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Kristen M . Drescher, PhD

Professor

Medical Microbiology and Immunology

Kristen Drescher

Contact

School of Medicine
Med Microbiology & Immunology
Medical Microbiology and Immunology (Doctorate)
Medical Microbiology and Immunology (Master of Science)
Graduate School
CRISS II - Criss 2

Kristen M . Drescher, PhD

Professor

Medical Microbiology and Immunology

Examples of the most recent publications can be found at this PubMed link.

Research Focus

Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS) in humans. Patients with MS normally experience a chronic progressive loss of motor and/or sensory functions. The origin of MS is unknown, although some investigators have postulated than an environmental agent (i.e. a virus or bacteria) may trigger the disease. My laboratory utilizes a mouse model of virus-induced demyelination (Theiler's murine encephalomyelitis virus) to study immune factors involved in the development of pathology and clinical disease.

Department

Med. Microbiology & Immunology

Position

Professor

Articles

  • Spektrum de Wissenschaft
    Drescher KM, Tracy S. Impfen gegen diabetes (German).
    August 2018 2018
  • Cytokine
    Riesberg LA, McDonald TL, Wang Y, Chen XM, Holzmer SW, Tracy SM, Drescher KM. Creatinine downregulates TNF-a in macrophage and T cell lines.
    110, p. 29-38 2018
  • Scientific American
    Drescher KM, Tracy S. Vanquishing Diabetes.
    318 (2), p. 54-59 2018
  • International Immunopharmacology
    Riesberg LA, Weed SA, McDonald TL, Eckerson JM, Drescher KM. Beyond muscles: the untapped potential of creatine
    37, p. 31-42 2016
  • Journal of Immunology
    Hu G, Gong AY, Wang Y, Ma S, Chen X, Chen J, Su CJ, Shibata A, Strauss-Soukup JK, Drescher KM, Chen XM. LincRNA-Cox2 promotes late inflammatory gene transcription in macrophages through modulating SWI/SNF-mediated chromatin remodeling.
    196 (6), p. 2799-2808 2016
  • Rev Med Virol
    Drescher KM, von Herrath M, Tracy S. Enteroviruses, hygiene and type 1 diabetes: toward a preventive vaccine
    25, p. 19-32 2015
  • J Microbiol Methods
    Smithee S, Tracy S, Drescher KM, Pitz LA, McDonald T. A novel, broadly applicable approach to isolation of fungi in diverse growth media
    105, p. 155-61 2014
  • Current Treatment Options in Oncology
    Lynch HT, Drescher K, Knezetic J, Lanspa S. Genetics, biomarkers, hereditary cancer syndrome diagnosis, heterogeneity and treatment: a review
    15, p. 429-442 2014
  • Cancers of the Colon and Rectum
    Lynch HT, Drescher KM, Sharma P, Snyder C., Lynch JF, Knezetic J., Mitchins M, Silberstein P, and Lanspa S. Lynch Syndrome as a Model for Identification of Hereditary High-Risk Patients in Cancers of the Colon and Rectum: A Multidisciplinary Approach to Diagnosis and Management. Benson, A, Chakravarthy A, Hamilton S, Sigurdson E, and Thomas C. (eds). 2013
  • Fronters in Genetics
    Hu G, Drescher KM, Chen XM. Exosomal miRNAs: Biological Properties and Therapeutic Potential.
    3, p. 56 2012
  • J Antibiotics
    McDonald T, Drescher KM, Weber A, Tracy S. Creatinine inhibits bacterial replication.
    65 (3), p. 153-156 2012
  • PLoS One
    Zhou R, Li X, Hu G, Gong AY, Drescher KM, Chen XM. miR-16 Targets Transcriptional Corepressor SMRT and Modulates NF-kappaB-Regulated Transactivation of Interleukin-8 Gene.
    7, p. e30772 2012
  • Diabetes/Metabolism Research and Reviews
    Tracy S, Drescher KM, Chapman NM. Enteroviruses and type 1 diabetes.
    27, p. 820-823 2011
  • International Immunopharmacology
    Leland KM, McDonald TL, Drescher KM. Effect of creatine, creatinine, and creatine ethyl ester on TLR expression in macrophages. International Immunopharmacology
    11, p. 1341-1347 2011
  • Clinical and Developmental Immunology
    Drescher KM, Sharma P, Lynch HT. Current hypotheses on how microsatellite instability leads to enhanced survival of Lynch Syndrome patients
    170432, p. 1-13 2010
  • Reviews in Medical Virology
    Tracy SM, Drescher KM, Jackson JD, Kim K, Kono K. Enteroviruses, type 1 diabetes and hygeine: a complex relationship
    20, p. 106-116 2010
  • Journal of Infectious Diseases
    Gong AY, Zhou R, Hu G, Liu J, Sosnowska D, Drescher KM, Dong H, Chen XM. Cryptosporidia parvum induces B7-H1 expression in cholangiocytes by downregulating microRNA 513
    201, p. 160-169 2010
  • Familial Cancer
    Drescher KM, Sharma P, Watson P, Gatalica Z, Thibodeau SN, Lynch HT. Lymphocyte recruitment into the tumor is altered in patients in MSI-H cancer
    8, p. 231-239 2009
  • International Reviews in Immunology
    Liu J, Drescher KM, Chen XM. MicroRNAs and epithelial immunity
    28, p. 139-154 2009
  • PLoS Pathogens
    Zhou R, Hu G, Liu J, Gong AY, Drescher KM, Chen XM. NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses
    5, p. e1000681 2009
  • Frontiers in Bioscience
    Drescher KM, Sosnowska D. Being a mouse in a man's world: what TMEV has taught us about human disease
    13, p. 3775-3785 2008
  • Virology
    Chapman NM, Kim KS, Drescher KM, Oka K, Tracy S. 5' terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart
    375, p. 480-491 2008
  • Gastroenterology
    Lynch HT, Drescher KM, de la Chapelle A. Immunology and the Lynch Syndrome
    134, p. 1246-1249 2008
  • Annals of New York Academy of Science
    Drescher KM and Tracy S. Establishment of a model to examine the early events involved in the development of virus-induced demyelinating lesions
    1103, p. 152-156 2007
  • Annals of New York Academy of Science
    Tracy S and Drescher KM. Coxsackievirus infections and NOD mice: Relevant models of protection from, and induction of, Type 1 Diabetes.
    1130, p. 143-151 2007
  • Virology
    Drescher KM and Tracy SM. Injection of the sciatic nerve with TMEV: a new model for peripheral nerve demyelination
    359, p. 233-242 2007
  • Not Applicable
    Immunology for Medical Students: T Cell Development 2006
  • Current Topics in Microbiology and Immunology
    Tracy S, Chapman NM, Drescher KM, Tapprich W. Evolution of virulence in picornaviruses in: Quasispecies: Concepts and Implications for Virology
    299, p. 193-210 2006
  • Journal of Virology
    Kanno T, Kim K, Kono K, Drescher KM, Chapman NM, Tracy SM. Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency.
    80, p. 5637-5643 2006
  • Clinical and Applied Immunology Reviews
    Drescher, KM and Lynch HT. Tumor infiltrating lymphocytes (TILs): Lessons learned in 30 years of study
    5 (3), p. 149-166 2005
  • Journal of General Virology
    Lee CK, Kono K, Haas E, Kim KS, Drescher KM, Chapman NM, Tracy S. Characterization of an infectious cDNA copy of the genome of a naturally-occurring, avirulent coxsackievirus B3 clinical isolate.
    86, p. 197-210 2005
  • 12th International Congress of Immunology
    Drescher KM, Kocakova P, Chapman NM, Tracy SM. CVB-based vaccines alter immune responses to self in virus-infected mice. , p. 341-344 2004
  • Virology
    Drescher KM, Kono K, Bopemagamage S, Carson SD, Tracy S Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection
    329, p. 381-394 2004
  • Journal of Neuroscience
    Pavelko, K.D., C.L. Howe, K.M. Drescher, J.D. Gamez, A.J. Johnson, T. Wei, R.M. Ransohoff, M. Rodriguez. Interleukin-6 protects anterior horn neurons from lethal virus-induced injury.
    23, p. 481-492 2003
  • Journal of Neurovirology
    Drescher, K.M., L.J. Zoecklein, and M. Rodriguez. ICAM-1 is crucial to protection from TMEV-induced neuronal damage but not demyelination.
    8, p. 452-458 2002
  • Not Applicable
    ”T-Cell ” Immunology for Medical Students. Nairn and Helbert. C.V. Mosby Co 2002
  • Journal of Virology
    Tracy, S., K.M. Drescher, N.M. Chapman, K.-S. Kim, S.D. Carson, S. Pirruccello, P.H. Lane, J.R. Romero, and J.S. Leser. Toward testing the hypothesis that Group B coxsackieviruses (CVB) trigger insulin-dependent diabetes: inoculating nonobese diabetic mice with CVB markedly lowers diabetes incidence.
    76, p. 12097-12111 2002
  • International Immunology
    Drescher, K.M., Johnston, S.L., Hogancamp, W., David, C.S., Rimm, I.J., Wettstein, P.J., and Rodriguez, M. Vb8+T cells protect from demyelinating disease in a viral model of multiple sclerosis:
    12, p. 271-280 2000
  • Journal of Immunology
    Drescher KM, Murray, PD, Lin X, Carlino J, Rodriguez M. TGF-b2 reduces demyelination, virus antigen expression, and macrophage recruitment in a viral model of multiple sclerosis
    164, p. 3207-3213 2000
  • Brain Pathology
    Drescher, K.M., Zoecklein, L.J., Pavelko, K.D., Rivera-Quinones, C., Hollenbaugh, D. and Rodriguez, M. CD40L is critical for protection from demyelinating disease and development of spontaneous remyelination in a mouse model of multiple sclerosis.
    10, p. 1-15 2000
  • Human Immunology
    Das, P., Drescher, K.M., Bradley, D.S., Rodriguez, M. and David, C.S. Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis
    61, p. 279-289 2000
  • Molecular and Cellular Neuroscience
    Pavelko, K.D.*, Drescher, K.M.*, McGavern, D.B., David, C.S., and Rodriguez, M. HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosis. *Both authors contributed equally to this manuscript.
    15, p. 495-509 2000
  • Brain Pathology
    Drescher KM, Murray PD, David CS, Pease LR, Rodriguez M. CNS cell populations are protected from virus-induced pathology by distinct arms of the immune system
    9, p. 21-31 1999
  • Experimental Neurology
    McGavern DB, Zoecklin L, Drescher KM, Rodriguez M. Quantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination
    158, p. 171-181 1999
  • Journal of Neuropathology and Experimental Neurology
    Njenga MK, Murray PD, McGavern DB, Drescher KM, Rodriguez M. Absence of spontaneous central nervous system remyelination in major histocompatibility complex class II-deficient mice infected with Theiler's virus
    58, p. 78-91 1999

Publications

  • Medicine & Science in Sports & Exercise
    The effect of creatine and creatinine on myocellular injury in doxorubicin-treated skeletal muscle myoblastsBredahl, Eric1; Najdawi, Wisam1; Hook, Sarah1; Eckerson, Joan, FACSM1; Siedlik, Jake1; Drescher, Kristen2American College of Sports Medicine
    50 5S, p. 644 2018
  • Medicine & Science in Sports & Exercise
    Effect of Resistance Training on Contractile Force Production during Doxorubicin-Treatment:Kaufenberg, Mikayla1; Tigner, Allison1; Hook, Sarah1; Twaddell, MacKenzie1; Wagner, Meghan1; Bredahl, Eric1; Siedlik, Jake1; Eckerson, Joan, FACSM1; Drescher, Kristen2American College of Sports Medicine
    50 5S, p. 644 2018
  • St. Albert's day/Creighton University Research day
    THE EFFECT OF CREATINE AND CREATININE ON CREATINE METABOLISM IN DOXORUBICIN-TREATED SKELETAL MUSCLE MYOBLASTSWisam Najdawi, Sarah M. Hook, Joan M. Eckerson FACSM, Jake A. Siedlik, Kristen M. Drescher, and Eric C. Bredahl,
    2018, p. --- 2018
  • St. Albert's day/Creighton University Research day
    THE EFFECT OF RESISTANCE TRAINING ON CONTRACTILE FORCE PRODUCTION DURING DOXORUBICIN TREATMENTMikayla Kaufenberg, Tigner, A.T., Hook, S.M., Twaddell, M.D., Wagner, M.K., Siedlik, J.A., Eckerson, J.M., Drescher, K.M., Bredahl, E.C.,
    2018, p. --- 2018
  • Nebraska Physiological Society
    THE EFFECT OF CREATINE AND CREATININE TREATMENT ON SHORT-TERM ENERGY METABOLISM IN DOXORUBICIN-TREATED SKELETAL MUSCLE MYOBLASTS Hook, S.M.1, Najdawi, W.O.1, Eckerson, J.M.1, Siedlik, J.A.1, Drescher, K.M.2, Bredahl, E.C.1
    2017, p. -- 2017
  • Nebraska Physiological Society
    EFFECT OF RESISTANCE TRAINING ON CONTRACTILE FORCE PRODUCTION DURING DOXORUBICIN-TREATMENT Tigner, A.T.1, Kaufenberg, M.M.1, Hook, S.M.1, Twaddell, M.D.1, Wagner, M.K.1, Siedlik, J.A.1, Eckerson, J.M.1, Drescher, K.M.2, Bredahl, E.C.1
    2017, p. --- 2017
  • Medicine & Science in Sports & Exercise
    The Effect of Creatine Supplementation on Upper Body Strength and Immune Function in Men:Eckerson, Joan M. FACSM1; Riesberg, Lisa A.1; Serreyn, Kyle1; Yee, Jennifer1; Moore, Geri A.1; Katsavelis, Dimitrios1; Bredahl, Eric1; Drescher, Kristen1; Fukuda, David2; Kurata, Laura1; Moon, Brittany1American College of Sports Medicine
    49 5S, p. 1027 2017
  • Medicine & Science in Sports & Exercise
    The Effects Of Creatine And Creatinine On Rates Of Apoptosis In Doxorubicin-treated Myoblasts:Bredahl, Eric C.; Kottensette, Sarah A.; Marshall, Nathaniel R.; Wagner, Meghan K.; Drescher, Kristen; Eckerson, Joan M.American College of Sports Medicine
    49 5S, p. 7 2017
  • International Congress of Virology
    KM Drescher, J Sunde, SM Tracy. Neuregulin-1 is upregulated in the sciatic nerve following infection with TMEV.
    11, p. v212 2005
  • International Congress of Virology
    Tracy S, Drescher KM. Group B coxsackievirus infections in NOD mice: towards clarifying the role of enteroviruses in human type 1 diabetes onset
    11, p. v173 2005
  • J American College of Cardiology
    JSM Yeh, S Tracy, KM Drescher, J Sunde, K Kono, N Chapman, JJ Boyle, T Hussell, C Sennoga, RJ Eckersley, MJ Blomley, DO Haskard, P Nihoyannopouloss; E-selectin is expressed in coxsackievirus B3 myocarditis
    45, p. 142A 2005
  • Abstract Book
    Kristen M. Drescher, Paulina Kocakova, Nora M. Chapman, and Steven M. Tracy. Use of CVB-based Vaccines to Modify an Immune-Response to Self
    ACTRIMS 2004
  • Abstract Book
    Drescher KM, Kocakova P, Chapman NM, Tracy SM. Inhibition of Cellular Immune Response to Self-Epitopes in TMEV-Infected Mice
    Intl. Congress of Immunology 2004
  • Seventh International Symposium on Positive Stranded RNA Viruses
    SM Tracy, KM Drescher, K Kono, SD Carson, S Bopegamage; Coxsackievirus replicates in islets of old NOD mice and initiates diabetes
    1 2004
  • FASEB Journal
    Kocakova P, Drescher KM; C3 is required for efficient clearance of virus from brains of TMEV-infected mice
    18 2004
  • 26th International Congress of Internal Medicine
    Steven Tracy, Nora M. Chapman, Kyung-Soo Kim, Kristen M. Drescher, Pascale H. Lane, Samuel Pirruccello, J. Smith Leser. Vaccination of young nonobese diabetic (NOD) mice with group B coxsackievirus lowers type 1 diabetes incidence
    2002 2002

Editing and Reviews

  • European Journal of Cancer
    Lynch HT, Lanspa SJ, Snyder CL, Drescher KM. Microsatellite instability, disease-free survival and role of tumour infiltrating lymphocytes (Invited editorial on 'Predictors of disease-free survival in colorectal cancer with microsatellite instability: An AEGO study)
    51, p. 922-924 2015

Presentations

  • Presentation for the Health Sciences Educator Development Program How to Improve Your Teaching: Insight From the Evaluation Committee 2015
  • Drescher, KM and Tracy, SM Injection of the Sciatic Nerve with Theiler’s Virus: A Model of Virus-Induced Peripheral Demyelination; Positive Strand Meeting; Washington DC (poster) 2007
  • Tracy, SM and Drescher, KM COXSACKIEVIRUS AND NOD MICE: RELEVANT MODELS OF PROTECTION FROM, AND INDUCTION OF, TYPE 1 DIABETES 2006
  • Drescher, KM and Tracy, SM Establishment of a model to examine the events involved in the development of virus-induced demyelinating lesions. NY Acad Sciences, Animal Models of MS and TID, San Franscisco 2006
  • National Multiple Sclerosis Society - Nebraska Chapter; TRENDS meeting; Roundtable Discussion on Research 2006
  • Drescher KM and Tracy S Coxsackie B virus replication in pancreatic islets: virus associates with the four major islet cell types, not merely beta cells American Society of Virology, Madison, WI. 2006
  • 6. Tracy, S.M., Drescher, K.M., Jackson, J.D., Sanderson, S Vaccinating NOD mice against CVB-induced rapid T1D onset: type-specific immunity is not required to lower T1D incidence American Society of Virology, Madison, WI. 2006
  • Neuregulins in the peripheral nervous system in virus infections and autoimmune disease 2006
  • Role of C3 in a model of virus-induced encephalitis 2006
  • Impact of C3 deletion in a mouse model of virus induced demyelinating disease UNMC Department of Cell Biology and Genetics 2006
  • Birth of a successful women in medicine and science program in a private, Jesuit medical school; R.E. Sonnino, M. Gentry-Nielsen, K.M. Drescher, M. Schofield, A. Chatterjee; AAMC Meeting 2005
  • Neuregulin is upregulated in the sciatic nerve following infection with TMEV; KM Drescher, A Heller, S Tracy; International Congress of Virology 2005
  • Group B Coxsackievirus infections in NOD mice: Towards clarifying a role of enteroviruses in human type 1 diabetes onset, S, Tracy and K. Drescher, International Congress of Virology 2005
  • American College of Cardiology 2005
  • Hounsfield Lecture (Imperial College, London) Developing A Novel Ultrasound Method Of Imaging Molecular Activities Dr J Yeh Dr C Sennoga Prof M Blomley Mr P Muckett Dr R Eckersley Prof S Tracy Dr K Drescher Dr YW Li Dr C Tang Dr J Boyle Dr J Mason8 Dr S Nourshargh Prof J Seddon Prof D Haskard Dr P Nihoyannopoulos 2005
  • America's Conference on the Treatment and Immunology of Multiple Sclerosis 2004
  • CVB-induces diabetes in older NOD mice; SM Tracy, KM Drescher, K Kono, S Bopegamage, SD Carson 2004
  • International Congress on Immunology 2004
  • Coxsackie B virus replicates in islets of old NOD mice and initiates type 1 diabetes. Steven Tracy, Kristen M. Drescher, Ken Kono, Steven D. Carson, Shubhada Bopegamage; Seventh International Symposium on positive-strand RNA viruses; San Francisco, CA 2004
  • Paula Kocakova and Kristen M. Drescher C3 is required for efficient clearance of virus from the brains of TMEV-infected mice; Federation of the American Society of Experimental Biology 2004
  • Cary M. Wolter,Jill R. Fuhrman, and Kristen M. Drescher Localization of matrix metalloproteinases (MMPs) in the brains of TMEV-infected mice Midwest Medical Student Research Forum (poster) 2004
  • Oshunleti, O. and Drescher, K.M. Use of CVB chimeric viruses as vaccine vectors in an animal model of multiple sclerosis - National Medical Fellowship Program 2004
  • Paula Kocakova and Kristen M. Drescher C3 is required for efficient clearance of virus from the brains of TMEV-infected mice, Midwest Medical Student Research Forum 2004
  • Immunology Group - Use of CVB chimerae as vaccines in a model of multiple sclerosis 2002
  • Johnson, T.D., Marsh, L.B., Ray, T., Drescher, K.M. The relative contribution of B cells and complement in protection of the brain from Theiler's murine encephalomyelitis virus. Minority summer student poster session 2002
  • Tracy et al, X!!th International COngress of Virology 2002
  • Modulation of activin/inhibin mRNA levels following TMEV infection XIIth International Congress of Virology (Paris, France) 2002
  • Theiler's Virus model of multiple sclerosis 2002
  • Ukpo,O.C., S.E. Hopkins and K.M. Drescher. Identification of apoptotic cells in the brains and spinal cords of TMEV-infected mice. Minority Summer Student Research Forum (Poster) 2001
  • Hopkins, S.E., O.C. Ukpo, and K.M. Drescher. Apoptosis in the brains of TMEV-infected C57BL6/J and B10.Q mice. Minority High School Student Research Forum (Poster). 2001
  • Texas A & M University - Neuroscience Seminar Series 2001
  • University of Nebraska Medical Center - Department of Cell Biology and Anatomy 2001
  • Cooper, D.M. and Drescher, K.M. - Regional ASM Meeting - oral presentation 2001
  • University of Nebraska Medical Center - Immunology Interest Group 2001
  • Cooper, D.C. and Drescher, K.D. Midwest Student Research Forum - poster 2001
  • Cooper, D.M. and Drescher, K.D. - Regional AAAS Meeting - poster 2000
  • Flores, N., Cooper, D.M. and Drescher, K.M. - Minority summer student poster session 2000
  • 10/22/99;VA Hospital;'Expression of the HLA-DR3 Transgene reduces the severity of demyelination in a viral model of multiple sclerosis' 1999

Awards

  • National Award
    Jr. Investigator Award
    NY Academy of Sciences