedic, Oral, Rheumatology, Rehab, Skin.

Dr. David He received a certificate from the National Institute on Deafness and Other Communication Disorders for his service as a member of the Communication Disorders Review Committee from July 2016 - June 2020. 

Dr. Sandor Lovas co-authored research work titled "A-dependent regulation of RpoS contributes to Borrelia burgdorferi tick-borne transmission and mammalian infectivity" in the journal bioRXiv. DOI: https://doi.org/10.1101/2020.11.04.367946

Dr. Brian North presented his research titled “Molecular pathways at the intersection of aging and disease” in the Department of Genetics, Cell Biology and Anatomy at the University of Nebraska Medical Center, Omaha.

Dr. Jian Zuo and team published research work titled The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells” in the journal Scientific Reports. DOI: 10.1038/s41598-020-72181-6

Dr. Jian Zuo and collaborators published research work titled Aldh inhibitor restores auditory function in a mouse model of human deafness.” in the journal PLoS Genetics. DOI: 10.1371/journal.pgen.1009040

Dr. Laura Hansen and team published research work titled “Targeting 14-3-3e - CDC25A interactions to trigger apoptotic death in skin cancer” in the journal Oncotarget. DOI: 10.18632/oncotarget.27700

Dr. Laura Hansen and team published research work titled “Targeting 14-3-3e activates apoptotic signaling to prevent cutaneous squamous cell carcinoma” in the journal Carcinogenesis. DOI: 10.1093/carcin/bgaa091

Drs. Jian Zuo & Peter Steyger received a 5-year Office of Naval Research (ONR) Subaward on a project titled “Trans-Middle Ear Drug Delivery” (specific aims are to develop an in vitro screening tool to identify therapeutics for non-invasive local delivery to the inner ear via eardrops).”

Dr. David He received a Bellucci Fund Research Grant Award for project titled “SLC7A14 and Syndromic Hearing Loss.”

Dr. Tejbeer Kaur received a Bellucci Fund Research Grant Award for project titled “Role of Macrophages in Damage and Repair of Cochlear Ribbon Synapse.”

Dr. Garrett Soukup received a Bellucci Fund Research Grant Award for project titled “Deciphering pathways of microRNA enforcement of hair cell development and maintenance.”

Dr. Sarath Vijaykumar, in Dr. Jian Zuo’s research group, received a Bellucci Fund Research Grant Award for project titled “Developing Novel Therapeutics for Tinnitus using Gene-Expression Signature.”

Dr. Marisa Zallocchi, in Dr. Jian Zuo’s research group, received a Bellucci Fund Research Grant Award for project titled “Deciphering the Downstream Signaling Cascade Regulated by Integrin Alpha8 in Auditory Hair Cells.”

Dr. Jian Zuo received 1-year funding from Frequency Therapeutics on a project titled “Profile the gene signature of individual cell populations in the cochlea with or without perturbations using single cell RNAseq analysis.”

Drs. Laura Hansen & Sandor Lovas received a 5-year NIH R01 award for their project titled “Targeting aberrant anti-apoptotic signaling for prevention of skin cancer.”

Dr. Laura Hansen received 1-year NE LB606 DHHS Stem Cell Research Grant Award for a project titled “Targeting cancer stem cells for cutaneous SCC.”

Drs. Marisa Zallocchi and Jian Zuo received an SBIR Phase I award from NIH/NIDCD to examine “Therapeutics to prevent aminoglycoside-induced hearing loss.”

Dr. Laura Hansen received 1-year NE DHHS LB506 Award for a pilot project titled “Flower-Win dependent stem-cell maintenance in cutaneous squamous cell carcinoma”

Dr. David Smith co-authored research work titled “Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67” in the journal of ACS Infect Dis. DOI: 10.1021/acsinfecdis.0c00005

Dr. Tejbeer Kaur co-authored research work titled “Dynamic patterns of YAP1 expression and cellular localization in the developing and injured utricle” in the journal of bioRxiv. DOI: https://doi.org/10.1101/2020.05.06.081323

Dr. Tejbeer Kaur has been honored as a Guest Editor for Frontiers in Neuroscience and Cellular Neurophysiology for a special research topic on Cochlear Neuron and Ribbon Synapse: Development, Degeneration, Repair and Regeneration.

Dr. Tejbeer Kaur was invited to serve as a reviewer for NIH Auditory System Study Section (AuD) in June 2020.

Drs. Pezhman Salehi and Jian Zuo received a 1-year SBIR Phase I award from NIH/NIDCD to examine “Therapeutics to prevent cisplatin-induced hearing loss by transcriptomics.”

Dr. Marisa Zallocchi, in Dr. Jian Zuo’s research group received a 2-Year Department of Defense (DoD) Award for a project titled “Exploring the Beneficial Effects of Quinoline Derivatives after Noise-Induced Damage.”

Dr. Brian North presented his research titled “Characterizing pathways involved in controlling the age-dependent decline of BubR1” at the Keystone Symposium: Intra- and Intercellular Mechanisms of Aging in Vancouver, BC, Canada.

Dr. David He co-authored research work titled “Interaction with ectopic cochlear crista sensory epithelium disrupts basal cochlear sensory epithelium development in Lmx1a mutant mice” in the journal Cell Tissue Res. DOI: 10.1007/s00441-019-03163-y

Dr. Tejbeer Kaur was honored to serve as a panelist for spARO Mentoring Session on Job Search and Independence at 43rd Association for Research in Otolaryngology MidWinter Meeting in San Jose, California.

Dr. Tejbeer Kaur was a presenter and co-presenter in three presentations at the ARO 43rd Midwinter Research Meeting in San Jose, California.

Dr. Brian North received a Saving Tiny Hearts Society and Children’s Heart Foundation Grant Award for project titled “Regulation of the Cardiac Conduction System by BubR1.”

Dr. Brian North received a Curing Kids Cancer and an Andrew McDonough B+ Foundation Grant Award for project titled “Rational combination therapy targeting epigenetic pathways promoting mitotic catastrophe in childhood leukemia.”

Dr. Garrett Soukup co-authored the article review for research project titled “Neurosensory roles of the microRNA-183 family” in the journal Mol Neurobiol. DOI: 10.1007/s12035-019-01717-3


Creighton Researchers Probe Secrets of Skin Cancer

Some of skin cancer’s most closely held secrets are currently being pried loose in a Creighton University laboratory.

During the past six years, Laura Hansen, PhD, and Sandor Lovas, PhD, have monitored two signaling proteins they believe might play a key role in the development of skin cancer.

The results of that research, which was funded by a grant from the state of Nebraska, were significant enough that the National Institutes of Health has provided a five-year, $1.7 million grant to keep the line of inquiry alive. Read the Full Story in the News Center


'The richness of human experience': Creighton's Translational Hearing Center aims to prevent drug-induced hearing loss

When he was 14 months old, Peter Steyger, PhD, contracted bacterial meningitis. Physicians in his native Manchester, England, managed to save his life through a course of aminoglycoside antibiotics,
but a side-effect of those drugs robbed him of his hearing. Read the full story in the News Center


A Vision for Hearing Research

Creighton’s new Translational Hearing Center seeks significant breakthroughs, buoyed by a gift from the Bellucci DePaoli Family Foundation and a director who, himself, experienced childhood hearing loss. Read Creighton Magazine


INBRE Mentors
Nebraska INBRE Program. Read about the program


Hansen Appointed Creighton Medicine's Associate Dean for Research

Laura Hansen, PhD, has been appointed associate dean for research in the School of Medicine. In this role, Hansen will provide leadership, guidance and mentorship of research to faculty and staff, oversee internal and external collaborations in research, develop and expand major research programs and monitor research and grant compliance. The appointment was effective August 2019. Read more about Laura Hansen, PhD

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