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Garrett A . Soukup, PhD


Biomedical Sciences

G Soukup


School of Medicine
Biomedical Sciences
Graduate School
Biomedical Sciences (Master of Science)
Biomedical Sciences (Doctorate)
Translational Hearing
CRISS I - Criss 1 - 325

Garrett A . Soukup, PhD


Biomedical Sciences

Garrett Soukup is a biochemist and molecular biologist with a longstanding interest in RNA structure, function, and regulation of gene expression. He received a B.S. in Biology in 1991 from Northwest Missouri State University in Maryville, Missouri. He earned a Ph.D. in 1997 from the University of Nebraska Medical Center in Omaha, Nebraska, working with Dr. L. James Maher III there and at the Mayo Clinic in Rochester, Minnesota. He completed postdoctoral training in 2000 at Yale University in New Haven, Connecticut, working with Dr. Ronald R. Breaker. He joined the faculty at Creighton University School of Medicine in 2000, where he has served various roles in graduate and medical student education and research training. 


Research Focus

Garrett Soukup's research interests over his career have included RNA-ligand interactions, mechanisms of RNA catalysis, biological roles of functional RNAs including ribozymes and riboswitches, and regulatory roles of microRNAs in the development and maintenance of mechanosensory cells and sensory neurons important for hearing.


Biomedical Sciences




  • Molecular Neurobiology
    Banks SA, Pierce ML, Soukup GA. Sensational microRNAs: Neurosensory roles of the microRNA-183 family.
    57, p. 358-371 2020
  • Scientific Reports
    Weston MD, Tarang S, Pierce ML, Pyakurel U, Rocha-Sanchez SM, McGee J, Walsh EJ, Soukup GA. A mouse model of miR-96, miR-182 and miR-183 misexpression implicates miRNAs in cochlear cell fate and homeostasis.
    8, p. 3569 2018
  • PLoS One
    Ebeid M, Sripal P, Pecka J, Beisel KW, Kwan K, Soukup GA. Transcriptome-wide comparison of the impact of Atoh1 and miR-183 family on pluripotent stem cells and multipotent otic progenitor cells.
    12, p. e0180855 2017
  • ACS Chem Biol
    Kim J, Jeong S, Kertsburg A, Soukup GA, Lee SW. Conditional and target-specific transgene induction through RNA replacement using an allosteric trans-splicing ribozyme.
    9, p. 2491-2495 2014
  • PLoS One
    Zhang Q, Liu H, Soukup GA, He DZZ. Identifying microRNAs involved in aging of the lateral wall of the cochlear duct.
    9, p. e112857 2014
  • Journal of Neuroscience
    Liu H, Pecka JL, Zhang Q, Soukup GA, Beisel KW, He DZZ. Characterization of transcriptomes of cochlear inner and outer hair cells.
    34, p. 11085-11095 2014
  • PLoS One
    Zhang Q, Liu H, McGee J, Walsh EJ, Soukup GA, He DZZ. Identifying microRNAs involved in degeneration of the organ of Corti during age-related hearing loss.
    8, p. e62786 2013
  • Indian Journal of Human Genetics
    Barritt LC, Miller JM, Scheetz LR, Gardner K, Pierce ML, Soukup GA, Rocha-Sanchez SM. Conditional deletion of the human ortholog gene Dicer1 in Pax2-Cre expression domain impairs orofacial development.
    18, p. 310-319 2012
  • Genesis
    Kersigo J, D'Angelo A, Gray B, Soukup GA, Fritzsch B. The role of sensory organs and the forebrain for the development of the craniofacial shape as revealed by Foxg1-cre mediated microRNA loss.
    49, p. 326-341 2011
  • Developmental Dynamics
    Weston MD, Pierce ML, Jensen-Smith HC, Fritzsch B, Rocha-Sanchez S, Beisel KW, Soukup GA. MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival.
    240, p. 808-819 2011
  • Int J Parasitol
    Gong AY, Hu G, Zhou R, Liu J, Feng Y, Soukup GA, Chen XM. MicroRNA-221 controls expression of intercellular adhesion molecule-1 in epithelial cells in response to Cryptosporidium parvum infection.
    41, p. 397-403 2011
  • Chembiochem
    Klawuhn K, Jansen JA, Souchek J, Soukup GA, Soukup JK. Analysis of metal ion dependence in glmS ribozyme self-cleavage and coenzyme binding.
    11, p. 2567-1271 2010
  • Brain Res
    Soukup GA. Little but loud: small RNAs have a resounding affect on ear development.
    1277, p. 104-114 2009
  • Genome Medicine
    Weston MD, Soukup GA. MicroRNAs sound off.
    1, p. 59 2009
  • Developmental Biology
    Soukup GA, Fritzsch B, Pierce ML, Weston MD, Jahan I, McManus MT, Harfe BD. Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice.
    328, p. 328-341 2009
  • Journal of Immunology
    Gong AY, Zhou R, Hu G, Li X, Splinter PL, O'Hara SP, LaRusso NF, Soukup GA, Dong H, Chen XM. MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in cholangiocytes.
    182, p. 1325-1333 2009
  • Methods in Molecular Biology
    Soukup JK, Soukup GA. Identification of metabolite-riboswitch interactions using nucleotide analog interference mapping and suppression. In Methods in Molecular Biology: Riboswitches Methods and Protocols. Serganov A, Ed.
    540, p. 193-206 2009
  • Springer Publishing
    Soukup JK, Soukup GA. Structure and mechanism of the glmS ribozyme. In Springer Series in Biophysics 13: Non-protein coding RNAs. Walters NG, Woodson SA, Batey RT, Eds., p. 129-143 2009
  • Cell and Tissue Research
    Beisel K, Hansen L, Soukup G, Fritzsch B. Regenerating cochlear hair cells: quo vadis stem cell.
    333, p. 373-379 2008
  • Panminerva Med
    Pauley S, Kopecky B, Beisel K, Soukup G, Fritzsch B. Stem cells and molecular strategies to restore hearing.
    50, p. 41-53 2008
  • Evolution & Development
    Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA. MicroRNA-183 family conservation and expression in ciliated neurosensory organs.
    10, p. 106-113 2008
  • International Journal of Developmental Biology
    Fritzsch B, Beisel KW, Pauley S, Soukup G. Molecular evolution of the vertebrate mechanosensory cell and ear.
    51, p. 663-678 2007
  • Brain Res
    Weston MD, Pierce ML, Rocha-Sanchez S, Beisel KW, Soukup GA. MicroRNA gene expression in the mouse inner ear.
    1111, p. 95-104 2006
  • Nature Structural & Molecular Biology
    Jansen JA, McCarthy TJ, Soukup GA, Soukup JK. Backbone and nucleobase contacts to glucosamine-6-phosphate in the glmS ribozyme.
    13, p. 517-523 2006
  • Landes Bioscience
    Soukup GA. Allosteric ribozymes as molecular sensors and genetic regulatory switches. In Nucleic Acid Switches and Sensors. Silverman SK, Ed., p. 3-24 2006
  • Nucleic Acids Research
    Soukup GA. Core requirements for glmS ribozyme self-cleavage reveal a putative pseudoknot structure.
    34, p. 968-975 2006
  • Chemistry & Biology
    McCarthy TJ, Plog MA, Floy SA, Jansen JA, Soukup JK, Soukup GA. Ligand requirements for glmS ribozyme self-cleavage.
    12, p. 1221-1226 2005
  • Chemistry & Biology
    Soukup GA. Aptamers meet allostery.
    11, p. 1031-1032 2004
  • Current Opinion in Structural Biology
    Soukup JK, Soukup GA. Riboswitches exert genetic control through metabolite-induced conformational change.
    14, p. 344-349 2004
  • Am. J. Pharmacogenomics
    Steele D, Kertsburg A, Soukup GA. Engineered catalytic RNA and DNA: New biochemical tools for drug discovery and design.
    3, p. 131-144 2003
  • Nucleic Acids Research
    Kertsburg A, Soukup GA. A versatile communication module for controlling RNA folding and catalysis.
    30, p. 4599-4606 2002
  • Macmillian Reference USA
    Soukup GA. Nucleic acids: general properties. In Encyclopedia of Life Sciences. 2001
  • RNA
    Soukup GA, DeRose EC, Koizumi M, Breaker RR. Generating new ligand-binding RNAs by disintegration and affinity maturation of allosteric ribozymes.
    7, p. 524-536 2001
  • Nucleic Acids Research
    Jose AM, Soukup GA, Breaker RR. Cooperative binding of effectors by an allosteric ribozyme.
    29, p. 1631-1637 2001
  • Eaton Publishing
    Soukup GA, Breaker RR. Allosteric Ribozymes. In Ribozme Biochemistry and Biotechnology., p. 149-170 2000

Editing and Reviews

  • Academic Press
    Catalytic RNA. In Progress in Molecular Biology and Translational Science. Soukup GA, Ed.
    120 2013


  • 2021 Dedicated Teacher Award
    Creighton University School of Medicine