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Pharmacology News Archive

2021

Drs. Yaping Tu, P. Wei, and colleagues published a manuscript titled ‘PEG-GO@XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to-mesenchymal transition’ in the Eur J Pharmacol, 2021 Jan 14:173866. doi: 10.1016/j.ejphar.2021.173866. PMID: 33454376 (impact factor 3.26). https://pubmed.ncbi.nlm.nih.gov/33454376/

Dr. Shashank Dravid and colleagues published an article titled ‘Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model’ in the journal Neurobiol Dis. 2021 Jan 6;150:105254.doi:10.1016/j.nbd.2021.105254. https://pubmed.ncbi.nlm.nih.gov/33421565/

First year medical student Emma Malloy, working with Dr. Tal Teitz, won 1st place for her poster presentation of her research work “Dabrafenib Prevents Cisplatin-induced Hearing Loss in Mice” at the Creighton University Medical Student Poster Symposium held on January 16.

2020

Dr. Kristina Simeone, one of eight keynote speakers, presented ‘The Basic Science of Sleep and SUDEP’ at the international Partners Against Mortality in Epilepsy Conference (Virtual) in Dec 2020.

Dr. Kristina Simeone presented ‘Neuropeptides and Neurotransmitters in SUDEP’ at the international American Epilepsy Society Meeting (Virtual) in Dec 2020.

Dr. Tal Teitz received a 5-yr NIH R01 award of $2,025,911 for her project titled “Repurposing an FDA-approved Drug, B-Raf Kinase Inhibitor Dabrafenib for Protection from Cisplatin- and Noise- induced Hearing Loss”.

Dr. Jee-Yeon Hwang was invited to serve as a Guest Editor for a special topic titled “Epigenetic Regulation in Neurological Disorders and Diseases” of the journal Frontiers in Neuroscience. For further information: https://www.frontiersin.org/research-topics/17383/epigenetic-regulation-…

Dr. Tal Teitz was invited to co-organize the Creighton Virtual 2020/2021 Bellucci Symposia that will be held on June 3rd and June 4th, 2021. The title of the Symposia: “Drug Therapeutics for Hearing Loss, Academia and Industry Approaches”.

Dr. Holly Stessman and colleagues published an article titled “Schizophrenic Psychosis Symptoms in a Background of Mild-to-Moderate Carnitine Palmitoyltransferase II Deficiency: A Case Report” in the journal Reports 2020 3(4), 31; doi.org/10.3390/reports3040031

Dr. Tal Teitz and colleagues published an article titled “BRAF Inhibition Protects Against Hearing Loss in Mice” in the journal Science Advances; 6: eabd0561, 2nd December 2020.  doi: 10.1126/sciadv.abd0561 (Impact Factor 13.1).

Drs. Kristina Simeone, Tim Simeone and colleagues published an article title “Changes in Lipid Profiles of Epileptic Mouse Model” in the journal Metabolomics. 2020 October 6;16(10):106. doi: 10.1007/s11306-020-01729-4. PMID: 33021695

Dr. Shashank Dravid and colleagues published an article titled “Ultrastructural Localization of Glutamate Delta 1 (GluD1) Receptor Immunoreactivity in the Mouse and Monkey Striatum” in the Journal of Comparative Neurology. 2020 Oct 8. doi: 10:1002/cne.25051. Online ahead of print.

Dr. Shashank Dravid and colleagues published an article titled “Environmental Enrichment Increases Cue-Dependent Freezing and Behavioral Despair but Decreases Anxiety-like Behavior in Rats” in the journal Pharmacology Biochemistry and Behavior. 2020 Sep;196:172979. doi: 10.1016/j.pbb.2020.172979.

Dr. Tim Simeone served as a grant reviewer for the NIH study section Acute Neural Injury and Epilepsy (ANIE) on October 29-30, 2020.

Dr. Holly Stessman and colleagues published an article titled “ATF3 Coordinates Antitumor Synergy between Epigenetic Drugs and Protein Disulfide Isomerase Inhibitors” in Cancer Research 80: 3279-3291. doi: 10.1158/0008-5472.CAN-19-4046. (Impact factor 9.1)

Dr. Yaping Tu was invited by the Department of Defense Congressionally Directed Medical Research Programs (CDMRP) to serve as a grant reviewer for the 2020 Prostate Cancer Research Program (PCRP). He was assigned to the Endocrinology-1 (END-1) peer review panel.

Dr. Holly Stessman was a featured speaker at the BioNexus KC virtual series: Collaborating to spark innovative treatments, diagnostics, advocacy strategies, and broadened awareness about Autism Spectrum Disorder on September 23, 2020.

Dr. Kristina Simeone participated in the Sudden Unexpected Death in Epilepsy (SUDEP) Coalition Summit Sept 23-24, 2020. Hosted by the NIH, American Epilepsy Society, Epilepsy Foundation and SUDEP Institute, 40 basic science and clinical experts were tasked to identify short term and long term research goals that will lead to the prevention of SUDEP in the next 10 years.

Dr. Gopal Jadhav received an R-21 award from the NIH National Institute of Allergy and Infectious Diseases of $414,770 for his project titled “Development of small chemical-molecule inhibitors of quorum sensing regulator: a novel treatment for antibiotic resistant bacterial infections.”

Dr. Yaping Tu and colleagues published a manuscript titled “Kap1-associated transcriptional inhibitory complex regulates C2C12 myoblasts differentiation and mitochondrial biogenesis via miR-133a repression” in the journal Cell Death & Disease, doi.org/10.1038/s41419-020-25356 (impact factor 5.9)

Dr. Yaping Tu was invited to serve as a grant proposal reviewer for the Vici-programme, The Netherlands Organisation for Scientific Research (NWO/ZonMw).

Dr. Tal Teitz was invited to serve as a Guest Editor for a special issue titled “Drug-Induced Ototoxicity: Mechanisms and otoprotective strategies” of the journal Pharmaceuticals.

Dr. Shashank Dravid received a 5-yr NIH R01 award for his project titled “Trans-synaptic signaling complex in amygdala pain mechanisms.”

Dr. Gopal received a 2-yr Cancer and Smoking Disease Research Development Grant for his project titled “Chemical Optimization of Small Chemical Molecules to Probe Triggering Receptors Expressed on Myeloid Cells 1 (TREM1): Novel Treatment for Hepato Cellular Carcinoma”.

Drs. Yaping Tu, Peter Abel and colleagues published an article titled “TGF-?1-induced miR-424 promotes pulmonary myofibroblast differentiation by targeting Slit2 protein expression” in the journal Biochemical Pharmacology (2020)  180:  doi.org/10.1016/j.bcp.2020.114172.

Erica Sequeira, Marsha Pierce, Dina Akasheh, Stacy Sellers and Tom Murray published an article titled “Epicortical Brevetoxin Treatment Promotes Neural Repair and Functional Recovery after Ischemic Stroke” in the journal Marine Drugs (2020) 18: 374,  doi.org/10.3390/md18070374.

Dr. Shashank Dravid was invited to serve as a neuroscience grant reviewer for the Czech Science Foundation, the public funding agency of the Czech Republic.

Dr. Tal Teitz received a Bellucci Fund research grant award for her project titled “Cyclin-dependent Kinase-2 Inhibitor AZD5438 as a Candidate Therapeutic for Age-related Hearing Loss”.

Dr. Shashank Dravid received a Health Sciences Strategic Investment Fund research grant award for his project titled “Thalamic Choke Point for Epilepsy and NMDA Receptor and Subtypes”.

Dr. Janee Gelineau-van Waes received an LB692 New Initiatives Research grant award for her project titled Mouse Model of Dolutegravir-induced Neural Tube Defects”.

Dr. Tim Simeone received an LB692 New Initiatives Research grant award for his project titled “The role of splenic T cells in worsening disease progression in a model of SUDEP”.

Dr. Holly Stessman received a Nebraska Stem Cell research grant award for her project titled “KMT5B role in maintaining neural stem cell pools”. 

Dr. Holly Stessman and colleagues of the AutGO working group published an article titled “The AutGO Initiative: A Conceptual Framework for Developing Genetics-Outcomes Research Hypotheses.” in Autism Res. 2020;10.1002/aur.2331. doi:10.1002/aur.2331. PMID: 32618145.

Dr. Gopal Jadhav was an invited speaker at the International Webinar, Faculty Development Program on Current Research Scenarios: Pharmacy Practice and Technology.  His presentation was titled “Development of Novel selective ?1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease”.  The webinar was organized by the College of Pharmacy, All India Shri Shivaji Memorial Society, Pune University and was held June 17-21.

Dr. Kristina Simeone was invited to serve on the Basic Science Committee for the 2020 International Conference Partners Against Mortality in Epilepsy.

Sophomore undergraduate researcher Ally Einbeck, working with Dr. Charles Bockman, was awarded a CURAS Ferlic Summer Research Fellowship to investigate the role of propylene glycol and glycerin in causing altered airway contractility in mice exposed to e-cigarettes.

Drs. Kristina Simeone and Tim Simeone with colleagues at UNMC and Creighton published a manuscript titled “Aberrant Energy Metabolism and Redox Balance in Seizure Onset Zones of Epileptic Patients” in the Journal of Proteomics, doi.org/10.1016/j.jprot.2020.103812.

Dr. Holly Stessman and colleagues published a manuscript titled “Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15” in Human Molecular Genetics  28: 2900-2919. doi: 10.1093/hmg/ddz111. 

Dr. Holly Stessman and colleagues published a manuscript titled “Missense Variants in the Histone Acetyltransferase Complex Component Gene TRRAP Cause Autism and Syndromic Intellectual Disability” in American Journal of Human Genetics  104: 530-541. doi: 10.1016/j.ajhg.2019.01.010.

Dr. Timothy Simeone contributed a chapter titled “Ketogenic Diet and PPARgamma” to the book Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease, ranked #9 out of 21 best epilepsy books of all time list by Bookauthority (https://bookauthority.org/books/best-epilepsy-books#__prclt=kREQ06Xk). 

Dr. Charles Bockman has been nominated for the School of Medicine Golden Apple Award by the Medical Class of 2022.

Dr. Kristina Simeone has been nominated for the Educator of the Year award by the Pharmacy Campus Class of 2022. 

Dr. Kristina Simeone served as a reviewer for the Citizens United in Research Against Epilepsy - Taking Flight Grant Award study section, which met during May 2020.

Medical students Charissa Lau, Dorothy Kenny, Anne Cheng, and Haley Bremer, working with Dr. Holly Stessman, received School of Medicine summer research awards to investigate cancer, immunology, and muscle pathology related to KMT5B loss.

Sophomore undergraduate researcher Rebecca Black, working with Dr. Holly Stessman, was awarded a SURF Ferlic Summer Research Fellowship to investigate the role of KMT5B in lung development.

Dr. Charles Bockman received a CURAS Faculty Research Fund award to support undergraduate student involvement in his project titled “Effect of Electronic Nicotine Delivery Systems on Bronchi Contractility”.

Medical students Shelby Herr and Cameron Booth received School of Medicine summer research awards to investigate the autoresuscitation response to hypercapnia and hypoxia in epilepsy.  This work is under the guidance of Dr. Kristina Simeone.

Dr. Kristina Simeone with colleagues Tim Simeone and Peter Abel received a National Institutes of Health R21 research grant award for her research project titled “Mechanisms of SUDEP: Failure to Autoresuscitate”.

Dr. Gopal Jadhav and colleagues Pavan Kumar Prathipati and Harsh Chauhan published a manuscript titled “Surface plasmon resonance, Orbitrap mass spectrometry and Raman advancements: exciting new techniques in drug discovery” in the journal Expert Opinion on Drug Discovery,  March 2020.  DOI: 10.1080/17460441.2020.1745771.

Dr. Shashank Dravid and colleagues G Hu, F Niu, K Liao, P Periyasamy, S Sil, J Liu and S Buch published a manuscript titled “HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture” in the Journal of Neuroimmune Pharmacology, 2019, doi: 10.1007/s11481-019-09869-8.

Dr. Shashank Dravid and colleagues P Gawai, R Upadhyay, SG Gakare, L Sarode and RR Ugale RR published a manuscript titled “Antipsychotic-like profile of CIQ isomers in animal models of schizophrenia” in the journal Behavioural Pharmacology, 2019, doi: 10.1097/FBP.0000000000000532.

Dr. Shashank Dravid and colleagues J Liu, GP Shelkar, PJ Gandhi,  DY Gawande, A Hoover, RM Villalba, R Pavuluri and Y Smith published a manuscript titled “Striatal glutamate delta-1 receptor regulates behavioral flexibility and thalamostriatal connectivity” in the journal Neurobiology of Disease, 2020, doi: 10.1016/j.nbd.2020.104746.

Dr. Kristina Simeone and colleagues Shruthi Iyer, Ankita Aggarwal, Ted Warren, Jodi Hallgren, Peter Abel, and Tim Simeone published a manuscript titled “Progressive cardiorespiratory dysfunction in Kv1.1 knockout mice may provide temporal biomarkers of pending sudden unexpected death epilepsy (SUDEP): the contribution of orexin” in the Journal Epilepsia, DOI: 10.1111/epi.16434.

Dr. Kristina Simeone served as Chair of the “Basic Mechanisms in Epilepsy” platform session at the American Epilepsy Society Annual Meeting, December 6-10 in Baltimore, MD.

Dr. Timothy Simeone was invited to participate in a leadership workshop sponsored by the American Epilepsy Society on December 6th in Baltimore, MD.

Dr. Timothy Simeone served as co-chair of the Epilepsy Therapies Symposium titled “Neurostimulation for Epilepsy: Which, When, Where and How?” at the American Epilepsy Society Annual Meeting on December 7th in Baltimore, MD.

2019

Dr. Tal Teitz received a research grant award from the American Hearing Research Foundation.  The title of her proposal is “Repurposing an FDA Approved Drug Dabrafenib for Protection from Noise-induced Hearing Loss”.

Dr. Charles Bockman with Dr. Deniz Yilmazer-Hanke from Ulm University, Germany, published a paper titled ” Alpha2-adrenergic dysregulation in congenic DxH recombinant inbred mice selectively bred for a high fear-sensitized (H-FSS) startle response”, in the journal Pharmacology Biochemistry & Behavior (2019), https://doi.org/10.1016/j.pbb.2019.172835.

Dr. Jee-Yeon Hwang and colleagues had a review article titled “Autophagy and synaptic plasticity: epigenetic regulation” published in the journal Current Opinion in Neurobiol. 59: 207-212, 2019; doi: 10.1016/j.conb.2019.09.010.

Dr. Kristina Simeone was invited to speak at a Sleep and Epilepsy Workshop in May in Alexandria, Virginia. Her talk was titled: “Sleep deficiency and SUDEP”.

Dr. Shashank Dravid has been appointed to the National Science Foundation Grant Evaluation Panel to review Integrative Organismal Systems grants from the Neural Systems Cluster.  The panel met in Alexandria, Virginia, on September 18-20.

Sudden unexpected death in epilepsy (SUDEP) research conducted by Drs. Kristina Simeone, Peter Abel and Tim Simeone was highlighted in the October edition of CURE Discovery for SUDEP action day.  Each month CURE Discovery highlights current, exciting research being conducted in the epilepsy field.

Dr. Tim Simeone served as a grant reviewer for the private non-profit foundation Ataxia UK, which provides grants to find treatments and a cure for ataxia.

Dr. Yaping Tu with Dr. Peter Abel and colleagues had a paper titled “Transforming growth factor (TGF)-?1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis” published in the journal Cell Death & Disease 10: 670, 2019; doi.org/10.1038/s41419-019-1873-x.

Dr. Jee-Yeon Hwang was invited to give a talk at the University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea on September 20th.  The title of her talk was “The Role of GADD45 and DNA Demethylation in Neurodegeneration Associated with Global Ischemia.”

Dr. Tim Simeone gave a talk at the 2019 Summit on Ketogenic Diet Therapies held September 13th-14th in Phoenix, AZ. The title of his presentation was “Basic Mechanisms of the Ketogenic Diet: the state of our knowledge.”

Segewkal Heruye, a PhD graduate student in Dr. Tim Simeone’s laboratory, received a travel award from the meeting organizers to attend the Park City Epilepsy Meeting in Park City, Utah on October 6-8, 2019.

Dr. Yaping Tu has been invited to serve as a member of the Prostate Cancer Research Program -Endocrinology peer review grant panel of the Department of Defense.  The meeting will be held in Washington, DC on November 20-22.

Dr. Shashank Dravid has been appointed as a reviewer for the Research Grant Evaluation Committee of the Czech Science Foundation.  This is the main public funding agency in the Czech Republic supporting basic research.

Dr. Shashank Dravid has been named as an Associate Editor for the Nature Publishing journal “Scientific Reports”.

Jocelyn Plowman, a student from Augustana College working in Dr. Yaping Tu’s lab, won 2nd place for oral presentations at the Creighton Summer Research Institute Colloquium 2019, organized by Health Science Multicultural and Community Affairs and the Center for Promoting Health and Health Equity.  The title of her talk was “TGF-?1-induced microRNA 424 promotes fibroblast differentiation in idiopathic pulmonary fibrosis.”

Jude Kouassi, a student from Creighton Preparatory High School working in Dr. Yaping Tu’s lab, won 1st place for oral presentations at the Creighton Summer Research Institute Colloquium 2019, organized by Health Science Multicultural and Community Affairs and the Center for Promoting Health and Health Equity.  The title of his talk was “Discovery of a Small Molecule Y16 for Treating Pulmonary Hypertension.”

Dr. Tal Teitz was invited to give a talk at the 5th Chinese Hearing Research Conference held September 20-23 at Beijing Friendship Hospital, Beijing, China.  The title of her presentation is “Drug Development for Cisplatin- and Noise- induced Hearing Loss”.

Dr. Jay Bhatt received a New Initiatives Research Grant Award.  The title of his project is “Role of glutamate delta 1 receptor in oligodendrocyte precursor cells”.

Dr. Shashank Dravid received a research grant from the Nebraska Stem Cell Research Program.  The title of his project is “Targeting stem cells to facilitate remyelination in disease states”.

Dr. Gajanan Shelkar, a postdoc in Dr. Shashank Dravid’s lab, was selected as the Molecular Pharmacology Highlighted Trainee Author for August 2019 by the American Society for Pharmacology and Experimental Therapeutics.  The award is based on his publication titled “Modulation of burst firing of neurons in nucleus reticularis of the thalamus by GluN2C-containing NMDA receptors”  in Molecular Pharmacology (2019) 96: 218-228, doi.org/10.1124/mol.119.116780.  The highlighted trainee award identifies emerging scientific investigators publishing innovative work in the field of pharmacology. 

Dr. Janee Gelineau-van Waes was invited to serve on the grant review group of the Austrian Science Fund.   The grant proposals will be reviewed in September.

Dr. Yaping Tu has been invited to serve as a member of the American Heart Association’s Molecular Signaling and Cell Transport 2 - Predoctoral/Postdoctoral Fellowship Awards review committee.  The committee will meet on Thursday, October 24, 2019.

Dr. Tal Teitz received a research grant award from the Bellucci Foundation for her research project titled “Repurposing the Small Molecule B-Raf Kinase Inhibitor Dabrafenib for Protection from Cisplatin-induced Hearing Loss”.

Dr. Yaping Tu received a Health Sciences Strategic Investment Fund grant for his project titled “MiR-146b Repression and Pulmonary Fibrosis”.

Dr. Yaping Tu received a 6 year grant award from the Creighton University Cancer and Smoking Diseases Research Program as a component of the Cellular Signaling and Molecular Trafficking in Cancer Program.  The title of his project is “Dysregulated Mitochondrial Dynamics and Cancer Metastasis”.

Dr. Tim Simeone and colleagues published a meeting report titled “Highlights From the Annual Meeting of the American Epilepsy Society 2018” in Epilepsy Currents (2019) 19(3): 152-158,  doi: 10.1177/1535759719844486.

Dr. Shashank Dravid and colleagues published a paper titled “Modulation of burst firing of neurons in nucleus reticularis of the thalamus by GluN2C-containing NMDA receptors”  in Molecular Pharmacology (2019) 96: 218-228, doi.org/10.1124/mol.119.116780.

Dr. Shashank Dravid and colleagues published a paper titled “Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes”  in Scientific Reports (2019) 9: 7572, doi.org/10.1038/s41598-019-43957-2.

Dr. Shashank Dravid and colleagues published a paper titled “A mouse model of seizures in anti-N-methyl-d-aspartate receptor encephalitis”  in Epilepsia (2019) 60: 452-463, doi: 10.1111/epi.14662. 

Dr. Shashank Dravid was invited to present a research seminar at Texas Tech University Health Sciences Center in Lubbock, Texas on April 30, 2019.  The title of his talk was “Delta receptors: Unusual functions of members of ionotropic glutamate receptor family”.

Dr. Tim Simeone has been appointed to the Editorial Board of the journal Nutrients, published by the Multidisciplinary Digital Publishing Institute.

Dr. Yaping Tu has been appointed to the Editorial Board of the journal Scientific Reports, published by Springer Nature Publishing.

Dr. Dr. Yaping Tu has been invited to serve as a member of the American Heart Association’s Molecular Signaling and Cell Transport 2 - Predoctoral and Postdoctoral Fellowship Awards review committee.  The committee will meet on Thursday, October 24, 2019.

Dr. Janee Gelineau-van Waes and colleagues were awarded a George F. Haddix President’s Faculty Research Fund Grant titled “Developing a Mouse Model of Endometriosis to Test Novel Therapeutic Targets”.

Dr. Charles Bockman received a CURAS Faculty Research Fund Grant for his project titled “Effect of E-Cigarette Aerosol on Multiple Mechanisms Mediating Airway Contractility”. 

Dr. Tom Murray and colleagues published a paper titled “A Comparison of the Ability of Leu8- and Pro8-Oxytocin to Regulate Intracellular Ca2+ and Ca2+-Activated K+ Channels at Human and Marmoset Oxytocin Receptors” in Molecular Pharmacology (2019) 95:376, doi.org/10.1124/mol.118.114744.

Dr. Yaping Tu presented a talk titled “Airway Relaxation Mechanisms and Structural Basis of Osthole to Improve Lung Function in Asthma” at the Kansas City University of Medicine and Biosciences - Friday Science Series, on April 19.

Hannah Meissner, a medical student working in Dr. Yaping Tu’s laboratory, received the national chapter of Phi Rho Sigma 2019 Paul McClain Research Award. She will present her work titled “Androgen Receptor Increases Growth and Resistance to TRAIL in Triple Negative Breast Cancer Cells” at the Grand Chapter Meeting in Tampa Florida on June 7-8th. 

Dr. Tom Murray and co-authors had their manuscript titled  “A Comparison of the Ability of Leu8- and Pro8-Oxytocin to Regulate Intracellular Ca2+ and Ca2+-Activated K+ Channels at Human and Marmoset Oxytocin Receptors” highlighted and an image selected as the cover of the April 2019 issue of Molecular Pharmacology.

Graduate student Pauravi Gandhi, working in Dr. Shashank Dravid’s lab, won the Best Graduate/Professional Platform Presentation award for her research presentation titled “Regulation of Glutamatergic Synapses in Nociceptive Central Amygdala” at the St. Alberts/University Research Day forum held on April 2.

Graduate student Malavika Deodhar, working in Dr. Tim Simeone’s lab won the 3 Minute Thesis (3MT) People’s Choice Award for presentation of her research work titled “PPAR Gamma Phosphorylation: a Novel Target in Epilepsy” at the St. Alberts/University Research Day forum held on April 2.

PhD graduate student Cameron Kieffer, working in Dr. Peter Abel’s lab, has received the Graduate School Academic Achievement Award for 2019.  The award will be presented at the Graduate School Hooding Ceremony on Friday, May 17.

Dr. Yaping Tu received a 2 year R21 research grant award from the National Institutes of Health for his research project titled “Neuronal P-Rex 1 Repression: a Key Factor in Early-life Environmental Cigarette Smoke Exposure Mediated Risk of Asthma”.

Dr. Shashank Dravid and collaborators received a Nebraska EPSCoR Major Research Instrumentation grant award from the National Science Foundation for his proposal titled “A High Throughput Multi-User Biacore Surface Plasmon Resonance Resonance System for Studying Biomolecular and Biochemical Interactions”.

Dr. Jee-Yeon Hwang and colleagues published a paper titled ” Gadd45b Acts as Neuroprotective Effector in Global Ischemia-Induced Neuronal Death”,  in the International Neurourology Journal  (2019) 23: 11-21, doi.org/10.5213/inj.1938040.020.

Dr. Holly Stessman with colleague Rochelle Wickramasekara published a review article titled “Histone 4 Lysine 20 Methylation: A Case for Neurodevelopmental Disease”, in the journal Biology (2019) 8: 11, doi:10.3390/biology8010011.

Dr. Yaping Tu was invited to present a talk titled “Airway Relaxation Mechanisms and Structural Basis of Osthole to Improve Lung Function in Asthma” to the Pulmonary, Critical Care, Sleep & Allergy Conference held on March 14 at UNMC.

Mr. Michael Franco, an undergraduate student working in Dr. Charles Bockman’s lab, received a CURAS Dr. and Mrs. Randolph Ferlic Summer Undergraduate Research Fellowship award for his project titled “Effect of  E-cigarette aerosol on airway smooth muscle responsiveness”.

Ms. Lauryn Caster, an undergraduate student working in Dr. Tal Teitz’s lab, received a CURAS Summer Undergraduate Research and Creative Project Fellowship award for her project titled “Investigation of PDGFR as a Potential Drug Inhibitor Target to Successfully Protect Cochlear Hair Cells from Cisplatin Ototoxicity”.

Dr. Yaping Tu received a Project SEED research fellowship for a summer high school student for his project titled “Neuronal P-Rex1 repression: a key factor in early-life environmental cigarette smoke exposure mediated risk of asthma”.  This fellowship is awarded by the American Chemical Society to support research experiences for economically disadvantaged high school students.

Hannah Meissner, a medical student in Dr. Yaping Tu’s laboratory, was awarded 1st place for her presentation titled “Androgen Receptor Increases Growth and Resistance to TRAIL in Triple Negative Breast Cancer Cells” in the Research Symposium Session at the Global Health Midwest Conference held in Omaha on February 15-16.  

2018

Malavika Deodhar, a graduate student in Dr. Timothy Simeone’s laboratory, received travel awards from the Creighton Graduate School, AADVANTAGE Global Scholars and KETO 2018 to attend the 6th Global Symposium on Ketogenic Therapies for Neurological Disorders on October 5-9, 2018 in Jeju, South Korea.

Dr. Shashank Dravid and colleagues J. Liu, P.J. Gandhi, R. Pavuluri and G.P. Shelkar, published a paper titled ” Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens”, in the journal Translational Psychiatry (2018) 8:219, doi: 10.1038/s41398-018-0273-9. 

Dr. Kristina Simeone presented a talk titled “Ketogenic Diet treatment and sudden unexpected death in epilepsy” at the 6th Global Symposium on Ketogenic Therapies for Neurological Disorders on October 7, 2018 in Jeju, South Korea.

Dr. Timothy Simeone presented a talk titled “The role of PPARgamma in Epilepsy and KD efficacy” at the 6th Global Symposium on Ketogenic Therapies for Neurological Disorders on October 8, 2018 in Jeju, South Korea.

Dr. Kristina Simeone speaking on Dec. 1, 2018 in the “Pediatric State of the Art Symposium | Metabolism-Based and Ketogenic Therapies for Epilepsy: A Translational Approach”  at the 2018 American Epilepsy Society Annual Meeting in New Orleans, LA. Attendance at this symposium was about 1000 people. The title of her talk was “Metabolic Approaches for Treating Complications and Co-Morbidities of Epilepsy.”

Dr. Timothy Simeone chaired the Epilepsy Therapies Symposium: Practical Clinical Pearls for Advanced Outpatient Epilepsy Management in 2019 at the American Epilepsy Society Annual Meeting on December 4, 2018 in New Orleans, LA.

Dr. Yaping Tu with colleague Peter Abel published a paper titled “Up-regulated miR-133a orchestrates epithelial-mesenchymal transition of airway epithelial cells”, in the journal Scientific Reports, (2018) 8:15543, DOI:10.1038/s41598-018-33913-x.

Dr. Yaping Tu with collaborators Peter Abel and Tom Casale from the University of South Florida, published a paper titled “Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma”, in the Journal of Allergy and Clinical Immunology.

Dr. Timothy Simeone with colleague Kristina Simeone published a paper titled “Ketogenic diet regulates the antioxidant catalase via the transcription factor PPAR?2” in the journal Epilepsy Research. doi.org/10.1016/j.eplepsyres.2018.09.009. 

Dr. Yaping Tu has been invited to present his work as a guest speaker for The Second JinLing Forum on Membrane Protein Physiology and Drug Discovery.  The title of his talk is “P-Rex1 regulates airway hyperplasia in asthma”.  The meeting will be held November 29 - December 1 in Nanjing City, China.

Dr. Shashank Dravid received a 5 year R01 research grant award from the National Institutes of Health for his research project titled “Function of glutamate delta-1 receptor.”

Dr. Yaping Tu will serve as a member of the Clinical & Experimental Therapeutics-1 grant peer review panel of the Prostate Cancer Research Program for the Department of Defense.  The committee will meet in Washington, DC December 2-4, 2018.

Dr. Yaping Tu was recognized by the American Chemical Society as a Mentor for his long standing contribution to Project SEED, which supports chemistry-based high school student summer research projects.

Dr. Timothy Simeone served as a reviewer on the NINDS Special Emphasis Panel/Scientific Review Group 2018/05 ZNS1 SRB-K (11) for R13 conference grants which met on June 22, 2018.

Dr. Kristina Simeone presented a talk titled “Is SUDEP Risk Progressive” at the Parents Against Mortality in Epilepsy conference in Arlington, VA on June 16, 2018.

Cameron Kieffer, a graduate student working in Dr. Peter Abel’s lab, was awarded the 2018 Pharmaceutical Research and Manufacturers Association Foundation Fellowship in Regulatory Science.  This post-graduate fellowship is administered by Sanofi Pharmaceuticals and is based in Washington DC.

Jessica Grimmond, a student from Drake University working in Dr. Yaping Tu’s lab, won 2nd place for oral presentations at the Creighton Summer Research Institute Colloquium 2018, organized by the Office of Health Science Multicultural and Community Affairs.  The title of her talk was “Up-regulated miR-424 mediates TGF-? induced fibroblast differentiation in pulmonary fibrosis.”

Jude Kouassi, a student from Creighton Preparatory High School working in Dr. Yaping Tu’s lab, won 1st place for oral presentations at the Creighton Summer Research Institute Colloquium 2018, organized by the Office of Health Science Multicultural and Community Affairs.  The title of his talk was “Up-regulated Androgen Receptor Causes Resistance to TRAIL Induced Apoptosis in Triple Negative Breast Cancer.”

Dr. Shashank Dravid received a LB692 New Initiatives Research Grant for his project titled “NMDA Receptors in Astrocytes and Role in Addiction”.

Dr. Kristina Simeone received a Health Science Strategic Investment Fund Faculty Development Grant for her project titled “Seizures and Autoresuscitation”.

Dr. Yaping Tu with colleague Dr. Shafiq Khan from Clark Atlanta University published a paper titled “Novel role of Gi?2 in cell migration downstream of PI3-kinase/AKT and Rac1 in prostate cancer cells”, in the Journal of Cellular Physiology. Article DOI: 10.1002/jcp.26894.

Dr. Timothy Simeone served as a reviewer for the Citizens United for Research in Epilepsy Foundation Innovator Award.  The review committee met on May 16, 2018.

Dr. Yaping Tu will serve as a member of the American Heart Association’s Molecular Signaling and Cell Transduction Predoctoral and Postdoctoral Fellowship Awards review committee.  The committee will meet by teleconference on September 12, 2018.

Dr. Janee Gelineau-van Waes was an invited speaker at the Teratology Society Annual Meeting on June 22-28, 2018.  The title of her talk was “Fumonisin B1 (FB1) and Fingolimod (FTY720): Tortilla Toxin and Oral Therapeutic Target Sphingolipid Pathways During Neural Tube Closure”.

Dr. Timothy Simeone presented a seminar titled “Insights into Antiseizure Mechanisms Through the Lens of Dietary Therapies” for Neurology Grand Rounds at Creighton University on June 8, 2018.

Medical student Hannah Meissner received a Yamaguchi Scholar research award to work with Dr. Yaping Tu on a research project titled “Targeting androgen receptor and TRAIL: a novel treatment paradigm for breast cancer”.

Dr. Shashank Dravid with colleagues Hassan Alsaad, Nicholas DeKorver, Zhihao Mao, Jyothi Arikkath and Daniel Monaghan, published a paper in the journal Neurochemical Research titled: “In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons”. doi: 10.1007/s11064-018-2526-7

Dr. Shashank Dravid served as a grant reviewer for The Israel Science Foundation, Individual Research Grant Awards.

Dr. Shashank Dravid served as a grant reviewer for The French National Research Agency, Generic Call for Proposals 2018 Grant Awards.

Dr. Charles Bockman received a CURAS Faculty Research Award for a study titled “Effect of Chronic E-Cigarette Aerosol and Cigarette Smoke on Airway Hyper-reactivity.”

Dr. Kristina Simeone received a CURAS Faculty Research Award for a study titled “Respiratory Dysfunction Precedes Sudden Death in Epilepsy.”

Dr. Timothy Simeone presented a talk titled “Insights into Antiseizure Mechanisms Through the Lens of Dietary Therapies” at the Spring Brain Conference in Sedona, AZ on April 13.

Dr. Kristina Simeone served as a grant reviewer on the NIH NINDS Special Emphasis Study Section for U54 Centers Without Walls for Collaborative Research in the Epilepsies: Functional Evaluation of Human Genetic Variants grants which met on May 3-4, 2018.

Dr. Kristina Simeone was the keynote speaker for the Creighton Undergraduate Neuroscience Senior Awards dinner on April 28. She presented a talk titled “Sleep Deficiency and the Timing of Death”.

Dr. Peter Abel received the School of Pharmacy class of 2020 Educator of the Year Award. This award, voted by students, recognizes the outstanding teacher for the 2017-2018 academic year.

Medical student Pasha Lookian received an AA Student Research Fellowship to work with Dr. Holly Stessman on a research project titled “Gender bias in DDX3X modulation of non-melanoma squamous cell carcinoma”..

Graduate student Cameron Kieffer was invited to present a “Data Blitz” at the Experimental Biology meeting held in San Diego, CA on April 21-25.  The title of his talk was “Modeling Nerve Function in Airways”.

Dr. Shashank Dravid with colleagues published a paper entitled, “Region-specific expression of NMDA receptor GluN2C subunit in parvalbumin-positive neurons and astrocytes: Analysis of GluN2C expression using a novel reporter model.” in Neuroscience. doi.org/10.1016/j.neuroscience.2018.03.011.

Dr. Kristina Simeone with colleagues published a paper entitled, “Adenosine has two faces: Regionally dichotomous adenosine tone in a model of epilepsy with comorbid sleep disorders”  in Neurobiology of Disease. doi: 10.1016/j.nbd.2018.01.017.

Dr. Kristina Simeone presented a talk titled “Sleep deficiency and the timing of death” at the Carver College of Medicine, University of Iowa on March 29, 2018.

Dr. Timothy Simeone served as a reviewer on the NINDS Special Emphasis Panel/Scientific Review Group 2018/05 ZNS1 SRB-K (11) for R13 conference grants which met on February 13, 2018.

Medical student Pasha Lookian received a Yamaguchi Scholar research award to work with Dr. Holly Stessman on a research project titled “Gender bias in DDX3X modulation of non-melanoma squamous cell carcinoma”.

Pharmacology graduate student Cameron Kieffer, working with Dr. Peter Abel, won the Best Poster Presentation Award in the basic sciences graduate/professional category at the St. Albert’s University Research Day.  The title of his presentation was “Modeling neurotransmitter systems in mouse airways”.

Undergraduate student Michael Franco was awarded a Dr. and Mrs. Randolph Ferlic Summer Undergraduate Research Fellowship to work with Dr. Charles Bockman on a research project titled “Effect of e-cigarette vapor versus cigarette smoke on airway function: a comparative study”.

Undergraduate student Kaylee Schwasinger was awarded a Dr. and Mrs. Randolph Ferlic Summer Undergraduate Research Fellowship to work with Dr. Holly Stessman on a research project titled “Linking Immune Dysfunction and Autism through Mutations in KMT5B and SMC3”.

Dr. Yaping Tu with colleagues published a paper entitled, “p66Shc Regulates Migration of Castration-Resistant Prostate Cancer Cells” in the Journal of Cellular Signaling. doi.org/10.1016/j.cellsig.2018.02.008

Dr. Charles Bockman with colleagues published a paper entitled, “Nicotine Drug Discrimination and Nicotinic Acetylcholine Receptors in Differentially Reared Rats” in the journal Psychopharmacology. doi: 10.1007/s00213-018-4850-7

Pharmacology graduate students swept the Graduate Students/Residents Poster Presentation awards at the 49th Midwest Student Biomedical Research Forum held in Omaha on February 17.  Award winners included: 1st Place Graduate Student Poster Presentation [Tie] - Dina Akasheh Gomez “Voltage-Gated Sodium Channel Activation Triggers Calcium Influx and Hippocampal Neuron Complexity”.  Advisor: Dr. Thomas Murray; Department of Pharmacology, School of Medicine; 2nd Place Graduate Student Poster Presentation - Pauravi J. Gandhi  “Organization of Glutamatergic Inputs to Central Amygdala”. Advisor: Dr. Shashank M. Dravid; Department of Pharmacology, School of Medicine; 3rd Place Graduate Student Poster Presentation - Erica Sequeira “Comprehensive Study on the Potential Therapeutic use of Brevetoxin-2 to Aid Post-Stroke Recovery”.  Advisor: Dr. Thomas Murray; Department of Pharmacology, School of Medicine.

Dr. Kristina Simeone, Dr. Charles Bockman, Dr. Peter Abel and Dr. Tim Simeone with colleagues published a paper entitled, “Respiratory dysfunction progresses with age in Kcna1-null mice, a model of sudden unexpected death in epilepsy.” in Epilepsia. doi: 10.1111/epi.13971.

Dr. Timothy Simeone and Dr. Kristina Simeone with colleagues published a review article entitled, “Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?” in Neuropharmacology. doi:10.1016/j.neuropharm. 2018. 01.011.

Dr. Yaping Tu with colleagues published a paper entitled, “Anti-Androgen Abiraterone Acetate Improves the Therapeutic Efficacy of Statins on Castration-Resistant Prostate Cancer Cells.” in Journal of Oncology Research and Therapy. doi:JONT-139. DOI: 10.29011/2574-710X.000039.

Sarah Crews has advanced to the final round of the 2nd Annual Dr. Frank T. Peak Memorial Health Disparities Essay Competition through the Creighton University Center for Promoting Health and Health Equality with her essay entitled, “The Athena Approach: Utilizing White-Privilege and Gender-Roles as Tactical Strategies to Overcome the Discrimination of Minority Groups in the Healthcare System”.

Dr. Kristina Simeone presented a talk titled “Sleep deficiency and the timing of death” during the SUDEP special interest group at the 2017 Annual meeting of the American Epilepsy Society in Washington, D.C.

Dr. Kristina Simeone presented a talk titled “Ketogenic diet, co-morbid sleep disorders and sudden unexpected death in epilepsy” during the Dietary Therapies special interest group at the 2017 Annual meeting of the American Epilepsy Society in Washington, D.C.

Kristina Simeone, PhD, served as a special guest at the Epilepsy Social at the 2017 annual meeting of the Society for Neuroscience in Washington D.C.

Pharmacology PhD student Malavika Deodhar recently presented research work performed in Dr. Tim Simeone’s lab at the 2017 annual meeting of the Society for Neuroscience in Washington D.C. Her poster presentation was titled: “Pharmacoresponsiveness of seizures and sleep-wake patterns of Kcna1-null mice, a model of temporal lobe epilepsy with comorbid sleep disorders, to conventional anti-seizure drugs (ASDs).”

Sara Knowles, a former undergraduate biology student and Sarah Budney, a 3rd year medical student, recently presented research work performed in Dr. Timothy Simeone’s lab at the 2017 annual meeting of the Society for Neuroscience in Washington D.C. Their poster presentation was titled: “The Ketogenic Diet Regulates Catalase via the Transcription Factor Peroxisome Proliferator Activated Receptor Gamma 2.”
Dr. Kristina Simeone and Dr. Tim Simeone with colleagues published a paper entitled, “Accumulation of rest deficiency precedes sudden death of epileptic Kv1.1 knockout mice, a model of SUDEP.” in Epilepsia. doi: 10.1111/epi.13953.

2017

Dr. Charles Bockman received the School of Pharmacy distance class of 2019 Educator of the Year Award. This award, voted by students, recognizes the outstanding teacher and mentor for the 2017 academic year.

Cameron Kieffer received the Outstanding Poster Presentation Award for his presentation titled “Neurotransmitter Systems in Mouse Lungs” at the 2nd American Society for Pharmacology and Therapeutics/Chinese Pharmacological Society Joint Symposia on Pharmacology in Hangzhou, China.

Dr. Shashank Dravid and colleagues published a paper entitled “Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior” in Nature Neuroscience. doi:10.1038/s41593-017-0013-0

Dr. Shashank Dravid received a new NIH R21 grant from the National Institute of Neurological Disorders and Stroke entitled “NMDA receptor subtypes in basal ganglia”.

Dr. Peter Abel has been elected to the editorial leadership board of the journal Biochemical Pharmacology.

Dr. Shashank Dravid and colleagues published a paper entitled “A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors”  in Scientific Reports. PMID:28761055.

Benjamin Loewen, a junior college student from Tabor College, won 1st place in the College student SRI oral presentation competition. His topic: Targeting miR-133a regulated signal pathways to inhibit pulmonary fibroblast cell differentiation to myofibroblast cells.

Malcolm Gladney, a junior high school student from Roncalli Catholic School, won 1st place in the higher school student SRI oral presentation competition.  His topic:  Discovery of an Organic Compound Osthole as a New Bronchodilator for Treating Drug-Resistant Asthma.

The Department of Pharmacology with the Cancer and Smoking Related Disease Program hosted Dr. Jenny Pan-Yun Ting from the University of North Carolina at Chapel Hill who gave a seminar entitled “Intracellular Innate Immune Receptors Regulate Cancer, Inflammation, Infection and the Microbiome”.

Dr. Shashank Dravid and colleagues published a paper entitled “Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives” in Neuropharmacology. PMID: 28709671.

Dr. Kristina Simeone and collaborators published a paper entitled “Hypothalamic hamartoma: Neuropathology and epileptogenesis” in Epilepsia. doi: 10.1111/epi.13752.

The Department of Pharmacology in collaboration with the Department of Psychiatry hosted Dr. Jennifer Gerdts from the University of Washington to discuss the possible development of a joint basic science/clinical research program in autism.

Dr. Holly Stessman received an LB595 Cancer and Smoking Disease Research Program Development Award for her project entitled, “Beyond BRCA: Identifying High-Risk Genetic Variation in Hereditary Breast Cancer.”

Faculty and trainees participate in Bioinformatics Workshop

Researchers to Benefit from New Computer Cluster (PDF)

Drs. Tim Simeone and Kristina Simeone and colleagues published a paper entitled, “Synergistic protection against acute flurothyl-induced seizures by adjuvant treatment of the ketogenic diet with the type II diabetes drug pioglitazone” in Epilepsia. PMID: not currently available.

Dr. Holly Stessman received an award from the State of Nebraska Department of Health and Human Services (LB506) for her project entitled “Identifying high-risk genetic variation in familial breast and ovarian cancer”.

Dr. Yaping Tu received the 2017 Multicultural and Community Affairs Distinguished Faculty Award from the Creighton University Health Sciences - Multicultural and Community Affairs division. The award was presented at the recognition ceremony in the Skutt Center Ballroom on April 27.

Drs. Tim Simeone, Kristina Simeone and colleague Jong Rho published a review entitled, “Ketone Bodies as Anti-Seizure Agents” in Neurochemical Research. PMID: 28397070


Graduate student Cameron Kieffer, from Dr. Peter Abel’s lab, was awarded 2nd place in the ASPET Translational Pharmacology Division poster competition at the Experimental Biology Meeting in Chicago. The title of his poster was “Neurotransmitter Systems in Mouse Airways”.

Faculty, trainees, and staff attend and present at the Experimental Biology Meeting in Chicago.

Medical student Nicole Minalt, working with Drs. Peter Abel and Bob Townley, won a Sigmai Xi Award of Merit for her poster presentation at the 2017 Midwest Student Biomedical Research Forum held on March 4. Her poster was entitled “Affects of Cigarette Smoke, Allergens, and Il-33 in a Murine Model of Asthma”.

Medical student Sarah Budney, working with Dr. Tim Simeone, won a Sigmai Xi Award of Merit for her poster presentation at the 2017 Midwest Student Biomedical Research Forum held on March 4. Her poster was entitled “Elucidating the Effects of PPAR?2 Mediated by the Ketogenic Diet in Refractory Epilepsy”.

Dr. Yaping Tu and colleagues published a paper entitled, “Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5” in BMC Cancer. PMID: 28270124

Dr. Yaping Tu has been invited to present a seminar entitled “TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5” at the Meharry Translational Research Center and Department of Biochemistry and Cancer Biology, Meharry Medical College on March 17.

Dr. Shashank Dravid received an award from the Nebraska Tobacco Settlement Biomedical Research Development Fund (LB 692) to support optogenetics, in vivo neural recordings and behavioral analysis.

Dr. Holly Stessman and colleagues published a paper entitled “Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases” in Nature Genetics. PMID:28191889

Dr. Holly Stessman received a new grant award from the Simons Foundation entitled ”In vitro modeling of genetic subtypes of autism”.

Dr. Shashank Dravid and colleagues published a paper entitled, “The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function” in Scientific Reports. PMID: 27922130

Dr. Janee Gelineau-vanWaes and colleagues published a paper entitled, “Reduction of fumonisin toxicity by extrusion and nixtamalization (alkaline cooking)” in the Journal of Agricultural and Food Chemistry. PMID: 28170235