Alexandra R . Lucas, MD
Professor
Department
Medicine (Phoenix)
Position
Professor
Books
- , Chemokine-Glycosaminoglycan Interactions 2023
- Zanetti I. R., Mouse Models of Renal Allograft Transplant Rejection: Methods to Investigate Chemokine–GAG Interaction and Therapeutic Blockade 2023
- Chen P., Mouse Corneal Transplantation 2023
- Guo Q., Preclinical Testing of Viral Therapeutic Efficacy in Pristane-Induced Lupus Nephritis and Diffuse Alveolar Hemorrhage Mouse Models 2021
- Zhang L., Topical Application of Virus-Derived Immunomodulating Proteins and Peptides to Promote Wound Healing in Mouse Models 2021
- Lucas A., Overview of serpins and their roles in biological systems 2018
- Maldonado J., Next-generation sequencing library preparation for 16S rRNA microbiome analysis after serpin treatment 2018
- Ambadapadi S., Serpins, viruses, and the virome: New directions in therapy [Book Chapter] 2015
- Chen H., Viral serpin therapeutics: From concept to clinic 2011
- Rahman M. M., Viral TNF inhibitors as potential therapeutics 2009
- Lucas A., The serpin saga; development of a new class of virus derived anti-inflammatory protein immunotherapeutics 2009
- Bartee M. Y., Chapter 10 M-T7. Measuring Chemokine-Modulating Activity 2009
- Canham P. B., Collagen organization and biomechanics of the arteries and aneurysms of the human brain [Book Chapter] 2006
- Nash P., Serp-1, a poxvirus-encoded serpin, is expressed as a secreted glycoprotein that inhibits the inflammatory response to myxoma virus infection 1997
Publications
- Journal for immunotherapy of cancer
Li Xuemei, FXa-mediated PAR-2 promotes the efficacy of immunotherapy for hepatocellular carcinoma through immune escape and anoikis resistance by inducing PD-L1 transcription
12:7, p. e009565 2024 - Nature communications
Dodd-O Joseph, Author Correction: Antiviral fibrils of self-assembled peptides with tunable compositions
15:1, p. 1505 - 1505 2024 - Biomolecules (Basel, Switzerland)
Varkoly Kyle, Viral SERPINS—A Family of Highly Potent Immune-Modulating Therapeutic Proteins
13:9, p. 1393 2023 - EMBO molecular medicine
Zhang Liqiang, Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV ‐2 mouse models of infection, p. e17376 - e17376 2023 - EMBO Molecular Medicine
C Bouton M., The under-appreciated world of the serpin family of serine proteinase inhibitors
15:6 2023 - Digestive diseases and sciences
Feng Y., Retraction Note to: A Novel Method for the Prevention and Treatment of Small‑for‑Size Syndrome in Liver Transplantation(Digestive Diseases and Sciences, (2020), 65, (2619–2629), 10.1007/s10620-020-06055-2)
68:1 2023 - Methods in molecular biology (Clifton, N.J.)
Zanetti Isabela R, Mouse Models of Renal Allograft Transplant Rejection: Methods to Investigate Chemokine-GAG Interaction and Therapeutic Blockade
2597 2022 - Pathogens
Zanetti I. R., Virus-Derived Chemokine Modulating Protein Pre-Treatment Blocks Chemokine–Glycosaminoglycan Interactions and Significantly Reduces Transplant Immune Damage
11:5 2022 - Cancers
Christie J. D., Systemic Delivery of mLIGHT-Armed Myxoma Virus Is Therapeutic for Later-Stage Syngeneic Murine Lung Metastatic Osteosarcoma
14:2 2022 - Current Neuropharmacology
Kwiecien J. M., The role of astrogliosis in formation of the syrinx in spinal cord injury
19:2 2021 - Frontiers in Public Health
Fath A. R., Chronological Impact of Earthquakes on Blood Pressure: A Literature Review and Retrospective Study of Hypertension in Haiti Before and After the 2010 Earthquake
8 2021 - Biomedicines
Kwiecien J. M., Neuroprotective effect of subdural infusion of serp-1 in spinal cord trauma
8:10 2020 - Pharmaceutics
Yaron J. R., Recombinant myxoma virus‐derived immune modulator m‐t7 accelerates cutaneous wound healing and improves tissue remodeling
12:11 2020 - Journal of Clinical Medicine
Yaron J. R., Deriving immune modulating drugs from viruses— AA new class of biologics
9:4 2020 - Trends in molecular medicine
Yaron J. R., Modifying the Organ Matrix Pre-engraftment: A New Transplant Paradigm?
25:7 2019 - Folia Neuropathologica
Kwiecien J. M., Myxoma virus derived immune modulating proteins, M-T7 and Serp-1, reduce early inflammation after spinal cord injury in the rat model
57:1 2019 - Biochemistry
Mahon B. P., Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function
57:7 2018 - Cardiovascular and Hematological Disorders - Drug Targets
Al-Ani M., Atrial fibrillation ablation increases inflammation-chemokine modulation suppresses activation of leukocytes isolated after ablation
17:3 2017 - PLoS ONE
Kwiecien J. M., Loss of Kaiso expression in breast cancer cells prevents intra-vascular invasion in the lung and secondary metastasis
12:9 2017 - Infection and immunity
Velsko I. M., Periodontal pathogens invade gingiva and aortic adventitia and elicit inflammasome activation in αvβ6 integrin-deficient mice
83:12 2015 - Pathogens and Disease
Chukkapalli S. S., Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers
73:3 2015 - PLoS ONE
Velsko I. M., Fusobacterium nucleatum alters atherosclerosis risk factors and enhances inflammatory markers with an atheroprotective immune response in ApoEnull mice
10:6 2015 - Journal of Clinical and Experimental Cardiology
Lucas A., The virome: Viral ghost companion, virus wars
5:8 2014 - Journal of Clinical and Experimental Cardiology
Lucas A., Women in cardiology: The x factor and the heart of medicine
5:2 2014 - European Journal of Inflammation
Davids J. A., Viral anti-inflammatory proteins target diverging immune pathways with converging effects on arterial dilatation, plaque and apoptosis
12:1 2014 - PLoS ONE
Lucas A. R., Myxomavirus anti-inflammatory chemokine binding protein reduces the increased plaque growth induced by chronic porphyromonas gingivalis oral infection after balloon angioplasty aortic injury in mice
9:10 2014 - Cardiovascular and Hematological Disorders - Drug Targets
Chen H., The serpin solution; targeting thrombotic and thrombolytic serine proteases in inflammation
13:2 2013 - Journal of Cancer Science and Therapy
Zheng D., Myxomaviral anti-inflammatory serpin reduces myeloid-derived suppressor cells and human pancreatic cancer cell growth in mice
5:8 2013 - Cardiovascular and Hematological Disorders - Drug Targets
Zheng D., Serpins for diagnosis and therapy in cancer
13:2 2013 - Cardiovascular and Hematological Disorders - Drug Targets
Lucas A., Serpins as therapeutics - A potential biologic source for unique protein-based therapeutics
13:2 2013 - Antimicrobial Agents and Chemotherapy
Chen H., Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection
57:9 2013 - PLoS ONE
Rivera M. F., Polymicrobial Infection with Major Periodontal Pathogens Induced Periodontal Disease and Aortic Atherosclerosis in Hyperlipidemic ApoEnull Mice
8:2 2013 - Trends in molecular medicine
Zheng D., Virus-derived anti-inflammatory proteins: Potential therapeutics for cancer
18:6 2012 - Current Drug Delivery
Kennedy K. L., Local delivery of therapeutics for percutaneous coronary intervention
8:5 2011 - Infection and immunity
Nahid M. A., Polymicrobial infection with periodontal pathogens specifically enhances microRNA miR-146a in ApoE-/- mice during experimental periodontal disease
79:4 2011 - Photochemistry and photobiology
Korol R. M., Detection of altered extracellular matrix in surface layers of unstable carotid plaque: An optical spectroscopy, birefringence and microarray genetic analysis
87:5 2011 - Circulation: Cardiovascular Interventions
Lucas Alexandra, A randomized controlled, phase 2 trial of the viral serpin serp-1 in patients with acute coronary syndromes undergoing percutaneous coronary intervention
3:6 2010 - Thrombosis and haemostasis
Munuswamy-Ramanujam G., Neuroserpin, a thrombolytic serine protease inhibitor (serpin), blocks transplant vasculopathy with associated modification of T-helper cell subsets
103:3 2010 - Journal of leukocyte biology
Viswanathan K., Myxoma viral serpin, serp-1, inhibits human monocyte adhesion through regulation of actin-binding protein filamin B
85:3 2009 - Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry
Davids J. A., Viral anti-inflammatory proteins: The potential for immunotherapeutic applications in cancer
7:2 2008 - Journal of Biomedical Optics
Korol R. M., Fluorescence spectroscopy and birefringence of molecular changes in maturing rat tail tendon
12:2 2007 - Cardiovascular Pathology
Richardson M., Viral serpin, Serp-1, inhibits endogenous angiogenesis in the chicken chorioallantoic membrane model
16:4 2007 - Transplantation
Jiang J., Induction of indefinite cardiac allograft survival correlates with toll-like receptor 2 and 4 downregulation after serine protease inhibitor-1 (Serp-1) treatment
84:9 2007 - Endocrine, Metabolic and Immune Disorders - Drug Targets
Munuswamy-Ramanujam G., Viral anti-inflammatory reagents: The potential for treatment of arthritic and vasculitic disorders
6:4 2006 - Frontiers in Bioscience
Richardson J., Serpins, the vasculature, and viral therapeutics
11:1 P.889-1198 2006 - Journal of Biological Chemistry
Dai E., Identification of myxomaviral serpin reactive site loop sequences that regulate innate immune responses
281:12 2006 - Circulation
Lucas A. R., Inflammation in atherosclerosis: Some thoughts about acute coronary syndromes
113:17 2006 - Transplantation
Bédard E. L. R., Prevention of chronic renal allograft rejection by SERP-1 protein
81:6 2006 - Current Drug Targets - Cardiovascular and Haematological Disorders
Lucas A., Editorial
5:1 2005 - Photochemistry and photobiology
Christo A., In vivo optical analysis of quantitative changes in collagen and elastin during arterial remodeling
81:2 2005 - Virology
Cameron C. M., Myxoma virus M128L is expressed as a cell surface CD47-like virulence factor that contributes to the downregulation of macrophage activation in vivo
337:1 2005 - Journal of Immunology
Lucas A., Secreted immunomodulatory viral proteins as novel biotherapeutics
173:8 2004 - Transplantation
Liu L., Viral chemokine-binding proteins inhibit inflammatory responses and aortic allograft transplant vasculopathy in rat models
77:11 2004 - Current Drug Targets - Cardiovascular and Haematological Disorders
Lucas A., Preface
2:1 2002 - Lucas A., Circulating blood cells trigger acute inflammatory responses in the artery wall 2002
- Christov A., Fluorescence spectroscopic analysis (FSA) detects quantitative changes in atherosclerotic plaque collagen and elastin content in vivo 2002
- Current drug targets.Cardiovascular & haematological disorders
Bocksch L., Apolipoprotein E: possible therapeutic target for atherosclerosis.
1:2 2001 - Lasers in surgery and medicine
Christov A., Fluorescence spectroscopic analysis of circulating platelet activation during coronary angioplasty
28:5 2001 - Journal of the American College of Cardiology
Zalai C. V., Increased circulating monocyte activation in patients with unstable coronary syndromes
38:5 2001 - Photochemistry and photobiology
Christov A., Optical detection of triggered atherosclerotic plaque disruption by fluorescence emission analysis
72:2 2000 - Proceedings of SPIE - The International Society for Optical Engineering
Christov A., Laser-induced Fluorescence Spectroscopy (LFS): Detection of unstable thrombogenic atherosclerotic plaque formation in a rabbit model - A first look diagnostic approach
4161 2000 - Radiology
Clarke S. E., Comparison of two blood pool contrast agents for 0.5-T MR angiography: Experimental study in rabbits
214:3 2000 - Journal of Clinical Investigation
Liu L., The vital anti-inflammatory chemokine-binding protein M-T7 reduces intimal hyperplasia after vascular injury
105:11 2000 - Christov A., A three tiered fluorescence-based system for monitoring activation-related changes in human platelets 2000
- Metabolism: Clinical and Experimental
Hatton M. W. C., Metabolism and distribution of the virus-encoded serine proteinase inhibitor SERP-1 in healthy rabbits
49:11 2000 - Journal of Heart and Lung Transplantation
Lucas A., Transplant vasculopathy: Viral anti-inflammatory serpin regulation of atherogenesis
19:11 2000 - Circulation
Miller L. W., Inhibition of transplant vasculopathy in a rat aortic allograft model after infusion of anti-inflammatory viral serpin
101:13 2000 - Photochemistry and photobiology
Christov A. M., Laser-induced fluorescence (LIF) recognition of the structural composition of porcine heart valves
69:3 1999 - Lasers in surgery and medicine
Christov A., Detection of transplant vasculopathy in a rat aortic allograft model by fluorescence spectroscopic optical analysis
24:5 1999 - Virology
Lalani A. S., Role of the myxoma virus soluble CC-chemokine inhibitor glycoprotein, M- T1, during myxoma virus pathogenesis
256:2 1999 - Virology
Hnatiuk S., Role of the C-terminal RDEL motif of the myxoma virus M-T4 protein in terms of apoptosis regulation and viral pathogenesis
263:2 1999 - Virology
Graham K. A., The T1/35kDa family of poxvirus-secreted proteins bind chemokines and modulate leukocyte influx into virus-infected tissues
229:1 1997 - Arteriosclerosis, Thrombosis, and Vascular Biology
Dai E., Calreticulin, a potential vascular regulatory protein, reduces intimal hyperplasia after arterial injury
17:11 1997 - Lasers in surgery and medicine
Bauer J., Comparative study of Nd:YAG laser angioplasty at 1.06 μm, 1.32 μm, and 1.44 μm wavelengths: Decreased vascular spasm and early mortality with 1.44 μm laser ablation
19:3 1996 - Atherosclerosis
Lucas A., Development of an avian model for restenosis
119:1 1996 - Circulation
Lucas A., Virus-encoded serine proteinase inhibitor SERP-1 inhibits atherosclerotic plaque development after balloon angioplasty
94:11 1996 - Virology
Mossman K., Myxoma virus M-T7, a secreted homolog of the interferon-γ receptor, is a critical virulence factor for the development of myxomatosis in European rabbits
215:1 1996 - Pacing and Clinical Electrophysiology
PERK M., Laser Induced Fluorescence Identification of Sinoatrial and Atrioventricular Nodal Conduction Tissue
16:8 1993 - American Heart Journal
Lucas A. R., Angiographic contrast media interference with laser-induced fluorescence excitation and detection in atherosclerotic human coronary arteries
121:1 PART 1 1991 - American Heart Journal
Gal D., Atherosclerotic Yucatan microswine: An animalmodel with high-grade, fibrocalcific, nonfatty lesions suitable for testing catheter-based interventions
119:2 PART 1 1990 - Lasers in surgery and medicine
Gaffney E. J., Correlation of fluorescence emission with the plaque content and intimal thickness of atherosclerotic coronary arteries
9:3 1989 - The American Journal of Cardiology
Desnoyers M. R., Clinical and noninvasive hemodynamic results after aortic balloon valvuloplasty for aortic stenosis
62:16 1988 - Virology
Lucas A., In vivo and in vitro models of demyelinating diseases II. Persistence and host-regulated thermosensitivity in cells of neural derivation infected with mouse hepatitis and measles viruses
88:2 1978 - Cell
Lucas A., In vivo and in vitro models of demyelinating diseases: Tropism of the JHM strain of murine hepatitis virus for cells of glial origin
12:2 1977