Kristen M . Drescher, PhD

Professor

Medical Microbiology and Immunology

Contact

School of Medicine
Med Microbiology & Immunology
Medical Microbiology and Immunology (Doctorate)
Medical Microbiology and Immunology (Master of Science)
Graduate School
CRISS II - Criss 2 - 424

Kristen M . Drescher, PhD

Professor

Medical Microbiology and Immunology

Examples of the most recent publications can be found at this PubMed link.

Research Focus

Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS) in humans. Patients with MS normally experience a chronic progressive loss of motor and/or sensory functions. The origin of MS is unknown, although some investigators have postulated than an environmental agent (i.e. a virus or bacteria) may trigger the disease. My laboratory utilizes a mouse model of virus-induced demyelination (Theiler's murine encephalomyelitis virus) to study immune factors involved in the development of pathology and clinical disease.

Department

Med. Microbiology & Immunology

Position

Professor

Books

  • Maresso Karen Colbert, Prevention and Screening Risk Factors, Screening, and Chemoprevention [Book Chapter] 2014
  • RNA Technologies and Their Applications, RNA Technologies
    Liu Jun, MicroRNAs in Epithelial Antimicrobial Immunity [Book Chapter] 2010
  • Group B Coxsackieviruses
    Oberste Steven, Group B Coxsackieviruses [Book Chapter] 2008
  • Group B Coxsackieviruses
    Drescher Kristen M., The CVB and etiology of type 1 diabetes [Book Chapter] 2008
  • How Do We Best Employ Animal Models for Type 1 Diabetesand Multiple Sclerosis
    Tracy Steven, Coxsackievirus infections and NOD mice [Book Chapter] 2007

Articles

  • Kanno Toru, Erratum 2006

Publications

  • Journal of visualized experiments
    Nguyen Brian T., Transfection of a Molecular Clone of Naegleria gruberi rDNA into N. gruberi Trophozoites 2024
  • Microbiology resource announcements
    Nguyen Brian T, Complete sequence of the closed circular extrachromosomal element of Naegleria pringsheimi De Jonckheere (strain Singh), p. e0080623 2024
  • Microbiology resource announcements
    Nguyen Brian T., Complete sequence of the closed circular extrachromosomal element (CERE) of Naegleria australiensis De Jonckheere (strain PP 397) 2023
  • Nutrients
    Law David, Creatine and Resistance Training: A Combined Approach to Attenuate Doxorubicin-Induced Cardiotoxicity
    15:18, p. 4048 2023
  • Microbiology resource announcements
    Nguyen Brian T, Complete Sequence of the Closed Circular Extrachromosomal Element of Naegleria jadini Willaert and Ray (Strain ITMAP400), p. e0006123 - e0006123 2023
  • Nature communications
    Deng Silu, Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses
    14:1, p. 1456 - 17 2023
  • Medicine and science in sports and exercise
    Bredahl Eric C., Controlled Metabolic Depression With Adenosine Receptor Agonists
    54:9S, p. 670 - 670 2022
  • Medicine and science in sports and exercise
    Johnson Niklas, Effects Of Creatine Supplementation On The Viability Of Walker 256 Mammary Carcinomas
    54:9S, p. 607 - 607 2022
  • Journal of Neuroinflammation
    Mathy Nicholas W., A novel long intergenic non-coding RNA, Nostrill, regulates iNOS gene transcription and neurotoxicity in microglia
    18:1 2021
  • Plasmid
    Nguyen B. T., The extrachromosomal elements of the Naegleria genus
    115 2021
  • Nutrients
    Bredahl Eric C., The role of creatine in the development and activation of immune responses
    13:3, p. 1 - 17 2021
  • Nutrition and Cancer
    Bredahl Eric Christopher, Use of Creatine and Creatinine to Minimize Doxorubicin-Induced Cytotoxicity in Cardiac and Skeletal Muscle Myoblasts
    73:11-12, p. 2597 - 2604 2021
  • Microbiology Resource Announcements
    Mullican John C., Complete genome sequence of the naegleria fowleri (strain lee) closed circular extrachromosomal ribosomal DNA element
    9:49 2020
  • Medicine & Science in Sports & Exercise
    BREDAHL ERIC C., Resistance training during chemotherapy with doxorubicin
    52:12, p. 2529 - 2537 2020
  • Medicine and Science in Sports and Exercise
    Bredahl Eric C., Resistance Training during Chemotherapy with Doxorubicin
    52:12, p. 2529 - 2537 2020
  • Medicine and science in sports and exercise
    Najdawi Wisam, The Effect Of Doxorubicin On Myocardial Extracellular Matrix Degradation: 951 Board #185 May 29 3:30 PM - 5:00 PM
    51:6 Suppl, p. 245 - 245 2019
  • Medicine and science in sports and exercise
    Legenza Ashton, The Effects of Resistance Training On Cardiac Muscle Function During Cancer Cachexia
    51:6S, p. 613 - 613 2019
  • Antimicrobial agents and chemotherapy
    Pandya Amit N., Indole-2-carboxamides are active against mycobacterium abscessus in a mouse model of acute infection
    63:3 2019
  • Cytokine
    Riesberg Lisa A., Creatinine downregulates TNF-α in macrophage and T cell lines
    110, p. 29 - 38 2018
  • Medicine & Science in Sports & Exercise
    Kaufenberg Mikayla, Effect of Resistance Training on Contractile Force Production during Doxorubicin-Treatment
    50:5S, p. 644 - 644 2018
  • Medicine & Science in Sports & Exercise
    Bredahl Eric, The effect of creatine and creatinine on myocellular injury in doxorubicin-treated skeletal muscle myoblasts
    50:5S, p. 644 - 644 2018
  • Scientific American
    Drescher Kristen M., Medicine van quishing diabetes
    318:2, p. 54 - 59 2018
  • Medicine and science in sports and exercise
    Eckerson Joan M., The Effect of Creatine Supplementation on Upper Body Strength and Immune Function in Men
    49:5S, p. 1027 2017
  • Medicine & Science in Sports & Exercise
    Bredahl Eric C., The Effects Of Creatine And Creatinine On Rates Of Apoptosis In Doxorubicin-treated Myoblasts
    49:5S, p. 7 - 7 2017
  • International Immunopharmacology
    Riesberg Lisa A., Beyond Muscles: The Untapped Potential of Creatine
    37, p. 31 - 42 2016
  • Journal of Immunology
    Hu Guoku, LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling
    196:6, p. 2799 - 2808 2016
  • Reviews in Medical Virology
    Drescher Kristen M., Enteroviruses, hygiene and type 1 diabetes: toward a preventive vaccine
    25:1, p. 19 - 32 2015
  • Current Treatment Options in Oncology
    Lynch Henry T., Genetics, biomarkers, hereditary cancer syndrome diagnosis, heterogeneity and treatment: a review
    15:3, p. 429 - 442 2014
  • Journal of Microbiological Methods
    Smithee Shane, A novel, broadly applicable approach to isolation of fungi in diverse growth media
    105, p. 155 - 161 2014
  • Journal of Neuroimmunology
    Drescher Kristen M., miR-684 regulation of neurexophilin-1 and alpha-neurexin expression
    253:2-Jan, p. 63 - 63 2012
  • Frontiers in Genetics
    Hu Guoku, Exosomal microRNAs: biological properties and therapeutic potential.
    3, p. 56 2012
  • PLoS One
    Zhou Rui, miR-16 Targets Transcriptional Corepressor SMRT and Modulates NF-kappaB-Regulated Transactivation of Interleukin-8 Gene
    7:1, p. e30772 2012
  • Journal of Antibiotics
    McDonald Thomas, Creatinine inhibits bacterial replication
    65:3, p. 153 - 156 2012
  • Diabetes/Metabolism Research and Reviews
    Tracy Steven, Enteroviruses and type 1 diabetes
    27:8, p. 820 - 823 2011
  • Grün K, Heterotopic rat heart transplantation: Accumulation of Ubiquinone in the rat heart allograft depends on ischemia/reperfusion 2011
  • International Immunopharmacology
    Leland Korey M., Effect of creatine, creatinine, and creatine ethyl ester on TLR expression in macrophages
    11:9, p. 1341 - 1347 2011
  • Reviews in Medical Virology
    Tracy S., Enteroviruses, type 1 diabetes and hygiene
    20:2, p. 106 - 116 2010
  • Journal of Infectious Diseases
    Gong Ai-Yu, Cryptosporidium parvum Induces B7-H1 Expression in Cholangiocytes by Down-Regulating MicroRNA-513
    201:1, p. 160 - 169 2010
  • Clinical & developmental immunology
    Drescher Kristen M., Current hypotheses on how microsatellite instability leads to enhanced survival of lynch syndrome patients
    2010, p. 170432 2010
  • PLoS Pathogens
    Zhou Rui, NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses
    5:12, p. e1000681 2009
  • Familial Cancer
    Drescher Kristen M., Lymphocyte recruitment into the tumor site is altered in patients with MSI-H colon cancer
    8:3, p. 231 - 239 2009
  • The Journal of immunology (1950)
    Drescher Kristen M., Impact of TLR deletion on brain pathology in a mouse model of encephalitis (128.22)
    182:1_Supplement, p. 128 - 128.22 2009
  • International Reviews of Immunology
    Liu Jun, MicroRNAs and Epithelial Immunity
    28:4-Mar, p. 139 - 154 2009
  • Virology
    Chapman Nora M., 5′ terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart
    375:2, p. 480 - 491 2008
  • Gastroenterology
    Lynch Henry T., Immunology and the lynch syndrome
    134:4, p. 1246 - 1249 2008
  • Annals of the New York Academy of Sciences
    Drescher Kristen M., Establishment of a model to examine the early events involved in the development of virus-induced demyelinating lesions
    1103, p. 152 - 156 2007
  • Virology
    Drescher Kristen M., Injection of the sciatic nerve with TMEV
    359:1, p. 233 - 242 2007
  • Sonnino Roberta E., Partnership between a SOM - based Women in Medicine and Science and Minority Faculty Development programs and AAMC: Getting the message across 2006
  • Journal of Virology
    Kanno Toru, Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency
    80:11, p. 5637 - 5643 2006
  • Current Topics in Microbiology and Immunology
    Tracy S., Evolution of virulence in picornaviruses
    299, p. 193 - 209 2006
  • Clinical and Applied Immunology Reviews
    Drescher Kristen M., Tumor infiltrating lymphocytes (TILs): Lessons learned in 30 years of study
    5:3, p. 149 - 166 2005
  • Journal of General Virology
    Lee C. K., Characterization of an infectious cDNA copy of the genome of a naturally occurring, avirulent coxsackievirus B3 clinical isolate
    86:1, p. 197 - 210 2005
  • Virology
    Drescher Kristen M., Coxsackievirus B3 infection and type 1 diabetes development in NOD mice
    329:2, p. 381 - 394 2004
  • Journal of Neuroscience
    Pavelko Kevin D., Interleukin-6 protects anterior horn neurons from lethal virus-induced injury
    23:2, p. 481 - 492 2003
  • Journal of Virology
    Tracy S., Toward testing the hypothesis that Group B Coxsackieviruses (CVB) trigger insulin-dependent diabetes: inoculating nonobese diabetic mice with CVB markedly lowers diabetes incidence
    76:23, p. 12097 - 12111 2002
  • Journal of Neurovirology
    Drescher Kristen M., ICAM-1 is crucial for protection from TMEV-induced neuronal damage but not demyelination
    8:5, p. 452 - 458 2002
  • Drescher K, Effect of belaperidone on cholinergic activity in rat prefrontal cot nucleus accumbens and corpus striatum - interaction with methamphetamine 2001
  • Molecular and Cellular Neurosciences
    Pavelko Kevin D., HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosis
    15:6, p. 495 - 509 2000
  • Journal of Immunology
    Drescher Kristen M., TGF-β2 reduces demyelination, virus antigen expression, and macrophage recruitment in a viral model of multiple sclerosis
    164:6, p. 3207 - 3213 2000
  • International immunology
    Drescher K, V sub( beta )8 super(+) T cells protect from demyelinating disease in a viral model of multiple sclerosis
    12:3, p. 271 - 280 2000
  • Human Immunology
    Das Pritam, Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis
    61:3, p. 279 - 289 2000
  • Brain Pathology
    Drescher Kristen M., CD40L is critical for protection from demyelinating disease and development of spontaneous remyelination in a mouse model of multiple sclerosis
    10:1, p. 1 - 15 2000
  • International Immunology
    Drescher Kristen M., V(β)8+ T cells protect from demyelinating disease in a viral model of multiple sclerosis
    12:3, p. 271 - 280 2000
  • Experimental Neurology
    McGavern Dorian B., Quantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination
    158:1, p. 171 - 181 1999
  • Brain Pathology
    Drescher Kristen M., CNS cell populations are protected from virus-induced pathology by distinct arms of the immune system
    9:1, p. 21 - 31 1999
  • Journal of neuroimmunology
    Das P., HLA-Dr is critical for the induction of EAE, while HLA-DQ can modulate the severity of disease: Studies in HLA transgenic mice
    90:1, p. 62 - 62 1998
  • Journal of Neuroimmunology
    Drescher Kristen M., Failure of treatment with Linomide or oral myelin tolerization to ameliorate demyelination in a viral model of multiple sclerosis
    88:1-2, p. 111 - 119 1998
  • Journal of Clinical Investigation
    Drescher Kristen M., Expression of the human histocompatibility leukocyte antigen DR3 transgene reduces the severity of demyelination in a murine model of multiple sclerosis
    101:8, p. 1765 - 1774 1998
  • Immunological Reviews
    Drescher Kristen M., Antiviral immune responses modulate the nature of central nervous system (CNS) disease in a murine model of multiple sclerosis
    159, p. 177 - 193 1997
  • Virology
    Drescher Kristen M., Evidence for induction of interferon-α and interferon-β in retinal glial cells of Muller
    234:2, p. 309 - 316 1997
  • Investigative Ophthalmology and Visual Science
    Drescher Kristen M., Herpes simplex virus type 1 alters transcript levels of tumor necrosis factor-α and interleukin-6 in retinal glial cells
    37:11, p. 2302 - 2312 1996
  • Journal of Neuroimmunology
    Drescher Kristen M., Modulation of immune-associated surface markers and cytokine production by murine retinal glial cells
    64:1, p. 71 - 81 1996
  • Memórias do Instituto Oswaldo Cruz
    Drescher K. M., Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agents.
    88:1, p. 89 - 95 1993

Presentations

  • Presentation for the Health Sciences Educator Development Program How to Improve Your Teaching: Insight From the Evaluation Committee 2015
  • Drescher, KM and Tracy, SM Injection of the Sciatic Nerve with Theilers Virus: A Model of Virus-Induced Peripheral Demyelination; Positive Strand Meeting; Washington DC (poster) 2007
  • Tracy, SM and Drescher, KM COXSACKIEVIRUS AND NOD MICE: RELEVANT MODELS OF PROTECTION FROM, AND INDUCTION OF, TYPE 1 DIABETES 2006
  • Drescher, KM and Tracy, SM Establishment of a model to examine the events involved in the development of virus-induced demyelinating lesions. NY Acad Sciences, Animal Models of MS and TID, San Franscisco 2006
  • National Multiple Sclerosis Society - Nebraska Chapter; TRENDS meeting; Roundtable Discussion on Research 2006
  • Drescher KM and Tracy S Coxsackie B virus replication in pancreatic islets: virus associates with the four major islet cell types, not merely beta cells American Society of Virology, Madison, WI. 2006
  • 6. Tracy, S.M., Drescher, K.M., Jackson, J.D., Sanderson, S Vaccinating NOD mice against CVB-induced rapid T1D onset: type-specific immunity is not required to lower T1D incidence American Society of Virology, Madison, WI. 2006
  • Neuregulins in the peripheral nervous system in virus infections and autoimmune disease 2006
  • Role of C3 in a model of virus-induced encephalitis 2006
  • Impact of C3 deletion in a mouse model of virus induced demyelinating disease UNMC Department of Cell Biology and Genetics 2006
  • Birth of a successful women in medicine and science program in a private, Jesuit medical school; R.E. Sonnino, M. Gentry-Nielsen, K.M. Drescher, M. Schofield, A. Chatterjee; AAMC Meeting 2005
  • Neuregulin is upregulated in the sciatic nerve following infection with TMEV; KM Drescher, A Heller, S Tracy; International Congress of Virology 2005
  • Group B Coxsackievirus infections in NOD mice: Towards clarifying a role of enteroviruses in human type 1 diabetes onset, S, Tracy and K. Drescher, International Congress of Virology 2005
  • American College of Cardiology 2005
  • Hounsfield Lecture (Imperial College, London) Developing A Novel Ultrasound Method Of Imaging Molecular Activities Dr J Yeh Dr C Sennoga Prof M Blomley Mr P Muckett Dr R Eckersley Prof S Tracy Dr K Drescher Dr YW Li Dr C Tang Dr J Boyle Dr J Mason8 Dr S Nourshargh Prof J Seddon Prof D Haskard Dr P Nihoyannopoulos 2005
  • America's Conference on the Treatment and Immunology of Multiple Sclerosis 2004
  • CVB-induces diabetes in older NOD mice; SM Tracy, KM Drescher, K Kono, S Bopegamage, SD Carson 2004
  • International Congress on Immunology 2004
  • Coxsackie B virus replicates in islets of old NOD mice and initiates type 1 diabetes. Steven Tracy, Kristen M. Drescher, Ken Kono, Steven D. Carson, Shubhada Bopegamage; Seventh International Symposium on positive-strand RNA viruses; San Francisco, CA 2004
  • Paula Kocakova and Kristen M. Drescher C3 is required for efficient clearance of virus from the brains of TMEV-infected mice; Federation of the American Society of Experimental Biology 2004
  • Cary M. Wolter,Jill R. Fuhrman, and Kristen M. Drescher Localization of matrix metalloproteinases (MMPs) in the brains of TMEV-infected mice Midwest Medical Student Research Forum (poster) 2004
  • Oshunleti, O. and Drescher, K.M. Use of CVB chimeric viruses as vaccine vectors in an animal model of multiple sclerosis - National Medical Fellowship Program 2004
  • Paula Kocakova and Kristen M. Drescher C3 is required for efficient clearance of virus from the brains of TMEV-infected mice, Midwest Medical Student Research Forum 2004
  • Immunology Group - Use of CVB chimerae as vaccines in a model of multiple sclerosis 2002
  • Johnson, T.D., Marsh, L.B., Ray, T., Drescher, K.M. The relative contribution of B cells and complement in protection of the brain from Theiler's murine encephalomyelitis virus. Minority summer student poster session 2002
  • Tracy et al, X!!th International COngress of Virology 2002
  • Modulation of activin/inhibin mRNA levels following TMEV infection XIIth International Congress of Virology (Paris, France) 2002
  • Theiler's Virus model of multiple sclerosis 2002
  • Ukpo,O.C., S.E. Hopkins and K.M. Drescher. Identification of apoptotic cells in the brains and spinal cords of TMEV-infected mice. Minority Summer Student Research Forum (Poster) 2001
  • Hopkins, S.E., O.C. Ukpo, and K.M. Drescher. Apoptosis in the brains of TMEV-infected C57BL6/J and B10.Q mice. Minority High School Student Research Forum (Poster). 2001
  • Texas A & M University - Neuroscience Seminar Series 2001
  • University of Nebraska Medical Center - Department of Cell Biology and Anatomy 2001
  • Cooper, D.M. and Drescher, K.M. - Regional ASM Meeting - oral presentation 2001
  • University of Nebraska Medical Center - Immunology Interest Group 2001
  • Cooper, D.C. and Drescher, K.D. Midwest Student Research Forum - poster 2001
  • Cooper, D.M. and Drescher, K.D. - Regional AAAS Meeting - poster 2000
  • Flores, N., Cooper, D.M. and Drescher, K.M. - Minority summer student poster session 2000
  • 10/22/99;VA Hospital;"Expression of the HLA-DR3 Transgene reduces the severity of demyelination in a viral model of multiple sclerosis" 1999

Awards

  • National Award
    Jr. Investigator Award
    NY Academy of Sciences