Thomas F . Murray, PhD

Department

Pharmacology and Neuroscience

Position

Adjunct Professor

Articles

• Organic & Biomolecular Chemistry
  Philkhana SC, Mehrotra S, Murray TF, Reddy DS. Synthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers toward neuroprotection.
  14, p. 8457-73 2016
• Journal of Medicinal Chemistry
  Joshi AA, Murray TF, Aldrich JV. Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin
  58(22), p. 8783-95 2015
• PLoS One
  Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick WH. Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows.
  10(7), p. e0133297 2015
• Marine Drugs
  Murray,TF,Z.Cao,X. Li,X.Zou,M.Greenwood,WH Gerwick. Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons.
  13(2), p. 903-19 2015
• Journal of Natural Products
  Maio,WA,S.Mehrotra,BM Duggan,R.Tello-Aburto,TD Newar,WH Gerwick,TF Murray. Detailed Analysis of (-)-Palmyrolide A and Some Synthetic Derivatives as Voltage-Gated Sodium Channel Antagonists.
  77(11), p. 2553-60 2014
• Journal of Pharmacology and Experimental Therapeutics
  Cao Z, Cui Y, Busse E, Mehrotra S, Rainier JD, Murray TF. Gambierol inhibition of voltage-gated potassium channels augments spontaneous Ca2+ oscillations in cerebrocortical neurons.
  350(3), p. 615-23 2014
• British Journal of Pharmacology
  Aldrich JV, Senadheera SN, Ross NC, Reilley KA, Ganno ML, Eans SE, Murray TF, McLaughlin JP. Alanine Analogs of [D-Trp]CJ-15,208: Novel Opioid Activity Profiles and Prevention of Drugs-and Stress-Induced Reinstatement of Cocaine-Seeking Behavior.
  171(13), p. 3212-22 2014
• Journal of Pharmacology and Experimental Therapeutics
  Cao Z,Cui Y, Busse E, Mehrotra S,Rainier JD, Murray TF, Gambierol inhibition of voltage-gated potassium channels augments spontaneous Ca2+ oscillations in cerebrocortical neurons.
  Epub Ahead of print, p. 114.215319 2014
• ACS Med Chem Lett
  Lesma G,Salvadori S, Airaghi F, Murray TF, Recca T, Sacchetti A, Balboni G, Silvani A. Structural and biological exploration of Phe(3)-Phe(4)-modified endomorphin-2 peptidomimetics.
  4(8), p. 795-99 2014
• Biochem Biophys Acta
  Li H, Bowling JJ, Frionczek FR, Hong J, Jabba SV, Murray TF, Ha NC, Hamann MT, Jung JH, Asteropsin A: An unusual cystine-crosslinked peptide from porifera enhances neuronal Ca(2+) influx
  1830(3), p. 2591-9 2013
• Proceedings of the National Academy of Sciences
  George J, Baden D, Gerwick WH, Murray TF. Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity
  109 (48), p. 19840-45 2012
• Journal of Pharmacology and Experimental Therapeutics
  Reith M, Ali S, Hashim A, Sheikh IS, Theddu N, Gaddiraju NV, Mehrotra S, Schmitt KC, Murray TF, Sershen H, Unterwald EM, Davis FS. Novel C-1 Substituted Cocaine Analogues Unlike Cocaine or Benztropine
  Epub Ahead of print, p. jpet#193771 2012
• Journal of Organic Chemistry
  Nunnery, JK, Engene N, Byrum T, Cao Z, Jabba SV, Pereira AR, Matainaho T, Murray TF, Gerwick WH. Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.
  77 (9), p. 4198-4208 2012
• Journal of Natural Products
  Malloy KL,Suyama TL,Engene N,Debonsi H,Cao Z,Matainaho T,Spadafora C,Murray TF,Gerwick WH.Credneramides A and B: neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.
  22148360, p. Epub ahead of print 2011
• Journal of Natural Products
  Engene N, Choi H, Esquenazi E, Byrum T, Villa FA, Cao Z, Murray TF, Dorrestein PC, Gerwick L, Gerwick WH.Phylogeny-Guided Isolation of Ethyl Tumonoate A from the Marine Cyanobacterium cf. Oscillatoria margaritifera.
  74(8), p. 1737-1743 2011
• ChemMedChem
  Aldrich JV, Kulkarni SS, Senadheera SN, Ross NC, Reilley KJ, Eans SO, Ganno ML, Murray TF, McLaughlin JP.Unexpected Opioid Activity Profiles of Analogues of the Novel Peptide Kappa Opioid Receptor Ligand CJ-15,208.
  10.1002, p. Epub ahead of print 2011
• British Journal of Pharmacology
  Ross NC, Reilley KJ, Murray TF, Aldrich JV, McLaughlin JP. Novel opioid cyclic tetrapeptides: Trp isomers of CJ-15,208 exhibit distinct opioid receptor agonism and short-acting kappa opioid receptor antagonism. , p. Epub ahead of print 2011
• Environmental Health Perspectives
  Cao Z, Shafer TJ, Crofton KM, Gennings C, Murray TF. Additivity of Pyrethroid Actions on Sodium Influx in Cerebrocortical Neurons in Primary Culture. , p. Epub ahead of print 2011
• Molecular Pharmacology
  Kelamangalath L, Dravid SM, George J, Aldrich JV, Murray TF. Kappa-Opioid receptor inhibition of calcium oscillations in spinal cord neurons.
  79(6), p. 1061-71 2011
• Journal of Pharmacology and Experimental Therapeutics
  Cao Z, Shafer TJ, Murray TF. Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons.
  336(1), p. 197-205 2011
• Biopolymers
  Fang WJ, Bennett MA, Murray TF, Aldrich JV. Deletion of Ac-NMePhe(1) from [NMePhe(1) ]arodyn under acidic conditions, part 2: effects of substitutions on pharmacological activity.
  96(1), p. 103-10 2011
• BMC Neuroscience
  Cao Z, Gerwick WH, Murray TF. Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNa(v)1.2, rNa(v)1.4 and rNa(v)1.5 alpha subunits.
  11, p. 154 2010
• Organic Letters
  Pereira AR, Cao Z, Engene N, Soria-Mercado IE, Murray TF, Gerwick WH. Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria.
  12(20):, p. 4490-3 2010
• Journal of Natural Products
  Choi H, Pereira AR, Cao Z, Shuman CF, Engene N, Byrum T, Matainaho T, Murray TF, Mangoni A, Gerwick WH. The hoiamides, structurally intriguing neurotoxic lipopeptides from Papua New Guinea marine cyanobacteria.
  73(8), p. 1411-21 2010
• Biopolymers
  Fang WJ, Bennett MA, Murray TF, Aldrich JV.Deletion of Ac-NMePhe(1) from [NMePhe(1)]arodyn under Acidic Conditions: 2. effects of substitutions on pharmacological activity.PMID: 20560148 [PubMed - as supplied by publisher] 2010
• Toxicon
  Suyama TL, Cao Z, Murray TF, Gerwick WH. Ichthyotoxic brominated diphenyl ethers from a mixed assemblage of a red alga and cyanobacterium: structure clarification and biological properties. PMID: 19638282 [PubMed - indexed for MEDLINE]
  55(2-3), p. 204-10 2010
• Toxicological sciences
  Cao Z, LePage KT, Frederick MO, Nicolaou KC, Murray TF.Involvement of caspase activation in azaspiracid-induced neurotoxicity in neocortical neurons.PMID: 20047973 [PubMed - indexed for MEDLINE]
  114(2), p. 323-34 2010
• JPET
  Jabba SV, Prakash A, Dravid SM, Gerwick WH, Murray TF.Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels.PMID: 20026674 [PubMed - indexed for MEDLINE]
  332(3), p. 698-709 2009
• Journal of Medicinal Chemistry
  Sinha B, Cao Z, Murray TF, Aldrich JV. Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors.PMID: 19621878 [PubMed - indexed for MEDLINE]
  52(23), p. 7372-5 2009
• Journal of Medicinal Chemistry
  Patkar KA, Murray TF, Aldrich JV. The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues.PMID: 19807094 [PubMed - indexed for MEDLINE]
  52(21), p. 6814-21 2009
• Organic Letters
  Soria-Mercado IE, Pereira A, Cao Z, Murray TF, Gerwick WH.Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii.PMID: 19754100 [PubMed - indexed for MEDLINE]
  11(20), p. 4704-7 2009
• Journal of Medicinal Chemistry
  Fang WJ, Cui Y, Murray TF, Aldrich JV. Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis. PMID: 19715279 [PubMed - indexed for MEDLINE]
  52(18), p. 5619-25 2009
• Chemistry & Biology
  Pereira A, Cao Z, Murray TF, Gerwick WH. Hoiamide a, a sodium channel activator of unusual architecture from a consortium of two papua new Guinea cyanobacteria. PMID: 19716479 [PubMed - indexed for MEDLINE]
  16(8), p. 893-906 2009
• J. Neurosci.
  George J, Dravid SM, Prakash A, Xie J, Peterson J, Jabba SV, Baden DG, Murray TF. Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons. PMID: 19279266 [PubMed - indexed for MEDLINE]
  29(10), p. 3288-301 2009
• Bioconjug Chem.
  Aldrich JV, Kumar V, Murray TF, Guang W, Wang JB. Dual labeled peptides as tools to study receptors: nanomolar affinity derivatives of TIPP (Tyr-Tic-Phe-Phe) containing an affinity label and biotin as probes of delta opioid receptors. PMID: 19175314 [PubMed - indexed for MEDLINE]
  20(2), p. 201-4 2009
• Journal of Pharmacology and Experimental Therapeutics
  Cao Z, George J, Gerwick WH, Baden DG, Rainier JD, Murray TF. Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons. Epub 2008 Apr 30. PMID: 18448863 [PubMed - indexed for MEDLINE
  326(2), p. 604-13 2008
• American Journal of Veterinary Research
  Figueiredo MD, Moore JN, Vandenplas ML, Sun WC, Murray TF. Effects of the second-generation synthetic lipid A analogue E5564 on responses to endotoxin in [corrected] equine whole blood and monocytes.
  69(6), p. 796-803 2008
• Vet Immunol Immunopathol
  Sun WC, Moore JN, Hurley DJ, Vandenplas ML, Linden J, Cao Z, Murray TF. Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes.
  121(1-2), p. 91-100 2008
• Brain Res
  Cao Z, George J, Baden DG, Murray TF. Brevetoxin-induced phosphorylation of Pyk2 and Src in murine neocortical neurons involves distinct signaling pathways.
  1184, p. 17-27 2007
• Journal of Pharmacology and Experimental Therapeutics
  LePage KT, Rainier JD, Johnson HW, Baden DG, Murray TF. Gambierol acts as a functional antagonist of neurotoxin site 5 on voltage-gated sodium channels in cerebellar granule neurons.
  323(1), p. 174-9 2007
• American Journal of Veterinary Research
  Sun WC, Moore JN, Hurley DJ, Vandenplas ML, Linden JM, Murray TF. Pharmacologic characterization of novel adenosine A2A receptor agonists in equine neutrophils.
  68(9), p. 981-7 2007
• American Journal of Veterinary Research
  Sun, W-C., Moore, J.N., Hurley, D.J., Vadenplas, M.L. and Murray, T.F. Adenosine A2A receptor stimulation inhibits LPS-induced production of ROS by equine neutrophils in a cAMP-dependent, PKA-independent manner.
  68, p. 649-656 2007
• Journal of Physiology
  Dravid S.M., Erreger K., Yuan H., Nicholson K., Le P., Lyuboslavsky P., Almonte A., Murray E., Mosely C., Barber J., French A., Balster R., Murray T.F., Traynelis S.F. Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block.
  581, p. 107-128 2007
• Inhalation Toxicology
  Yan X, Benson JM, Gomez AP, Baden DG, Murray TF. Brevetoxin-induced neural insult in the retrosplenial cortex of mouse brain.
  18, p. 1109-1116 2006
• Journal of Veterinary Pharmacology and Therapeutics
  Brandon, C.I., Vandenplas, M., Dookwah, H., Linden, J. and Murray, T.F. Cloning and pharmacological characterization of the equine adenosine A2A receptor: a potential therapeutic target for the treatment of equine.
  29, p. 243-253 2006
• Journal of Veterinary Pharmacology and Therapeutics
  Brandon, C.I., Vandenplas, M., Dookwah, H. and Murray, T.F. Cloning and pharmacological characterization of the equine adenosine A3 receptor.
  29, p. 255-263 2006

Presentations

• S. Mehrotra and T.F. Murray. Regulation of cerebrocortical neuron spontaneous Ca2+ oscillations by metabotropic glutamate receptors. Program/Poster 120.03/A86. 2015 Neuroscience Meeting Planner. Chicago, IL, Society for Neuroscience, 2015. Online 2015
• Society for Neuroscience 2014 Annual Meeting, Washington DC, "Sodium Channel Activator-stimulated Neurite Outgrowth Involves the Brain-derived Neurotrophic Factor (BDNF) - Tropomyosin related Kinase B (TrkB) Signaling Pathway 2014
• Molecular Devices Symposium, Nanjing China, "High Throughput Screening and Discovery of Marine Natural Products that Target Neuronal Ion Channels." 2014
• China Pharmaceutical University, Nanjing China, "Sodium Channel Activator-Induced Enhancement of Cerebrocortical Neuron Neurite Outgrowth Requires both GluN2B NMDA Receptors and p21 Protein (Cdc42/Rac)-activated kinase 1 (PAK1)." 2014
• Cell Biology of the Neuron, Gordon Research Center, Waterville, NH, "Sodium channel activator-induced enhancement of cerebrocortical neuron neurite outgrowth requires both GluN2B NMDA receptors and p21 protein (Cdc42/Rac)-activated kinase 1(PAK1)" 2014
• The Society for Neuroscience 2013 Annual Meeting, San Diego, CA, "Voltage-gated sodium channel activator enhancement of immature cerebrocortical neuron development requires both the N-methyl-D-aspartate receptor 2B (GluN2B) and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1)" 2013
• The Society for Neuroscience 2013 Annual Meeting, San Diego, CA "Quantification of kappa opioid receptor ligand potency and efficacy using the FLIPR Membrane Potential Assay" 2013
• BIT's 3rd Annual World Congress of Marine Biotechnology Hangzhou, China "Discovery and Characterization of Marine Natural Products that Target Neuronal Ion Channels" 2013
• College of Life Sciences, Zhejiang University, Zhijingang Campus, Hangzhou, Zhejiang Province, China "Bidirectional Influence of the Marine Natural Product, Brevetoxin, on NMDA Receptor-Dependent Neuronal Structural Plasticity" 2013
• The Society of Neuroscience 2012 Annual Meeting, New Orleans, LA, "Novel C1-cocaine analogs unlike cocaine or benztropine" 2012
• Experimental Biology, San Diego, CA 2012
• The Society of Neuroscience 2011 Annual Meeting, Washington, DC, "Kappa-opioid receptor inhibition of calcium oscillations in spinal cord neurons" 2011
• 7th Annual Ion Channel Targets, South San Francisco, CA "Novel Marine Natural Products that Mimic Neuronal Activity-Dependent Neuroplasticity" 2011
• 2011 American Society Pharmacognosy Annual Meeting, San Diego, CA "Regulation of Neuronal Ion Channel Function By Marine Natural Products" 2011
• 2011 Therapeutic Potential of Kappa Opioids in Pain and Addiction, Seattle, WA, "Kappa-opioid receptor inhibition of calcium oscillations in spinal cord neurons" 2011
• University of Iowa, College of Pharmacy, Iowa City, Iowa. "Sodium channel activators that mimic activity-dependent neuronal plasticity:Novel targets for drug discovery." 2011
• Experimental Biology, San Diego, CA, "Biphasic influence of sodium channel ativation on neuronal structural plasticity" FASEB J 3-17-11 25:1003.3 2011
• Experimental Biology, San Diego, CA, "Sodium channel activator-induced neurite outgrowth is NMDA receptor dependent and involves a TrkB-PLC{gamma}-Akt pathway" FASEB J 3-17-11 25:1003.3 2011
• Institute of Biophysics of the Chinese Academy of Sciences, Beijing, China, "Voltage-gated sodium channels regulate neurite outgrowth in developing neurons" 2010
• The Second International Symposium on Membrane Biology, Ning-Bo, China, "Novel sodium channel activators mimic activity-dependent neuronal plasticity" 2010
• Society for Neuroscience, Neuroscience Meeting Planner, San Diego, CA. "Intracelluar sodium regulation of NMDA receptor-dependent neuronal plasticity" 2010
• Society for Neuroscience, Neuroscience Meeting Planner, San Diego, CA. "Kappa opioid receptor regulation of spontaneous calcium oscillations in embryonic spinal cord neurons" 2010
• Screening Europe, Barcelona, Spain, "Voltage-gated sodium channel activators with differing efficacies stimulate neurite outgrowth in cerebrocortical neurons." 2010
• Target Discovery World Congress, San Francisco, CA, "Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in cerebrocortical neurons." 2009
• Presentation, "Adenosine as an endogenous anticonvulsant: preclinical characterization and clinical implications" at Merck & Co. 2009
• George, J. and Murray, T.F. Sodium channel activation modulates synchronized calcium oscillations and neuronal morphology in immature cerebrocortical neurons. FASEB Journal 23:946.1, 2009 2009
• Neuroscience Research Areas of Emphasis at Creighton University School of Medicine," Jesuit Medical Colleges Symposium, St. Louis University 2009
• Presentation at University of Mississippi, "Discovery and characterization of neuroactive marine natural products: voltage-gated sodium channels as a common target 2009
• Jabba, S., Gerwick, W.H., and Murray, T.F. Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels. Program # 807.2, Society for Neuroscience 2008
• "Drug Discovery Strategies and High Throughput Screening in an Academic Environment" at Galleon Pharmaceuticals, Horsham, PA 2008
• Ion Channel Targets, South San Francisco, CA, "Influence of Lipid Soluble Gating Modifier Toxins on Sodium Influx in Neocortical Neurons" 2008
• Seminar entitled Neuronal responses to sodium channel gating modifiers: From neurotoxicity to dendritogenesis at the Barrow Neurological Institute, Phoenix, AZ, May 20, 2008. 2008
• George, J., Cao, Z. and Murray, T.F. Brevetoxin sensitizes immature cerebrocortical neurons to NMDA receptor signaling through activation of voltage-gated sodium channels. FASEB Journal 22:721.6, 2008. 2008
• Cao, Z., George, J., Gerwick, W.H. and Murray, T.F. Voltage-dependent sodium channel gating modifier toxins produce sodium influx in neocortical neurons. #1727 The Toxicologist (Society for Toxicology) 2008. 2008
• Seminar entitled Marine natural products as sodium channel gating modifiers: Neurotoxicants or novel therapeutics? at Scripps Institution of Oceanography, University of California at San Diego, November 5, 2007. 2007
• Murray, T.F., Xie, J., Peterson, J. and Baden D.G. Brevetoxin activation of voltage-gated sodium channels stimulates neurite outgrowth in immature cerebrocortical neurons. Program No. 34.13. 2007 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2007. Online. 2007
• Seminar entitled Neuronal responses to voltage-gated sodium channel activators: From neurotoxicity to dendritic development at the Department of Neuroscience, Medical University of South Carolina, Charleston, SC, September 21, 2007. 2007
• Ion Channel Targets, Boston MA, September 10, 2007, Evaluating Ion Channel Mechanisms in Murine Neuronal Cultures and Human Embryonic Stem Cell-Derived Neurons Using FLIPR and Flex Station. 2007
• Xie, J. Peterson, J. Murray, T.F. Brevetoxin enhanced neurite growth involves voltage-gated sodium channel activation with engagement of NMDA receptors and CaM-kinase kinase FASEB JOURNAL 21 (6): A785-A786, 2007 2007
• Murray, T.F., Yan, X., Gomez, A.P., Baden, D.G., and Benson, J.M. Brevetoxin-induced neural insult in the retrosplenial cortex of mouse brain following inhalation exposure. The Toxicologist 96, 363, 2007. 2007
• LePage, K.T., Rainier, J.D. and Murray, T.F. Gambierol acts as a functional antagonist of neurotoxin site 5 on voltage-gated sodium channels in cerebellar granule cells. The Toxicologist 96, 364, 2007. 2007
• Cao,Z., Baden, D.G. and T.F. Murray. Brevetoxin-induced phosphorylation of Pyk2 and Src in murine neocortical neurons occurs through distinct pathways Program No. 130.12. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006. Online. 2006
• LePage, K.T., Stice, S.L. and T.F.Murray. Activation of voltage-gated sodium channels produces Ca2+ influx in human neural progenitor cell lines derived from embryonic stem cells Program No. 130.14. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006. Online. 2006

Awards

• Jack L. Beal Award
  Detailed Analysis of (-)-Palmyrolide A and Some Synthetic Derivatives as Voltage-Gated Sodium Channel Antagonists. Suneet Mehrota, Brendan A. Duggan, Rodolfo Tello-Aburto, Tara D. Newar, William H. Gerwick, Thomas F. Murray, and William A. Maio* J. Nat. Prod., 2014, 77, 2553-2560. DOI: 10.1021/np500644k
  Journal of Natural Products
• Arthur E. Schwarting Award
  The Hoiamides, Structurally Intriguing Neurotoxic Lipopeptides from Papua New Guinea Marine Cyanobacteria. Hyukjae Choi, Alban R. Pereira, Zhengzu Cao, Cynthia F. Shuman, Niclas Engene, Tara Byrum, Teatulohi Matainaho, Thomas F. Murray, Alfonso Mangoni, and William H. Gerwick J. Nat. Prod.; (Article); 2010; 73(11); 1411-1421. DOI 10.1021/np100468n
  Journal of Natural Products