Thomas F . Murray, PhD

Department

Pharmacology and Neuroscience

Position

Adjunct Professor

Books

• Crowell-Davis Sharon L., de Souza Dantas Leticia Mattos, Murray Thomas F., Veterinary psychopharmacology 2019
• Crowell-Davis Sharon, Murray Thomas, Veterinary Psychopharmacology 2008

General

• Fang Wei-Jie, Aldrich Jane V., Murray Thomas F., Bennett Marco A., An unexpected side reaction involving the deletion of an acetylated N-methyl-amino acid from the N-terminus of peptides 2006
• Peck Angela M., Kumar Vivek, Murray Thomas F., Aldrich Jane V., Synthesis and pharmacological evaluation of dual labeled delta opioid receptor peptides 2006
• Wang Xin, Murray Thomas F., Aldrich Jane V., Synthesis and pharmacological evaluation of a new generation of TIPP-derived dual-labeled ligands for delta opioid receptors 2006
• Murray Thomas F., Neurosciences in the third millennium 2004
• Leighty Matthew W., Murray Thomas F., Aldrich Jane V., Structure-activity relationships of a novel cyclic dynorphin A analog with kappa opioid receptor antagonist activity 2004

Articles

• Veterinary Psychopharmacology
  Murray Thomas F., Neuropeptides [Book Chapter] 2019
• Veterinary Psychopharmacology
  Murray Thomas F., Biogenic amine neurotransmitters [Book Chapter] 2019
• Veterinary Psychopharmacology
  Murray Thomas F., Amino acid neurotransmitters [Book Chapter] 2019
• Veterinary Psychopharmacology
  Murray Thomas F., General principles of psychopharmacology [Book Chapter] 2019
• Veterinary Psychopharmacology
  Murray Thomas F., Biogenic amine transmitters [Book Chapter] 2019
• Peptides for the New Millennium
  Choi Heekyung, Murray Thomas F., Aldrich Jane V., Synthesis and evaluation of potential affinity labels for opioid receptors [Book Chapter] 2002
• Peptides: The Wave of the Future
  Bennett Marco A., Murray Thomas F., Aldrich Jane V., Structure-Activity Relationships of Arodyn, a Novel Dynorphin A-(1–11) Analogue [Book Chapter] 2001
• Peptides: The Wave of the Future
  Sasiela Christy A., Aldrich Jane V., Bennett Marco A., Murray Thomas F., C-Terminal Structure-Activity Relationships for the Novel Opioid Peptide JVA-901 (Venorphin) [Book Chapter] 2001
• Peptides: The Wave of the Future
  Patkar Kshitij A., Murray Thomas F., Aldrich Jane V., Design and Synthesis of Dynorphin A-(1–11) Analogs with C-Terminal Modifications and Evaluation of their Opioid Activity [Book Chapter] 2001
• Methods in Neurosciences
  Orchinik Miles, Murray Thomas F., Steroid Hormone Binding to Membrane Receptors [Book Chapter] 1994
• Purines in Cellular Signaling
  Leid M., Franklin P. H., Murray T. F., Antagonist Radioligand Binding to Solubilized Porcine Atrial A1 Adenosine Receptors [Book Chapter] 1990
• Probing bioactive mechanisms
  Murray T. F., Franklin P. H., Blair T. A., Leid M., Siebenaller J. F., A1 Adenosine Receptors in the Heart: Functional and Biochemical Consequences of Activation [Book Chapter] 1989

Publications

• Molecules (Basel, Switzerland)
  Gisemba Solomon A., Aldrich Jane V., Ferracane Michael J., Murray Thomas F., A Bicyclic Analog of the Linear Peptide Arodyn Is a Potent and Selective Kappa Opioid Receptor Antagonist
  29:13, p. 3109 2024
• Pharmaceuticals (Basel, Switzerland)
  Scherrer Kristen H., Medina Jessica M., Eans Shainnel O., Mclaughlin Jay P., Senadheera Sanjeewa N., Khaliq Tanvir, Murray Thomas F., Aldrich Jane V., Tryptophan Substitution in CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference
  16:9, p. 1218 2023
• Marine Drugs
  Mehrotra Suneet, Murray Thomas F., Pierce Marsha L., Dravid Shashank M., Stimulation of Neurite Outgrowth in Cerebrocortical Neurons by Sodium Channel Activator Brevetoxin-2 Requires Both N-Methyl-D-aspartate Receptor 2B (GluN2B) and p21 Protein (Cdc42/Rac)-Activated Kinase 1 (PAK1)
  20:9 2022
• Journal of natural products (Washington, D.C.)
  Mehrotra Suneet, Gerwick William H, Pierce Marsha L, Cao Zhengyu, Jabba Sairam V, Murray Thomas F, Antillatoxin-Stimulated Neurite Outgrowth Involves the Brain-Derived Neurotrophic Factor (BDNF) - Tropomyosin Related Kinase B (TrkB) Signaling Pathway
  85:3, p. 562 - 571 2022
• Advances in neurotoxicology
  Murray Thomas F., Neurotoxic: Ciguatoxin and brevetoxin—From excitotoxicity to neurotherapeutics
  6, p. 89 - 104 2021
• The FASEB journal
  Toews Myron L., French Jeffrey A., Taylor Jack H., Schulte Nancy A., Murray Thomas F., Binding and Signaling Properties of the Leu8 and Pro8 Isoforms of Oxytocin for Oxytocin Receptors from Four Primate Species
  32, p. 555.1 - 555.1 2018
• Proceedings for Annual Meeting of The Japanese Pharmacological Society
  Sequeira Erica, Pierce Marsha, Gomez Dina, Murray Thomas, Comprehensive Study on the Potential Therapeutic Use of Brevetoxin-2 to Aid Post-stroke Recovery
  WCP2018, p. PO4-1-13 2018
• Proceedings for Annual Meeting of The Japanese Pharmacological Society
  Gomez Dina A, Murray Thomas F, VOLTAGE-GATED SODIUM CHANNEL ACTIVATION TRIGGERS CALCIUM INFLUX AND HIPPOCAMPAL NEURON COMPLEXITY
  WCP2018, p. PO4-1-99 2018
• Journal of Natural Products
  Naman C. Benjamin, Almaliti Jehad, Glukhov Evgenia, Armstrong Lorene, Caro-Diaz Eduardo J., Pierce Marsha L., Fenner Amanda, Spadafora Carmenza, Debonsi Hosana M., Dorrestein Pieter C., Murray Thomas F., Gerwick William H., Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium Cf. Symploca Species
  80:8, p. 2328 - 2334 2017
• Journal of Natural Products
  Kinnel Robin B., Sherman David, Mevers Emily, Pereira Alban R., Monroe Emily A., Esquenazi Eduardo, Leao Tiago, Moss Nathan, Korobeynikov Anton, Murray Thomas F., Gerwick William H., Dorrestein Pieter C., A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea Producens
  80:5, p. 1514 - 1521 2017
• Fang Wei-Jie, Aldrich Jane V, Gui Yanjun, Murray Thomas F, Design, Synthesis, and Pharmacological Activities of Dynorphin A Analogs Cyclized by Ring-Closing Metathesis 2017
• The FASEB journal
  Gomez Dina, Murray Thomas, Effects of Brevetoxin and NMDA on Dendritic Arborization in Murine Organotypic Hippocampal Slice Culture
  31:S1 2017
• The FASEB journal
  Sequeira Erica, Murray Thomas, Pierce Marsha, Gomez Dina, Brevetoxin Induced Dendritic Arborization and Functional Recovery in a Murine Post‐Stroke Model
  31:S1 2017
• Journal of Medicinal Chemistry
  Joshi A. A., Murray Thomas F., Aldrich J. V., Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin
  58:22, p. 8783 - 8795 2015
• PLoS One
  Boudreau P. D., Monroe E. A., Mehrotra Suneet, Desfor S., Gerwick W. H., Dorrestein P. C., Murray Thomas F., Korobeynikov A., Sherman D. H., Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows
  10:7, p. (23 pages) 2015
• The FASEB journal
  Gomez Dina, Murray Thomas, Activation of Voltage‐Gated Sodium Channels with Brevetoxin‐2 (PbTx‐2) Increases Dendritic Spine Density in Murine Organotypic Hippocampal Slice Culture
  29:S1 2015
• Marine Drugs
  Cao Z., Gerwick W. H., Murray Thomas F., Greenwood Michael, Li X., Zou X., Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons
  13:2, p. 903 - 919 2015
• Journal of Pharmacology and Experimental Therapeutics
  Cao Zhengyu, Busse Eric, Cui Yanjun, Mehrotra Suneet, Rainier Jon D., Murray Thomas F., Gambierol inhibition of voltage-gated potassium channels augments spontaneous Ca2+ oscillations in cerebrocortical neurons
  350:3, p. 615 - 623 2014
• British Journal of Pharmacology
  Aldrich J. V., Senadheera S. N., Ross N. C., Reilley K. A., Ganno M. L., Eans S. E., Murray Thomas F., McLaughlin J. P., Alanine analogues of [D-Trp]CJ-15,208: novel opioid activity profiles and prevention of drug- and stress-induced reinstatement of cocaine-seeking behaviour
  171:13, p. 3212 - 3222 2014
• ACS Medicinal Chemistry Letters
  Lesma G., Murray Thomas F., Recca T., Sacchetti A., Balboni G., Salvadori S., Airaghi F., Silvani A., Structural and Biological Exploration of Phe(3)-Phe(4)-Modified Endomorphin-2 Peptidomimetics
  4:8, p. 795 - 799 2013
• The FASEB journal
  Jabba Sairam V, Murray Thomas F, Sodium channel activator‐stimulated neuronal development involves BDNF‐TrkB signaling
  26:S1 2012
• Journal of Natural Products
  Malloy Karla L., Suyama Takashi L., Engene Niclas, Debonsi Hosana, Cao Zhengyu, Matainaho Teatulohi, Spadafora Carmenza, Murray Thomas F., Gerwick William H., Credneramides A and B
  75:1, p. 60 - 66 2012
• Journal of Natural Products
  Malloy Karla L., Suyama Takashi L., Engene Niclas, Debonsi Hosana, Gerwick William H., Cao Zhengyu, Matainaho Teatulohi, Spadafora Carmenza, Murray Thomas F., Credneramides A and B: Neuromodulatory Phenethylamine and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty Acid from cf. Trichodesmium sp nov
  75:1, p. 60 - 66 2012
• The FASEB journal
  Jabba Sairam V, Murray Thomas F, Sodium channel activator‐induced neurite outgrowth is NMDA receptor dependent and involves a TrkB‐PLCγ‐PI3K‐Akt pathway
  25:S1, p. 1003.3 - 1003.3 2011
• The FASEB journal
  George Joju, Murray Thomas F, Biphasic influence of sodium channel activation on neuronal structural plasticity
  25:S1, p. 1003.5 - 1003.5 2011
• Molecular Pharmacology
  Kelamangalath L., Murray Thomas F., Dravid Shashank M., George J., Aldrich J., Kappa-opioid receptor inhibition of calcium oscillations in spinal cord neurons
  79:6, p. 1061 - 1071 2011
• The FASEB journal
  George Joju, Murray Thomas F, Sodium channel activator‐induced neuronal development is NMDA receptor dependent and involves a Ca2+/calmodulin kinase (CaMK)‐CREB‐BDNF signaling pathway
  24, p. 770.11 - 770.11 2010
• The FASEB journal
  Jabba Sairam V, Gerwick William H, Murray Thomas F, Involvement of Phosphoinositide 3‐kinase‐Akt signaling pathway in sodium channel activator‐induced neurite outgrowth
  24:S1, p. lb472 - lb472 2010
• Journal of Pharmacology and Experimental Therapeutics
  Jabba S. V., Prakash A., Dravid Shashank M., Gerwick W. H., Murray Thomas F., Antillatoxin, a Novel Lipopeptide, Enhances Neurite Outgrowth in Immature Cerebrocortical Neurons Through Activation of Voltage-Gated Sodium Channels
  332:3, p. 698 - 709 2010
• Journal of Medicinal Chemistry
  Patkar Kshitij A., Murray Thomas F., Aldrich Jane V., The effects of C-terminal modifications on the opioid activity of [N-benzylTyr1]dynorphin A-(1-11) analogues
  52:21, p. 6814 - 6821 2009
• The FASEB journal
  George Joju, Murray Thomas F, Sodium channel activation modulates synchronized calcium oscillations and neuronal morphology in immature cerebrocortical neurons
  23:S1 2009
• ChemInform
  Aldrich Jane V., Murray Thomas F., Wang Xin, Peck Angela M., Dattachowdhury Bhaswati, Kumar Vivek, ChemInform Abstract: Solid-Phase Synthesis and Application of Labeled Peptide Derivatives: Probes of Receptor-Opioid Peptide Interactions
  40:13, p. no - no 2009
• Journal of Neuroscience
  George Joju, Peterson Jennifer, Dravid Shashank M., Prakash Anand, Xie Jun, Jabba Sairam V., Baden Daniel G., Murray Thomas F., Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons
  29:10, p. 3288 - 3301 2009
• Journal of Medicinal Chemistry
  Patkar Kshitij A., Murray Thomas F., Aldrich Jane V., The Effects of C-terminal Modifications on the Opioid Activity of [N-BenzylTyr1]Dynorphin A-(1-11) Analogs
  52:21, p. 6814 - 6821 2009
• European journal of pharmaceutical sciences
  Wasdo Scott, Murray Thomas, Nickels Donna, Singh Surjit, Sloan Kenneth B., Shanks Thea, Ulmer Karen, Juntunen Juha, Devarajan Hema, Modeling of flux through silicone membranes from water
  34:4, p. 321 - 332 2008
• The FASEB journal
  George Joju, Cao Zhengyu, Murray Thomas F, Brevetoxin sensitizes immature cerebrocortical neurons to NMDA receptor signaling through activation of voltage‐gated sodium channels
  22:S1 2008
• American Journal of Veterinary Research
  Sun Wan Chun, Moore James N., Hurley David J., Vandenplas Michel L., Murray Thomas F., Linden Joel M., Pharmacologic characterization of novel adenosine A2A receptor agonists in equine neutrophils
  68:9, p. 981 - 987 2007
• American Journal of Veterinary Research
  Moore James N., Hurley David J., Vandenplas Michel L., Linden Joel M., Murray Thomas F., Pharmacologic characterization of novel adenosine A2A receptor agonists in equine neutrophils
  68:9, p. 981 - 987 2007
• Journal of Physiology
  Dravid Shashank M., Almonte Antoine, Nicholson Katherine, Le Phuong, Lyuboslavsky Polina, Murray Ernest, Mosely Cara, Murray Thomas F., Barber Jeremy, French Adam, Balster Robert, Traynelis Stephen F., Erreger Kevin, Yuan Hongjie, Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block
  581:1, p. 107 - 128 2007
• The FASEB journal
  Xie Jun, Peterson Jennifer, Murray Thomas F, Brevetoxin enhanced neurite growth involves voltage‐gated sodium channel activation with engagement of NMDA receptors and CaM‐kinase kinase
  21:6, p. A785 - A786 2007
• The FASEB journal
  Koos Brian John, Yan Xiuzhen, Kruger Lawrence, Linden Joel, Murray Thomas F, Characterization of [125I]ZM241385 binding to adenosine A2A receptors in thalamus and pineal gland of sheep brain
  20:5, p. A1216 - A1216 2006
• Neuropharmacology
  LePage K. T., Low C. M., Ishmael J. E., Traynelis S. F., Murray T. F., Differential binding properties of [3H]dextrorphan and [ 3H]MK-801 in heterologously expressed NMDA receptors
  49:1, p. 1 - 16 2005
• Neuropharmacology
  LePage K. T., Murray Thomas F., Ishmael J. E., Low C. M., Traynelis S. F., Differential binding properties of [ 3H]dextrorphan and [ 3H]MK-801 in heterologously expressed NMDA receptors
  49:1, p. 1 - 16 2005
• Brain Research
  Dravid Shashank M., Baden Daniel G., Murray Thomas F., Brevetoxin augments NMDA receptor signaling in murine neocortical neurons
  1031:1, p. 30 - 38 2005
• Critical Reviews in Neurobiology
  LePage Keith T., Jester Edward L., Dickey Robert W., Gerwick William H., Murray Thomas F., On the use of neuro-2a neuroblastoma cells versus intact neurons in primary culture for neurotoxicity studies
  17:1, p. 27 - 50 2005
• Journal of Neurochemistry
  Dravid Shashank M., Baden Daniel G., Murray Thomas F., Brevetoxin activation of voltage-gated sodium channels regulates Ca 2+ dynamics and ERK1/2 phosphorylation in murine neocortical neurons
  89:3, p. 739 - 749 2004
• Brain Research
  Dravid Shashank M., Murray Thomas F., Spontaneous synchronized calcium oscillations in neocortical neurons in the presence of physiological [Mg2+]
  1006:1, p. 8 - 17 2004
• Harmful algae 2002 : proceedings of the Xth International Conference on Harmful Algae, St. Pete Beach, Florida, USA, October 21-25, 2002 / edited by Karen A. Steidinger [and others]. International Conference on Harmful Algae (10th : 200
  Benson J.M., Hahn F.F., Tibbetts B.M., Murray T.F., Bowen L.E., March T.F., Langley R.J., Baden D.G., Bourdelais A.J., Naar J., Zaias J., Florida Red Tide: Inhalation Toxicity of Karenia brevis Extract in Rats
  10, p. 502 - 504 2004
• Neuroscience Letters
  Dravid Shashank M., Murray Thomas F., Fluorescent detection of Ca2+-permeable AMPA/kainate receptor activation in murine neocortical neurons
  351:3, p. 145 - 148 2003
• Pharmaceutical research
  Sloan Kenneth B., Murray Thomas, Wasdo Scott, Ezike-Mkparu Udo, Waranis Robert, Nickels Donna, Singh Surjit, Shanks Thea, Tovar John, Ulmer Karen, Topical delivery of 5-fluorouracil and 6-mercaptopurine by their alkylcarbonyloxymethyl prodrugs from water: Vehicle effects on design of prodrugs
  20:4, p. 639 - 645 2003
• Symposium on the Chemistry of Natural Products, symposium papers
  Shioiri Takayuki, 30 Kalkitoxin, a Potent Neurotoxin from the Marine Cyanobacterium Lyngbya majuscula, p. 175 - 180 2000
• VIII International conference on Harmful algae - Abstracts and Posters Classification
  Herman Frederick, Murray Thomas, Domoic acid neurotoxicity in cultured cerebellar granule neurons is mediated by NMDA receptors that are activated as a consequence of excitatory amino acid release, p. vp - vp 1997
• Journal of Biochemical Toxicology
  Berman Frederick W., Murray Thomas F., Characterization of [3H]MK-801 binding to N-methyl-D-aspartate receptors in cultured rat cerebellar granule neurons and involvement in glutamate-mediated toxicity
  11:5, p. 217 - 226 1996
• Journal of Biochemical Toxicology
  Berman Frederick W., Murray Thomas F., Characterization of glutamate toxicity in cultured rat cerebellar granule neurons at reduced temperature
  11:3, p. 111 - 119 1996
• Biochemistry and Molecular Biology of Fishes
  Siebenaller Joseph F., Murray Thomas F., Chapter 8 the effects of pressure on G protein-coupled signal transduction
  5:C, p. 147 - 174 1995
• Biochemistry and Molecular Biology of Fishes
  Siebenaller Joseph F., Murray Thomas F., Membrane preparation and receptor assays — adenosine
  3:C, p. 477 - 486 1994
• Journal of medicinal chemistry
  Snyder K. R., Murray T. F., DeLander G. E., Aldrich J. V., Erratum: Synthesis and opioid activity of dynorphin A-(1-13)NH2 analogues containing cis- and trans-4-aminocyclohexanecarboxylic acid (Journal of Medicinal Chemistry (1993) 36 (1101))
  36:13, p. 1921 - 1922 1993
• Molecular pharmacology
  Franklin P H, Murray T, High affinity ( super(3)H)dextrorphan binding in rat brain is localized to a noncompetitive antagonist site of the activated N-methyl-D-aspartate receptor-cation channel
  41:1, p. 134 - 146 1992
• Proceedings of the National Academy of Sciences - PNAS
  Orchinik M, Moore F. L, Murray T. F, Franklin P. H, Guyanyl nucleotides modulate binding to steroid receptors in neuronal membranes : (corticosteroid receptors/G protein/stress/sexual behavior)
  89:9, p. 3830 - 3834 1992
• Journal of experimental biology
  Siebenaller JOSEPH F., Hagar ARTHUR F., Murray THOMAS F., The Effects of Hydrostatic Pressure on A1 Adenosine Receptor Signal Transduction in Brain Membranes of Two Congeneric Marine Fishes
  159:1, p. 23 - 43 1991
• The Biological bulletin (Lancaster)
  Siebenaller Joseph F., Murray Thomas F., A1 Adenosine Receptor Modulation of Adenylyl Cyclase of a Deep-Living Teleost Fish, Antimora rostrata
  178:1, p. 65 - 73 1990
• Japanese Journal of Pharmacology
  Murray Thomas F., Leid Mark, , Characterization of solubilized porcine atrial A_1 adenosine receptors
  52:suppl.2, p. 9 - 9 1990
• The Biological bulletin (Lancaster)
  Siebenaller J. F, Murray T. F, A1 adenosine receptor modulation of adenylyl cyclase od a deep-liing teleost fish, Antimora rostrata
  178:1, p. 65 - 73 1990
• Japanese Journal of Pharmacology
  Murray Thomas F., Zhang Ge, Franklin Paul H., , A_1 adenosine receptor activation suppresses seizures evoked from the prepiriform cortex
  52:suppl.2, p. 100 - 100 1990
• Japanese journal of pharmacology
  Murray Thomas F., Zhang Ge, Franklin Paul H., A1 adenosine receptor activation suppresses seizures evoked from the prepiriform cortex
  52, p. 100 - 100 1990
• Neuroscience letters
  Zhang G E, Franklin P. H, Murray T. F, Anticonvulvant effect of N-ethylcarboxamidoadenosine against kainic acid-induced behavioral seizures in the rat prepiriform cortex
  114:3, p. 345 - 350 1990
• Japanese journal of pharmacology
  Murray Thomas F., Leid Mark, Characterization of solubilized porcine atrial adenosine receptors
  52, p. 9 - 9 1990
• Proceedings of the Western Pharmacology Society
  Zhang G., Franklin P. H., Murray T. F., Activation of adenosine receptors suppresses behavioral seizures induced by kainic acid in the rat prepiriform cortex
  32 1989
• The Biological bulletin (Lancaster)
  Siebenaller JOSEPH F., Murray THOMAS F., Evolutionary Temperature Adaptation of Agonist Binding to the A 1 Adenosine Receptor
  175:3, p. 410 - 416 1988
• Proceedings of the Western Pharmacology Society
  Leid M., Franklin P. H., Murray T. F., Characterization of cardiac A1 adenosine receptors with the antagonist radioligand 8-cyclopentyl-1,3[3H]-dipropylxanthine
  31 1988
• Proceedings of the Western Pharmacology Society
  Murray T. F., Siebenaller J. F., Phylogenetic distribution of A1 adenosine receptors in nervous tissue
  VOL. 29 1986

Presentations

• S. Mehrotra and T.F. Murray. Regulation of cerebrocortical neuron spontaneous Ca2+ oscillations by metabotropic glutamate receptors. Program/Poster 120.03/A86. 2015 Neuroscience Meeting Planner. Chicago, IL, Society for Neuroscience, 2015. Online 2015
• Society for Neuroscience 2014 Annual Meeting, Washington DC, "Sodium Channel Activator-stimulated Neurite Outgrowth Involves the Brain-derived Neurotrophic Factor (BDNF) - Tropomyosin related Kinase B (TrkB) Signaling Pathway 2014
• Molecular Devices Symposium, Nanjing China, "High Throughput Screening and Discovery of Marine Natural Products that Target Neuronal Ion Channels." 2014
• China Pharmaceutical University, Nanjing China, "Sodium Channel Activator-Induced Enhancement of Cerebrocortical Neuron Neurite Outgrowth Requires both GluN2B NMDA Receptors and p21 Protein (Cdc42/Rac)-activated kinase 1 (PAK1)." 2014
• Cell Biology of the Neuron, Gordon Research Center, Waterville, NH, "Sodium channel activator-induced enhancement of cerebrocortical neuron neurite outgrowth requires both GluN2B NMDA receptors and p21 protein (Cdc42/Rac)-activated kinase 1(PAK1)" 2014
• The Society for Neuroscience 2013 Annual Meeting, San Diego, CA, "Voltage-gated sodium channel activator enhancement of immature cerebrocortical neuron development requires both the N-methyl-D-aspartate receptor 2B (GluN2B) and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1)" 2013
• The Society for Neuroscience 2013 Annual Meeting, San Diego, CA "Quantification of kappa opioid receptor ligand potency and efficacy using the FLIPR Membrane Potential Assay" 2013
• BIT's 3rd Annual World Congress of Marine Biotechnology Hangzhou, China "Discovery and Characterization of Marine Natural Products that Target Neuronal Ion Channels" 2013
• College of Life Sciences, Zhejiang University, Zhijingang Campus, Hangzhou, Zhejiang Province, China "Bidirectional Influence of the Marine Natural Product, Brevetoxin, on NMDA Receptor-Dependent Neuronal Structural Plasticity" 2013
• The Society of Neuroscience 2012 Annual Meeting, New Orleans, LA, "Novel C1-cocaine analogs unlike cocaine or benztropine" 2012
• Experimental Biology, San Diego, CA 2012
• The Society of Neuroscience 2011 Annual Meeting, Washington, DC, "Kappa-opioid receptor inhibition of calcium oscillations in spinal cord neurons" 2011
• 7th Annual Ion Channel Targets, South San Francisco, CA "Novel Marine Natural Products that Mimic Neuronal Activity-Dependent Neuroplasticity" 2011
• 2011 American Society Pharmacognosy Annual Meeting, San Diego, CA "Regulation of Neuronal Ion Channel Function By Marine Natural Products" 2011
• 2011 Therapeutic Potential of Kappa Opioids in Pain and Addiction, Seattle, WA, "Kappa-opioid receptor inhibition of calcium oscillations in spinal cord neurons" 2011
• University of Iowa, College of Pharmacy, Iowa City, Iowa. "Sodium channel activators that mimic activity-dependent neuronal plasticity:Novel targets for drug discovery." 2011
• Experimental Biology, San Diego, CA, "Biphasic influence of sodium channel ativation on neuronal structural plasticity" FASEB J 3-17-11 25:1003.3 2011
• Experimental Biology, San Diego, CA, "Sodium channel activator-induced neurite outgrowth is NMDA receptor dependent and involves a TrkB-PLC{gamma}-Akt pathway" FASEB J 3-17-11 25:1003.3 2011
• Institute of Biophysics of the Chinese Academy of Sciences, Beijing, China, "Voltage-gated sodium channels regulate neurite outgrowth in developing neurons" 2010
• The Second International Symposium on Membrane Biology, Ning-Bo, China, "Novel sodium channel activators mimic activity-dependent neuronal plasticity" 2010
• Society for Neuroscience, Neuroscience Meeting Planner, San Diego, CA. "Intracelluar sodium regulation of NMDA receptor-dependent neuronal plasticity" 2010
• Society for Neuroscience, Neuroscience Meeting Planner, San Diego, CA. "Kappa opioid receptor regulation of spontaneous calcium oscillations in embryonic spinal cord neurons" 2010
• Screening Europe, Barcelona, Spain, "Voltage-gated sodium channel activators with differing efficacies stimulate neurite outgrowth in cerebrocortical neurons." 2010
• Target Discovery World Congress, San Francisco, CA, "Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in cerebrocortical neurons." 2009
• Presentation, "Adenosine as an endogenous anticonvulsant: preclinical characterization and clinical implications" at Merck & Co. 2009
• George, J. and Murray, T.F. Sodium channel activation modulates synchronized calcium oscillations and neuronal morphology in immature cerebrocortical neurons. FASEB Journal 23:946.1, 2009 2009
• "Neuroscience Research Areas of Emphasis at Creighton University School of Medicine," Jesuit Medical Colleges Symposium, St. Louis University 2009
• Presentation at University of Mississippi, "Discovery and characterization of neuroactive marine natural products: voltage-gated sodium channels as a common target" 2009
• Jabba, S., Gerwick, W.H., and Murray, T.F. Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels. Program # 807.2, Society for Neuroscience 2008
• "Drug Discovery Strategies and High Throughput Screening in an Academic Environment" at Galleon Pharmaceuticals, Horsham, PA 2008
• Ion Channel Targets, South San Francisco, CA, "Influence of Lipid Soluble Gating Modifier Toxins on Sodium Influx in Neocortical Neurons" 2008
• Seminar entitled "Neuronal responses to sodium channel gating modifiers: From neurotoxicity to dendritogenesis" at the Barrow Neurological Institute, Phoenix, AZ, May 20, 2008. 2008
• George, J., Cao, Z. and Murray, T.F. Brevetoxin sensitizes immature cerebrocortical neurons to NMDA receptor signaling through activation of voltage-gated sodium channels. FASEB Journal 22:721.6, 2008. 2008
• Cao, Z., George, J., Gerwick, W.H. and Murray, T.F. Voltage-dependent sodium channel gating modifier toxins produce sodium influx in neocortical neurons. #1727 The Toxicologist (Society for Toxicology) 2008. 2008
• Seminar entitled "Marine natural products as sodium channel gating modifiers: Neurotoxicants or novel therapeutics?" at Scripps Institution of Oceanography, University of California at San Diego, November 5, 2007. 2007
• Murray, T.F., Xie, J., Peterson, J. and Baden D.G. Brevetoxin activation of voltage-gated sodium channels stimulates neurite outgrowth in immature cerebrocortical neurons. Program No. 34.13. 2007 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2007. Online. 2007
• Seminar entitled "Neuronal responses to voltage-gated sodium channel activators: From neurotoxicity to dendritic development" at the Department of Neuroscience, Medical University of South Carolina, Charleston, SC, September 21, 2007. 2007
• Ion Channel Targets, Boston MA, September 10, 2007, "Evaluating Ion Channel Mechanisms in Murine Neuronal Cultures and Human Embryonic Stem Cell-Derived Neurons Using FLIPR and Flex Station." 2007
• Xie, J. Peterson, J. Murray, T.F. Brevetoxin enhanced neurite growth involves voltage-gated sodium channel activation with engagement of NMDA receptors and CaM-kinase kinase FASEB JOURNAL 21 (6): A785-A786, 2007 2007
• Murray, T.F., Yan, X., Gomez, A.P., Baden, D.G., and Benson, J.M. Brevetoxin-induced neural insult in the retrosplenial cortex of mouse brain following inhalation exposure. The Toxicologist 96, 363, 2007. 2007
• LePage, K.T., Rainier, J.D. and Murray, T.F. Gambierol acts as a functional antagonist of neurotoxin site 5 on voltage-gated sodium channels in cerebellar granule cells. The Toxicologist 96, 364, 2007. 2007
• Cao,Z., Baden, D.G. and T.F. Murray. Brevetoxin-induced phosphorylation of Pyk2 and Src in murine neocortical neurons occurs through distinct pathways Program No. 130.12. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006. Online. 2006
• LePage, K.T., Stice, S.L. and T.F.Murray. Activation of voltage-gated sodium channels produces Ca2+ influx in human neural progenitor cell lines derived from embryonic stem cells Program No. 130.14. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006. Online. 2006

Awards

• Jack L. Beal Award
  Detailed Analysis of (-)-Palmyrolide A and Some Synthetic Derivatives as Voltage-Gated Sodium Channel Antagonists. Suneet Mehrota, Brendan A. Duggan, Rodolfo Tello-Aburto, Tara D. Newar, William H. Gerwick, Thomas F. Murray, and William A. Maio* J. Nat. Prod., 2014, 77, 2553-2560. DOI: 10.1021/np500644k
  Journal of Natural Products
• Arthur E. Schwarting Award
  The Hoiamides, Structurally Intriguing Neurotoxic Lipopeptides from Papua New Guinea Marine Cyanobacteria. Hyukjae Choi, Alban R. Pereira, Zhengzu Cao, Cynthia F. Shuman, Niclas Engene, Tara Byrum, Teatulohi Matainaho, Thomas F. Murray, Alfonso Mangoni, and William H. Gerwick J. Nat. Prod.; (Article); 2010; 73(11); 1411-1421. DOI 10.1021/np100468n
  Journal of Natural Products