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Laura A . Hansen, PhD

Associate Dean, Research

Professor

Laura Hansen

Contact

School of Medicine
Biomedical Sciences
Graduate School
Biomedical Sciences (Master of Science)
Biomedical Sciences (Doctorate)
SOM Leadership
CRISS II - Criss 2

Laura A . Hansen, PhD

Associate Dean, Research

Professor

My research delineates aberrant signaling in skin cancers in order to develop new clinically useful, mechanism-based approaches for prevention and treatment of nonmelanoma skin cancer. We recently discovered the aberrant subcellular localization of several signaling proteins in cutaneous squamous cell carcinoma that alters protein-protein interactions to activate pro-survival signaling. We have designed and developed novel 14-3-3 epsilon and CDC25A peptide inhibitors in collaboration with Dr. Sandor Lovas for targeting protein-protein interactions for the prevention of skin tumor development and progression. Other research focuses on elucidating mechanisms through which cell competition, through Flower (FWE) proteins and other signaling mechanisms, allows cancer cells of higher fitness to outcompete nontumorigenic cells and lead to skin cancer development and progression.

Research Focus

The long-term objective of Dr. Hansen’s research is to develop new clinically-useful, mechanism-based approaches the prevention and treatment of skin cancer. Research in the Hansen lab revolves around the question, “How do environmental exposures reprogram molecular pathways to lead to cancer and how does this provide novel targets for cancer treatment or prevention?” Current research projects are focused on dysregulation of checkpoint signaling pathways to suppress apoptosis, novel estrogen receptor signaling, and cell competition through Flower signaling in skin cancer.    

Department

Biomedical Sciences

Position

Professor

Articles

  • Journal of Biomedical Optics
    , 'Development and characterization of phasor-based analysis for FLIM to evaluate the metabolic and epigenetic impact of HER2 inhibition on Squamous Cell Carcinoma (SCC) cultures' 2021
  • Oncotarget
    Holmes, T.R., Al-Matouq, J., Holmes, M., Nicola, L., Lovas, S., and Hansen, L.A. Targeting 14-3-3e-CDC25A interactions to trigger apoptotic cell death in skin cancer. Accepted for publication in Oncotarget, 2020.Impact factor: 5.16 2020
  • Carcinogenesis
    Holmes, T, Al-Matouq, J., Holmes, M., Sioda, N., Rudd, J., Bloom, C., Nicola, L., Palermo, N., Madson, J., Lovas, S., Hansen, L.A. Targeting 14-3-3epsilon activated apoptotic signaling to prevent cutaneous squamous cell carcinoma. Accepted, Carcinogenesis, 2020. Impact factor: 5.334 2020
  • Oncotarget
    Holmes, T.R., Al-Matouq, J., Holmes, M., Nicola, L., Lovas, S., and Hansen, L.A. Targeting 14-3-3e-CDC25A interactions to trigger apoptotic cell death in skin cancer. Accepted for publication in Oncotarget, 2019. 2019
  • Nature
    Madan, E., Pelham, C.J., Nagane, M., Parker, T.M., Fazio, K., Shaik, K. Vieira, A., Galzerano, A., Canas-Marques, R., Yuan, Y., Yamashita, T., Post, S.R., Soldini, D., Yamashita, H., Accardi, D., Pinto, M.A.F., Camatcho, D., Hansen, L.A., Carvalho, C., Beltran, A., Kuppusamy, P., Gogna, R., Moreno, E. Fitness fingerprints of human cells promote competitive growth in cancer. Nature, Jul 24 doi: 10.1038/s41586-019-1429-3, 2019 2019
  • Molecular Carcinogenesis
    Al-Matouq, J., Holmes, T.R., and Hansen, L.A. CDC25C over-expression in non-melanoma skin cancer suppresses cell death. Molecular Carcinogenesis, Jun 24 doi: 10.1002/mc23075, 2019 PMID: 31237025 2019
  • Molecular Carcinogenesis
    Relocalization of signaling proteins in skin cancer and implications for treatment. Holmes, T.R., Dindu, S., and Hansen, L.A. Invited review for Molecular Carcinogenesis, May 6, doi.10.1002/mc.23036, 2019 2019
  • Journal of Biological Chemistry
    Madan, E., Parker, T.., Bauer, M.R., Dhiman, A., Pelham, C.J., Nagane, M., Kuppusamy, M.L., Holmes, M., Holmes, T.R., Shaik, K., Shee, K., Kiparoidze, S., Smith, S.D. Park, Y.A., Gomm, J.J., Jones, L.J., Tomas, A.R., Cunha, A.C., Selvendiran, k., Hansen, L.A., Fersht, A.R., Hideg, k., Gogna, R., Kuppusamy, P. The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53. Journal of Biological Chemistry, 293(12):4262-4276, 2018 PMID:29382728 PMCID:PMC5868245  DOI: 10.1074/jbc.RA117.000950
    293 (12), p. 4262-4276 2018
  • Journal of Biological Chemistry
    Madan, E., Parker, T.., Bauer, M.R., Dhiman, A., Pelham, C.J., Nagane, M., Kuppusamy, M.L., Holmes, M., Holes, T.R., Shaik, K., Shee, K., Kiparoidze, S., Smith, S.D. Park, Y.A., Gomm, J.J., Jones, L.J., Tomas, A.R., Cunha, A.C., Selvendiran, k., Hansen, L.A., Fersht, A.R., Hideg, k., Gogna, R., Kuppusamy, P. The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53. Journal of Biological Chemistry, 2018 PMID:29382728 PMCID:PMC5868245  DOI: 10.1074/jbc.RA117.000950
    293(12), p. 4262-4276 2018
  • Cancer Letters
    Al-Matouq, J., Holmes, T.R., Hammiller, B., Tran, N., Holmes, M., Freeman, S.C., and Hansen, L.A. Accumulation of cytoplasmic CDC25A in cutaneous squamous cell carcinoma leads to a dependency on CDC25A for cancer cell survival and tumor growth. Cancer Letters 2018  doi: 10.1016/j.canlet.2017.09.023. PMID: 28951130
    23;410, p. 41-49 2017
  • Cancer Letter
    1.   Al-Matouq, J., Holmes, T.R., Hammiller, B., Tran, N., Holmes, M., Freeman, S.C., and Hansen, L.A. Accumulation of cytoplasmic CDC25A in cutaneous squamous cell carcinoma leads to a dependency on CDC25A for cancer cell survival and tumor growth. Cancer Letters, in review, 2017. 2017
  • Journal of Dermatological Science
    Hammiller, B., Karuturi, B.V.K., Miller, C., Holmes, M., Labhasetwar, V., Madsen, G., and Hansen, L.A. Delivery of antioxidant enzymes for prevention of ultraviolet irradiation-induced epidermal damage. PMID 28793966. doi: 10.1016/j.jdermsci.2017.07.015, 2017 2017
  • Experimental Dermatology
    Bichsel, K.J., Hammiller, B., Trempus, C.S., Li, Y., Hansen, L.A. The epidermal growth factor receptor decreases Stathmin 1 levels and triggers catagen entry in the mouse. 
    25(4), p. 175-81 2016
  • Frontiers in Oncology
    Hammiller, B.O., El-Abaseri, T.B., Dlugosz, A.A., and Hansen, L.A. A method for the immortalization of newborn mouse skin keratinocytes. PMID: 24798404
    5, p. 177 2015
  • Molecular Carcinogenesis
    Rao, V.H., K. Vogel, J.K. Yanagida, N. Marwaha, A. Kandel, C. Trempus, S.K. Repertinger, and L.A. Hansen. Erbb2 up-regulation of ADAM12 expression accelerates skin cancer progression. doi: 10.1002/mc.22171,
    54(10) , p. 1026-36 2015
  • Elsevier
    L.A. Hansen Basal cell carcinoma in Reference Module in Biomedical Sciences 2015
  • Elsevier
    Hansen, L.A. Skin cancer. Reference Module for Biomedical Sciences. doi: 10.1016/B978-0-12-801238-3.05303-4 2015
  • Elsevier
    Squamous Cell Carcinoma Reference Module in Biomedical Sciences.Hansen, L.A. doi: 10.1016/B978-0-12-801238-3.05309-5 2015
  • Journal of Dermatological Science
    Shirley SH, Hammiller B, Hansen LA, Crysup B, Hudson LG, Kusewitt DF Role of the epidermal growth factor receptor in ultraviolet radiation induction of Snail family transcription factors Role of the epidermal growth factor receptor in ultraviolet radiation induction of Snail family transcription factors.
    76(2), p. 149-151 2014
  • Elsevier
    L.A. Hansen Mycosis Fungoides in Reference Module in Biomedical Sciences. Elseview 2014
  • Elsevier
    Melanoma. Reference Module in Biomedical Sciences. Elsevier.Hansen, L.A.  doi: 10.1016/B978-0-12-801238-3.05138-2 2014
  • PLoS One
    Bichsel, K., N. Gogia, T. Malouff, E. Forney, and L.A. Hansen. Genetic deletion of Egfr results in resistance to cyclophosphamide-induced alopecia in mouse skin.
    8(7), p. e69368 2013
  • ISRN Dermatology
    T.B. El-Abaseri, B. Hammiller, S.K. Repertinger-Fisher, and L.A. Hansen. The epidermal growth factor receptor increase cytokine production and cutaneous inflammation in response to ultraviolet irradiation, p. 1-11 2013
  • Carcinogenesis
    Yanagida, J., Hammiller, B., Behrens, M., Al-Matouq, J., Trempus, C.S., Repertinger, S., and Hansen, L.A. Accelerated elimination of ultraviolet-induced DNA damage through apoptosis in CDC25A deficient skin, p. 1754-61 2012
  • Oncogene
    Rao, V.H., Kandel, A., Lynch, D., Pena, Z., Marwaha, N., Deng, C., Watson, P., and Hansen, L.A. A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion
    31(33), p. 2888-98 2012
  • Anatomical Record
    Maklad, A., Conway, M., and Hansen, L.A. Development of innervation to maxillary whiskers in mice
    293(9), p. 1553-67 2012
  • Springer Publishing
    Repertinger, S.K., Madson, J.G., Bichsel, k.J., and Hansen, L.A. The epidermal growth factor receptor in normal and neoplastic epithelia in Signaling Pathways in Squamous Cancer, Van Waes and Glick, ed.s 2010
  • American Journal of Pathology
    Madson, J.G., Lynch, D.T., Svoboda, J., Ophardt, R., Yanagida, J., Putta, S.K., Bowles, A., Trempus, C.S., Tennant, R.W., and Hansen, L.A. Erbb2 suppresses DNA damage-induced checkpoint activation and UV-induced mouse skin tumorigenesis
    174(6), p. 2357-66 2009
  • Molecular Carcinogenesis
    Virador, V.M., Flores-Obando, R.E., Berry, A., Patel, R., Zakhari, J., Lo, Y-C., Strain, K., Anders, J., Cataisson, C., Hansen, L.A., and Yuspa, S.H. The human prommyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis
    48(7), p. 599-609 2009
  • Journal of Investigative Dermatology
    Maklad, A., Nicolai, J., Bichsel, J.J., Lee, T-C., Threadgill, D.W., and Hnasen, L.A. The epidermal growth factor receptor is required for proper innervation to the skin
    129(3), p. 690-9 2009
  • Cell and Tissue Research
    Beisel, K., Hansen, L, Soukup, Gl, and Fritzsch, B. Regenerating cochlear hair cells: quo vadis stem cell
    333(3), p. 373-9 2008
  • Toxicological Pathology
    Lynch, D., Svoboda, J., Putta, S., Hofland, H.E.J., Chern, W.H.,and Hansen, L.A. Mouse skin models for carcinogenic hazard identification: utilities and challenges
    35, p. 853-64 2007
  • Journal of Biomedicine and Biotechnology
    El-Abaseri, T.B., and Hansen, L.A. EGFR activation and ultraviolet light induced skin carcinogenesis
    2007(3), p. 97939 2007
  • Molecular Carcinogenesis
    Madson, J.G. and Hansen, L.A. Multiple mechanisms of Erbb2 action in ultraviolet irradiated skin
    46(8), p. 624-628 2007
  • Brain Res
    Morris, J.K., Maklad, A., Hansen, L., Feng, F., Sorenson, C., Lee, K-F., Macklin, W., and Fritzsch, B. A disorganized innervation of the inner ear persists in the absence of ErbB2
    1091, p. 186-99 2006
  • American Journal of Pathology
    Madson, J.G., Lynch, D.T., Tinkum, K.L., Putta, S.K., and Hansen, L.A. Erbb2 regulates inflammation and proliferation in the skin following ultraviolet irradiation
    169(4), p. 1402 2006
  • Carcinogenesis
    El-Abaseri, T.B., Putta, S., and Hansen, L.A. Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor
    27(2), p. 225-231 2006
  • Journal of Investigative Dermatology
    Khan GA, Bhattacharya G, Mailander PC, Meza JL, Hansen LA, Chakravarti D. Related Articles, Links Harvey-ras gene expression and epidermal cell proliferation in dibenzo[a,l]pyrene-treated early preneoplastic SENCAR mouse skin.
    125(3), p. 567-74 2005
  • Toxicological Pathology
    Fuhrman, J., Shafer, L., Repertinger, S., Chan, T., and Hansen, L.A. Mechanisms of SEPA 0009-induced tumorigenesis in v-rasHa transgenic Tg.AC mice
    33(6), p. 623-630 2005
  • Cancer Research

    65(9), p. 3958-3965 2005
  • Cell and Tissue Research
    Maklad, A., B.Fritzsch, and L.A.Hansen. Innervation of the maxillary vibrissae in mice: anterograde and retrograde tract tracing. Cell and Tissue Research
    315, p. 167-180 2004
  • J Biol Chem
    Wei, S.-J., C.S. Trempus, R.C. Ali, L.A. Hansen, and R.W. Tennant. TPA and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells.
    279(7), p. 5993-6004 2004
  • Cell and Tissue Research
    Maklad, A., B. Fritzsch, and L.A. Hansen
    315, p. 167-180 2004
  • Not Applicable
    Hansen, L.A. Skin Cancer in xPharm. Elsevier Science, Inc. 2004
  • Not Applicable
    Hansen, L.A. Mycosis Fungoides in xPharm. Elsevier Science, Inc. 2004
  • Not Applicable
    Hansen, L.A. Basal cell carcinoma, in xPharm. Elsevier Science, Inc. 2004
  • Not Applicable
    Hansen, L.A. Melanoma, in xPharm. Elsevier Science, Inc. 2004
  • Not Applicable
    Hansen, L.A. Squamous cell carcinoma, in xPharm. Elsevier Science, Inc. 2004
  • Journal of Investigative Dermatology
    Repertinger, S., E. Campagnaro, T. El-Abaseri, J. Fuhrman, S.H. Yuspa, and L.A. Hansen, In press 2004
  • Oncogene
    Seker, H., Rubbi., C., Linke, S.P., Bowman, E.D., Garfield, S., Hansen, L., Milner, J., and Harris, C.C. DNA damage induces p53 dependent nuclear trafficking of PML. S
    22, p. 1620-28 2003
  • Cancer Research
    Hansen,L.A., D.Brown, V.Virador, K.Strain, B.Dancheck, T.Tanaka, F.Andreola, R.Rountree, J.M.Arbeit, L.M.De Luca, S.Kogan, and S.H.Yuspa. A PMLRARalpha transgene results in a retinoid deficient phenotype associated with enhanced susceptibility to skin tumorigenesis. In press in Cancer Research
    63, p. 5257-5265 2003
  • Cancer Research
    Hansen, L.A., D. Brown, V. Virador, T.Tanaka, F. Andreola, K, Strain, B. Dancheck, R. Riley, J.M. Arbeit, L.M. De Luca, S. Kogan, and S.H. Yuspa
    63, p. 5257-5265 2003
  • Oncogene
    Seker, H., Rubbi, C., Linke, S.P., Bowman, E.D., Garfield, S., Hansen, L., Borden, K.L.B., Milner, J., and Harris, C.C.
    22, p. 1620-1628 2003
  • Cancer Research
    Woodworth, CD, Gaiotti, D, Michael, E, Hansen, L, Nees, M Title: Targeted disruption of the epidermal growth factor receptor inhibits development of papillomas and carcinomas from human papillomavirus-immortalized keratinocytes.
    60(16), p. 4397-4402 2000
  • Cancer Research
    Hansen LA, Woodson RL 2nd, Holbus S, Strain K, Lo YC, Yuspa SH Title: The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors.
    60(13), p. 3328-3332 2000
  • Carcinogenesis
    Hansen LA, Sigman CC, Andreola F, Ross SA, Kelloff GJ, De Luca LM
    21(7), p. 1271-9 2000
  • Hansen, L.A. Squamous cell carcinoma. xPharm (in press); Eds.: David B. Bylund and S.J. Enna; Elsevier Science, Inc.
  • Hansen, L.A. Skin cancer. xPharm (in press); Eds.: David B. Bylund and S.J. Enna; Elsevier Science, Inc.
  • Bioessays
    Fritzsch, B., Beisel, K.W., and Hansen, L.A. The molecular basis of neurosensory cell formation in ear development: a blueprint for hair cell and sensory neuron regeneration!
    28, p. 1181-93

Publications

  • Investigative Skin Carcinogenesis Conference Proceedings
    Abstract, Targeting of estrogen receptor-α36 suppresses growth of cutaneous squamous cell carcinoma, Caleb Freeman, Matti Holmes, Zhao-Yi Wang, and Laura A. Hansen International Investigational Skin Carcinogenesis Conference, Orlando, Florida May 2018 2018
  • American Association for Cancer Research
    Abstract, Targeting CDC25A suppression of apoptosis in cutaneous squamous cell carcinoma depends on 14-3-3e, Thomas R. Holmes and Laura A. Hansen, American Association for Cancer Research proceedings 2018
  • Abstract, Targeting of estrogen receptor-alpha36 decreases skin cancer stem cells and increase differentiation. Holmes, M., Pham, D., Nicholson, Y., Hammiller, B., Wang, T, Wang, Z-Y, and Hansen, L.A. Creighton University Research Day 2017
  • Abstract, EPIDERMAL GROWTH FACTOR RECEPTOR REGULATION OF STATHMIN1 IN MOUSE SKIN CANCER. Aileen Park, Brianna Hammiller, Carol Trempus, Laura A. Hansen, Midwest Student Biomedical Research Forum 2017
  • EFFICACY OF PRO-NPTM ANTIOXIDANT DELIVERY FOR PREVENTION OF ULTRAVIOLET IRRADIATION-INDUCED DAMAGE IN MOUSE SKINSean Smith, Yawah Nicholson, Brianna Hammiller, Christina Miller, Tammy Wang, Gary Madsen, Laura A. Hansen, Midwest Student Biomedical Research Forum 2017
  • CYTOPLASMIC ACCUMULATION OF CDC25A ENHANCES CELL SURVIVAL IN CUTANEOUS SQUAMOUS CELL CARCINOMA, Holmes, T., Hansen., L.A. MSBRF, 2017 2017
  • Tyler Bendrick, Thomas Holmes, and Laura Hansen. CDC25A inhibition in squamous cell carcinoma. Ferlich Poster Symposium 2016
  • Thomas Holmes, Brianna Hammiller, and Laura A. Hansen, CDC25A and Expoertins in cutaneous SCC. Creighton University Research Day 2016
  • Cara S. Franey, Thomas Holmes, Brianna Hammiller, Yawah Nicholson, Laura A. Hansen. EFFECT OF CDC25A OR 14-3-3 INHIBITION ON SQUAMOUS CELL CARCINOMA, Midwest Student Biomedical Research Forum 2016
  • Thesis completed by my M.S. advisee John Lehman entitled ADAM12 in head and neck cancer 2015
  • Cassidy Plunkett, Brianna Hammiller, Kyle Bichsel, Jessica Gaulter, and Laura A. Hansen Epidermal growth factor receptor regulation of Stathmin 1 in mouse skin cancer, Creighton University Honors Day 2015
  • Midwest Student Biomedical Research Forum
    Timothy Malouff, Kyle J. Bichsel, Yanhua Li, Brianna Hammiller, Carol Trempus, Laura A. Hansen EGFR AND STATHMIN1 IN PROGRESSION THROUGH THE HAIR CYCLE 2015
  • Midwest Student Biomedical Research Forum
    Lauren Nicola; Nicholas Tran; Jenan Al-Matouq; Brianna Hammiller; and Laura A. Hansen CYTOPLASMIC LOCALIZATION OF 14-3-3 IS ASSOCIATED WITH SUPPRESSION OF CELL DEATH IN CUTANEOUS SQUAMOUS CELL CARCINOMA 2015
  • Dissertation by my Ph.D. advisee Jenan Al-Matouq entitled Role of CDC25 phosphatases in non-melanoma skin cancer. 2014 2014
  • AACR Proceedings Apoptosis and Cancer
    Inhibition of erbB2 suppresses UV-induced skin tumorigenesis through a mechanism independent of EGFR Justin G. Madson1, Gregory S. Ramirez1, Carol Trempus2, Raymond W. Tennant2, and Laura A. Hansen11 Creighton University, Omaha, NE and 2National Institute for Environmental Health Sciences, Research Triangle Park, NC 2006
  • Creighton University Honors Program Symposium
    EGFR and erbB2 receptor tyrosine kinase targeted siRNA decreases receptor expression 2005
  • American Association for Cancer Research
    Epidermal growth factor receptor activation of MAP kinases regulates progression through multiple cell cycle phases 2005
  • American Association for Cancer Research
    Regulation of gene expression by erbB2 in response to ultraviolet irradiation of the skin 2005
  • Montagna Symposium for Cancer Research
    Chemoprevention of ultraviolet light-induced skin tumorigenesis by inhibition of the epidermal growth factor receptor 2004
  • American Association for Cancer Research
    Annual meeting, Inhibition of EGFR suppresses ultraviolet irradiation-induced tumorigenesis through multiple mechanisms 2004
  • Midwest Student Biomedical Research Forum
    Abstract entitled: The epidermal growth factor receptor regulates cutaneous proliferation through ERK and p38 MAP kinase pathways 2004
  • Not Applicable
    Virador, V.M., Hansen, L.A., Flores-Obando, Patel, R., Strain, K., Lo, Y.-C., Berry, A., and Yuspa, S.H. 2003
  • Proceedings of the AACR
    El-Abaseri, T. and Hansen, L.A. 2003
  • Not Applicable
    Lie, M., Patel, S., and Hansen, L.A. 2003
  • Proceedings / Workshops
    El-Abaseri, T., and Hansen, L.A. 2003
  • AACR Proceedings Apoptosis and Cancer
    The epidermal growth facotr receptor suppresses ultraviolet light-induced cell cycle arrest and apoptosis in keratinocytes. Laura A. Hansen, Sanjay Patel, Mercy Ossa-bucle, Laura Marsh, Taghrid El-Abaseri, p. A53 2002

General

  • Molecular Carcinogenesis
    Al-Matouq, J., Holmes, T.R., and Hansen, L.A. CDC25C over-expression in non-melanoma skin cancer suppresses cell death. Molecular Carcinogenesis, Jun 24 doi: 10.1002/mc23075, 2019 PMID: 31237025  2019
  • Molecular Carcinogenesis
    Relocalization of signaling proteins in skin cancer and implications for treatment. Holmes, T.R., Dindu, S., and Hansen, L.A. Invited review for Molecular Carcinogenesis, Epub May 6, doi.10.1002/mc.23036, 2019  2019
  • J Biol Chem
    Madan, E., Parker, T.., Bauer, M.R., Dhiman, A., Pelham, C.J., Nagane, M., Kuppusamy, M.L., Holmes, M., Holmes, T.R., Shaik, K., Shee, K., Kiparoidze, S., Smith, S.D. Park, Y.A., Gomm, J.J., Jones, L.J., Tomas, A.R., Cunha, A.C., Selvendiran, k., Hansen, L.A., Fersht, A.R., Hideg, k., Gogna, R., Kuppusamy, P. The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53. Journal of Biological Chemistry, 293(12):4262-4276, 2018 PMID:29382728 PMCID:PMC5868245  DOI: 10.1074/jbc.RA117.000950 
    293(12), p. 4262-4276 2018

Presentations

  • Society for Investigative Dermatology Annual Meeting 2020
  • MSBRF poster presentation, Flower isoforms regulate keratinocyte differentiation during cutaneous squamous cell carcinoma development. Justin Rudd, Kelsey Novak, Matti Holmes, Kelsey Hulen, Laura Hansen 2020
  • EFFECTS OF ES1P3 AND ZF47-88 ON CELL VIABILITY OF SCC12.B2 AND SCC13 CELLS Ryan O’Gara, Thomas R. Holmes, Kelsey Hulen, Sándor Lovas, Laura A. Hansen Midwest Student Biomedical Research Forum, 2020 2020
  • 1.     Two-photon imaging of NADH in SKH1 mice reveals changes in keratinocyte metabolism with chronic UVA exposure. Dominick Myers, Katie D. Sotelo, Dan L. Che, Marifel F. Gabriel, Ben G. Huerter, Kelsey A. Jackson, Molly Myers, Duyen Nguyen, Brooke L. Yang, Laura A. Hansen, Michael G. Nichols, 83rd Annual Meeting of the Biophysical Society, Baltimore Maryland, March 2019 2019
  • Sarah C. Gwazdacz, Sarah L. Schilchte, Matti Holmes, Natasha Sioda, Matthew C. Zimmerman, Gary Madsen, and Laura A. Hansen. The delivery and use of Pro-NPTM in the reduction of UV-induced oxygen radicals in skin. Midwest Student Biomedical Research Forum, March 2019. 2019
  • Natasha Sioda, Tommy Holmes, Sarah Gwazdacz, Matti Homes, and Laura A. Hansen. Targeting 14-3-3 decreases anti-apoptotic signaling in squamous cell carcinoma in vivo. Midwest Student Biomedical Research Forum, March 2019. 2019
  • Megan Machek, Matti Holmes, Caleb Freeman, Zhao-Yi Wang, Laura A. Hansen. Treatment of squamous cell carcinoma using ER-a36 targeted drug icaritin. Midwest Student Biomedical Research Forum, March 2019. 2019
  • Sandor Lovas, Thomas Holmes, Nicholas Y. Palermo, and Laura A. Hansen. Developing pepetide analogs for skin cancer treatment. International Peptide Conference, 2019. 2019
  • Invited Speaker, Title: Targeting CDC25A and 14-3-3e interactions in nonmelanoma skin cancer, International Investigative Skin Carcinogenesis Conference, Austin TX, October, 2018. 2018
  • Targeting of estrogen receptor-α36 suppresses growth of cutaneous squamous cell carcinoma, Caleb Freeman, Matti Holmes, Zhao-Yi Wang, and Laura A. Hansen International Investigational Skin Carcinogenesis Conference, Orlando, Florida 2018
  • Invited Speaker, Title: CDC25 and 14-3-3 in UV-induced skin cancer progression, American Society for Photobiology annual meeting 2018
  • Targeting CDC25A suppression of apoptosis in cutaneous squamous cell carcinoma depends on 14-3-3e, Thomas R. Holmes and Laura A. Hansen, American Association for Cancer Research annual meeting, Chicago, IL 2018
  • Flower Proteins and Cell Competition in Skin Cancer Kimberly M. Fazio, Nicholas Tran, Matti Holmes, Ekaterina Halivelakis, Celena Derderian, Justin G. Madson, Rajan Gogna, Laura A. Hansen, MSBRF 2018
  • ESTROGEN RECEPTOR-a36 TARGETING BY ICARITIN RESTRICTS IN VIVO GROWTH OF SQUAMOUS CELL CARCINOMA IN XENOGRAFT BY INCREASING DIFFERENTIATION, DECREASING PROLIFERATION, AND REDUCING THE CANCER STEM CELL POPULATION, S. Caleb Freeman, Matti Holmes, Nicholas Tran, Kimberly Fazio, Zhao-Yi Wang2, Laura A. Hansen, MSBRF 2018
  • TARGETING OF ESTROGEN RECEPTOR-α36 DECREASES SKIN CANCER STEM CELL NUMBERS AND SUPPRESSES SKIN CANCER GROWTH, Matti Holmes1\, Caleb Freeman, Dan Pham, Tommy R. Holmes, Tammy Wang, Zhao-Yi Wang, Laura A. Hansen, MSBRF 2018
  • Invited Speaker, Title: Novel Targets for Skin Carcinogenesis, LB595 Cancer and Smoking-related Diseases Program 2017
  • Invited Speaker, Title: Estrogen Receptor alpha 36 in skin cancer progression 2017
  • Presentation of research for LB595 site visit 2017
  • Invited speaker, Title: Relocalized CDC25A suppresses cell death in cutaneous squamous cell carcinoma, The 12th International Skin Carcinogenesis Conference. 2017
  • Invited Speaker, Title: Mechanisms of skin cancer development and progression, Department of Pharmacology, CUSOM 2016
  • Seminar, Role of CDC25C phosphatase in non-melanoma skin cancer, LB595 2015
  • Cassidy Plunkett, Brianna Hammiller, Kyle Bichsel, Jessica Gaulter, and Laura A. Hansen Epidermal growth factor receptor regulation of Stathmin 1 in mouse skin cancer, Creighton University Honors Day 2015
  • Timothy Malouff, Kyle J. Bichsel, Yanhua Li, Brianna Hammiller, Carol Trempus, Laura A. Hansen EGFR AND STATHMIN1 IN PROGRESSION THROUGH THE HAIR CYCLE Midwest Student Biomedical Research Forum, 2015 *Third place poster presentation. 2015
  • Lauren Nicola; Nicholas Tran; Jenan Al-Matouq; Brianna Hammiller; and Laura A. Hansen CYTOPLASMIC LOCALIZATION OF 14-3-3 IS ASSOCIATED WITH SUPPRESSION OF CELL DEATH IN CUTANEOUS SQUAMOUS CELL CARCINOMA Midwest Student Biomedical Research Forum 2015
  • Invited Speaker, Title: HER2-regulated signaling in squamous cell carcinoma: 14-3-3 and CDC25, CU Department of Biomedical Sciences, 2014
  • Invited Speaker, Title: HER2-regulated signaling in squamous cell carcinoma: ADAM12 and CDC25 phosphatases, Kansas State University 2014
  • Al-Matouq, J.A., Ho, K.A., and Hansen, L.A. Increased cytoplasmic CDC25A phosphatases in cutaneous cquamous cell carcinoma leads to 14-3-3epsilon relocalization and suppression of apoptosis. Presentation at the American Association for Cancer Research Meeting, May 2014 2014
  • Hansen, L.A. Novel biomarkers and therapeutic targets for nonmelanoma skin cancer. Oral presentation for LB595, April 2014 2014
  • Al-Matouq, J.A., Ho, K.A., and Hansen, L.A. Increased cytoplasmic CDC25A phosphatases in cutaneous cquamous cell carcinoma leads to 14-3-3epsilon relocalization and suppression of apoptosis. Poster presentation at the Midwest Biomedical Student Research Forum, February, 2014 2014
  • Platform presentation at the Society of Toxicology annual meeting in Baltimore MD 2009
  • Invited speaker at Pennsylvania State University, College Station, PA 2008
  • Invited seminar at UNL, Epidermal growth factor receptor: surprises from the skin 2008
  • Invited speaker, VA, Omaha, NE 2008
  • Erbb2 and ultraviolet irradiation in skin carcinogenesis, University of Nebraska, Lincoln, NE 2006
  • Inhibition of erbB2 suppresses UV-induced skin tumorigenesis through a mechanism independent of EGFR, American Association for Cancer Research 2006
  • The role of Erbb2 in the response of the skin to UV, Nebraska Center for Cellular Signaling 2006
  • Seminar title: The role of erbB2 in UV-induced skin carcinogenesis. 2005
  • Seminar title: EGFR in cutaneous innervation 2004
  • EGFR in peripheral nervous system innervation 2004
  • The epidermal growth factor receptor in cancer biology 2003
  • Invited speaker, Growth factor receptors, sunlight, and skin cancer, National Institute for Environmental Health Sciences, Research Triangle Park, NC 2003
  • Invited speaker at the Great Plains States Society for Molecular Biology and Genetics annual meeting 2003
  • Invited speaker, 4th Annual Steve Schiff Center for Skin Cancer Research Symposium, Title: The epidermal growth factor receptor regulates cell cycling and cell death during skin carcinogenesis 2002
  • Invited speaker, VA hospital, Title: The epidermal growth factor receptor regulates cell death and division during skin carcinogenesis 2001
  • Invited speaker, 3rd Midwest Regional AAAS Meeting, Title: Regulation of cell growth and death by the epidermal growth factor receptor during skin carcinogenesis 2001
  • Invited speaker, Department of Pharmacology Seminar Series, UNMC, Title: Regulation of cutaneous cell division and cell death by the epidermal growth factor receptor 2001
  • Panel discussion member, National Institute for Environmental Health Sciences Science Forum Topic: Searching for Faculty Positions, A Discussion by TIP Grantees 2001
  • A PMLRARalpha transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis, poster presentation at the American Association for Cancer Research annual meeting 2001
  • UNMC Department of Cell Biology, seminar, Title: Epidermal growth factor receptor mediated maintenance of cell proliferation in skin tumorigenesis. 2001
  • 3/5/2001 UNMC Department of Biochemistry, seminar, Regulation of cell division and differentiation by the epidermal growth factor receptor in the skin. 2001

Federal

  • INBRE
    PI: M. Nichols (Co-I: Hansen)
    Title: Metabolic imaging of disease progression in skin cancer by FLIM

  • NIH RO1 ES015585
    Title: Mechanisms of UV-induced skin carcinogenesis

  • NIH ARRA
    Title: Summer student supplement to RO1

  • NIH Center of Biomedical Research Excellence (COBRE) (PI: Wheelock) Project PI 50% effort
    My project title: erbB2 in UV-induced skin carcinogenesis
    National Institutes of Health
    Award: $686,821 direct costs for my portion, $276,599 indirect (total award approximately $10,000,000 over five years)

  • NIH RO1 (PI: Kusewitt) Collaborating investigator
    Title: Modulators of EMT in skin carcinogenesis

  • NIH COBRE (PI: Smith) Project Principal Investigator 40% effort
    Title: The molecular biology of neurosensory development (My individual project title is “The role of EGFR in sensory development.)

  • NIH K-22 Award ES00365-01
    Title: The role of EGFR in UV-induced skin carcinogenesis

Industry/Corporation

  • ProTransit Nanotherapy Project
    Title: The Protective Efficacy of PLGA Nanoparticles Encapsulating Antioxidant Enzymes against UV Radiation Exposure

  • Connetics Corporation
    Title: Mechanisms of tumorigenesis in Tg.AC mice

  • Connetics Corporation
    Title: Analysis of the effects of topically applied agents to Tg.AC skin

  • Macrochem Corporation
    Title: Mechanisms of SEPA-induced carcinogenesis in Tg.AC mice

State

  • State of NE-LB506

  • State of NE-LB595
    Title: Molecular and cellular mechanisms of carcinogenesis program

  • State of NE-LB595
    Title: Cancer and smoking-related diseases seminar series

  • NE-LB595 Pilot Project
    Title: ADAM12 and head and neck cancer progression

  • NE-LB595 Pilot Project
    Title: Oral carcinogenesis and ADAM12

  • State of NE-LB506
    Title: HER2 and the response to chemotherapeutic agents in SCC

  • State of NE-LB692
    Title: Does defective catagen entry trigger folliculitis in Egfr mutant skin?

  • State of NE-LB595
    Title: Mechanisms of cell cycle regulation by Erbb2

  • State of NE-LB692
    Title: The role of erbB2 in PNS, skin, and ear as revealed by conditional mutation analysis

Foundation/Association

  • The Dobleman Institute for Head and Neck Cancer Research

    Title: Matching funds for ADAM12 and head and neck cancer progression

  • Health Future Foundation Scholar Award
    Title: Regulation of cell cycle progression by HER2 in mammary cancer cells

Other

  • CURAS Project
    Title: Cytoplasmic CDC25A localization and suppression of apoptosis in cancer cells.

Awards

  • Dr. Robert Heaney Graduate Research Mentor Award
    Creighton University
  • 1st place Graduate Student Platform Presentation by student Justin Rudd
    1st place Graduate Student Platform Presentation by student Justin Rudd in Basic Sciences during University Research Week
  • University Research Award
    Creighton University
  • First Place Prize for Graduate Student Poster
    Awarded to my advisee Matti Holmes for her research performed in my lab
    Creighton University Research Day
  • Third place prive for poster presentation by medical student and mentee Timothy Malouff at the Midwest Biomedical Student Research Forum
    Third place prive for poster presentation by medical student and mentee Timothy Malouff at the Midwest Biomedical Student Research Forum
  • Third place poster awarded to my Ph.D. student Justin Madson at the Midwest Biomedical Student Research Forum
    Third place poster awarded to my Ph.D. student Justin Madson at the Midwest Biomedical Student Research Forum
  • Society of Investigative Dermatology Eugene M. Farber Endowment Award
    Society of Investigative Dermatology Eugene M. Farber Endowment Award

Consulting

  • Protransit Nanotherapy, LLC External Advisory Board
    Board Member
    Protransit Nanotherapy
    2015 - 2015