Professor
Pharmacy

Contact
Catherine A . Opere, BPharm, MBA, PhD
Professor
Pharmacy
Research Focus
Oxidative stress (OS) is an underlying pathology in retinal neurodegenerative diseases such as age-related macular degeneration, diabetic retinopathy and glaucoma (Dreyer EB. J. Glaucoma. 7(1):62-67). These ocular retinopathies account for a large number of cases of blindness and visual impairment among the elderly in the US, warranting research into potential therapeutic options to prevent visual impairment (Vision Problems in the U.S. Prevalence of Adult Vision Impairment and Age-Related Eye Disease in America. Prevent Blindness America. http://www.visionproblemsus.org/introduction.html). My research focus is directed towards identifying the underlying mechanisms by which OS interacts with pharmacological receptors in ocular tissues, with the aim of revealing potential pharmacological targets that can be manipulated for therapeutic interventions. My specific areas of interests include studies on the regulation of uveal sympathetic and retinal excitatory neurotransmission by OS and OS-metabolites of long chain polyunsaturated fatty acids (PUFAs). Other areas of study include the regulation of retinal ganglion cells and neural tissue survival by OS-PUFA metabolites; regulation of neurotransmitter release, intraocular pressure and aqueous humor dynamics by hydrogen sulfide donors; development of innovative, slow release hydrogen sulfide donor formulations that can achieve sustainable concentrations in the anterior and posterior segments of the eye for management of glaucoma and other retinopathies; identification and characterization of subtypes of prejunctional (autoreceptors and heteroreceptors) receptors in the mammalian anterior uvea and retina. Receptors of interest include those for glutamate, histamine, prostanoids and cannabinoids.Department
Pharmacy Sciences
Position
Professor
Books
- Handbook of Basic and Clinical Occular Pharmacology
Njie-Mbye YF, Opere CA, McKoy M.Ocular autonomic & physiology. Handbook of Basic and Clinical Ocular Pharmacology. 2020 - Obesity: Epidemiology, Pathophysiology, and Prevention
Opere, C. A., Ohia, S. E., Kulkarni, M., Njie-Mbye, Y. F. Role of Neurotransitters in obesity regulation, p. 113-124 2013 - Elsevier
Njie-Mbye YF, Barrett A, Kulkarni M, Opere CA, Ohia SE. Ocular Health. Bagchi D, Rahman I, eds. Inflammation, Advancing Age and Nutrition: Research, Science and Interventions, 1st ed. Elsevier. Imprint: Academic Press; ISBN: 9780123978035; 2013; http://store.elsevier.com/9780123978073.
1st Ed. 2013 - Phytochemicals for Obesity Treatment: Pathophysiology and Weight Management
Ohia, S. E., Opere, C. A., Kulkarni, M., Njie-Mbye, Y. F. Role of Neurotransmitters in obesity regulation., p. 113-124 2012 - Research Signpost Transworld Research Network
Njie-Mbye YF, Anjanette F, Zhao M, Ohia SE, Opere CA. Oxidative stress in ocular tissues: pathophysiological and pharmacological implications. In: Catala A eds. Lipid peroxidation: biological implications. Research Signpost Transworld Research Network, 2011. 2011 - Research Signpost Transworld Research Network
Opere CA, Zhao M, Njie-Mbye YF, Ohia SE. Biological consequences of lipid peroxidation of long chain polyunsaturated fatty acids in ocular tissues: role of the isoprostanes and neuroprostanes. In: Catala A eds. Lipid peroxidation: biological implications. Research Signpost Transworld Research Network, 2011. ISBN: 978-81-7895-527-8. 2011
Articles
- Pharmaceuticals
Heruye SH, Maffofou Nkenyi LN, Singh NU, Yalzadeh D, Ngele KK, Njie-Mbye Y-F, Ohia SE, Opere CA. 2020. Current Trends in the Pharmacology of Cataracts https://doi.org/10.3390/ph13010015
13(1), p. (15 pages) 2020 - Pharmaceuticals
Heruye SH, Maffofou N LN, Singh NU, Njie M YF, Ohia SE, Opere CA.Current trends in the pharmacotherapy of cataracts.13(1):15. https://doi.org/10.3390/ph13010015 2020 - AIMS Neuroscience
Kulkarni-Chitnis M, Mitchell-Bush L, Belford R, Robinson J, Opere CA, Ohia SE, Mbye YFN. Interaction between hydrogen sulfide, nitric oxide, and carbon monoxide pathways in the bovine isolated retina. https://www.aimspress.com/article/10.3934/Neuroscience.2019.3.104
6(3), p. 104-115 2019 - Journal of Pharmacological and Toxicological Methods
Heruye S, Maffofou N LN, Singh NU, Munt D, Njie-Mbye YF, Ohia SE, Opere CA. Standardization of a new method for assessing the development of cataract in cultured bovine lenses. .
98, p. (7 pages) 2019 - AAPS PharmSciTech
Vora D, Kumari D, Heruye SH, Opere CA, Chauhan H. Preparation, Characterization and Anti-oxidant evaluation of Novel Polyphenol loaded Polymeric Solid-Lipid Nanoparticles for Cataract Treatment.
20(163) 2019 - Journal of Ocular Pharmacology and Therapeutics
Njie-Mbye YF, Robinson J, Mitchell-Bush L, Mckoy M, Opere CA, Ohia SE, Sharif N. Pharmacology of Serotonin Receptors Causing Contraction of Isolated Bovine Posterior Ciliary Arteries: Role in Ocular Blood Flow doi: 10.1089/jop.2017.0124. Epub 2018 Jan 25. PMID: 29369737
34(1-2), p. 134-140 2018 - Journal of Ocular Pharmacology and Therapeutics
Ohia SE, Njie-Mbye YF, Robinson J, Mitchell L, Mckoy M, Opere CA, Sharif NA. Serotonin-2B/2C Receptors Mediate Bovine Ciliary Muscle Contraction: Role in Intraocular Pressure Regulation. Epub 2018 Jan 24. PMID:29364761
34(1-2), p. 70-75 2018 - Neurochemical Research
Bankhele P, Salvi A, Jamil J, Njie-Mby YF, Ohia SE, Opere CA. Comparative effect of hydrogen sulfide-releasing compounds on [3H]D-aspartate release from bovine isolated retinae. doi: 10.1007/s11064-018-2471-5. [Epub ahead of print] PMID:29353375
43(3), p. 692-701 2018 - Journal of Ocular Pharmacology and Therapeutics
Opere CA, Heruye S, Njie-Mbye YF, Ohia SE, Sharif NA. Regulation of excitatory amino acid transmission in the retina: studies on neuroprotection. doi: 10.1089/jop.2017.0085. Epub 2017 Dec 21. PMID:29267132
34(1-2), p. 107-118 2017 - Jounal of Ocular Pharmacology and Therapeutics
Ohia SE, Robinson J, Mitchell L, Ngele KK, Heruye SH, Opere CA, Njie-Mbye YF. Regulation of aqueous humor dynamics by hydrogen sulfide: potential role in glaucoma pharmacotherapy. doi: 10.1089/jop.2017.0077. Epub 2017 Dec 7. PMID:29215951
34(1-2), p. 61-69 2017 - Jounal of Ocular Pharmacology and Therapeutics
Robinson J, Okoro E, Ezuedu C, Bush L, Opere CA, Ohia SE, Njie-Mbye YF. Effects of Hydrogen Sulfide-Releasing Compounds on Aqueous Humor Outflow Facility in Porcine Ocular Anterior Segments, Ex Vivo. doi: 10.1089/jop.2016.0037. PMID:28099049
33(2), p. 91-97 2017 - AAPS PharmSciTech
Patil A, Singh S, Opere CA, Dash A. Sustained release delivery System of a slow hydrogen sulfide donor – GYY 4137 for potential application in glaucoma. DOI 10.1208/s12249-017-0712-6; 2017. http://link.springer.com/article/10.1208/s12249-017-0712-6
18 2017 - Jounal of Ocular Pharmacology and Therapeutics
Salvi A, Bankhele P, Jamil JM, Kulkarni-Chitnis M, Njie-Mbye YF, Ohia SE, Opere CA. “Effect of hydrogen sulfide donors on intraocular pressure in rabbits”. doi: 10.1089/jop.2015.0144. PMID: 27092593
32(6), p. 371-375 2016 - US Pharmacist
Opere CA, O’Brien KK, Elhaj MH. Optic Neuritis: A brief review.
41(1), p. 35-40 2016 - Neurochemical Research
Salvi A, Bankhele P, Jamil JM, Kulkarni-Chitnis M, Njie-Mbye YF, Ohia SE, Opere CA. “Pharmacological actions of hydrogen sulfide donors on sympathetic neurotransmission in the bovine anterior uvea, in vitro”. [Epub ahead of print] PMID: 26700431.
41(5), p. 1020-1028 2015 - US Pharmacist
Bossou AR, Castillo S, O’Brien KK, Opere CA, Destache CJ. “Preventive HIV vaccines: Progress and challenges”.
40(10), p. 46-50 2015 - Experimental Eye Research
Kulkarni-Chitnis, M., Njie-Mbye, Y. F., Mitchell, L., Robinson, J., Whiteman, M., Wood, M. E., Opere, C. A., Ohia, S. E. Inhibitory action of novel hydrogen sulfide donors on bovine isolated posterior ciliary arteries
134, p. 73-79 2015 - Neurochemical Research
Jamil, J., Bankhele, P., Salvi, A., Mannix, J. E., Oger, C., Guy, A., Galano, J. M., Durand, T., Njie-Mbye, Y. F., Ohia, S. E., Opere, C. A. Role of the non-enzymatic metabolite of eicosapentaenoic acid, 5-epi-5-F3t-isoprostane in the regulation of [(3)H]D-aspartate release in isolated bovine retina
39, p. 2360-2369 2014 - AAPS PharmSciTech
Ali, H., Opere, C., Singh, S. In Vitro-Controlled Release Delivery System for Hydrogen Sulfide Donor
15, p. 910-919 2014 - Experimental Eye Research
Chitnis, Madhura K., Njie-Mbye, Ya F., Opere, Catherine A., Wood, Mark E., Whiteman, Matthew, Ohia, Sunny E. Pharmacological actions of the slow release hydrogen sulfide donor GYY4137 on phenylephrine-induced tone in isolated bovine ciliary artery 2014 - Frontiers in Physiology
Ya, Fatou N., Kulkarni-Chitnis, Madhura, Opere, Catherine A., Barrett, Aaron, Ohia, Sunny E., Passi, Alberto, Gasull, Xavier Lipid peroxidation: pathophysiological and pharmacological implications in the eye
4, p. 1-10 2013 - Prostaglandins & other lipid mediators
Galano, Jean-Marie, Mas, Emilie, Barden, Anne, Mori, Trevor A., Signorini, Cinzia, De Felice, Claudio, Barrett, Aaron, Opere, Catherine, Pinot, Edith, Schwedhelm, Edzard, Benndorf, Ralf, Roy, J?r?me, Le Guennec, Jean-Yves, Oger, Camille, Durand, Thierry Isoprostanes and Neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans
107, p. 95-102 2013 - Experimental Eye Research
Njie-Mbye, Y. F., Kulkarni, M., Opere, C.A., Ohia, S. E. Mechanism of action of hydrogen sulfide on cyclic AMP formation in rat retinal pigment epithelial cells
98, p. 16-22 2012 - Frontiers in Physiology
Njie-Mbye, Y. F., Opere, C. A., Ohia, S. E., Chitnis, M. Hydrogen sulfide: role in ion channel and transporter modulation in the eye
3, p. 1-9 2012 - Nitric Oxide
Njie-Mbye, Ya F., Chitnis, Madhura, Opere, Catherine, Ohia, Sunny P41 Hydrogen sulfide: Endogenous production and regulatory role in ocular tissues
27, p. S30 2012 - U.S. Pharmacist
Opere CA, O’Brien KK, Shea JL. “Understanding diabetic retinopathy.” US Pharmacist, April, 2011. Role: contribution to preparation of manuscript. 2011 - Neurochemical Research
Jamil, J., Wright, A., Harrison, N., Kegey, E., Flowers, A. F., Flyod, N. J., Kotera, C., Guy, A., Galano, J. M., Durand, T., Njie-Mbye, Y. F., Ohia, S. E., Opere, C. A. Regulation of [(3)H]D-Aspartate Release by the 5-F(2t)-Isoprostane and Its 5-Epimer in Isolated Bovine Retina
37, p. 574-582 2011 - Neurochemical Research
Kulkarni, Madhura, Njie-Mbye, Ya, Okpobiri, Ikechukwu, Zhao, Min, Opere, Catherine A., Ohia, Sunny Endogenous Production of Hydrogen Sulfide in Isolated Bovine Eye
36, p. 1540-1545 2011 - Current eye research
Ohia, Sunny E., Opere, Catherine A., Monjok, Emmanuel M., Kouamou, Ghislaine, Leday, Angela M., Njie-Mbye, Ya Role of Hydrogen Sulfide Production in Inhibitory Action of L-Cysteine on Isolated Porcine Irides
35, p. 402-407 2010 - Neurochemical Research
Njie-Mbye, Ya, Bongmba, Odelia Y. N., Onyema, Chinwe C., Chitnis, Abhishek, Kulkarni, Madhura, Opere, Catherine A., LeDay, Angela M., Ohia, Sunny E. Effect of Hydrogen Sulfide on Cyclic AMP Production in Isolated Bovine and Porcine Neural Retinae
35, p. 487-494 2010 - Elsevier
Kotera C, Opere CA. Practolol. xPharm (On-line pharmacology information service of Elsevier), eds: F. Dowd, 2010; http://www.mdl.com/products/knowledge/xpharm/index.jsp. 2010 - Elsevier
Kotera C, Opere CA. Mannitol. xPharm (On-line pharmacology information service of Elsevier), eds: F. Dowd, 2010; http://www.mdl.com/products/knowledge/xpharm/index.jsp. 2010 - Neurochemical Research
Zhao, Min, Destache, Christopher J., Ohia, Sunny E., Opere, Catherine A. Role of Prostanoid Production and Receptors in the Regulation of Retinal Endogenous Amino Acid Neurotransmitters by 8-Isoprostaglandin E-2, Ex Vivo
34, p. 2170-2180 2009 - Neurochemical Research
Monjok, E. M., Kulkarni, K. H., Njie, Y. F., Ohia, S. E., Opere, Catherine A. Regulation of [(3)h] d: -aspartate release from mammalian isolated retinae by hydrogen sulfide
34, p. 1962-1968 2009 - Neurochemical Research
Kulkarni, Kaustubh H., Monjok, Emmanuel M., Zeyssig, Robert, Kouamou, Ghislaine, Bongmba, Odelia N., Opere, Catherine A., Njie, Ya F., Ohia, Sunny E. Effect of Hydrogen Sulfide on Sympathetic Neurotransmission and Catecholamine Levels in Isolated Porcine Iris-Ciliary Body
34, p. 400-406 2009 - xPharm
Opere, Catherine A. Aquaporin 2 2009 - xPharm
Opere, Catherine A. Aquaporin family 2009 - Experimental Eye Research
Monjok, Emmanuel M., Kulkarni, Kaustubh H., Kouamou, Ghislaine, Mckoy, Marshalyn, Opere, Catherine A., Bongmba, Odelia N., Njie, Ya F., Ohia, Sunny E. Inhibitory action of hydrogen sulfide on muscarinic receptor-induced contraction of isolated porcine irides
87, p. 612-616 2008 - Methods and findings in experimental and clinical pharmacology
Opere, C. A., Ford, K., Zhao, M., Ohia, S. E. Regulation of neurotransmitter release from ocular tissues by isoprostanes
30, p. 697-701 2008 - Neurochemical Research
Min Zhao, Opere, Catherine A. Prejunctional Inhibitory Effects of Isoprostanes on Dopaminergic Neurotransmission in Bovine Retinae, In vitro
33, p. 37-42 2008 - xPharm
Opere, D., Opere, Catherine A. Aquaporin 1 2008 - xPharm
Opere, C. A. Procainamide 2007 - Current eye research
Opere, C. A., Zheng, W. D., Zhao, M., Lee, J. S., Kulkarni, K. H., Ohia, S. E. Inhibition of potassium- and ischemia-evoked [H-3] D-aspartate release from isolated bovine retina by cannabinoids
31, p. 645-653 2006 - Neurochemical Research
Kulkarni, K. H., Opere, C. A., Leday, A. M., Shara, M. A., Ohia, S. E. Regulation of norepinephrine release from isolated bovine irides by histamine
31, p. 891-897 2006 - Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis
Ohia, S. E., Opere, C. A., LeDay, A. M. Pharmacological consequences of oxidative stress in ocular tissues
579, p. 22-36 2005 - Neurochemical Research
Opere, C. A., Zheng, W. D., Huang, J. F., Adewale, A., Kruglet, M., Ohia, S. E. Dual effect of isoprostanes on the release of [H-3]D-aspartate from isolated bovine retinae: Role of arachidonic acid metabolites
30, p. 129-137 2005 - Current eye research
LeDay, A. M., Kulkarni, K. H., Opere, C. A., Ohia, S. E. Arachidonic acid metabolites and peroxide-induced inhibition of [H-3]D-aspartate release from bovine isolated retinae
28, p. 367-372 2004 - Neurochemical Research
LeDay, A. M., Awe, S. O., Kulkarni, K., Harris, L. C., Opere, C., Dash, A., Ohia, S. E. Effect of peroxides on [H-3]D-aspartate release from bovine isolated retinae
29, p. 811-818 2004 - Journal of Ocular Pharmacology and Therapeutics
Ohia, S. E., Awe, S. O., Opere, C. A., LeDay, A. M., Harris, L. C., Kulkarni, K., Sharif, N. A. Glucose-deprivation-induced [H-3]D-aspartate release from isolated bovine and human retinae
19, p. 599-609 2003 - Journal of Ocular Pharmacology and Therapeutics
Harris, L. C., Awe, S. O., Opere, C. A., Leday, A. M., Ohia, S. E., Sharif, N. A. Pharmacology of serotonin receptors modulating electrically-induced [H-3]-norepinephrine release from isolated mammalian iris-ciliary bodies
18, p. 339-348 2002 - Experimental Eye Research
Harris, L. C., Olubusayo, S., Opere, C. A., Leday, A. M., Ohia, S. E., Sharif, N. A. [H-3]-serotonin release from bovine iris-ciliary body: Pharmacology of prejunctional serotonin (5-HT7) autoreceptors
73, p. 59-67 2001 - Free Radical Research
Opere, C. A., Awe, S. O., Harris, L. C., LeDay, A. M., Ohia, S. E. Potentiation of sympathetic neurotransmission in bovine isolated irides by isoprostanes
35, p. 257-264 2001 - Current eye research
Ohia, S. E., Awe, S. O., Opere, C. A., LeDay, A. M., Harris, L. C., Sharif, N. A. Hypoxia-induced [H-3]D-aspartate release from isolated bovine retina: modulation by calcium-channel blockers and glutamatergic agonists and antagonists
23, p. 386-393 2001 - Journal of Ocular Pharmacology and Therapeutics
Matutte, B., Awe, S. O., Ameh, F. A., Leday, A. M., Rice, J. C., Opere, C. A., Ohia, S. E. Role of catalase in pre- and postjunctional responses of mammalian irides to hydrogen peroxide
16, p. 429-438 2000 - Neurochemical Research
Ohia, S. E., Opere, C. A., Awe, S. O., Adams, L., Sharif, N. A. Human, bovine, and rabbit retinal glutamate-induced [H-3]D-aspartate release: Role in excitotoxicity
25, p. 853-860 2000 - Neurochemical Research
Graham, J., Awe, S. O., LeDay, A. M., Rice, J. C., Ramos, G., Harris, L. C., Opere, C. A., Ohia, S. E. Effect of inhibition of cyclooxygenase on pre- and postjunctional actions of peroxides in the iris-ciliary body
25, p. 519-525 2000 - Neurochemical Research
Awe, S. O., Opere, C. A., Harris, L. C., Uketui, A. J., Ohia, S. E. Effect of isoprostanes on sympathetic neurotransmission in the human isolated iris-ciliary body
25, p. 491-496 2000
Presentations
- Singh N, Opere CA, Singh S. Developing a novel lipid-based system of diallyl trisulfide (DATS) for sustained delivery of hydrogen sulfide for the treatment of glaucoma.2020 American Association of Pharmaceutical Scientists, October 25-28, 2020. New Orleans, LA, USA. 2020
- From bench to bedside: the drug discovery process. Graduate student seminar series MPS 793. Zoom Meeting. 2020
- Developing an efficient ocular delivery system for the hydrogen sulfide releasing compound, diallyl trisulfide. Singh N, Opere CA, Singh S.2020 American Society for Pharmacology and Experimental Therapeutics. San Diego, CA. 2020
- Blanchard S, Opere CA.Integration of Pharmacology into an Occupational Therapy Health Conditions Course. Workshop proposal accepted. 2020 Annual AOTA meeting, March 27-30. Boston, MA. 2020
- Developing a novel lipid-based system of diallyl trisulfide for sustained delivery of hydrogen sulfide for the treatment of Glaucoma. Singh N, Opere CA, Singh S.Midwest Student Biomedical Research Forum, February 2020. Creighton University, Omaha, NE 2020
- Regulation of Cataractogenesis by Hydrogen Sulfide-NSAID Hybrid Compounds in Cultured Bovine Lenses. Opere CA 2020
- Ohia SE, Ya Fatou NM, Mitchell L, Robinson J, Ngele K, Opere CA. Regulation of Endogenous Hydrogen Sulfide Concentrations by Cannabinoid in Bovine Isolated Retina. 2020 ARVO Meeting. Baltimore, Maryland. 2020
- Opere CA, Bankhele P, Salvi A, Jamil J, Munt D, Njie-Mbye YF, Chitnis M, Ohia SE. "Comparative inhibition of neurotransmission by N-acetylcysteine and L-cysteine in bovine isolated retina." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, abstract #1886, Orlando, FL May 4-8, 2014. 2014
- Njie-Mbye YF, Robinson J, Ezeudu C, Mitchell L, Chitnis MK, Opere CA, Ohia SE. "Effect of hydrogen sulfide releasing compounds on aqueous humor dynamics." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, abstract #2890, Orlando, FL May 4-8, 2014. 2014
- Ohia SE, Chitnis MK, Njie-Mbye YF, Robinson J, Ezeudu C, Mitchell L, Opere CA, Whiteman M. "Effect of novel hydrogen sulfide donors (AP67 and AP72) on isolated bovine ciliary artery." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, abstract #4348, Orlando, FL May 4-8, 2014. 2014
- Chitnis MK, Belford R, Robinson J, Mitchell L, Njie-Mbye YF, Opere CA, Ohia SE. "Interaction between hydrogen sulfide and nitric oxide in isolated bovine retina." Presented at the: Experimental Biology meeting, abstract #1060.2, San Diego, CA April 26-30, 2014. 2014
- Robinson J, Ezeudu C, Mitchell L, Chitnis MK, Opere CA, Ohia SE, Njie-Mbye YF. "Involvement of KATP channels in hydrogen sulfide-induced increase in aqueous humor outflow." Presented at the: Experimental Biology meeting, abstract #1060.3, San Diego, CA April 26-30, 2014. 2014
- Opere CA, Bankhele P, Salvi A, Jamil J, Munt D, Njie Mbye YF, Chitnis M, Ohia SE. "Comparative pharmacological actions of N-acetylcysteine and L-cysteine on excitatory neurotransmission in isolated bovine retina." Presented at the: Experimental Biology meeting, abstract #1060.4, San Diego, CA April 26-30, 2014. 2014
- Opere CA, Salvi A, Bankhele P, Jamil J, Njie-Mbye YF, Kulkarni K, Ohia SE. "Inhibitory action of hydrogen sulfide donor, ACS 67 on sympathetic neurotransmitter release in isolated bovine iris-ciliary bodies." Presented at the: ISER symposium, abstract #15, Sarasota, Fl, Sept 29-Oct 2, 2013. 2013
- Njie-Mbye YF, Robinson J, Kulkarni M, Opere CA, Ohia SE. "Hydrogen sulfide and aqueous humor outflow." Presented at the: ISER symposium, Abstract #4, Sarasota, Fl, Sept 29-Oct 2, 2013. 2013
- Jamil J, Kegey E, Flowers AF, Flyod NJ, Salvi A, Bankhele P, Guy A, Galano JM, Durand T, Njie-Mbye YF, Kulkarni M, Ohia SE, Opere CA. "Further studies on the role of arachidonic acid metabolites in the regulation of potassium-induced [3H]D-aspartate release from isolated bovine retinae by 5-epi-5-F3t-isoprostane." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting. ID: 1616232; abstract #6315; Seattle, WA, May 5-9, 2013. 2013
- Bankhele P, Jamal J, Salvi A, Njie Mbye YF, Kulkarni M, Ohia SE, Opere CA. "Further studies on the inhibition of [3H]D-aspartate release by hydrogen sulfide donors in isolated bovine retina." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, Abstract #6325, Seattle, WA, May 5-9, 2013. 2013
- Salvi A, Bankhele P, Jamal J, Njie Mbye YF, Kulkarni M, Ohia SE, Opere CA. "Regulation of mammalian sympathetic neurotransmitter release and intraocular pressure by hydrogen sulfide donor, GYY 4137." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, ID: 1615348; abstract #1976, Seattle, WA, May 5-9, 2013. 2013
- Njie-Mbye YF, Robinson J, Okpobiri A, Kulkarni M, Opere CA, Ohia SE. "Effect of NaHS, a fast-releasing hydrogen sulfide donor on aqueous humor outflow in porcine trabecular meshwork." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, ID 1616794; abstract #3563; Seattle, WA, May 5-9, 2013. 2013
- Ohia SE, Okpobiri A, Njie-Mbye YF, Robinson J, Kulkarni M, Opere CA. "Pharmacological actions of L-cysteine on isolated bovine ciliary muscles." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, ID 1616651, abstract #787; Seattle, WA, May 5-9, 2013. 2013
- Opere CA, Jamil J, Salvi A, Bankhele P, Flowers AF, Floyd N, Durand T, Galano JM, Guy A, Oger C, Njie-Mbye YF, Kulkarni K, Ohia SE. "Regulation of potassium-induced [3H]D-aspartate release from isolated bovine retina by 5-epi-5-F3t-isoprostane: Role of prostanoid receptors." Presented at the: Experimental Biology meeting, Abstract #7268, Boston, MA April 20-24, 2013. 2013
- Robinson J, Njie-Mbye YF, Okpobiri A, Kulkarni M, Opere CA, Ohia SE. "Hydrogen sulfide increases aqueous humor outflow in porcine trabecular meshwork." Presented at the: Experimental Biology meeting, Abstract #5025, Boston, MA April 20-24, 2013. 2013
- Okpobiri A, Njie-Mbye YF, Robinson J, Kulkarni M, Opere CA, Ohia SE. "Effect of hydrogen sulfide on isolated bovine ocular smooth muscle." Presented at the: Experimental Biology meeting, Abstract #5534, Boston, MA April 20-24, 2013. 2013
- Salvi A, Bankhele P, Jamal J, Njie-Mbye YF, Kulkarni M, Ohia SE, Opere CA. "Regulation of mammalian sympathetic neurotransmitter release and intraocular pressure by hydrogen sulfide donor, GYY 4137." Presented at the: Creighton University St. Alberts Day, Abstract #81, Harper Center, Creighton University, Omaha, NE, Mar 26, 2013. 2013
- Bankhele P, Jamil J, Salvi A, Opere CA. "Further studies on the Inhibition of [3H]D-aspartate release by hydrogen sulfide donors in isolated bovine retina." Presented at the: Creighton University St. Alberts Day, Abstract #83, Harper Center, Creighton University, Omaha, NE, Mar 26, 2013. 2013
- Opere CA, Flowers A, Floyd N, Kegey E, Jamil J, Durand T, Galano JM, Guy A, Oger C, Njie-Mbye YF, Ohia SE. "Enhancement of excitatory neurotransmitter release by metabolites of long chain polyunsaturated fatty acids in bovine retina, in vitro." Presented at the: Fourth European Workshop on Lipid Mediators, Pasteur Institute - Paris, September 27-28, 2012. 2012
- Opere CA, Jamil J, Salvi A, Bankhele P, Njie-Mbye YF, Kulkarni M, Ohia SE. "Inhibition of [3H]D-aspartate release by hydrogen sulfide in isolated bovine retina." Presented at the: Second International Conference on H2S Biology and Medicine, Abstract #P110, Atlanta, Georgia, Sept 20-22, 2012. 2012
- Njie-Mbye YF, Kulkarni M, Opere CA, Ohia SE. "Hydrogen Sulfide: Endogenous Production and Regulatory Role in Ocular Tissues." Presented at the: Second International Conference on H2S Biology and Medicine, Abstract #P41, Atlanta, Georgia, Sept 20-22, 2012. 2012
- Opere CA, Flowers A, Jamil J, Kegey E, Floyd N, Salvi A, Bankhele A, Durand T, Galano JM, Guy A, Oger C. "Regulation of excitatory neurotransmitter release by metabolites of long chain polyunsaturated fatty acids in bovine retina, in vitro." Presented at the: Frontiers in Lipid Biology, American Society of Biochemistry and Molecular Biology (ASMB); International Conference on the Bioscience of Lipids (ICBL) and The Canadian Lipoprotein Conference (CLC), Abstract # 2374, Banff Alberta, Canada, September 5-8, 2012. 2012
- Chitnis MK, Njie-Mbye YF, Opere CA, Ohia SE. "Hydrogen sulfide-induced increase in cyclic AMP production in RPE-J cells: Role of prostanoids, adenyl cyclase and KATP channels." Presented at the: ISER meeting, Berlin, Germany, July 21-25, 2012. Abstract #P061 2012
- Opere CA, Flowers A, Floyd N, Kegey E, Jamil J, Durand T, Galano JM, Guy A, Oger C, Njie-Mbye YF, Ohia SE. "Role of prostanoid receptors in the excitatory effect of neuroprostanes on potassium induced [3H]D-aspartate release in isolated bovine retina." Presented at the : 19me journe IRPF de Chimie Sorze, France, 15 Juin 2012. 2012
- Kulkarni M, Njie-Mbye YF, Opere CA, Whiteman M, Ohia SE. "Effect of slow releasing hydrogen sulfide donor GYY4137 on isolated bovine ciliary artery." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, Abstracts March 26, 2012 53:6866. May 6-9, 2012, Ft. Lauderdale, Fl. 2012
- Opere CA, Flowers AF, Floyd N, Kegey E, Jamil J, Durand T, Galano JM, Guy A, Oger C, Njie-Mbye YF, Ohia SE. "Role of prostanoid receptors in the excitatory effect of neuroprostanes on potassium induced [3H]D-aspartate release in isolated bovine retina." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, Abstracts March 26, 2012 53:5386. May 6-9, 2012, Ft. Lauderdale, Fl. 2012
- Flowers AF, Floyd N, Kegey E, Jamil J, Durand T, Galano JM, Guy A, Njie-Mbye YF, Kulkarni K, Ohia SE, Opere CA. "Regulation of K+-induced [3H]D-aspartate release by synthetic neuroprostanes in isolated bovine retina." Presented at the: The Experimental Biology meeting, Journal. 2012;26:843.4. 2012
- Stroud DD, Kulkarni M, Njie-Mbye YF, Opere CA, Ohia SE. "Pharmacological actions of L-cysteine on isolated bovine irides." Presented at the: The Experimental Biology meeting, Journal. 2012;26:1049.4 2012
- Kegey E, Jamil JM, Harrison NC, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE, Opere CA. "Role of prostanoid receptors in the inhibitory effect of 5-F2t-IsoP and its 5-epimer on potassium-induced [3H]D-aspartate release in isolated bovine retina." Presented at the: 8Th GERLI Lipidomics Meeting, Bioactive Lipids, Membranes and Bioactive lipids, Lyon, October, 25-28-2011. 2011
- Ali H, Opere CA, Singh S. "An easy to use, safe, and efficient spectrophotometric method for the determination of hydrogen sulfide released from its analogues." Presented at the: American Association of Pharmaceutical Scientists, October, 23-27, 2011. Walter E. Washington Convention Center, Washington, D.C. 2011
- Ali H, Opere CA, Singh S. "Phase-sensitive smart polymer-based sustained release delivery system for hydrogen sulfide analogue." Presented at the: Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, October, 23-27, 2011. Walter E. Washington Convention Center, Washington, D.C. 2011
- Kegey E, Jamil JM, Harrison NC, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE, Opere CA. "Role of prostanoid receptors in the inhibitory effect of 5-F2t-IsoP and its 5-epimer on potassium-induced [3H]D-aspartate release in isolated bovine retina." Presented at the: 2nd International conference on Enviromental Stressors in Biology and Medicine Siena, 5-7 October 2011 2011
- Kulkarni M, Njie-Mbye YF, Okpobiri I, Zhao M, Opere CA, Ohia SE. "Regulation of endogenous hydrogen sulfide production in isolated bovine retina by carbon monoxide and nitric oxide." Program/poster 5669/A581, May 5, 2011, Ft. Lauderdale, Fl. 2011
- Zhao M, Taylor M, Njie-Mbye YF, Kulkarni M, Opere CA, Ohia SE. "Hydrogen sulfide-induced relaxation of isolated bovine ciliary artery." Program/poster 2658/A139, May 3, 2011, Ft. Lauderdale, Fl. 2011
- Opere CA, Njie-Mbye YF, Jamil J, Durand T, Galano JM, Guy A, Kulkarni M, Zhao M, Ohia SE. "Regulation of cyclic AMP production in rat RPE-J cells by the synthetic neuroprostane," BA-12high. Program/poster 2067/D1074, May 2, 2011, Ft. Lauderdale, Fl. 2011
- Opere CA, Jamil JM, Wright A, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE. "Neuroprostanes inhibit [3H]D-aspartate release in bovine retina, in vitro." Presented at the: Journes CHEVREUL 2011, "LIPIDS & BRAIN 2" Paris 28-30 March 2011. 2011
- Kegey E, Jamil J, Harrison N, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE, Opere CA. "Role of prostanoid receptors in the inhibitory effect of synthetic isoprostanes on potassium-induced [3H]D-aspartate release in isolated bovine retina ." Presented at the: Experimental Biology Meeting, March 17, 2011 25:799.4 2011
- Opere CA, Jamil JM, Wright A, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE. "Neuroprostanes inhibit [3H]D-aspartate release in bovine retina, in vitro." Presented at the: 7th GERLI Lipodomic Meeting: Lipids in all States, 3-6 October, Anglet-Biarritz, France, 2010. 2010
- Opere CA, Jamil JM, Wright A, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE. "Neuroprostanes inhibit [3H]D-aspartate release in bovine retina, in vitro." Presented at the: Third European Workshop on Lipid Mediators, Pasteur Institute - Paris, June 3-4, 2010 2010
- Ohia SE, Kulkarni M, Njie-Mbye YF, Jackson D, Zhao M, Opere CA. "Measurement of hydrogen sulfide concentration in isolated bovine eyes." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, May 2-6, 2010 Abstract #3305/D786. 2010
- Njie-Mbye YF, Kulkarni M, Jackson D, Zhao M, Opere CA, Ohia SE. "Mechanism of action of hydrogen sulfide on cyclic AMP formation in RPE-J cells." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, May 2-6, 2010, Abstract # 3315/D796. 2010
- Opere CA, Jamil JM, Wright A, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE. "Regulation of [3H]D-aspartate release by neuroprostanes in bovine retina, in vitro." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, May 2-6, 2010, Abstract # 3315/D796. 2010
- Opere CA, Jamil J, Wright A, Njie-Mbye YF, Ohia SE. "Peroxide-induced production of metabolites of polyunsaturated fatty acids in bovine retina, in vitro." Presented at the: Experimental Biology Meeting, April 6, 2010 24:971.2 2010
- Njie-Mbye YF, Kulkarni M, Opere CA, Ohia SE. "Hydrogen sulfide stimulates cyclic AMP formation in mammalian retina through the adenylyl cyclase pathway." Presented at the: Experimental Biology Meeting, April 6, 2010 24:962.2 2010
Federal
“Hydrogen sulfide-releasing compounds and IOP regulation”. Role: Co-Investigator (Co-I), Evaluate the regulation of aqueous humor dynamics by hydrogen sulfide donors in rabbits, in vivo. PI, Njie-Mbye YF, Texas Southern University; 2012-2015,NIH AREA R15 award.
Foundation/Association
“Regulation of [3H]D-aspartate release by metabolites of LCPUFAs in bovine retina, in vitro.” Role: Principal Investigator (PI), 2011, FASEB/MARC Summer Research Opportunity Award.
“Mechanisms by which arachidonic acid metabolites regulate excitatory neurotransmitters in bovine retina.” FASEB/MARC Summer Research Opportunity Award.
“Regulation of [3H]D-aspartate release by metabolites of LCPUFAs in bovine retina, in vitro.” FASEB/MARC Summer Research Opportunity Award.
Other
“Regulation of protein expression by isoprostanes in mammalian retina.” SPAHP Faculty Research Development Grant.
Awards
- Faculty/Student FASEB/MARC Travel Award
Faculty/Student FASEB/MARC Travel Award to attend 2014 Experimental Biology meeting in San Diego, CA April 26 -30, 2014.
FASEB/MARC - Faculty/Student FASEB/MARC Travel Award
Faculty/Student FASEB/MARC Travel Award to attend 2013 Society for Advancement of Hispanics/Chicanos and Native Americans in Science (SACNAS) meeting in San Antonio, TX, October 3-6, 2013.
FASEB/MARC - Faculty/Student FASEB/MARC Travel Award
Faculty/Student FASEB/MARC Travel Award to attend 2013 Experimental Biology meeting in Boston, MA, April 20 -24, 2013.
FASEB/MARC - Faculty/Student FASEB/MARC Travel Award
Faculty/Student FASEB/MARC Travel Award to attend 2012 Experimental Biology meeting in San Diego, CA, April 21 -26, 2012.
FASEB/MARC - Faculty/Student FASEB/MARC Travel Award
Faculty/Student FASEB/MARC Travel Award to attend 2011 SACNAS meeting in San Jose, CA, Oct 27 - 30, 2011.
FASEB/MARC - Summer Research Opportunity Award
Summer Research Opportunity Award, Office of MARC and Professional Development Programs, Federation of American Societies for Experimental Biology
Office of MARC - Faculty/Student FASEB/MARC Travel Award
Faculty/Student FASEB/MARC Travel Award to attend 2011 Experimental Biology meeting in Washington D.C., April 9-13, 2011.
FASEB/MARC - Faculty/Student FASEB/MARC Travel Award
Faculty/Student FASEB/MARC Travel Award to attend 2010 Annual Biomedical Research Conference for Minority Students (ABRCMS) meeting in Charlotte, NC November 10-13, 2010.
FASEB/MARC - Faculty/Student FASEB/MARC Travel Award
Faculty/Student FASEB/MARC Travel Award to attend 2010 SACNAS meeting in Anaheim, CA, September 30 - October 3, 2010.
FASEB/MARC - Summer Research Opportunity Award
Summer Research Opportunity Award, Office of MARC and Professional Development Programs, Federation of American Societies for Experimental Biology
Office of MARC - SPAHP Summer Research Award
SPAHP Summer Research Award (with Pharm.D. Student, Finnegan Anjanette)
SPAHP Summer Research Award - Faculty/Student FASEB/MARC Travel Award
Faculty/Student FASEB/MARC Travel Award to attend 2010 Experimental Biology Meeting in Anaheim, CA, April 24-28, 2010.
FASEB/MARC