Schuyler Chambers, PhD
Assistant Professor
Contact
College of Arts and Sciences
Chemistry
Chemistry Faculty
RGSB - Rigge Science Building - 226
Schuyler Chambers, PhD
Assistant Professor
Research Focus
Research in the Chambers Lab harnesses synthetic carbohydrate chemistry to interrogate the biology of bacterial communities and bacterial polysaccharides. Broadly, the research program has two major facets: 1) the design and synthesis of carbohydrate-based tools to study glycobiology and antimicrobial resistance, and 2) the development of non-perturbative biochemical isolation methods to characterize unknown bacterial polysaccharides and biopolymers. Our research reveals the structural composition of biofilm communities and extracellular polysaccharides produced by pathogenic microbes, so that we can better translate our chemical understanding of these biopolymers into the design and synthesis of drug-delivery agents and antibiotic adjuvants to combat antibiotic resistant infections.Department
Chemistry and Biochemistry
Position
Assistant Professor
Publications
- Nature Communications
Verma Preeti, Chambers Schuyler A., Cegelski Lynette, Zimmer Jochen, Ho Ruoya, Insights into phosphoethanolamine cellulose synthesis and secretion across the Gram-negative cell envelope
15:1 2024 - ACS Central Science
Moore Rebecca E., Spicer Sabrina K., Lu Jacky, Chambers Schuyler A., Noble Kristen N., Lochner Jonathan, Christofferson Rebecca C., Vasco Karla A., Manning Shannon D., Townsend Steven D., Gaddy Jennifer A., The Utility of Human Milk Oligosaccharides against Group B Streptococcus Infections of Reproductive Tissues and Cognate Adverse Pregnancy Outcomes
9:9 2023 - ChemBioChem
Visser Joshua A., Cegelski Lynette, Yager Deborah, Chambers Schuyler A., Lim Ji Youn, Cao Xujun, Nordihydroguaiaretic Acid (NDGA) Inhibits CsgA Polymerization, Bacterial Amyloid Biogenesis, and Biofilm Formation
24:18 2023 - ACS Infectious Diseases
Stephens Victoria R., Moore Rebecca E., Spicer Sabrina K., Talbert Julie A., Lu Jacky, Chinni Riya, Chambers Schuyler A., Townsend Steven D., Manning Shannon D., Rogers Lisa M., Aronoff David M., Vue Zer, Neikirk Kit, Hinton Antentor O., Damo Steven M., Noble Kristen N., Eastman Alison J., McCallister Monique M., Osteen Kevin G., Gaddy Jennifer A., Environmental Toxicant Exposure Paralyzes Human Placental Macrophage Responses to Microbial Threat
9:12 2023 - Chembiochem : a European journal of chemical biology
Lu Jacky, Haley Kathryn P., Francis Jamisha D., Guevara Miriam A., Doster Ryan S., Craft Kelly M., Moore Rebecca E., Chambers Schuyler A., Delgado Alberto G., Piazuelo Maria Blanca, Damo Steven M., Townsend Steven D., Gaddy Jennifer A., Cover Feature: The Innate Immune Glycoprotein Lactoferrin Represses the Helicobacter pylori cag Type IV Secretion System (ChemBioChem 18/2021)
22:18, p. 2737 - 2737 2021 - Chembiochem : a European journal of chemical biology
Lu Jacky, Francis Jamisha D., Guevara Miriam A., Moore Rebecca E., Chambers Schuyler A., Doster Ryan S., Eastman Alison J., Rogers Lisa M., Noble Kristen N., Manning Shannon D., Damo Steven M., Aronoff David M., Townsend Steven D., Gaddy Jennifer A., Front Cover: Antibacterial and Anti‐biofilm Activity of the Human Breast Milk Glycoprotein Lactoferrin against Group B Streptococcus (ChemBioChem 12/2021)
22:12, p. 2010 - 2010 2021 - Frontiers in Cellular and Infection Microbiology
Lu Jacky, Gaddy Jennifer A., Guevara Miriam A., Francis Jamisha D., Spicer Sabrina K., Moore Rebecca E., Chambers Schuyler A., Craft Kelly M., Manning Shannon D., Townsend Steven D., Analysis of Susceptibility to the Antimicrobial and Anti-Biofilm Activity of Human Milk Lactoferrin in Clinical Strains of Streptococcus agalactiae With Diverse Capsular and Sequence Types
11 2021 - ChemBioChem
Lu Jacky, Haley Kathryn P., Francis Jamisha D., Guevara Miriam A., Doster Ryan S., Craft Kelly M., Moore Rebecca E., Chambers Schuyler A., Delgado Alberto G., Piazuelo Maria Blanca, Damo Steven M., Townsend Steven D., Gaddy Jennifer A., The Innate Immune Glycoprotein Lactoferrin Represses the Helicobacter pylori cag Type IV Secretion System
22:18 2021 - Journal of Organic Chemistry
Moore Rebecca E., Gaddy Jennifer A., Townsend Steven D., Marion Keevan C., Craft Kelly M., Xu Lianyan L., Chambers Schuyler A., Nguyen Johny M., Leveraging Stereoelectronic Effects in Biofilm Eradication: Synthetic β-Amino Human Milk Oligosaccharides Impede Microbial Adhesion As Observed by Scanning Electron Microscopy
85:24 2021 - ChemBioChem
Lu Jacky, Moore Rebecca E., Chambers Schuyler A., Doster Ryan S., Eastman Alison J., Rogers Lisa M., Noble Kristen N., Manning Shannon D., Damo Steven M., Aronoff David M., Townsend Steven D., Gaddy Jennifer A., Francis Jamisha D., Guevara Miriam A., Antibacterial and Anti-biofilm Activity of the Human Breast Milk Glycoprotein Lactoferrin against Group B Streptococcus
22:12 2021 - BMC Microbiology
Boone Ranashia L., Chambers Schuyler A., Doster Ryan S., Manning Shannon D., Townsend Steven D., Dent Leon, Marshall Dana, Gaddy Jennifer A., Damo Steven M., Whitehead Briana, Avery Tyra M., Lu Jacky, Francis Jamisha D., Guevara Miriam A., Moore Rebecca E., Analysis of virulence phenotypes and antibiotic resistance in clinical strains of Acinetobacter baumannii isolated in Nashville, Tennessee
21:1 2021 - ACS Infectious Diseases
Avery Tyra M., Boone Ranashia L., Lu Jacky, Spicer Sabrina K., Guevara Miriam A., Moore Rebecca E., Chambers Schuyler A., Manning Shannon D., Dent Leon, Marshall Dana, Damo Steven M., Townsend Steven D., Gaddy Jennifer A., Analysis of Antimicrobial and Antibiofilm Activity of Human Milk Lactoferrin Compared to Bovine Lactoferrin against Multidrug Resistant and Susceptible Acinetobacter baumannii Clinical Isolates
7:8 2021 - ACS Infectious Diseases
Noble Kristen, Guevara Miriam A., Doster Ryan S., Chambers Schuyler A., Rogers Lisa M., Spicer Sabrina K., Eastman Alison J., Francis Jamisha D., Moore Rebecca E., Manning Shannon D., Rajagopal Lakshmi, Aronoff David M., Townsend Steven D., Gaddy Jennifer A., Lu Jacky, Group B Streptococcus cpsE Is Required for Serotype v Capsule Production and Aids in Biofilm Formation and Ascending Infection of the Reproductive Tract during Pregnancy
7:9 2021 - Carbohydrate Research
Chambers Schuyler A., Townsend Steven D., Bioorthogonal human milk oligosaccharide probes for antimicrobial target identification within Streptococcus agalactiae
488 2020 - mBio
Chambers Schuyler A., Sherrod Stacy D., Aronoff David M., McLean John A., Gaddy Jennifer A., Townsend Steven D., Moore Rebecca E., Craft Kelly M., Thomas Harrison C., Das Rishub, Manning Shannon D., Codreanu Simona G., A solution to antifolate resistance in group B streptococcus: Untargeted metabolomics identifies human milk oligosaccharide-induced perturbations that result in potentiation of trimethoprim
11:2 2020 - MethodsX
Chambers Schuyler A., Townsend Steven D., Two-step conversion of unprotected oligosaccharides to generate bioorthogonal oligosaccharide tool compounds
7 2020 - ACS Infectious Diseases
Guevara Miriam A., Damo Steven M., Osteen Kevin G., Manning Shannon D., Aronoff David M., Halasa Natasha B., Townsend Steven D., Gaddy Jennifer A., Lu Jacky, Moore Rebecca E., Chambers Schuyler A., Eastman Alison J., Francis Jamisha D., Noble Kristen N., Doster Ryan S., Vitamin D and Streptococci: The Interface of Nutrition, Host Immune Response, and Antimicrobial Activity in Response to Infection
6:12 2020 - Chemistry - A European Journal
Chambers Schuyler A., Gaddy Jennifer A., Townsend Steven D., Synthetic Ellagic Acid Glycosides Inhibit Early Stage Adhesion of Streptococcus agalactiae Biofilms as Observed by Scanning Electron Microscopy
26:44 2020 - ACS Infectious Diseases
Lu Jacky, Francis Jamisha, Doster Ryan S., Haley Kathryn P., Moore Rebecca E., Chambers Schuyler A., Aronoff David M., Craft Kelly M., Osteen Kevin, Damo Steven M., Manning Shannon, Townsend Steven D., Gaddy Jennifer A., Lactoferrin: A Critical Mediator of Both Host Immune Response and Antimicrobial Activity in Response to Streptococcal Infections
6:7 2020 - Biochemical Society Transactions
Chambers Schuyler A., Townsend Steven D., Like mother, like microbe: Human milk oligosaccharide mediated microbiome symbiosis
48:3 2020 - ACS Chemical Neuroscience
Chambers Schuyler A., Desousa Jenna M., Huseman Eric D., Townsend Steven D., The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production
9:10 2018