Clifford Gee, PhD

Department

Chemistry and Biochemistry

Position

Assistant Professor

Books

• , Applications of Fluorine Magnetic Resonance for Small-Molecule Screening, Ligand Development, and Oxygen Sensing 2017

Publications

• mBio
  Miao Yi, Shadrick William, Liu Jiuyu, Jenner Alexander R., Yadav Vikas, Lee Richard E., Brennan Richard G., Washington Erica J., Tenor Jennifer L., Nichols Connie B., Gee Clifford, Schäfer Martin, Perfect John R., Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways 2025
• Nature communications
  Scott Daniel C, Ochoada Jason, Miller Darcie J, Jayasinghe Thilina, Paulo Joao A, Dharuman Suresh, Griffith Elizabeth, Chai Sergio C, Ronnebaum Jarrid, Gee Clifford T, Elledge Stephen J, Harper J Wade, Chen Taosheng, Lee Richard E, King Moeko T, Tangallapally Rajendra, Lee Chan, Lee Ha Won, Yang Lei, Li Yong, Loudon Victoria C, Schulman Brenda A, Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2
  15:1, p. 8829 - 19 2024
• ACS Medicinal Chemistry Letters
  Buchholz Caroline R., Sneddon Molly S., Harki Daniel A., McPherson Joseph E., Das Sourav, Gee Clifford T., Grillo Michael J., Chai Sergio C., Lee Richard E., Chen Taosheng, Shelat Anang A., Pomerantz William C. K., Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors
  14:10 2023
• Molecular Cell
  Scott Daniel C., King Moeko T., Baek Kheewoong, Vaithiyalingam Sivaraja, Purser Nicholas, Nourse Amanda, Chai Sergio C., Chen Taosheng, Lee Richard E., Li Jerry, Elledge Stephen J., Kleiger Gary, Schulman Brenda A., Gee Clifford T., Kalathur Ravi, E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity
  83:5 2023
• Tuberculosis
  Fernando Dinesh M., Gee Clifford T., Griffith Elizabeth C., Meyer Christopher J., Wilt Laura A., Lee Richard E., Tangallapally Rajendra, Wallace Miranda J., Miller Darcie J., , Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringe
  132 2022
• Tuberculosis
  Fernando Dinesh M., Lee Richard E., Wilt Laura A., Gee Clifford T., Griffith Elizabeth C., Meyer Christopher J., Tangallapally Rajendra, Wallace Miranda J., Miller Darcie J., Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringent peptide binding pocket
  132 2022
• Journal of Medicinal Chemistry
  Cui Huarui, Hoell Zachariah J., Divakaran Anand, Johnson Jorden A., Ellingson Mikael O., Scholtz Cole R., Zahid Huda, Griffith Elizabeth C., Gee Clifford T., Harki Daniel A., Pomerantz William C. K., Aihara Hideki, Lee Amani L., Khanal Shalil, Shi Ke, Shah Vijay H., Lee Richard E., A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes
  65:3 2022
• Journal of Chemical Education
  Bur Scott K., Bade Morgan L., Pomerantz William C. K., Gee Clifford T., Fragment-Based Ligand Discovery Using Protein-Observed 19F NMR: A Second Semester Organic Chemistry CURE Project
  98:6 2021
• Nature Communications
  Yang Seung Wook, Min Jaeki, Miller Darcie J., Mayasundari Anand, Rodrigues Patrick, Griffith Elizabeth C., Gee Clifford T., Li Lei, Li Wei, Lee Richard E., Potts Patrick Ryan, Rankovic Zoran, Chen Taosheng, Lin Wenwei, Huang Xin, Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
  11:1 2020
• ACS Infectious Diseases
  Wallace Miranda J., Chen Taosheng, Lee Richard E., Lee Robin B., Griffith Elizabeth C., Phelps Gregory A., Wright William C., Dharuman Suresh, Fernando Dinesh M., Elmore John M., Yao Jiangwei, Reeve Stephanie M., Gee Clifford T., Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria
  6:3 2020
• ACS Infectious Diseases
  Grzegorzewicz Anna E., Liu Jiuyu, Jackson Mary, Belardinelli Juan Manuel, Jones Victoria, Mcneil Michael R., Lee Richard E., Das Sourav, Gee Clifford, Mechanisms of Resistance Associated with the Inhibition of the Dehydration Step of Type II Fatty Acid Synthase in Mycobacterium tuberculosis
  6:2 2020
• ChemBioChem
  Gee Clifford T., Arntson Keith E., Koleski Edward J., Staebell Rachel Lynn, Pomerantz William C. K., Dual Labeling of the CBP/p300 KIX Domain for 19F NMR Leads to Identification of a New Small-Molecule Binding Site
  19:9 2018
• Journal of Medicinal Chemistry
  Ayoub Alex M., Jiang Jiewei, Hawk Laura M.L., Herzig Ryan J., Wisniewski Andrea J., Gee Clifford T., Offei-Addo Nana K., Zhao Peiliang, Zhu Jin-Yi, Berndt Norbert, Scott Thomas G., Qi Jun, Bradner James E., Pomerantz William C.K., Ward Timothy R., Schönbrunn Ernst, Georg Gunda I., BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen
  60:12 2017
• ACS Nano
  Lee Amani L., Egger Sam M., Juelfs Adam R., Gee Clifford T., Weegman Bradley P., Einstein Samuel A., Ring Hattie L., Garwood Michael, Pomerantz William C. K., Haynes Christy L., Hurley Katie R., Swindlehurst Garrett, Oxygen Sensing with Perfluorocarbon-Loaded Ultraporous Mesostructured Silica Nanoparticles
  11:6 2017
• Journal of Chemical Education
  Gee Clifford T., Kehoe Eric, Pomerantz William C. K., Penn R. Lee, Quantifying Protein Concentrations Using Smartphone Colorimetry: A New Method for an Established Test
  94:7 2017
• Nature Protocols
  Gee Clifford T., Wisniewski Andrea J., Urick Andrew K., Mishra Neeraj K., Hawk Laura M.L., Pomerantz William C.K., Arntson Keith E., Protein-observed 19F-NMR for fragment screening, affinity quantification and druggability assessment
  11:8 2016
• RSC Advances
  Hawk Laura M. L., Pomerantz William C. K., Gee Clifford T., Urick Andrew K., Hu Haitao, Paramagnetic relaxation enhancement for protein-observed 19F NMR as an enabling approach for efficient fragment screening
  6:98 2016
• Angewandte Chemie - International Edition
  Gee Clifford T., Pomerantz William C. K., Koleski Edward J., Fragment screening and druggability assessment for the CBP/p300 KIX domain through protein-observed 19F NMR spectroscopy
  54:12 2015

Grants

• INBRE: Protein Tetris: Profiling Substrates of the Bacterial Peptide Transporters SaOpp3A and SaDtpT/Sponsor: University of Nebraska Medical Center/UNMC

• INBRE: Protein Tetris: Profiling the Substrates of Bacterial Transporters/Sponsor: University of Nebraska Medical Center/UNMC

Awards

• 2023 IGGY Award
  Office of Student Success