Jason C . Bartz

Department

Med. Microbiology & Immunology

Position

Professor

Books

• Neuroimmune Pharmacology and Therapeutics
  Steadman Benjamin S., Bartz Jason C., Prion Diseases of Animals and Humans [Book Chapter] 2024
• Bartelt-Hunt Shannon L, Bartz Jason C, Yuan Qi, Prions in the Environment - Chapter 10 [Book Chapter] 2023
• Prions and Diseases
  Shikiya Ronald A., Bartz Jason C., Prion Strain Interference [Book Chapter] 2023
• Prions and Neurodegenerative Diseases
  Holec Sara A.M., Block Alyssa J., Bartz Jason C., The role of prion strain diversity in the development of successful therapeutic treatments [Book Chapter] 2020
• Handbook of Clinical Neurology
  Diack Abigail B., Bartz Jason C., Experimental models of human prion diseases and prion strains [Book Chapter] 2018
• Viral Infections of Humans : Epidemiology and Control
  Belay Ermias D., Bartz Jason C., Prion Diseases [Book Chapter] 2014
• Prions and Diseases : Volume 1, Physiology and Pathophysiology
  Schutt Charles R., Bartz Jason C., Shikiya Ronald A., Prion strain interference [Book Chapter] 2013
• Prions and Diseases : Volume 2, Animals, Humans and the Environment
  Bartelt-Hunt Shannon L., Bartz Jason C., Saunders Samuel E., Prions in the environment [Book Chapter] 2013
• Bartelt-Hunt S. L., Saunders S. E., Bartz Jason C., Soil Binds Prions and Influences their Biologic Properties 2012

Articles

• Sigurdson Christina J., Bartz Jason C., Nilsson K. Peter R., Tracking protein aggregate interactions 2011

Publications

• Prion
  Grunklee Madeline K., Lichtenberg Stuart S., Lurndahl Nicole A., Schwabenlander Marc D., Yuan Qi, Karwan Diana L., Li E. Anu, Bartz Jason C., Larsen Peter A., Wolf Tiffany M., Detection of chronic wasting disease prions in soil at an illegal white-tailed deer carcass disposal site
  19:1, p. 8 - 19 2025
• Emerging infectious diseases
  Milstein Marissa, Li Manci, Gresch Sarah C., Schwabenlander Marc D., Bartz Jason C., Bryant Damani N., Christenson Peter R., Lindsey Laramie L., Lurndahl Nicole, Wolf Tiffany M., Oh Sang-Hyun, Rowden Gage R., Shoemaker Rachel L., Larsen Peter A., Lichtenberg Stuart S., Detection and Decontamination of Chronic Wasting Disease Prions during Venison Processing
  31:4 2025
• Pathogens (Basel)
  Walter W. David, Bartz Jason C., Hopkins M. Camille, Herbst Allen, Lue Chia-Hua, Overview of North American Isolates of Chronic Wasting Disease Used for Strain Research
  14:3, p. 250 2025
• Journal of visualized experiments
  Simmons Sara M., Yuan Qi, Bartz Jason C., Prion Safety Laboratory Swipe Test 2025
• Prion
  Kincaid Anthony E., McNulty Erin E., Kraft Caitlyn N., Bartz Jason C., Mathiason Candace K., Denkers Nathaniel D., Expression of the cellular prion protein by mast cells in white-tailed deer carotid body, cervical lymph nodes and ganglia
  18:1, p. 94 - 102 2024
• mSphere
  Kincaid Anthony E., Magrum Shawn M., Clouse Melissa D., Bartz Jason C., Direct prion neuroinvasion following inhalation into the nasal cavity, p. e0086324 2024
• mBio
  Steadman Benjamin S., Bian Jifeng, Shikiya Ronald A., Bartz Jason C., Minor prion substrains overcome transmission barriers, p. e0272124 2024
• mSphere
  Simmons Sara M., Taylor Jack, Payne Vivianne L., Hrdlicka Jay G., Larsen Peter A., Wolf Tiffany M., Schwabenlander Marc D., Yuan Qi, Bartz Jason C., Rapid and sensitive determination of residual prion infectivity from prion-decontaminated surfaces, p. e0050424 2024
• Pathogens (Basel)
  Bartz Jason C., Benavente Rebeca, Hoover Edward A., Caughey Byron, Christensen Sonja, Herbst Allen, Mathiason Candace K., Walsh Daniel P., Morales Rodrigo, McKenzie Debbie, Schwabenlander Marc D., , Chronic Wasting Disease: State of the Science
  13:2, p. 138 2024
• Biology (Basel, Switzerland)
  Simmons Sara M, Bartz Jason C, Strain-Specific Targeting and Destruction of Cells by Prions
  13:1, p. 57 2024
• Journal of enzyme inhibition and medicinal chemistry
  Kim Dong Hwan, Kim Hyo Shin, Nam Tae-gyu, Kim Yong-Sun, Jeon Jae-Ho, Lee Sungeun, Ryou Chongsuk, Yoo Miryeong, Cheon Yong-Pil, Bartz Jason C., Son Young-Jin, Choi Eun-Kyoung, Lee Hakmin, Kim Jaehyeon, Lee Dongyun, Im So Myoung, Kim Ye Eun, Synthesis and anti-prion aggregation activity of acylthiosemicarbazide analogues
  38:1, p. 2191164 2023
• Prion
  Sweetland Gregory D., Eggleston Connor, Bartz Jason C., Mathiason Candace K., Kincaid Anthony E., Expression of the cellular prion protein by mast cells in the human carotid body
  17:1, p. 67 - 74 2023
• PLoS pathogens
  Gunnels Tess, Shikiya Ronald A, Bartz Jason C, York Taylor C, Block Alyssa J, Evidence for preexisting prion substrain diversity in a biologically cloned prion strain
  19:9, p. e1011632 - e1011632 2023
• Environment international
  Yuan Qi, Bartelt-Hunt Shannon L., Rowden Gage, Wolf Tiffany M., Schwabenlander Marc D., Larsen Peter A., Bartz Jason C., Sensitive detection of chronic wasting disease prions recovered from environmentally relevant surfaces
  166 2022
• Pathogens
  Picasso-Risso Catalina, Schwabenlander Marc D., Rowden Gage, Carstensen Michelle, Bartz Jason C., Larsen Peter A., Wolf Tiffany M., Assessment of Real-Time Quaking-Induced Conversion (RT-QuIC) Assay, Immunohistochemistry and ELISA for Detection of Chronic Wasting Disease under Field Conditions in White-Tailed Deer
  11:5 2022
• Cell and Tissue Research
  Block Alyssa J., Bartz Jason C., Prion strains 2022
• PLoS pathogens
  Block Alyssa J., Walters Ryan W., Shikiya Ronald A., Eckland Thomas E., Kincaid Anthony E., Ma Jiyan, Bartz Jason C., Efficient interspecies transmission of synthetic prions
  17:July 2021
• Acta Neuropathologica
  Bartz Jason C., Environmental and host factors that contribute to prion strain evolution
  142:1, p. 5 - 16 2021
• Journal of Biomolecular Structure and Dynamics
  Soto Patricia, Claflin India A., Bursott Alyssa L., Schwab-McCoy Aimee D., Bartz Jason C., Cellular prion protein gene polymorphisms linked to differential scrapie susceptibility correlate with distinct residue connectivity between secondary structure elements
  39:1, p. 129 - 139 2021
• Journal of Biological Chemistry
  Kang Hae Eun, Kim Sehun, Bian Jifeng, Kane Sarah J., Selwyn Vanessa, Crowell Jenna, Bartz Jason C., Telling Glenn C., Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination
  295:30, p. 10420 - 10433 2020
• Journal of Clinical Investigation
  Bartz Jason C., Underglycosylated prion protein modulates plaque formation in the brain
  130:3, p. 1087 - 1089 2020
• Journal of Clinical Investigation
  Bartz Jason C., Underglycosylated Prion protein modulates plaque formation in the brain
  130:3, p. 1087 - 1089 2020
• Annual Review of Pathology: Mechanisms of Disease
  Sigurdson Christina J., Bartz Jason C., Glatzel Markus, Cellular and Molecular Mechanisms of Prion Disease
  14, p. 497 - 516 2019
• PLoS pathogens
  Eckland Thomas E., Shikiya Ronald A., Bartz Jason C., Independent amplification of co-infected long incubation period low conversion efficiency prion strains
  14:10 2018
• Colloids and Surfaces B: Biointerfaces
  Phan Hanh T.M., Giasson Benoit I., Bartz Jason C., Ayers Jacob, Schubert Mathias, Rodenhausen Keith B., Kananizadeh Negin, Li Yusong, Bartelt-Hunt Shannon L., Adsorption and decontamination of α-synuclein from medically and environmentally-relevant surfaces
  166, p. 98 - 107 2018
• Journal of Virology
  Yuan Qi, Bartz Jason C., Telling Glenn, Bartelt-Hunt Shannon L., Dehydration of prions on environmentally relevant surfaces protects them from inactivation by freezing and thawing
  92:8 2018
• Journal of Immunology
  Kane Sarah J., Farley Taylor K., Gordon Elizabeth O., Estep Joshua, Telling Glenn C., Bender Heather R., Moreno Julie A., Bartz Jason, Pickering Matthew C., Zabel Mark D., Complement regulatory protein factor H is a soluble prion receptor that potentiates peripheral prion pathogenesis
  199:11, p. 3821 - 3827 2017
• Plos Pathogens
  Shikiya Ronald A., Holec Sara A. M., Mathiason Candace K., Kincaid Anthony E., Langenfeld Katie A., Eckland Thomas E., Trinh Jonathan, Bartz Jason C., PrPSc Formation and Clearance as Determinants of Prion Tropism
  13:3, p. e1006298 - e1006298 2017
• Proceedings of the National Academy of Sciences of the United States of America
  Bian J., Castilla J., Telling G. C., Bartz Jason C., Meyerett-Reid C., Kim S., Calvi C. L., Hoover E. A., Khaychuk V., Angers R. C., Fernandez-Borges N., Vidal E., Agrimi U., Richt J. A., Prion Replication without Host Adaptation during Interspecies Transmissions
  114:5, p. 1141 - 1146 2017
• Journal of Virology
  Kincaid Anthony E., Bartz Jason C., Ayers Jacob I., Specificity, Size, and Frequency of Spaces that Characterize the Mechanism of Bulk Transepithelial Transport of Prions in the Nasal Cavities of Hamsters and Mice
  90:18, p. 8293 - 8301 2016
• PLoS Pathogens
  Bartz Jason C., From Slow Viruses to Prions
  12:7, p. (3 pages) 2016
• Journal of Virology
  Langenfeld Katie A., Shikiya Ronald A., Kincaid Anthony E., Bartz Jason C., Incongruity between Prion Conversion and Incubation Period Following CoInfection
  90:12, p. 5715 - 5723 2016
• Biophysical journal
  Woo Jesse, Nieri Chad, Gonzalez Roger, Bartz Jason C., Soto Patricia, Conformational Dynamics of Prion Proteins at the Membrane Interface
  110:3, p. 419a - 419a 2016
• Cold Spring Harbor Perspectives in Medicine
  Bartz Jason C., Prion strain diversity
  6:12 2016
• PLoS One
  Phan H. T., Bartelt-Hunt S., Rodenhausen K. B., Schubert M., Bartz Jason C., Investigation of Bovine Serum Albumin (BSA) Attachment onto Self-Assembled Monolayers (SAMs) Using Combinatorial Quartz Crystal Microbalance with Dissipation (QCM-D) and Spectroscopic Ellipsometry (SE)
  10:10, p. (20 pages) 2015
• Journal of Virology
  Elder Alan M., Henderson Davin M., Nalls Amy V., Mathiason Candace K., Hoover Edward A., Kincaid Anthony E., Bartz Jason C., Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations
  89:14, p. 7421 - 7424 2015
• New Horizons in Translational Medicine
  Elder Alan M., Bartz Jason C., Mathiason Candace K., Henderson Davin M., Nalls Amy V., Kincaid Anthony E., Hoover Edward A., Longitudinal analysis of blood-borne prion infection
  2:4-5, p. 128 - 128 2015
• PLoS Pathogens
  Yuan Q., Bartz Jason C., Bartelt-Hunt S., Eckland Thomas E., Telling G., Mitigation of prion infectivity and conversion capacity by a simulated natural process--repeated cycles of drying and wetting
  11:2, p. e1004638 2015
• PLoS One
  Clouse Melissa D., Shikiya Ronald A., Bartz Jason C., Kincaid Anthony E., Nasal Associated Lymphoid Tissue of the Syrian Golden Hamster Expresses High Levels of PrPC
  10:2, p. e0117935 (10 pages) 2015
• Biophysical journal
  Soto Patricia, Bartz Jason C., Graft William, Gonzalez Roger, Nieri Chad, Zhao Bo, Prion Proteins and Mechanisms of Interaction with Model Membranes
  108:2, p. 91a - 91a 2015
• Prion
  Shikiya Ronald A., Bartz Jason C., Eckland Thomas E., Young Alan J., Prion formation, but not clearance, is supported by protein misfolding cyclic amplification
  8:6, p. 415 - 420 2014
• PLoS pathogens
  Bartelt-Hunt Shannon L., Bartz Jason C., Behavior of Prions in the Environment
  9:2 2013
• Journal of Virology
  Kincaid Anthony E., Bartz Jason C., Hudson K.F., Richey M.W., Rapid Transepithelial Transport of Prions following Inhalation
  86:23, p. 12731 - 12740 2012
• Journal of Biological Chemistry
  Kang Hae Eun, Angers Rachel, Langenfeld Katie, Calvi Carla, Bartz Jason, Hunter Nora, Telling Glenn C., Khaychuk Vadim, Saylor Vicki, Bian Jifeng, Weng Chu Chun, Saijo Eri, Kim Sehun, Ramos Laylaa, Characterization of conformation-dependent prion protein epitopes
  287:44, p. 37219 - 37232 2012
• PloS one
  Saunders Samuel E., Bartelt-Hunt Shannon L., Bartz Jason C., Resistance of soil-bound prions to rumen digestion
  7:8 2012
• Chemosphere
  Saunders Samuel E., Bartz Jason C., Bartelt-Hunt Shannon L., Soil-mediated prion transmission
  87:7, p. 661 - 667 2012
• Nebraska Academy of Sciences, PO Box 880410 Lincoln NE 68588-0410 United States. [np]. Apr 2012
  Colling Ian, Soto Patricia, Bartz Jason, BINDING MODES OF AGAAAAGATO SYRIAN HAMSTER PRION PROTEINS 2012
• Emerging Infectious Diseases
  Saunders Samuel E., Bartelt-Hunt Shannon L., Bartz Jason C., Occurrence, transmission, and zoonotic potential of chronic wasting disease
  18:3, p. 369 - 376 2012
• Journal of visualized experiments : JoVE
  Saunders Samuel E., Shikiya Ronald A., Bartz Jason C., Protein misfolding cyclic amplification of prions. 2012
• Applied and Environmental Microbiology
  Saunders Samuel E., Bartelt-Hunt Shannon L., Bartz Jason C., Vercauteren Kurt C., An enzymatic treatment of soil-bound prions effectively inhibits replication
  77:13, p. 4313 - 4317 2011
• Journal of Virology
  Saunders Samuel E., Bartelt-Hunt Shannon L., Shikiya Ronald A., Langenfeld Katie, Bartz Jason C., Replication efficiency of soil-bound prions varies with soil type
  85:11, p. 5476 - 5482 2011
• Journal of Virology
  Shikiya R. A., Bartz Jason C., In vitro generation of high titer prions
  85:24, p. 13439 - 13442 2011
• PLoS Pathogens
  Ayers J. I., Aguzzi A., Kincaid Anthony E., Schutt C. R., Shikiya R. A., Bartz Jason C., The Strain-Encoded Relationship between PrP Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease
  7:3, p. e1001317 2011
• PloS one
  Mays Charles E., Yeom Jihyun, Kim Younghwan, Kang Hae Eun, Bian Jifeng, Khaychuk Vadim, Bartz Jason C., Telling Glenn C., Ryou Chongsuk, In vitro amplification of misfolded prion protein using lysate of cultured cells
  6:3 2011
• PloS one
  Saunders Samuel E., Bartelt-Hunt Shannon, Bartz Jason C., Yuan Qi, Effects of solution chemistry and aging time on prion protein adsorption and replication of soil-bound prions
  6:4 2011
• Journal of Virology
  Shikiya R. A., Bartz Jason C., Ayers J. I., Schutt C. R., Kincaid Anthony E., Co-infecting prion strains compete for a limiting cellular resource
  84:11, p. 5706 - 5714 2010
• Environmental Science and Technology
  Saunders Samuel E., Bartelt-Hunt Shannon L., Bartz Jason C., Vercauteren Kurt C., Enzymatic digestion of chronic wasting disease prions bound to soil
  44:11, p. 4129 - 4135 2010
• Environmental Science and Technology
  Saunders Samuel E., Bartz Jason C., Bartelt-Hunt Shannon L., Prion protein adsorption to soil in a competitive matrix is slow and reduced
  43:20, p. 7728 - 7733 2009
• Environmental Science and Technology
  Saunders Samuel E., Bartelt-Hunt Shannon L., Bartz Jason C., Influence of prion strain on prion protein adsorption to soil in a competitive matrix
  43:14, p. 5242 - 5248 2009
• PLoS pathogens
  Singh Ajay, Isaac Alfred Orina, Luo Xiu, Kong Qingzhong, Mohan Maradumane L., Cohen Mark L., Chen Fusong, Bartz Jason, Singh Neena, Abnormal brain iron homeostasis in human and animal prion disorders
  5:3 2009
• Journal of Virology
  Ayers Jacob I., Kincaid Anthony E., Bartz Jason C., Prion strain targeting independent of strain-specific neuronal tropism.
  83:1, p. 81 - 87 2009
• Prion
  Kramer Michelle L., Bartz Jason C., Rapid, high-throughput detection of PrPSc by 96-well immunoassay
  3:1, p. 44 - 48 2009
• Journal of Comparative Pathology
  Sigurdson C. J., Eliason G. A., Mathiason C. K., Perrott M. R., Spraker T. R., Glatzel M., Manco G., Bartz J. C., Miller M. W., Hoover E. A., Experimental Chronic Wasting Disease (CWD) in the Ferret
  138:4, p. 189 - 196 2008
• Prion
  Schutt Charles R., Bartz Jason C., Prion interference with multiple prion isolates.
  2:2, p. 61 - 63 2008
• Journal of Virology
  Kincaid Anthony E., Bartz Jason C., The nasal cavity is a route for prion infection in hamsters
  81:9, p. 4482 - 4491 2007
• Journal of Virology
  Bartz Jason C., Hutter J. A. L., Kramer M. L., Sheehan M. H., Ayers J. I., Bessen R. A., Kincaid Anthony E., Prion interference is due to a reduction in strain-specific PrPSc levels
  81:2, p. 689 - 697 2007
• Veterinary Pathology
  Hamir A. N., Kunkle R. A., Miller J. M., Bartz J. C., Richt J. A., First and second cattle passage of transmissible mink encephalopathy by intracerebral inoculation
  43:2, p. 118 - 126 2006
• Journal of Virology
  Marsh R. F., Bessen R. A., Bartz Jason C., Kincaid Anthony E., Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiti sciureus)
  79:21, p. 13794 - 13796 2005
• Journal of Inorganic Biochemistry
  Shara Michael, Brenneman Karrie A., Yasmin Taharat, Kincaid Anthony E., Limpach Aimee L., Bartz Jason, Chatterjee Archana, Bagchi Manashi, Stohs Sidney J., Bagchi Debasis, Safety and toxicological evaluation of a novel niacin-bound chromium (III) complex
  99:11, p. 2161 - 2183 2005
• Journal of Virology
  Bartz Jason C., Tucker T., Kincaid Anthony E., Bessen R. A., DeJoia C., Extraneural prion neuroinvasion without lymphoreticular system infection
  79:18, p. 11858 - 11863 2005
• Bartz Jason, Prion Transport to Secondary Lymphoreticular System Tissues 2005
• Journal of Virology
  Mulcahy Ellyn R., Bartz Jason C., Kincaid A. E., Bessen R. A., Prion infection of skeletal muscle cells and papillae in the tongue
  78:13, p. 6792 - 6798 2004
• Journal of General Virology
  Bartz Jason C., Aiken J. M., Bessen Richard A., Delay in onset of prion disease for the HY strain of transmissible mink encephalopathy as a result of prior peripheral inoculation with the replication-deficient DY strain
  85, p. 265 - 273 2004
• Journal of Virology
  Bartz Jason C., Kincaid Anthony E., Bessen Richard A., Rapid prion neuroinvasion following tongue infection
  77:1, p. 583 - 591 2003
• Journal of Virology
  Bartz Jason C., Kincaid Anthony E., Bessen Richard A., Retrograde transport of transmissible mink encephalopathy within descending motor tracts
  76:11, p. 5759 - 5768 2002
• Journal of Virology
  Bartz Jason C., Bessen Richard A., Mckenzie Debbie, Marsh Richard F., Aiken Judd M., Adaptation and selection of prion protein strain conformations following interspecies transmission of transmissible mink encephalopathy
  74:12, p. 5542 - 5547 2000
• Journal of Biological Chemistry
  McKenzie Debbie, Aiken Judd, Bartz Jason, Mirwald Jean, Olander Doris, Marsh Richard, Reversibility of scrapie inactivation is enhanced by copper
  273:40, p. 25545 - 25547 1998
• Bulletin de l'Institut Pasteur
  McKenzie D., Bartz J., Aiken J., A molecular basis for transmissible spongiform encephalopathy agent strain differences
  96:1, p. 35 - 47 1998
• Seminars in Virology
  McKenzie D., Bartz J. C., Marsh R. F., Transmissible mink encephalopathy
  7:3, p. 201 - 206 1996
• Journal of General Virology
  Bartz J. C., McKenzie D. I., Bessen R. A., Marsh R. F., Aiken J. M., Transmissible mink encephalopathy species barrier effect between ferret and mink
  75:11, p. 2947 - 2953 1994

Awards

• Dr. Robert Heaney Graduate Research Mentor Award
  Creighton University
• Maiben Lecturer
  Nebraska Academy of Sciences
• Distinguished Lecturer
  American Society for Microbiology
• Richard A. Bessen Memorial Lecturer
  Rocky Mountain Virology Meeting
• Academy for Excellence in Team Science
  University of Minnesota
• University Research Award
  Creighton University
• Young Investigator Award
  Creighton University
• Richard F. Marsh Award for Outstanding Graduate Student Research
  University of Wisconsin