Oxidative stress (OS) is an underlying pathology in retinal neurodegenerative diseases such as age-related macular degeneration, diabetic retinopathy and glaucoma (Dreyer EB. J. Glaucoma. 7(1):62-67). These ocular retinopathies account for a large number of cases of blindness and visual impairment among the elderly in the US, warranting research into potential therapeutic options to prevent visual impairment (Vision Problems in the U.S. Prevalence of Adult Vision Impairment and Age-Related Eye Disease in America. Prevent Blindness America. http://www.visionproblemsus.org/introduction.html). My research focus is directed towards identifying the underlying mechanisms by which OS interacts with pharmacological receptors in ocular tissues, with the aim of revealing potential pharmacological targets that can be manipulated for therapeutic interventions. My specific areas of interests include studies on the regulation of uveal sympathetic and retinal excitatory neurotransmission by OS and OS-metabolites of long chain polyunsaturated fatty acids (PUFAs). Other areas of study include the regulation of retinal ganglion cells and neural tissue survival by OS-PUFA metabolites; regulation of neurotransmitter release, intraocular pressure and aqueous humor dynamics by hydrogen sulfide donors; development of innovative, slow release hydrogen sulfide donor formulations that can achieve sustainable concentrations in the anterior and posterior segments of the eye for management of glaucoma and other retinopathies; identification and characterization of subtypes of prejunctional (autoreceptors and heteroreceptors) receptors in the mammalian anterior uvea and retina. Receptors of interest include those for glutamate, histamine, prostanoids and cannabinoids.
Handbook of Basic and Clinical Occular Pharmacology Njie-Mbye YF, Opere CA, McKoy M.Ocular autonomic & physiology. Handbook of Basic and Clinical Ocular Pharmacology. 2020
Obesity: Epidemiology, Pathophysiology, and Prevention Opere, C. A., Ohia, S. E., Kulkarni, M., Njie-Mbye, Y. F. Role of Neurotransitters in obesity regulation, p. 113-124 2013
Elsevier Njie-Mbye YF, Barrett A, Kulkarni M, Opere CA, Ohia SE. Ocular Health. Bagchi D, Rahman I, eds. Inflammation, Advancing Age and Nutrition: Research, Science and Interventions, 1st ed. Elsevier. Imprint: Academic Press; ISBN: 9780123978035; 2013; http://store.elsevier.com/9780123978073. 1st Ed. 2013
Phytochemicals for Obesity Treatment: Pathophysiology and Weight Management Ohia, S. E., Opere, C. A., Kulkarni, M., Njie-Mbye, Y. F. Role of Neurotransmitters in obesity regulation., p. 113-124 2012
Research Signpost Transworld Research Network Njie-Mbye YF, Anjanette F, Zhao M, Ohia SE, Opere CA. Oxidative stress in ocular tissues: pathophysiological and pharmacological implications. In: Catala A eds. Lipid peroxidation: biological implications. Research Signpost Transworld Research Network, 2011. 2011
Research Signpost Transworld Research Network Opere CA, Zhao M, Njie-Mbye YF, Ohia SE. Biological consequences of lipid peroxidation of long chain polyunsaturated fatty acids in ocular tissues: role of the isoprostanes and neuroprostanes. In: Catala A eds. Lipid peroxidation: biological implications. Research Signpost Transworld Research Network, 2011. ISBN: 978-81-7895-527-8. 2011
Articles
Pharmaceuticals Heruye SH, Maffofou Nkenyi LN, Singh NU, Yalzadeh D, Ngele KK, Njie-Mbye Y-F, Ohia SE, Opere CA. 2020. Current Trends in the Pharmacology of Cataracts https://doi.org/10.3390/ph13010015 13(1), p. (15 pages) 2020
Pharmaceuticals Heruye SH, Maffofou N LN, Singh NU, Njie M YF, Ohia SE, Opere CA.Current trends in the pharmacotherapy of cataracts.13(1):15. https://doi.org/10.3390/ph13010015 2020
AIMS Neuroscience Kulkarni-Chitnis M, Mitchell-Bush L, Belford R, Robinson J, Opere CA, Ohia SE, Mbye YFN. Interaction between hydrogen sulfide, nitric oxide, and carbon monoxide pathways in the bovine isolated retina. https://www.aimspress.com/article/10.3934/Neuroscience.2019.3.104 6(3), p. 104-115 2019
Journal of Pharmacological and Toxicological Methods Heruye S, Maffofou N LN, Singh NU, Munt D, Njie-Mbye YF, Ohia SE, Opere CA. Standardization of a new method for assessing the development of cataract in cultured bovine lenses. . 98, p. (7 pages) 2019
AAPS PharmSciTech Vora D, Kumari D, Heruye SH, Opere CA, Chauhan H. Preparation, Characterization and Anti-oxidant evaluation of Novel Polyphenol loaded Polymeric Solid-Lipid Nanoparticles for Cataract Treatment. 20(163) 2019
Journal of Ocular Pharmacology and Therapeutics Njie-Mbye YF, Robinson J, Mitchell-Bush L, Mckoy M, Opere CA, Ohia SE, Sharif N. Pharmacology of Serotonin Receptors Causing Contraction of Isolated Bovine Posterior Ciliary Arteries: Role in Ocular Blood Flow doi: 10.1089/jop.2017.0124. Epub 2018 Jan 25. PMID: 29369737 34(1-2), p. 134-140 2018
Journal of Ocular Pharmacology and Therapeutics Ohia SE, Njie-Mbye YF, Robinson J, Mitchell L, Mckoy M, Opere CA, Sharif NA. Serotonin-2B/2C Receptors Mediate Bovine Ciliary Muscle Contraction: Role in Intraocular Pressure Regulation. Epub 2018 Jan 24. PMID:29364761 34(1-2), p. 70-75 2018
Neurochemical Research Bankhele P, Salvi A, Jamil J, Njie-Mby YF, Ohia SE, Opere CA. Comparative effect of hydrogen sulfide-releasing compounds on [3H]D-aspartate release from bovine isolated retinae. doi: 10.1007/s11064-018-2471-5. [Epub ahead of print] PMID:29353375 43(3), p. 692-701 2018
Journal of Ocular Pharmacology and Therapeutics Opere CA, Heruye S, Njie-Mbye YF, Ohia SE, Sharif NA. Regulation of excitatory amino acid transmission in the retina: studies on neuroprotection. doi: 10.1089/jop.2017.0085. Epub 2017 Dec 21. PMID:29267132 34(1-2), p. 107-118 2017
Jounal of Ocular Pharmacology and Therapeutics Ohia SE, Robinson J, Mitchell L, Ngele KK, Heruye SH, Opere CA, Njie-Mbye YF. Regulation of aqueous humor dynamics by hydrogen sulfide: potential role in glaucoma pharmacotherapy. doi: 10.1089/jop.2017.0077. Epub 2017 Dec 7. PMID:29215951 34(1-2), p. 61-69 2017
Jounal of Ocular Pharmacology and Therapeutics Robinson J, Okoro E, Ezuedu C, Bush L, Opere CA, Ohia SE, Njie-Mbye YF. Effects of Hydrogen Sulfide-Releasing Compounds on Aqueous Humor Outflow Facility in Porcine Ocular Anterior Segments, Ex Vivo. doi: 10.1089/jop.2016.0037. PMID:28099049 33(2), p. 91-97 2017
AAPS PharmSciTech Patil A, Singh S, Opere CA, Dash A. Sustained release delivery System of a slow hydrogen sulfide donor – GYY 4137 for potential application in glaucoma. DOI 10.1208/s12249-017-0712-6; 2017. http://link.springer.com/article/10.1208/s12249-017-0712-6 18 2017
Jounal of Ocular Pharmacology and Therapeutics Salvi A, Bankhele P, Jamil JM, Kulkarni-Chitnis M, Njie-Mbye YF, Ohia SE, Opere CA. “Effect of hydrogen sulfide donors on intraocular pressure in rabbits”. doi: 10.1089/jop.2015.0144. PMID: 27092593 32(6), p. 371-375 2016
US Pharmacist Opere CA, O’Brien KK, Elhaj MH. Optic Neuritis: A brief review. 41(1), p. 35-40 2016
Neurochemical Research Salvi A, Bankhele P, Jamil JM, Kulkarni-Chitnis M, Njie-Mbye YF, Ohia SE, Opere CA. “Pharmacological actions of hydrogen sulfide donors on sympathetic neurotransmission in the bovine anterior uvea, in vitro”. [Epub ahead of print] PMID: 26700431. 41(5), p. 1020-1028 2015
US Pharmacist Bossou AR, Castillo S, O’Brien KK, Opere CA, Destache CJ. “Preventive HIV vaccines: Progress and challenges”. 40(10), p. 46-50 2015
Experimental Eye Research Kulkarni-Chitnis, M., Njie-Mbye, Y. F., Mitchell, L., Robinson, J., Whiteman, M., Wood, M. E., Opere, C. A., Ohia, S. E. Inhibitory action of novel hydrogen sulfide donors on bovine isolated posterior ciliary arteries 134, p. 73-79 2015
Neurochemical Research Jamil, J., Bankhele, P., Salvi, A., Mannix, J. E., Oger, C., Guy, A., Galano, J. M., Durand, T., Njie-Mbye, Y. F., Ohia, S. E., Opere, C. A. Role of the non-enzymatic metabolite of eicosapentaenoic acid, 5-epi-5-F3t-isoprostane in the regulation of [(3)H]D-aspartate release in isolated bovine retina 39, p. 2360-2369 2014
AAPS PharmSciTech Ali, H., Opere, C., Singh, S. In Vitro-Controlled Release Delivery System for Hydrogen Sulfide Donor 15, p. 910-919 2014
Experimental Eye Research Chitnis, Madhura K., Njie-Mbye, Ya F., Opere, Catherine A., Wood, Mark E., Whiteman, Matthew, Ohia, Sunny E. Pharmacological actions of the slow release hydrogen sulfide donor GYY4137 on phenylephrine-induced tone in isolated bovine ciliary artery 2014
Frontiers in Physiology Ya, Fatou N., Kulkarni-Chitnis, Madhura, Opere, Catherine A., Barrett, Aaron, Ohia, Sunny E., Passi, Alberto, Gasull, Xavier Lipid peroxidation: pathophysiological and pharmacological implications in the eye 4, p. 1-10 2013
Prostaglandins & other lipid mediators Galano, Jean-Marie, Mas, Emilie, Barden, Anne, Mori, Trevor A., Signorini, Cinzia, De Felice, Claudio, Barrett, Aaron, Opere, Catherine, Pinot, Edith, Schwedhelm, Edzard, Benndorf, Ralf, Roy, J?r?me, Le Guennec, Jean-Yves, Oger, Camille, Durand, Thierry Isoprostanes and Neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans 107, p. 95-102 2013
Experimental Eye Research Njie-Mbye, Y. F., Kulkarni, M., Opere, C.A., Ohia, S. E. Mechanism of action of hydrogen sulfide on cyclic AMP formation in rat retinal pigment epithelial cells 98, p. 16-22 2012
Frontiers in Physiology Njie-Mbye, Y. F., Opere, C. A., Ohia, S. E., Chitnis, M. Hydrogen sulfide: role in ion channel and transporter modulation in the eye 3, p. 1-9 2012
Nitric Oxide Njie-Mbye, Ya F., Chitnis, Madhura, Opere, Catherine, Ohia, Sunny P41 Hydrogen sulfide: Endogenous production and regulatory role in ocular tissues 27, p. S30 2012
U.S. Pharmacist Opere CA, O’Brien KK, Shea JL. “Understanding diabetic retinopathy.” US Pharmacist, April, 2011. Role: contribution to preparation of manuscript. 2011
Neurochemical Research Jamil, J., Wright, A., Harrison, N., Kegey, E., Flowers, A. F., Flyod, N. J., Kotera, C., Guy, A., Galano, J. M., Durand, T., Njie-Mbye, Y. F., Ohia, S. E., Opere, C. A. Regulation of [(3)H]D-Aspartate Release by the 5-F(2t)-Isoprostane and Its 5-Epimer in Isolated Bovine Retina 37, p. 574-582 2011
Neurochemical Research Kulkarni, Madhura, Njie-Mbye, Ya, Okpobiri, Ikechukwu, Zhao, Min, Opere, Catherine A., Ohia, Sunny Endogenous Production of Hydrogen Sulfide in Isolated Bovine Eye 36, p. 1540-1545 2011
Current eye research Ohia, Sunny E., Opere, Catherine A., Monjok, Emmanuel M., Kouamou, Ghislaine, Leday, Angela M., Njie-Mbye, Ya Role of Hydrogen Sulfide Production in Inhibitory Action of L-Cysteine on Isolated Porcine Irides 35, p. 402-407 2010
Neurochemical Research Njie-Mbye, Ya, Bongmba, Odelia Y. N., Onyema, Chinwe C., Chitnis, Abhishek, Kulkarni, Madhura, Opere, Catherine A., LeDay, Angela M., Ohia, Sunny E. Effect of Hydrogen Sulfide on Cyclic AMP Production in Isolated Bovine and Porcine Neural Retinae 35, p. 487-494 2010
Elsevier Kotera C, Opere CA. Practolol. xPharm (On-line pharmacology information service of Elsevier), eds: F. Dowd, 2010; http://www.mdl.com/products/knowledge/xpharm/index.jsp. 2010
Elsevier Kotera C, Opere CA. Mannitol. xPharm (On-line pharmacology information service of Elsevier), eds: F. Dowd, 2010; http://www.mdl.com/products/knowledge/xpharm/index.jsp. 2010
Neurochemical Research Zhao, Min, Destache, Christopher J., Ohia, Sunny E., Opere, Catherine A. Role of Prostanoid Production and Receptors in the Regulation of Retinal Endogenous Amino Acid Neurotransmitters by 8-Isoprostaglandin E-2, Ex Vivo 34, p. 2170-2180 2009
Neurochemical Research Monjok, E. M., Kulkarni, K. H., Njie, Y. F., Ohia, S. E., Opere, Catherine A. Regulation of [(3)h] d: -aspartate release from mammalian isolated retinae by hydrogen sulfide 34, p. 1962-1968 2009
Neurochemical Research Kulkarni, Kaustubh H., Monjok, Emmanuel M., Zeyssig, Robert, Kouamou, Ghislaine, Bongmba, Odelia N., Opere, Catherine A., Njie, Ya F., Ohia, Sunny E. Effect of Hydrogen Sulfide on Sympathetic Neurotransmission and Catecholamine Levels in Isolated Porcine Iris-Ciliary Body 34, p. 400-406 2009
xPharm Opere, Catherine A. Aquaporin 2 2009
xPharm Opere, Catherine A. Aquaporin family 2009
Experimental Eye Research Monjok, Emmanuel M., Kulkarni, Kaustubh H., Kouamou, Ghislaine, Mckoy, Marshalyn, Opere, Catherine A., Bongmba, Odelia N., Njie, Ya F., Ohia, Sunny E. Inhibitory action of hydrogen sulfide on muscarinic receptor-induced contraction of isolated porcine irides 87, p. 612-616 2008
Methods and findings in experimental and clinical pharmacology Opere, C. A., Ford, K., Zhao, M., Ohia, S. E. Regulation of neurotransmitter release from ocular tissues by isoprostanes 30, p. 697-701 2008
Neurochemical Research Min Zhao, Opere, Catherine A. Prejunctional Inhibitory Effects of Isoprostanes on Dopaminergic Neurotransmission in Bovine Retinae, In vitro 33, p. 37-42 2008
xPharm Opere, D., Opere, Catherine A. Aquaporin 1 2008
xPharm Opere, C. A. Procainamide 2007
Current eye research Opere, C. A., Zheng, W. D., Zhao, M., Lee, J. S., Kulkarni, K. H., Ohia, S. E. Inhibition of potassium- and ischemia-evoked [H-3] D-aspartate release from isolated bovine retina by cannabinoids 31, p. 645-653 2006
Neurochemical Research Kulkarni, K. H., Opere, C. A., Leday, A. M., Shara, M. A., Ohia, S. E. Regulation of norepinephrine release from isolated bovine irides by histamine 31, p. 891-897 2006
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis Ohia, S. E., Opere, C. A., LeDay, A. M. Pharmacological consequences of oxidative stress in ocular tissues 579, p. 22-36 2005
Neurochemical Research Opere, C. A., Zheng, W. D., Huang, J. F., Adewale, A., Kruglet, M., Ohia, S. E. Dual effect of isoprostanes on the release of [H-3]D-aspartate from isolated bovine retinae: Role of arachidonic acid metabolites 30, p. 129-137 2005
Current eye research LeDay, A. M., Kulkarni, K. H., Opere, C. A., Ohia, S. E. Arachidonic acid metabolites and peroxide-induced inhibition of [H-3]D-aspartate release from bovine isolated retinae 28, p. 367-372 2004
Neurochemical Research LeDay, A. M., Awe, S. O., Kulkarni, K., Harris, L. C., Opere, C., Dash, A., Ohia, S. E. Effect of peroxides on [H-3]D-aspartate release from bovine isolated retinae 29, p. 811-818 2004
Journal of Ocular Pharmacology and Therapeutics Ohia, S. E., Awe, S. O., Opere, C. A., LeDay, A. M., Harris, L. C., Kulkarni, K., Sharif, N. A. Glucose-deprivation-induced [H-3]D-aspartate release from isolated bovine and human retinae 19, p. 599-609 2003
Journal of Ocular Pharmacology and Therapeutics Harris, L. C., Awe, S. O., Opere, C. A., Leday, A. M., Ohia, S. E., Sharif, N. A. Pharmacology of serotonin receptors modulating electrically-induced [H-3]-norepinephrine release from isolated mammalian iris-ciliary bodies 18, p. 339-348 2002
Experimental Eye Research Harris, L. C., Olubusayo, S., Opere, C. A., Leday, A. M., Ohia, S. E., Sharif, N. A. [H-3]-serotonin release from bovine iris-ciliary body: Pharmacology of prejunctional serotonin (5-HT7) autoreceptors 73, p. 59-67 2001
Free Radical Research Opere, C. A., Awe, S. O., Harris, L. C., LeDay, A. M., Ohia, S. E. Potentiation of sympathetic neurotransmission in bovine isolated irides by isoprostanes 35, p. 257-264 2001
Current eye research Ohia, S. E., Awe, S. O., Opere, C. A., LeDay, A. M., Harris, L. C., Sharif, N. A. Hypoxia-induced [H-3]D-aspartate release from isolated bovine retina: modulation by calcium-channel blockers and glutamatergic agonists and antagonists 23, p. 386-393 2001
Journal of Ocular Pharmacology and Therapeutics Matutte, B., Awe, S. O., Ameh, F. A., Leday, A. M., Rice, J. C., Opere, C. A., Ohia, S. E. Role of catalase in pre- and postjunctional responses of mammalian irides to hydrogen peroxide 16, p. 429-438 2000
Neurochemical Research Ohia, S. E., Opere, C. A., Awe, S. O., Adams, L., Sharif, N. A. Human, bovine, and rabbit retinal glutamate-induced [H-3]D-aspartate release: Role in excitotoxicity 25, p. 853-860 2000
Neurochemical Research Graham, J., Awe, S. O., LeDay, A. M., Rice, J. C., Ramos, G., Harris, L. C., Opere, C. A., Ohia, S. E. Effect of inhibition of cyclooxygenase on pre- and postjunctional actions of peroxides in the iris-ciliary body 25, p. 519-525 2000
Neurochemical Research Awe, S. O., Opere, C. A., Harris, L. C., Uketui, A. J., Ohia, S. E. Effect of isoprostanes on sympathetic neurotransmission in the human isolated iris-ciliary body 25, p. 491-496 2000
Presentations
Singh N, Opere CA, Singh S. Developing a novel lipid-based system of diallyl trisulfide (DATS) for sustained delivery of hydrogen sulfide for the treatment of glaucoma.2020 American Association of Pharmaceutical Scientists, October 25-28, 2020. New Orleans, LA, USA. 2020
From bench to bedside: the drug discovery process. Graduate student seminar series MPS 793. Zoom Meeting. 2020
Developing an efficient ocular delivery system for the hydrogen sulfide releasing compound, diallyl trisulfide. Singh N, Opere CA, Singh S.2020 American Society for Pharmacology and Experimental Therapeutics. San Diego, CA. 2020
Blanchard S, Opere CA.Integration of Pharmacology into an Occupational Therapy Health Conditions Course. Workshop proposal accepted. 2020 Annual AOTA meeting, March 27-30. Boston, MA. 2020
Developing a novel lipid-based system of diallyl trisulfide for sustained delivery of hydrogen sulfide for the treatment of Glaucoma. Singh N, Opere CA, Singh S.Midwest Student Biomedical Research Forum, February 2020. Creighton University, Omaha, NE 2020
Regulation of Cataractogenesis by Hydrogen Sulfide-NSAID Hybrid Compounds in Cultured Bovine Lenses. Opere CA 2020
Ohia SE, Ya Fatou NM, Mitchell L, Robinson J, Ngele K, Opere CA. Regulation of Endogenous Hydrogen Sulfide Concentrations by Cannabinoid in Bovine Isolated Retina. 2020 ARVO Meeting. Baltimore, Maryland. 2020
Opere CA, Bankhele P, Salvi A, Jamil J, Munt D, Njie-Mbye YF, Chitnis M, Ohia SE. "Comparative inhibition of neurotransmission by N-acetylcysteine and L-cysteine in bovine isolated retina." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, abstract #1886, Orlando, FL May 4-8, 2014. 2014
Njie-Mbye YF, Robinson J, Ezeudu C, Mitchell L, Chitnis MK, Opere CA, Ohia SE. "Effect of hydrogen sulfide releasing compounds on aqueous humor dynamics." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, abstract #2890, Orlando, FL May 4-8, 2014. 2014
Ohia SE, Chitnis MK, Njie-Mbye YF, Robinson J, Ezeudu C, Mitchell L, Opere CA, Whiteman M. "Effect of novel hydrogen sulfide donors (AP67 and AP72) on isolated bovine ciliary artery." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, abstract #4348, Orlando, FL May 4-8, 2014. 2014
Chitnis MK, Belford R, Robinson J, Mitchell L, Njie-Mbye YF, Opere CA, Ohia SE. "Interaction between hydrogen sulfide and nitric oxide in isolated bovine retina." Presented at the: Experimental Biology meeting, abstract #1060.2, San Diego, CA April 26-30, 2014. 2014
Robinson J, Ezeudu C, Mitchell L, Chitnis MK, Opere CA, Ohia SE, Njie-Mbye YF. "Involvement of KATP channels in hydrogen sulfide-induced increase in aqueous humor outflow." Presented at the: Experimental Biology meeting, abstract #1060.3, San Diego, CA April 26-30, 2014. 2014
Opere CA, Bankhele P, Salvi A, Jamil J, Munt D, Njie Mbye YF, Chitnis M, Ohia SE. "Comparative pharmacological actions of N-acetylcysteine and L-cysteine on excitatory neurotransmission in isolated bovine retina." Presented at the: Experimental Biology meeting, abstract #1060.4, San Diego, CA April 26-30, 2014. 2014
Opere CA, Salvi A, Bankhele P, Jamil J, Njie-Mbye YF, Kulkarni K, Ohia SE. "Inhibitory action of hydrogen sulfide donor, ACS 67 on sympathetic neurotransmitter release in isolated bovine iris-ciliary bodies." Presented at the: ISER symposium, abstract #15, Sarasota, Fl, Sept 29-Oct 2, 2013. 2013
Njie-Mbye YF, Robinson J, Kulkarni M, Opere CA, Ohia SE. "Hydrogen sulfide and aqueous humor outflow." Presented at the: ISER symposium, Abstract #4, Sarasota, Fl, Sept 29-Oct 2, 2013. 2013
Jamil J, Kegey E, Flowers AF, Flyod NJ, Salvi A, Bankhele P, Guy A, Galano JM, Durand T, Njie-Mbye YF, Kulkarni M, Ohia SE, Opere CA. "Further studies on the role of arachidonic acid metabolites in the regulation of potassium-induced [3H]D-aspartate release from isolated bovine retinae by 5-epi-5-F3t-isoprostane." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting. ID: 1616232; abstract #6315; Seattle, WA, May 5-9, 2013. 2013
Bankhele P, Jamal J, Salvi A, Njie Mbye YF, Kulkarni M, Ohia SE, Opere CA. "Further studies on the inhibition of [3H]D-aspartate release by hydrogen sulfide donors in isolated bovine retina." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, Abstract #6325, Seattle, WA, May 5-9, 2013. 2013
Salvi A, Bankhele P, Jamal J, Njie Mbye YF, Kulkarni M, Ohia SE, Opere CA. "Regulation of mammalian sympathetic neurotransmitter release and intraocular pressure by hydrogen sulfide donor, GYY 4137." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, ID: 1615348; abstract #1976, Seattle, WA, May 5-9, 2013. 2013
Njie-Mbye YF, Robinson J, Okpobiri A, Kulkarni M, Opere CA, Ohia SE. "Effect of NaHS, a fast-releasing hydrogen sulfide donor on aqueous humor outflow in porcine trabecular meshwork." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, ID 1616794; abstract #3563; Seattle, WA, May 5-9, 2013. 2013
Ohia SE, Okpobiri A, Njie-Mbye YF, Robinson J, Kulkarni M, Opere CA. "Pharmacological actions of L-cysteine on isolated bovine ciliary muscles." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, ID 1616651, abstract #787; Seattle, WA, May 5-9, 2013. 2013
Opere CA, Jamil J, Salvi A, Bankhele P, Flowers AF, Floyd N, Durand T, Galano JM, Guy A, Oger C, Njie-Mbye YF, Kulkarni K, Ohia SE. "Regulation of potassium-induced [3H]D-aspartate release from isolated bovine retina by 5-epi-5-F3t-isoprostane: Role of prostanoid receptors." Presented at the: Experimental Biology meeting, Abstract #7268, Boston, MA April 20-24, 2013. 2013
Robinson J, Njie-Mbye YF, Okpobiri A, Kulkarni M, Opere CA, Ohia SE. "Hydrogen sulfide increases aqueous humor outflow in porcine trabecular meshwork." Presented at the: Experimental Biology meeting, Abstract #5025, Boston, MA April 20-24, 2013. 2013
Okpobiri A, Njie-Mbye YF, Robinson J, Kulkarni M, Opere CA, Ohia SE. "Effect of hydrogen sulfide on isolated bovine ocular smooth muscle." Presented at the: Experimental Biology meeting, Abstract #5534, Boston, MA April 20-24, 2013. 2013
Salvi A, Bankhele P, Jamal J, Njie-Mbye YF, Kulkarni M, Ohia SE, Opere CA. "Regulation of mammalian sympathetic neurotransmitter release and intraocular pressure by hydrogen sulfide donor, GYY 4137." Presented at the: Creighton University St. Alberts Day, Abstract #81, Harper Center, Creighton University, Omaha, NE, Mar 26, 2013. 2013
Bankhele P, Jamil J, Salvi A, Opere CA. "Further studies on the Inhibition of [3H]D-aspartate release by hydrogen sulfide donors in isolated bovine retina." Presented at the: Creighton University St. Alberts Day, Abstract #83, Harper Center, Creighton University, Omaha, NE, Mar 26, 2013. 2013
Opere CA, Flowers A, Floyd N, Kegey E, Jamil J, Durand T, Galano JM, Guy A, Oger C, Njie-Mbye YF, Ohia SE. "Enhancement of excitatory neurotransmitter release by metabolites of long chain polyunsaturated fatty acids in bovine retina, in vitro." Presented at the: Fourth European Workshop on Lipid Mediators, Pasteur Institute - Paris, September 27-28, 2012. 2012
Opere CA, Jamil J, Salvi A, Bankhele P, Njie-Mbye YF, Kulkarni M, Ohia SE. "Inhibition of [3H]D-aspartate release by hydrogen sulfide in isolated bovine retina." Presented at the: Second International Conference on H2S Biology and Medicine, Abstract #P110, Atlanta, Georgia, Sept 20-22, 2012. 2012
Njie-Mbye YF, Kulkarni M, Opere CA, Ohia SE. "Hydrogen Sulfide: Endogenous Production and Regulatory Role in Ocular Tissues." Presented at the: Second International Conference on H2S Biology and Medicine, Abstract #P41, Atlanta, Georgia, Sept 20-22, 2012. 2012
Opere CA, Flowers A, Jamil J, Kegey E, Floyd N, Salvi A, Bankhele A, Durand T, Galano JM, Guy A, Oger C. "Regulation of excitatory neurotransmitter release by metabolites of long chain polyunsaturated fatty acids in bovine retina, in vitro." Presented at the: Frontiers in Lipid Biology, American Society of Biochemistry and Molecular Biology (ASMB); International Conference on the Bioscience of Lipids (ICBL) and The Canadian Lipoprotein Conference (CLC), Abstract # 2374, Banff Alberta, Canada, September 5-8, 2012. 2012
Chitnis MK, Njie-Mbye YF, Opere CA, Ohia SE. "Hydrogen sulfide-induced increase in cyclic AMP production in RPE-J cells: Role of prostanoids, adenyl cyclase and KATP channels." Presented at the: ISER meeting, Berlin, Germany, July 21-25, 2012. Abstract #P061 2012
Opere CA, Flowers A, Floyd N, Kegey E, Jamil J, Durand T, Galano JM, Guy A, Oger C, Njie-Mbye YF, Ohia SE. "Role of prostanoid receptors in the excitatory effect of neuroprostanes on potassium induced [3H]D-aspartate release in isolated bovine retina." Presented at the : 19me journe IRPF de Chimie Sorze, France, 15 Juin 2012. 2012
Kulkarni M, Njie-Mbye YF, Opere CA, Whiteman M, Ohia SE. "Effect of slow releasing hydrogen sulfide donor GYY4137 on isolated bovine ciliary artery." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, Abstracts March 26, 2012 53:6866. May 6-9, 2012, Ft. Lauderdale, Fl. 2012
Opere CA, Flowers AF, Floyd N, Kegey E, Jamil J, Durand T, Galano JM, Guy A, Oger C, Njie-Mbye YF, Ohia SE. "Role of prostanoid receptors in the excitatory effect of neuroprostanes on potassium induced [3H]D-aspartate release in isolated bovine retina." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, Abstracts March 26, 2012 53:5386. May 6-9, 2012, Ft. Lauderdale, Fl. 2012
Flowers AF, Floyd N, Kegey E, Jamil J, Durand T, Galano JM, Guy A, Njie-Mbye YF, Kulkarni K, Ohia SE, Opere CA. "Regulation of K+-induced [3H]D-aspartate release by synthetic neuroprostanes in isolated bovine retina." Presented at the: The Experimental Biology meeting, Journal. 2012;26:843.4. 2012
Stroud DD, Kulkarni M, Njie-Mbye YF, Opere CA, Ohia SE. "Pharmacological actions of L-cysteine on isolated bovine irides." Presented at the: The Experimental Biology meeting, Journal. 2012;26:1049.4 2012
Kegey E, Jamil JM, Harrison NC, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE, Opere CA. "Role of prostanoid receptors in the inhibitory effect of 5-F2t-IsoP and its 5-epimer on potassium-induced [3H]D-aspartate release in isolated bovine retina." Presented at the: 8Th GERLI Lipidomics Meeting, Bioactive Lipids, Membranes and Bioactive lipids, Lyon, October, 25-28-2011. 2011
Ali H, Opere CA, Singh S. "An easy to use, safe, and efficient spectrophotometric method for the determination of hydrogen sulfide released from its analogues." Presented at the: American Association of Pharmaceutical Scientists, October, 23-27, 2011. Walter E. Washington Convention Center, Washington, D.C. 2011
Ali H, Opere CA, Singh S. "Phase-sensitive smart polymer-based sustained release delivery system for hydrogen sulfide analogue." Presented at the: Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, October, 23-27, 2011. Walter E. Washington Convention Center, Washington, D.C. 2011
Kegey E, Jamil JM, Harrison NC, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE, Opere CA. "Role of prostanoid receptors in the inhibitory effect of 5-F2t-IsoP and its 5-epimer on potassium-induced [3H]D-aspartate release in isolated bovine retina." Presented at the: 2nd International conference on Enviromental Stressors in Biology and Medicine Siena, 5-7 October 2011 2011
Kulkarni M, Njie-Mbye YF, Okpobiri I, Zhao M, Opere CA, Ohia SE. "Regulation of endogenous hydrogen sulfide production in isolated bovine retina by carbon monoxide and nitric oxide." Program/poster 5669/A581, May 5, 2011, Ft. Lauderdale, Fl. 2011
Zhao M, Taylor M, Njie-Mbye YF, Kulkarni M, Opere CA, Ohia SE. "Hydrogen sulfide-induced relaxation of isolated bovine ciliary artery." Program/poster 2658/A139, May 3, 2011, Ft. Lauderdale, Fl. 2011
Opere CA, Njie-Mbye YF, Jamil J, Durand T, Galano JM, Guy A, Kulkarni M, Zhao M, Ohia SE. "Regulation of cyclic AMP production in rat RPE-J cells by the synthetic neuroprostane," BA-12high. Program/poster 2067/D1074, May 2, 2011, Ft. Lauderdale, Fl. 2011
Opere CA, Jamil JM, Wright A, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE. "Neuroprostanes inhibit [3H]D-aspartate release in bovine retina, in vitro." Presented at the: Journes CHEVREUL 2011, "LIPIDS & BRAIN 2" Paris 28-30 March 2011. 2011
Kegey E, Jamil J, Harrison N, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE, Opere CA. "Role of prostanoid receptors in the inhibitory effect of synthetic isoprostanes on potassium-induced [3H]D-aspartate release in isolated bovine retina ." Presented at the: Experimental Biology Meeting, March 17, 2011 25:799.4 2011
Opere CA, Jamil JM, Wright A, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE. "Neuroprostanes inhibit [3H]D-aspartate release in bovine retina, in vitro." Presented at the: 7th GERLI Lipodomic Meeting: Lipids in all States, 3-6 October, Anglet-Biarritz, France, 2010. 2010
Opere CA, Jamil JM, Wright A, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE. "Neuroprostanes inhibit [3H]D-aspartate release in bovine retina, in vitro." Presented at the: Third European Workshop on Lipid Mediators, Pasteur Institute - Paris, June 3-4, 2010 2010
Ohia SE, Kulkarni M, Njie-Mbye YF, Jackson D, Zhao M, Opere CA. "Measurement of hydrogen sulfide concentration in isolated bovine eyes." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, May 2-6, 2010 Abstract #3305/D786. 2010
Njie-Mbye YF, Kulkarni M, Jackson D, Zhao M, Opere CA, Ohia SE. "Mechanism of action of hydrogen sulfide on cyclic AMP formation in RPE-J cells." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, May 2-6, 2010, Abstract # 3315/D796. 2010
Opere CA, Jamil JM, Wright A, Durand T, Galano JM, Guy A, Njie-Mbye YF, Ohia SE. "Regulation of [3H]D-aspartate release by neuroprostanes in bovine retina, in vitro." Presented at the: Association for Research in Vision and Ophthalmology Annual Meeting, May 2-6, 2010, Abstract # 3315/D796. 2010
Opere CA, Jamil J, Wright A, Njie-Mbye YF, Ohia SE. "Peroxide-induced production of metabolites of polyunsaturated fatty acids in bovine retina, in vitro." Presented at the: Experimental Biology Meeting, April 6, 2010 24:971.2 2010
Njie-Mbye YF, Kulkarni M, Opere CA, Ohia SE. "Hydrogen sulfide stimulates cyclic AMP formation in mammalian retina through the adenylyl cyclase pathway." Presented at the: Experimental Biology Meeting, April 6, 2010 24:962.2 2010