Jason C . Bartz

Department

Med. Microbiology & Immunology

Position

Professor

Books

• Neuroimmune Pharmacology and Therapeutics
  Steadman Benjamin S., etal Prion Diseases of Animals and Humans [Book Chapter] 2024
• Bartelt-Hunt Shannon L, etal Prions in the Environment - Chapter 10 [Book Chapter] 2023
• Prions and Diseases
  Shikiya Ronald A., etal Prion Strain Interference [Book Chapter] 2023
• Prions and Neurodegenerative Diseases
  Holec Sara A.M., etal The role of prion strain diversity in the development of successful therapeutic treatments [Book Chapter] 2020
• Handbook of Clinical Neurology
  Diack Abigail B., etal Experimental models of human prion diseases and prion strains [Book Chapter] 2018
• Viral Infections of Humans : Epidemiology and Control
  Belay Ermias D., etal Prion Diseases [Book Chapter] 2014
• Prions and Diseases : Volume 1, Physiology and Pathophysiology
  Schutt Charles R., etal Prion strain interference [Book Chapter] 2013
• Prions and Diseases : Volume 2, Animals, Humans and the Environment
  Bartelt-Hunt Shannon L., etal Prions in the environment [Book Chapter] 2013
• Bartelt-Hunt S. L., etal Soil Binds Prions and Influences their Biologic Properties 2012

Articles

• Sigurdson Christina J., etal Tracking protein aggregate interactions 2011

Publications

• Acta neuropathologica
  Holec Sara A. M., etal Co-infection with two α-synuclein strains reveals novel synergistic interactions
  150:1, p. 50 2025
• Prion
  Grunklee Madeline K., etal Detection of chronic wasting disease prions in soil at an illegal white-tailed deer carcass disposal site
  19:1, p. 8 - 19 2025
• Emerging infectious diseases
  Milstein Marissa, etal Detection and Decontamination of Chronic Wasting Disease Prions during Venison Processing
  31:4 2025
• Pathogens (Basel)
  Walter W. David, etal Overview of North American Isolates of Chronic Wasting Disease Used for Strain Research
  14:3, p. 250 2025
• Journal of visualized experiments
  Simmons Sara M., etal Prion Safety Laboratory Swipe Test 2025
• Prion
  Kincaid Anthony E., etal Expression of the cellular prion protein by mast cells in white-tailed deer carotid body, cervical lymph nodes and ganglia
  18:1, p. 94 - 102 2024
• mSphere
  Kincaid Anthony E., etal Direct prion neuroinvasion following inhalation into the nasal cavity, p. e0086324 2024
• mBio
  Steadman Benjamin S., etal Minor prion substrains overcome transmission barriers, p. e0272124 2024
• mSphere
  Simmons Sara M., etal Rapid and sensitive determination of residual prion infectivity from prion-decontaminated surfaces, p. e0050424 2024
• Pathogens (Basel)
  Bartz Jason C., etal Chronic Wasting Disease: State of the Science
  13:2, p. 138 2024
• Biology (Basel, Switzerland)
  Simmons Sara M, etal Strain-Specific Targeting and Destruction of Cells by Prions
  13:1, p. 57 2024
• Prion
  Sweetland Gregory D., etal Expression of the cellular prion protein by mast cells in the human carotid body
  17:1, p. 67 - 74 2023
• Journal of enzyme inhibition and medicinal chemistry
  Kim Dong Hwan, etal Synthesis and anti-prion aggregation activity of acylthiosemicarbazide analogues
  38:1, p. 2191164 2023
• PLoS pathogens
  Gunnels Tess, etal Evidence for preexisting prion substrain diversity in a biologically cloned prion strain
  19:9, p. e1011632 - e1011632 2023
• Environment international
  Yuan Qi, etal Sensitive detection of chronic wasting disease prions recovered from environmentally relevant surfaces
  166 2022
• Pathogens
  Picasso-Risso Catalina, etal Assessment of Real-Time Quaking-Induced Conversion (RT-QuIC) Assay, Immunohistochemistry and ELISA for Detection of Chronic Wasting Disease under Field Conditions in White-Tailed Deer
  11:5 2022
• Cell and Tissue Research
  Block Alyssa J., etal Prion strains 2022
• PLoS pathogens
  Block Alyssa J., etal Efficient interspecies transmission of synthetic prions
  17:July 2021
• Acta Neuropathologica
  Bartz Jason C., Environmental and host factors that contribute to prion strain evolution
  142:1, p. 5 - 16 2021
• Journal of Biomolecular Structure and Dynamics
  Soto Patricia, etal Cellular prion protein gene polymorphisms linked to differential scrapie susceptibility correlate with distinct residue connectivity between secondary structure elements
  39:1, p. 129 - 139 2021
• Journal of Biological Chemistry
  Kang Hae Eun, etal Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination
  295:30, p. 10420 - 10433 2020
• Journal of Clinical Investigation
  Bartz Jason C., Underglycosylated prion protein modulates plaque formation in the brain
  130:3, p. 1087 - 1089 2020
• Journal of Clinical Investigation
  Bartz Jason C., Underglycosylated Prion protein modulates plaque formation in the brain
  130:3, p. 1087 - 1089 2020
• Annual Review of Pathology: Mechanisms of Disease
  Sigurdson Christina J., etal Cellular and Molecular Mechanisms of Prion Disease
  14, p. 497 - 516 2019
• PLoS pathogens
  Eckland Thomas E., etal Independent amplification of co-infected long incubation period low conversion efficiency prion strains
  14:10 2018
• Colloids and Surfaces B: Biointerfaces
  Phan Hanh T.M., etal Adsorption and decontamination of α-synuclein from medically and environmentally-relevant surfaces
  166, p. 98 - 107 2018
• Journal of Virology
  Yuan Qi, etal Dehydration of prions on environmentally relevant surfaces protects them from inactivation by freezing and thawing
  92:8 2018
• Journal of Immunology
  Kane Sarah J., etal Complement regulatory protein factor H is a soluble prion receptor that potentiates peripheral prion pathogenesis
  199:11, p. 3821 - 3827 2017
• Plos Pathogens
  Shikiya Ronald A., etal PrPSc Formation and Clearance as Determinants of Prion Tropism
  13:3, p. e1006298 - e1006298 2017
• Proceedings of the National Academy of Sciences of the United States of America
  Bian J., etal Prion Replication without Host Adaptation during Interspecies Transmissions
  114:5, p. 1141 - 1146 2017
• Journal of Virology
  Kincaid Anthony E., etal Specificity, Size, and Frequency of Spaces that Characterize the Mechanism of Bulk Transepithelial Transport of Prions in the Nasal Cavities of Hamsters and Mice
  90:18, p. 8293 - 8301 2016
• PLoS Pathogens
  Bartz Jason C., From Slow Viruses to Prions
  12:7, p. (3 pages) 2016
• Journal of Virology
  Langenfeld Katie A., etal Incongruity between Prion Conversion and Incubation Period Following CoInfection
  90:12, p. 5715 - 5723 2016
• Biophysical journal
  Woo Jesse, etal Conformational Dynamics of Prion Proteins at the Membrane Interface
  110:3, p. 419a - 419a 2016
• Cold Spring Harbor Perspectives in Medicine
  Bartz Jason C., Prion strain diversity
  6:12 2016
• PLoS One
  Phan H. T., etal Investigation of Bovine Serum Albumin (BSA) Attachment onto Self-Assembled Monolayers (SAMs) Using Combinatorial Quartz Crystal Microbalance with Dissipation (QCM-D) and Spectroscopic Ellipsometry (SE)
  10:10, p. (20 pages) 2015
• Journal of Virology
  Elder Alan M., etal Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations
  89:14, p. 7421 - 7424 2015
• New Horizons in Translational Medicine
  Elder Alan M., etal Longitudinal analysis of blood-borne prion infection
  2:4-5, p. 128 - 128 2015
• PLoS Pathogens
  Yuan Q., etal Mitigation of prion infectivity and conversion capacity by a simulated natural process--repeated cycles of drying and wetting
  11:2, p. e1004638 2015
• PLoS One
  Clouse Melissa D., etal Nasal Associated Lymphoid Tissue of the Syrian Golden Hamster Expresses High Levels of PrPC
  10:2, p. e0117935 (10 pages) 2015
• Biophysical journal
  Soto Patricia, etal Prion Proteins and Mechanisms of Interaction with Model Membranes
  108:2, p. 91a - 91a 2015
• Prion
  Shikiya Ronald A., etal Prion formation, but not clearance, is supported by protein misfolding cyclic amplification
  8:6, p. 415 - 420 2014
• PLoS pathogens
  Bartelt-Hunt Shannon L., etal Behavior of Prions in the Environment
  9:2 2013
• Journal of Virology
  Kincaid Anthony E., etal Rapid Transepithelial Transport of Prions following Inhalation
  86:23, p. 12731 - 12740 2012
• Journal of Biological Chemistry
  Kang Hae Eun, etal Characterization of conformation-dependent prion protein epitopes
  287:44, p. 37219 - 37232 2012
• PloS one
  Saunders Samuel E., etal Resistance of soil-bound prions to rumen digestion
  7:8 2012
• Chemosphere
  Saunders Samuel E., etal Soil-mediated prion transmission
  87:7, p. 661 - 667 2012
• Nebraska Academy of Sciences, PO Box 880410 Lincoln NE 68588-0410 United States. [np]. Apr 2012
  Colling Ian, etal BINDING MODES OF AGAAAAGATO SYRIAN HAMSTER PRION PROTEINS 2012
• Emerging Infectious Diseases
  Saunders Samuel E., etal Occurrence, transmission, and zoonotic potential of chronic wasting disease
  18:3, p. 369 - 376 2012
• Journal of visualized experiments : JoVE
  Saunders Samuel E., etal Protein misfolding cyclic amplification of prions. 2012
• Applied and Environmental Microbiology
  Saunders Samuel E., etal An enzymatic treatment of soil-bound prions effectively inhibits replication
  77:13, p. 4313 - 4317 2011
• Journal of Virology
  Saunders Samuel E., etal Replication efficiency of soil-bound prions varies with soil type
  85:11, p. 5476 - 5482 2011
• Journal of Virology
  Shikiya R. A., etal In vitro generation of high titer prions
  85:24, p. 13439 - 13442 2011
• PLoS Pathogens
  Ayers J. I., etal The Strain-Encoded Relationship between PrP Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease
  7:3, p. e1001317 2011
• PloS one
  Mays Charles E., etal In vitro amplification of misfolded prion protein using lysate of cultured cells
  6:3 2011
• PloS one
  Saunders Samuel E., etal Effects of solution chemistry and aging time on prion protein adsorption and replication of soil-bound prions
  6:4 2011
• Journal of Virology
  Shikiya R. A., etal Co-infecting prion strains compete for a limiting cellular resource
  84:11, p. 5706 - 5714 2010
• Environmental Science and Technology
  Saunders Samuel E., etal Prion protein adsorption to soil in a competitive matrix is slow and reduced
  43:20, p. 7728 - 7733 2009
• Environmental Science and Technology
  Saunders Samuel E., etal Influence of prion strain on prion protein adsorption to soil in a competitive matrix
  43:14, p. 5242 - 5248 2009
• PLoS pathogens
  Singh Ajay, etal Abnormal brain iron homeostasis in human and animal prion disorders
  5:3 2009
• Journal of Virology
  Ayers Jacob I., etal Prion strain targeting independent of strain-specific neuronal tropism.
  83:1, p. 81 - 87 2009
• Prion
  Kramer Michelle L., etal Rapid, high-throughput detection of PrPSc by 96-well immunoassay
  3:1, p. 44 - 48 2009
• Journal of Comparative Pathology
  Sigurdson C. J., etal Experimental Chronic Wasting Disease (CWD) in the Ferret
  138:4, p. 189 - 196 2008
• Prion
  Schutt Charles R., etal Prion interference with multiple prion isolates.
  2:2, p. 61 - 63 2008
• Journal of Virology
  Kincaid Anthony E., etal The nasal cavity is a route for prion infection in hamsters
  81:9, p. 4482 - 4491 2007
• Journal of Virology
  Bartz Jason C., etal Prion interference is due to a reduction in strain-specific PrPSc levels
  81:2, p. 689 - 697 2007
• Veterinary Pathology
  Hamir A. N., etal First and second cattle passage of transmissible mink encephalopathy by intracerebral inoculation
  43:2, p. 118 - 126 2006
• Journal of Virology
  Marsh R. F., etal Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiti sciureus)
  79:21, p. 13794 - 13796 2005
• Journal of Inorganic Biochemistry
  Shara Michael, etal Safety and toxicological evaluation of a novel niacin-bound chromium (III) complex
  99:11, p. 2161 - 2183 2005
• Journal of Virology
  Bartz Jason C., etal Extraneural prion neuroinvasion without lymphoreticular system infection
  79:18, p. 11858 - 11863 2005
• Bartz Jason, Prion Transport to Secondary Lymphoreticular System Tissues 2005
• Journal of Virology
  Mulcahy Ellyn R., etal Prion infection of skeletal muscle cells and papillae in the tongue
  78:13, p. 6792 - 6798 2004
• Journal of General Virology
  Bartz Jason C., etal Delay in onset of prion disease for the HY strain of transmissible mink encephalopathy as a result of prior peripheral inoculation with the replication-deficient DY strain
  85, p. 265 - 273 2004
• Journal of Virology
  Bartz Jason C., etal Rapid prion neuroinvasion following tongue infection
  77:1, p. 583 - 591 2003
• Journal of Virology
  Bartz Jason C., etal Retrograde transport of transmissible mink encephalopathy within descending motor tracts
  76:11, p. 5759 - 5768 2002
• Journal of Virology
  Bartz Jason C., etal Adaptation and selection of prion protein strain conformations following interspecies transmission of transmissible mink encephalopathy
  74:12, p. 5542 - 5547 2000
• Journal of Biological Chemistry
  McKenzie Debbie, etal Reversibility of scrapie inactivation is enhanced by copper
  273:40, p. 25545 - 25547 1998
• Bulletin de l'Institut Pasteur
  McKenzie D., etal A molecular basis for transmissible spongiform encephalopathy agent strain differences
  96:1, p. 35 - 47 1998
• Seminars in Virology
  McKenzie D., etal Transmissible mink encephalopathy
  7:3, p. 201 - 206 1996
• Journal of General Virology
  Bartz J. C., etal Transmissible mink encephalopathy species barrier effect between ferret and mink
  75:11, p. 2947 - 2953 1994

Presentations

• Prion evolution: The role of prion strain interference. 2024
• Prion strain evolution 2024
• Rapid and sensitive determination of residual prion infectivity from prion decontaminated surfaces 2024
• Emergence of substrains from a biologically cloned prion strain 2024
• Prion strain evolution 2024
• "The environmental fate of prions" Rocky Mountain Virology Meeting, Ft. Collins Colorado 2015
• Prion strain tropism - NeuroPrion 2015 2015
• University of Nebraska Medical Center - Prion disease lecture for Pharmacology 930 2015
• University of Nebraska - Lincoln. Prion disease lecture for Viral Pathogenesis graduate student class 2014
• University of Nebraska: The biology of prion diseases 2014
• Iowa State University: Prion strain interference 2014
• University of Nebraska: Prion strain interference 2014
• "Prion strain selection in the central nervous system" University of Minnesota, Minneapolis. 2005
• "Prion strain selection" United States Department of Agriculture, Animal Research Service. Ames, IA. 2005
• "Prion strain selection and targeting in the central nervous system" Nebraska center for virology external advisory meeting. Lincoln, NE. 2005
• "Prion diseases of humans and animals" Nebraska Infection Control Network 25th anniversary educational conference. Omaha NE. August 11-12, 2005. 2005
• Sigurdson, C., Aguzzi, A., Hoover, E., MAthiason, C., Perrott, M., Glatzel, M., Bartz, J.C., Manco, G., Sprker, T. and Miller, M. (2005). Chronic wasting disease: across the species barrier. The Second International Chronic Wasting Disease Symposium. Madison WI. July 12-14, 2005. 2005
• Ayers, J.A., Kincaid, A.E. and Bartz, J.C. (2005). Prion strain targeting. The Second International Chronic Wasting Disease Symposium. Madison WI. July 12-14, 2005. 2005
• "Prion strain selection in the central nervous system" The Second International Chronic Wasting Disease Symposium. Madison WI. July 12-14, 2005. 2005
• "Prion pathogenesis" AOAC International meeting and exposition. Kansas City, Missouri. 2005
• "Prion diseases of humans and animals" Nebraska and Iowa Clinical Science Laboratory Meeting. Mid-America Center, Council Bluffs, IA. 2005
• "Prion strain targeting and competition in the central nervous system" Department of Veterinary Science, South Dakota State University, Brookings SD. 2005
• "Interspecies transmission of prion diseases" Creighton University Medicine 2005
• "Interspecies transmission of prion diseases" Oklahoma State University, Stillwater OK. 2005
• "Interspecies transmission of prion diseases" University of Nebraska Medical Center Department of Genetics, Cell Biology and Anatomy Seminar Series, Omaha, NE. 2005
• "Prion diseases of humans and animals" University of Nebraska Medical Center Molecular Diagnostics Laboratory Group, Omaha, NE. 2005
• Kincaid, A.E, Kramer, M. and Bartz, J.C. (2005). Prion strain competition in the central nervous system. Keystone Symposia "Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases)". Snowbird, UT. 2005
• "Interspecies transmission of prions" Nebraska Infectious Disease Seminar. 2004
• "Prion competition in the central nervous system" Animal prion diseases and the Americas, Ames IA. 2004
• "Prion strain targeting and competition" Fourth annual Nebraska Center for Virology Symposium in Virology. University of Nebraska Lincoln. 2004
• "Interspecies transmission of prion diseases" Chronic wasting disease / transmissible spongiform encephalopathy symposium, North Dakota Department of Agriculture, Bismarck, ND. 2004
• "The Design of a Single Round Infectivity Assay for Mason-Pfizer Monkey Virus Using Green Fluorscing Protein" BRIN Student Jessica Hutter-Doane College 2004
• "Interspecies Transmission of Prion Diseases" 2004
• " Interspecies transmission of prion diseases" Creighton University Medical Center, Osteoporosis research center seminar. Omaha NE. 2004

Federal

• NIH R01 - Characteristics of prion entry and neuroinvasion following nasal cavity infection

• NIH R01 Supplement - Mechanisms of prion strain selection

• NIH R01 Supplement - Mechanisms of prion strain selection

• USDA NRI - In vitro differentiation of prion conformations to define strains to aid in surveillance

• NIH COBRE - Prion strain targeting and competition in the central nervous system

• United States Department of Defense National Prion Research Program - Prion transport to secondary lymphoreticular system tissues

• USDA NRI - Thioflavine T detection of the prion protein

State

• LB 692 - Mechanisms of environmental selective pressure on prion strain properties

• LB 692 - Determination of prion transport via intranasal routes

Awards

• Dr. Robert Heaney Graduate Research Mentor Award
  Creighton University
• Maiben Lecturer
  Nebraska Academy of Sciences
• Distinguished Lecturer
  American Society for Microbiology
• Richard A. Bessen Memorial Lecturer
  Rocky Mountain Virology Meeting
• Academy for Excellence in Team Science
  University of Minnesota
• University Research Award
  Creighton University
• Young Investigator Award
  Creighton University
• Richard F. Marsh Award for Outstanding Graduate Student Research
  University of Wisconsin