Sandor Lovas, PhD

Department

Biomedical Sciences

Position

Professor

Books

• American Peptide Symposia
  Gembitsky Dmitry S., Modulation of NK-2 receptor associated G-protein signaling by alternation of the aromatic residue at position six in neurokinin A analogs.in Peptides for the New Millenium Fields [Book Chapter] 2019
• Understanding Biology Using Peptides
  Herédi-Szabó Krisztina, Antiproliferative Effect of Lamprey Gonadotropin-Releasing Hormone III on Cancer Cells from Non-Reproductive Organs [Book Chapter] 2018
• Lovas Sandor, Misfolding and Oligomerization of Amyloid Beta(1-40) 2015
• Peptides: The Wave of the Future
  Ahmed Shawn I., Role of the C-terminal and Central Region of Gastrin for Recognition by the Human CCK2 Receptor [Book Chapter] 2001
• Peptides: The Wave of the Future
  Tóth Gergely, Helix stabilizing aromatic-backbone interactions [Book Chapter] 2001
• Peptides: The Wave of the Future
  Wibowo Felicitas I., Human colon cancers recognize N-carboxymethyl gastrin by a non-CCK1, non-CCK2 receptor [Book Chapter] 2001
• Peptides: The Wave of the Future
  Otvos Laszlo, The Proline-rich antibacterial peptide family inhibits chaperone-assisted protein folding [Book Chapter] 2001
• Lovas Sándor, Molecular Modeling of Neuropeptides - 18 [Book Chapter] 1997
• Murnin Mark, Organ/Tissue Preparations for the Assessment of Agonist/Antagonist Activity - 30 [Book Chapter] 1997

Articles

• Mezo I., Erratum 1998

Publications

• Science advances
  Vijayakumar Sarath, In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
  10:25, p. eadk2299 2024
• International journal of molecular sciences
  Kamayirese Seraphine, The Development of CDC25A-Derived Phosphoseryl Peptides That Bind 14-3-3ε with High Affinities
  25:9, p. 4918 2024
• ACS omega
  Kamayirese Seraphine, Optimizing Phosphopeptide Structures That Target 14-3-3ε in Cutaneous Squamous Cell Carcinoma 2024
• The Journal of biological chemistry
  Rudd Justin C., Membrane structure and internalization dynamics of human Flower isoforms hFWE3 and hFWE4 indicate a conserved endocytic role for hFWE4, p. 104945 - 104945 2023
• Burns William A, Dynamic Solvent Accessible Surface Areas of Proteogenic Amino Acids as a Function of Explored Phi,Psi Dihedral Angle Space 2023
• The Journal of biological chemistry
  Rudd Justin, Abstract 1432: Structural determination and internalization dynamics of human Flower isoforms
  299:3, p. 103795 2023
• Carcinogenesis
  Holmes Thomas R., Targeting 14-3-3ϵ activates apoptotic signaling to prevent cutaneous squamous cell carcinoma
  42:2, p. 232 - 242 2021
• Oncotarget
  Holmes Thomas R., Targeting 14-3-3ε-CDC25A interactions to trigger apoptotic cell death in skin cancer
  11:35, p. 3267 - 3278 2020
• International journal of molecular sciences
  Voit-Ostricki Leah, Conformation and domain movement analysis of human matrix metalloproteinase-2
  20:17 2019
• Proteins
  Watts C. R., Structural Properties of Amyloid Beta(1-40) Dimer Explored by Replica Exchange Molecular Dynamics Simulations
  85:6, p. 1024 - 1045 2017
• Protein and Peptide Letters
  Knappe D., Proline-Rich Antimicrobial Peptides Optimized for Binding to Escherichia Coli Chaperone DnaK
  23:12, p. 1061 - 1071 2016
• Journal of Biological Chemistry
  Lovas Sandor, Glutamate Transporter Homolog-based Model Predicts That Anion-pi Interaction Is the Mechanism for the Voltage-dependent Response of Prestin
  290:40, p. 24326 - 24339 2015
• Biopolymers
  Otvos L., Optimization of adiponectin-derived peptides for inhibition of cancer cell growth and signaling
  104:3, p. 155 - 166 2015
• Frontiers in Chemistry
  Otvos Laszlo,Jr, Development of second generation peptides modulating cellular adiponectin receptor responses
  2, p. Article 93 (15 pages) 2014
• Hearing Research
  He David Z. Z., Prestin at year 14: progress and prospect
  311, p. 25 - 35 2014
• Current Pharmaceutical Design
  Hatfield Marcus P. D., Conformational sampling techniques
  20:20, p. 3303 - 3313 2014
• Journal of Physical Chemistry. B
  Lovas Sandor, Molecular Mechanism of Misfolding and Aggregation of Amyloid Beta (13-23)
  117:20, p. 6175 - 6186 2013
• Journal of Cell Science
  Tan Xiaodong, A motif of eleven amino acids is a structural adaptation that facilitates motor capability of eutherian prestin
  125:4, p. 1039 - 1047 2012
• Journal of Peptide Science
  Palermo N. Y., Hexapeptide Fragment of Carcinoembryonic Antigen which Acts as an Agonist of Heterogeneous Ribonucleoprotein, p. 252 - 260 2012
• Biopolymers
  Otvos Laszlo, Jr., Peptide-Based leptin Receptor Antagonists for Cancer Treatment and Appetite Regulation
  96:2, p. 117 - 125 2011
• Journal of Physical Chemistry. B
  Hatfield M. P., The CLN025 decapeptide retains a β-hairpin conformation in urea and guanidinium chloride
  115:17, p. 4971 - 4981 2011
• BMC biotechnology
  Otvos Laszlo, Design and development of a peptide-based adiponectin receptor agonist for cancer treatment.
  11, p. 90 2011
• Biopolymers
  Hatfield M. P., VCD spectroscopic properties of the beta-hairpin forming miniprotein CLN025 in various solvents
  93:5, p. 442 - 450 2010
• Peptides
  Copps Jeffrey, Bioactivity of analogs of the N-terminal region of gastrin-17
  30:12, p. 2263 - 2267 2009
• Peptides
  Copps Jeffrey, The structure of bioactive analogs of the N-terminal region of gastrin-17
  30:12, p. 2250 - 2262 2009
• Advances in experimental medicine and biology
  Palermo Nicholas Y., The impact of aromatic residues on the tertiary fold of avian pancreatic polypeptide.
  611, p. 89 - 90 2009
• Biopolymers
  Csontos Jozsef, The role of weakly polar and H-bonding interactions in the stabilization of the conformers of FGG, WGG, and YGG: An aqueous phase computational study
  89:11, p. 1002 - 1011 2008
• Journal of Computational Chemistry
  Komáromi István, Development of glycyl radical parameters for the OPLS-AA/L force field
  29:12, p. 1999 - 2009 2008
• Journal of Computational Chemistry
  Csontos J., The effect of electron correlation on the conformational space of melatonin
  29:9, p. 1466 - 1471 2008
• International Journal of Quantum Chemistry
  Palermo N. Y., Role of aromatic residues in stabilizing the secondary and tertiary structure of avian pancreatic polypeptide
  108:4, p. 814 - 819 2008
• Methods in Molecular Biology
  Copps J., Molecular dynamics simulations of peptides
  494, p. 115 - 126 2008
• J.Comput.Chem.
  Csontos J., Calculation of weakly polar interaction energies in polypeptides using density functional and local Moller-Plesset perturbation theory
  29:8, p. 1344 - 1352 2008
• International Journal of Peptide Research and Therapeutics
  Ötvös Ferenc, Synthesis and structure-activity relationship of [Nle10] neurokinin A (4-10) analogs with constraint in the backbone and at position six
  13:1-2, p. 329 - 336 2007
• Journal of Computational Chemistry
  Palermo N. Y., Aromatic-backbone interactions in model alpha-helical peptides
  28:7, p. 1208 - 1214 2007
• Protein and Peptide Letters
  Borics Attila, Conformational analysis of Ac-NPGQ-NH2 and Ac-VPaH-NH 2 by vibrational circular dichroism spectroscopy combined with molecular dynamics and quantum chemical calculations
  14:4, p. 353 - 359 2007
• Peptides
  Copps Jeffrey, Gastrin 1-6 promotes growth of colon cancer cells through non-CCK receptors
  28:3, p. 632 - 635 2007
• Peptides
  Copps J., Gastrin 1-6 promotes growth of colon cancer cells through non-CCK receptors
  28:3, p. 632 - 635 2007
• Biopolymers
  Borics A., Optical spectroscopic elucidation of beta-turns in disulfide bridged cyclic tetrapeptides
  85:1, p. 1 - 11 2007
• Biopolymers
  Copps Jeffrey D., VCD spectroscopic and molecular dynamics analysis of the Trp-cage miniprotein TC5b
  88:3, p. 427 - 437 2007
• Journal of Peptide Science
  Heredi-Szabo K., Is IGnRH-III the most potent GnRH analog containing only natural amino acids that specifically inhibits the growth of human breast cancer cells?
  12:11, p. 714 - 720 2006
• Owen M., The conformational preference of Ca-centered protein radicals. 2006
• Biopolymers
  Borics A., Optical spectroscopic elucidation of different types of b-turns in disulfide bridged cyclic tetrapeptides 2006
• Biopolymers
  Copps J., Avian pancreatic polypeptide fragments refold to native aPP conformation when combined in solution: A CD and VCD study
  83, p. 32 - 38 2006
• Peptides
  Ahmed Shawn, Importance of N- and C-terminal regions of gastrin-Gly for preferential binding to high and low affinity gastrin-Gly receptors
  26:7, p. 1207 - 1212 2005
• Peptides
  Ahmed S., Importance of N- and C-terminal regions of gastrin-Gly for preferential binding to high and low affinity gastrin-Gly receptors
  26:7, p. 1207 - 1212 2005
• Journal of Physical Chemistry A
  Chass Gregory A., Characterization of the conformational probability of N-acetyl- Phenylalanyl-NH 2 by RHF, DFT, and MP2 computation and AIM analyses, confirmed by jet-cooled infrared data
  109:24, p. 5289 - 5302 2005
• Peptides
  Herédi-Szabó Krisztina, Importance of the central region of lamprey gonadotropin-releasing hormone III in the inhibition of breast cancer cell growth
  26:3, p. 419 - 422 2005
• FEBS Letters
  Ahmed Shawn, High and low affinity receptors mediate growth effects of gastrin and gastrin-Gly on DLD-1 human colonic carcinoma cells
  556:1-3, p. 199 - 203 2004
• FEBS Letters
  Ahmed Shawn I., High and low affinity receptors mediate growth effects of gastrin and gastrin-Gly on DLD-1 human colonic carcinoma cells
  556:3-Jan, p. 199 - 203 2004
• Journal of Molecular Structure: THEOCHEM
  Sahai Michelle A., A modular numbering system of selected oligopeptides for molecular computations
  666-667, p. 169 - 218 2003
• Journal of Molecular Structure: THEOCHEM
  Lau Suzanne K., An exploratory ab initio conformational analysis of selected fragments of nicotinamide adenine dinucleotide (NAD+). Part I
  666-667, p. 415 - 429 2003
• Journal of Molecular Structure. Theochem
  Sahai Michelle A., A modular numbering system of selected oligopeptides for molecular computations: using pre-computed amino acid building blocks
  666-667, p. 169 - 218 2003
• Journal of Physical Chemistry B
  Bhattacharjee Samita, Influence of tyrosine on the electronic circular dichroism of helical peptides
  107:33, p. 8682 - 8688 2003
• The Journal of Physical Chemistry B
  Bhattacharjee Samita, Influence of Tyrosine on the Electronic Circular Dichroism of Helical Peptides
  107:33, p. 8682 - 8688 2003
• Journal of Physical Chemistry. B
  Bhattacharjee S., Influence of Tyrosine on the Electronic Circular Dichroism of Helical Peptides
  107:33, p. 8682 - 8688 2003
• Biopolymers
  Borics Attila, Fourier transform vibrational circular dichroism as a decisive tool for conformational studies of peptides containing tyrosyl residues
  72:1, p. 21 - 24 2003
• Journal of the Chemical Society. Perkin Transactions 2
  Keglevich György, Structure and stability of oxaphosphetes formed as intermediates in the reaction of tertiary phosphine oxides and acetylenic derivatives
  2:10, p. 1645 - 1646 2002
• European Journal of Biochemistry
  Kragol G., Identification of crucial residues for the antibacterial activity of the proline-rich peptide, pyrrhocoricin
  269:17, p. 4226 - 4237 2002
• European Journal of Biochemistry
  Kragol Goran, Identification of crucial residues for the antibacterial activity of the proline-rich peptide, pyrrhocoricin
  269:17, p. 4226 - 4237 2002
• Journal of the American Chemical Society
  Toth Gergely, Investigation of aromatic-backbone amide interactions in the model peptide acetyl-phe-gly-gly-N-methyl amide using molecular dynamics simulations and protein database search
  123:47, p. 11782 - 11790 2001
• Journal of the American Chemical Society
  Tóth G., Investigation of aromatic-backbone amide interactions in the model peptide Acetyl-Phe-Gly-Gly-N-Methyl amide using molecular dynamics simulations and protein database search
  123:47, p. 11782 - 11790 2001
• The journal of peptide research : official journal of the American Peptide Society
  Ahmed S I, Importance of the C-terminal Phenylalanine of Gastrin for Binding to the Human CCK2 Receptor
  58:4, p. 332 - 337 2001
• Protein Engineering
  Toth Gergely, Stabilization of local structures by pi-CH and aromatic-backbone amide interactions involving prolyl and aromatic residues
  14:8, p. 543 - 547 2001
• Journal of Molecular Structure: THEOCHEM
  Körtvélyesi Tamás, Effect of Ala-substitution, N- and C-terminal modification and the presence of counter ions on the structure of amyloid peptide fragment 25-35
  545:1-3, p. 215 - 223 2001
• Journal of Biomolecular Structure & Dynamics
  Watts Charles R., Conformational space comparison of GnRH and IGnRH-III using molecular dynamics, cluster analysis and Monte Carlo thermodynamic integration
  18:5, p. 733 - 748 2001
• British Journal of Cancer
  Murphy Richard F., Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions
  84:7, p. 926 - 935 2001
• Biochemistry
  Kragol G., The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding
  40:10, p. 3016 - 3026 2001
• Biochemistry
  Kragol G., The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding
  40:10, p. 3016 - 3026 2001
• Journal of Biomolecular Structure and Dynamics
  Watts Charles R., Conformational space comparison of GnRH and lGnRH-III using molecular dynamics, cluster analysis and Monte Carlo thermodynamic integration
  18:5, p. 733 - 748 2001
• Protein Engineering
  Tóth G., Stabilization of local structures by π-CH and aromatic-backbone amide interactions involving prolyl and aromatic residues
  14:8, p. 543 - 547 2001
• Drugs of the Future
  Pályi I., GnRH analog conjugates with high anticancer selectivity
  26:1, p. 51 - 59 2001
• Letters in Peptide Science
  Bozso Z., Difficulties in coupling to conformationally constrained aromatic amino acids
  7:3, p. 157 - 163 2000
• Biochemistry
  Otvos L., Interaction between heat shock proteins and antimicrobial peptides
  39:46, p. 14150 - 14159 2000
• Cell Proliferation
  Kalnay A., Influence on antiproliferative activity of structural modification and conjugation of gonadotropin-releasing hormone (GnRH) analogues
  33:5, p. 275 - 285 2000
• Journal of Medicinal Chemistry
  Gembitsky Dmitry S., Importance of the aromatic residue at position 6 of [Nle10]neurokinin A(4-10) for binding to the NK-2 receptor and receptor activation
  42:15, p. 3004 - 3007 1999
• Proceedings of the National Academy of Sciences of the United States of America
  Pályi I., Gonadotropin-releasing hormone analogue conjugates with strong selective antitumor activity
  96:5, p. 2361 - 2366 1999
• Journal of Peptide Research
  Ötvös F., Coupling difficulty following replacement of Tyr with HOTic during synthesis of an analog of an EGF B-loop fragment
  53:3, p. 302 - 307 1999
• Proteins: Structure, Function and Genetics
  Watts Charles R., Molecular dynamics simulations of epidermal growth factor and transforming growth factor-α structures in water
  33:3, p. 396 - 407 1998
• Journal of Peptide Research
  Lovas Sándor, Direct anticancer activity of gonadotropin-releasing hormone-III
  52:5, p. 384 - 389 1998
• Methods in molecular biology (Clifton, N.J.)
  Tóth G., Tritium labeling of neuropeptides.
  73, p. 219 - 230 1997
• Methods in molecular biology (Clifton, N.J.)
  Lovas S., Molecular modeling of neuropeptides.
  73, p. 209 - 217 1997
• Methods in molecular biology (Clifton, N.J.)
  Murnin M., Organ/tissue preparations for the assessment of agonist/antagonist activity.
  73, p. 343 - 352 1997
• Helvetica Chimica Acta
  Ötvös Ferenc, 13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity
  79:1, p. 133 - 136 1996
• European Journal of Biochemistry
  Szendrei Gyorgyi I., Aspartate‐Bond Isomerization Affects the Major Conformations of Synthetic Peptides
  226:3, p. 917 - 924 1994
• Journal of Molecular Structure
  Lovas Sándor, Solvated structure analysis of a conformationally restricted analogue of phenylalanine in a dipeptide model by the AM1-SM2 method
  311, p. 297 - 304 1994
• Journal of Molecular Structure: THEOCHEM
  Lovas Sándor, Solvated structure analysis of a conformationally restricted analogue of phenylalanine in a dipeptide model by the AM1-SM2 method
  311, p. 297 - 304 1994
• Biochemical Society Transactions
  Lovas S., Structure-activity relationships of para-substituted Phe analogues of [Nle10]NKA(4-10)
  22:1, p. 5S 1994
• Peptides
  Badgery-Parker Tim, Receptor binding profile of neuropeptide γ and its fragments
  14:4, p. 771 - 775 1993
• Journal of Molecular Structure. Theochem
  Borics Attila, The benefits of a pre-computed amino acid structure database in quantum chemical geometry optimizations of β-turns of peptides
  666-667:0, p. 355 - 359 -0001

Federal

• NSF-EPSCoR Major Research Research Instrumentation Program:
  High-Performance Computing Cluster for Biomolecular Calculations

• NSF-EPSCoR Major Research Research Instrumentation Program,
  Project title: A high-throughput multi-user Biacore surface plasmon resonance system for studying biomolecular and biochemical interactions.

Other

• NSF-EPSCoR Major Research Research Instrumentation Program:
  High-Performance Computing Cluster for Biomolecular Calculations

State

• LB595 Program; Project Title: Molecular Mechanisms and Novel Targets in Cancer. Project PI: Novel therapeutic targets for nonmelanoma skin cancer Dates: 7/1/14-6/30/19; Role: collaborator