Kenneth Louis Kramer, PhD
Chair, Department of Medical Education
Associate Professor

Contact
School of Medicine
Graduate School
Neuroscience (Master of Science)
Medical Sciences (Master of Science)
Medical Education
HLSB - Hixson Lied Science Building
Kenneth Louis Kramer, PhD
Chair, Department of Medical Education
Associate Professor
Research Focus
The vertebrate inner ear relies on specialized bundles of cilia on the apical surface of sensory hair cells to transduce sound and movement into electrical signals. The Kramer Lab uses the transparency of the early zebrafish embryo to visualize how ciliary linkages to extracellular structures regulate inner ear function. Using modern genetic and imaging tools, we collaborate with several labs across campus to determine how zebrafish mutants and drug treatments affect hearing and balance behaviors.Curriculum Vitae
Curriculum Vitae: Kenneth L. Kramer, PhDDepartment
Medical Education
Position
Associate Professor
Articles
- Mechanisms of Development
KD Thiessen, SJ Grzegorski, Y Chin, LN Higuchi, CJ Wilkinson, JA Shavit, and KL Kramer. (2019). Zebrafish otolith biomineralization requires polyketide synthase. Mechanisms of Development 157: 1-9. PMC6531356.
157, p. 1-9 2019 - Scientific Data
CL Barta, H Liu, L Chen, Y Li, KP Giffen, KL Kramer, KW Beisel, DZ He. (2018) RNA-seq transcriptomic analysis of adult zebrafish inner ear hair cells. Scientific Data 5: 180005.
5, p. 180005 2018 - The Medical Student Press Journal
C Inserra and KL Kramer. (2015) Visualization of Stereocilin in the Developing Zebrafish Ear.
2 (2) 2015 - Cell Reports
MV Galanternik, KL Kramer, T Piotrowski.Heparan Sulfate Proteoglycans regulate Fgf signaling, ligand diffusion and cell polarity during collective cell migration
10 (3), p. 414–428 2015 - Developmental Dynamics
YW Lundberg, Y Xu, KD Thiessen, and KL Kramer. Mechanisms of otoconia and otolith development.
244 (3), p. 239-53 2014 - Angiogenesis
B Gorsi, F Liu, X Ma, TJ Chico, A Srinivasan, KL Kramer, E Bridges, R Monteiro, AL Harris, R Patient, and SE Stringer. The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity.
17(1) , p. 77-91 2013
Publications
- Experimental Biology
KP Giffen, H Liu, KL Kramer, and DZ He. (2019). Characterizing the Role of Kcnq5a in Zebrafish Inner Ear Hair Cells. Poster Presentation at Experimental Biology Annual Meeting. 2019 - Society for Neuroscience
LL Bruce, E Dorchuck, BN Hassman, A Mezher, O Olucha, and KL Kramer. (2018). The role of grp and grpr in the extinction of cued fear memory in zebrafish. 2018 - FASEB Journal
KD Thiessen, EM Supe, and KL Kramer. (2018). Zebrafish as a Model for Benign Paroxysmal Positional Vertigo.
32, p. 510.3 2018 - Annual MidWinter Research Meeting of the Association for research in Otolaryngology
KP Giffen, H Liu, L Chen, ST Stringham, KL Kramer, KW Beisel, and DZ He. (2018). Unique Expression of Gene Orthologs in Zebrafish and Mouse Non-sensory Supporting Cell Populations of the Inner Ear. 2018 - Annual MidWinter Research Meeting of the Association for research in Otolaryngology
H Liu, L Chen, KP Giffen, Y Li, KL Kramer, KW Beisel, and DZ He. (2018). Molecular Mechanisms Underlying Differences Between Zebrafish and Mouse Hair Cell Specializations. 2018 - Annual Meeting of the Society for Glycobiology
Kevin D. Thiessen and Kenneth L. Kramer. Keratan sulfate mediates zebrafish otolith development and growth. 2013 - 2013 Central Region IDeA Conference in Kansas City
Anne E. James, Kevin D. Thiessen, and Kenneth L. Kramer. Alpha-Tectorin mediates auditory hair cell attachment to zebrafish otoliths. 2013 - St. Albert's day/Creighton University Research day
Anne E. James, Kevin D. Thiessen, and Kenneth L. Kramer. The role of alpha-Tectorin in zebrafish inner ear development. 2013 - St. Albert's day/Creighton University Research day
Christopher R. DeVries, Kenneth L. Kramer, and Laura L. Bruce. Expression of glypican 3 in homologous amygdala-like regions of diverse vertebrates. 2013 - Annual MidWinter Research Meeting of the Association for research in Otolaryngology
Kevin D. Thiessen and Kenneth L. Kramer. Keratan sulfate mediates zebrafish otolith development. 2013
General
- Frontiers in Neuroscience
KP Giffen, H Liu, KL Kramer, and DZ He. (2019). Expression of protein-coding gene orthologs in zebrafish and mouse inner ear non-sensory supporting cells. Frontiers in Neuroscience 13: 1117.
13, p. 1117 2019
Presentations
- KD Thiessen, EM Supe, and KL Kramer. (2019). Otol1a as a Biomarker for Vestibular Dysfunction in Zebrafish. Poster Presentation at Bellucci Symposium. 2019
- KD Thiessen and KL Kramer. (2019). Balance and Biomarkers for Vestibular Disorders. Oral Presentation at the Omaha Veterans Administration Research Seminar Series. 2019
- CJ Altfillisch and KL Kramer. (2019). The Role of Stereocilin-B in Otolith Attachment. Poster Presentation at Midwest Student Biomedical Research Forum. 2019
- KP Giffen, H Liu, KL Kramer, and DZ He. (2019). Characterizing the Role of Kcnq5a in Zebrafish Inner Ear Hair Cells. Poster Presentation at Experimental Biology Annual Meeting. 2019
- KD Thiessen, EM Supe, and KL Kramer. (2019). Otol1a as a Biomarker for Vestibular Dysfunction in Zebrafish. Poster Presentation at Midwest Student Biomedical Research Forum. 2019
- AJ Blanck and KL Kramer. (2019). Characterizing the Role of Kinociliin in the Zebrafish Inner Ear. Poster Presentation at Midwest Student Biomedical Research Forum. 2019
- LL Bruce, E Dorchuck, BN Hassman, A Mezher, O Olucha, and KL Kramer. (2018). The role of grp and grpr in the extinction of cued fear memory in zebrafish. Poster Presentation at Society for Neuroscience. 2018
- N Choi, KL Kramer, and Bruce LL. (2018). Role of gastrin-releasing peptide and its receptor in zebrafish behavior. Oral Presentation at Annual Biomedical Research Conference for HS-MACA students. 2018
- KD Thiessen, EM Supe, and KL Kramer. Zebrafish Otolith Biomineralization Requires Polyketide Synthase. (2018). Poster presentation at International Zebrafish Society Conference. 2018
- KD Thiessen, EM Supe, and KL Kramer. (2018). Otolin-1a as a Biomarker for Vestibular Dysfunction Following Microgravity Exposure in Zebrafish. Poster presentation at COBRE External Advisory Committee Meeting. 2018
- KD Thiessen, EM Supe, and KL Kramer. Zebrafish as a Model for Benign Paroxysmal Positional Vertigo. (2018). Poster Presentation at Experimental Biology Annual Meeting. 2018
- KD Thiessen, EM Supe, and KL Kramer. (2018). Otolin-1a as a Biomarker for Vestibular Dysfunction Following Microgravity Exposure in Zebrafish. Oral presentation at Nebraska Academy of Sciences Annual Meeting. 2018
- E Supe, KD Thiessen, and KL Kramer. (2018). Zebrafish as a Model for Benign Paroxysmal Positional Vertigo. Poster Presentation at Creighton's St Albert's Day. 2018
- B Hassman, E Dorchuck, C Prince, K Reidelberger, KL Kramer, and LL Bruce. (2018). Comparison of behavioral tests to assess fear and anxiety in a teleost, Danio rerio, and an amphibian, Xenopus tropicalis. Poster Presentation at Creighton's St Albert's Day. 2018
- Zebrafish as a Model for Characterizing Biomarkers of Vestibular Dysfunction. Seminar at Boys Town National Research Hospital. 2018
- A Mezher, LL Bruce, KL Kramer. (2018). Evolution of Genetic Networks Regulating Fear Behaviors. Poster at Midwest Student Biomedical Research Forum. 2018
- ST Stringham, KP Giffen, H Liu, KL Kramer, and DZ He. (2018). Enrichment of Glutamate Transporter slc1A3 Orthologs in Zebrafish and Mouse Hair Cells of the Inner Ear. Poster at Midwest Student Biomedical Research Forum. 2018
- KP Giffen, H Liu, L Chen, ST Stringham, KL Kramer, KW Beisel, and DZ He. (2018). Unique Expression of Gene Orthologs in Zebrafish and Mouse Non-sensory Supporting Cell Populations of the Inner Ear. Poster at Midwest Student Biomedical Research Forum. 2018
- KP Giffen, H Liu, L Chen, ST Stringham, KL Kramer, KW Beisel, and DZ He. (2018). Unique Expression of Gene Orthologs in Zebrafish and Mouse Non-sensory Supporting Cell Populations of the Inner Ear. Poster Presentation at the Association of Research Otolaryngology Annual Meeting. 2018
- H Liu, L Chen, KP Giffen, Y Li, KL Kramer, KW Beisel, and DZ He. (2018). Molecular Mechanisms Underlying Differences Between Zebrafish and Mouse Hair Cell Specializations. Poster Presentation at the Association of Research Otolaryngology Annual Meeting. 2018
- B Hassman, E Dorchuck, C Prince, K Reidelberger, KL Kramer, and LL Bruce. (2017). Comparison of behavioral tests to assess fear and anxiety in a teleost, Danio rerio, and an amphibian, Xenopus tropicalis. Poster Presentation at Society for Neuroscience. 2017
- CJ Altfillisch, DB Nerland, CJ Inserra, MF Chlopek, and KL Kramer. (2017). Stereocilin-b Tethers the Zebrafish Otolith to Sensory Hair Cell in the Inner Ear. Poster at Experimental Biology Annual Meeting. 2017
- KD Thiessen, LN Higuchi, and KL Kramer. Polyketide Synthase is Required for Zebrafish Otolith Biomineralization. (2017). Poster Presentation at Experimental Biology Annual Meeting. 2017
- B Hassman, E Dorchuck, KL Kramer, and LL Bruce. (2017). Behavioral Tests for Assessing Learning in Xenopus Tropicalis. Oral Presentation at The Nebraska Academy of Sciences Annual Meeting. 2017
- CL Harrison and KL Kramer. Characterization of Specific Glycans in the Zebrafish Inner Ear. (2017). Poster Presentation at Creighton Honors Day. 2017
- SH Byer, LL Bruce, and KL Kramer. Understanding the Role of Amygdalar Proteoglycan Glypican-3 in Zebrafish Aversive Behavior Response. (2017). Poster Presentation at Creighton Honors Day. 2017
- CJ Altfillisch, DB Nerland, CJ Inserra, MF Chlopek, and KL Kramer. (2017). Stereocilin-b Tethers the Zebrafish Otolith to Sensory Hair Cell in the Inner Ear. Poster Presentation at Creighton's St Albert's Day. 2017
- E Supe, KD Thiessen, and KL Kramer. (2017). Zebrafish as a Model for Benign Paroxysmal Positional Vertigo. Poster Presentation at Creighton's St Albert's Day. 2017
- HJ Lang, and KL Kramer. (2017). Investigation of Enhancers that Drive Specific Expression in the Amygdala. Poster Presentation at Creighton's St Albert's Day. 2017
- CL Harrison and KL Kramer. (2017). Characterization of Specific Glycans in the Zebrafish Inner Ear. Poster Presentation at Creighton's St Albert's Day. 2017
- KD Thiessen, LN Higuchi, and KL Kramer. (2017). Polyketide Synthase is Required for Zebrafish Otolith Biomineralization. Poster Presentation at Midwest Student Biomedical Research Forum. 2017
- JE Marvin and KL Kramer. (2017). The glycosyltransferase Loki uses a high-energy donor to indirectly transglycosylate methylumbelliferone. Poster at Midwest Student Biomedical Research Forum. 2017
- JH Werner, KL Kramer, and LL Bruce. (2017). Localizing Homologs of Gene-Specific Amygdalar Neurons in the Chicken Brain, Gallus Gallus Domesticus. Poster at Midwest Student Biomedical Research Forum. 2017
- CJ Inserra and KL Kramer. Stereocilin Paralogs Have Distinct Roles in Zebrafish Inner Ear Development. Poster Presentation at the Association of Research Otolaryngology Annual Meeting. 2017
- B Timm, KL Kramer, and LL Bruce. (2016). Localizing homologs of gene specific amygdalar areas in embryonic chick brain Gallus gallus domesticus. Poster Presentation at Annual Biomedical Research Conference for HS-MACA students. 2016
- "Sugar Balance: How Glycans Control Inner Ear Development" 2016
- Catharine N Kral, Benjamin F Kopecky, and Kenneth L Kramer. TECTA, Otog, and Otogl Influence Zebrafish Otolith Organization. Poster Presentation at Creighton Honor's Day. 2016
- Catharine N Kral, Benjamin F Kopecky, and Kenneth L Kramer. TECTA, Otog, and Otogl Influence Zebrafish Otolith Organization. Poster Presentation at St. Albert's Day. 2016
- Kevin D Thiessen and Kenneth L Kramer. Role of Otolin-1b During Otolith Nucleation in Zebrafish. Oral Presentation at St. Albert's Day. 2016
- KD Thiessen and KL Kramer. The Otolithic Membrane Mediates Otolith Organization. Poster Presentation at Experimental Biology Annual Meeting 2016
- C Barta, H Liu, KL Kramer, KW Beisel, DZ He. (2016). Transcriptome Characterization of Adult Zebrafish Inner-Ear Hair Cells. Poster Presentation at the Association of Research Otolaryngology Annual Meeting. 2016
- EW Villanueva and KL Kramer. Age-Related Changes in the Inner Ear of the Adult Zebrafish. Poster Presentation at Creighton Honor's Day. 2015
- C Altfillisch, K Arnold, L Higuchi, KL Kramer, MG Nichols, HC Jensen Smith. Differences in Aminoglycoside Entry and Mitochondrial Metabolism in Regenerative and Non-Regenerative Sensory. Poster Presentation at St. Albert's Day. 2015
- K Arnold, C Altfillisch, L Higuchi, KL Kramer, MG Nichols, HC Jensen Smith. Differences in Mitochondrial Metabolism in Regenerative and Non-Regenerative Sensory. Poster Presentation at St. Albert's Day. 2015
- KD Thiessen and KL Kramer. Endolymph facilitates otolith nucleation in early zebrafish ear development. Poster Presentation at St. Albert's Day. 2015
- CJ Inserra and KL Kramer. Visualization of Stereocilin in the developing zebrafish ear. Poster Presentation at Midwest Student Biomedical Research Forum. 2015
- KD Thiessen and KL Kramer. Endolymph facilitates otolith nucleation in early zebrafish ear development. Poster Presentation at Midwest Student Biomedical Research Forum. 2015
- Otolith organization is mediated by otogelin-like. Oral Presentation at the Association of Research Otolaryngology Annual Meeting. 2015
- "Otogelin in Zebrafish Otolith Attachment and Organization" 2014
- Seeding zebrafish otoliths: sweet & salty mediators of zebrafish ear development 2014
- "From Sweet to salty: mediators of zebrafish ear development" 2013
- Development of hearing in zebrafish. 2013
- Keratan sulfate mediates zebrafish ear development. 2013
State
Role of Glycosaminoglycans in Zebrafish Development
Direct analysis of glycans during zebrafish development
Federal
Role of Keratan Sulfate in Zebrafish Ear Development
Other
Role of Kinocilia-Specific Proteins in Zebrafish Vestibular Function.
Role of gpc3 in fear behavior. CURAS Faculty Research Fund.
ZOIC-Zebrafish in Omaha Inner City Classrooms
Awards
- Golden Apples
CUSOM Class of 2025 and the Class of 2024 - Teaching for Tomorrow Faculty Award
Creighton University Student Union - Golden Apple Award
Class of 2022, Creighton University School of Medicine - Dedicated Teaching Award
Creighton University School of Medicine - Course/Clerkship Director Award
Creighton University School of Medicine - Basic Science Teaching Scholar Award
Creighton University School of Medicine