Timothy A . Simeone

Department

Pharmacology and Neuroscience

Position

Professor

Books

• Ketogenic Diet and Metabolic Therapies
  Masino Susan A., D’Agostino Dominic P., Kossoff Eric H., Boison Detlev, Rho Jong M., Simeone Timothy A., Ketogenic Diet and PPARγ [Book Chapter] 2022
• Ketogenic Diet and Metabolic Therapies
  Boison Detlev, Simeone Timothy A., Ketogenic Diet and PPARgamma [Book Chapter] 2016
• The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
  Simeone T. A., Rho J. M., Antiepileptic drugs [Book Chapter] 2016
• Homeostatic Control of Brain Function
  Simeone Kristina, Roundtree Harrison, Johnson Chaz, Samson Kaeli, Simeone Tim, Tarokh Leila, Sleep [Book Chapter] 2015
• Epilepsy : Mechanisms, Models, and Translational Perspectives
  Simeone Timothy A., Mechanisms of antiepileptic drug action [Book Chapter] 2010
• Encyclopedia of Basic Epilepsy Research
  Simeone T. A., Rho J. M., Antiepileptic Drugs [Book Chapter] 2009
• Encyclopedia of Basic Epilepsy Research
  Simeone Timothy A., Rho J. M., Antiepileptic Drug Mechanisms [Book Chapter] 2009

Publications

• Epilepsia (Copenhagen)
  Iyer Shruthi H., Draves Samantha B., Simeone Timothy A., Simeone Kristina A., Hinman Jillian E., Matthews Stephanie A., Development and characterization of an autoresuscitation test for preclinical SUDEP models 2025
• Nutrients
  Rafiei Parisa, Revis McKenna, Rendon Daniel E., Neesen Emma J., Dunlay Madeline, Glisan Adrianna L., Simeone Timothy A., Mian Huda S., Matthews Stephanie A., Simeone Kristina A., Iyer Shruthi H., Draves Samantha B., In Preclinical Epilepsy, GLUT1 and GFAP Dysregulation in Cells Surrounding the Third Ventricle, Including Tanycytes, Is Differentially Restored with Ketogenic Diet Treatment
  17:11, p. 1824 2025
• The Journal of pharmacology and experimental therapeutics
  Hinman Jillian, Matthews Stephanie, Haggerty Amberlee, Aggarwal Ankita, Iyer Shruthi, Hallgren Jodi, Simeone Kristina, Simeone Timothy, Contribution of Seizures and Sympathetic Activation on the Adaptive Immune Response of Kcna1-null Mice, a Model of Spontaneous Recurrent Seizures (Abstract ID: 190411)
  392:3 2025
• Neurobiology of disease
  Iyer Shruthi H., Simeone Timothy A., Simeone Kristina A., Hinman Jillian E., Warren Ted, Matthews Stephanie A., Altered ventilatory responses to hypercapnia-hypoxia challenges in a preclinical SUDEP model involve orexin neurons
  199, p. 106592 2024
• Biomolecules (Basel, Switzerland)
  Baker Carly E., Mathy Nicholas W., Wilton Delaney, Simeone Timothy, Marta Aaron G., Zimmerman Nathan D., Korade Zeljka, Kochvar Andrew, Kramer Kenneth L., Stessman Holly A. F., Shibata Annemarie, CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression
  14:8, p. 914 2024
• Nutrients
  Iyer Shruthi H, Yeh Mary Y, Netzel Lauren, Lindsey Molly G, Wallace McKenzie, Simeone Timothy A, Simeone Kristina A, Dietary and Metabolic Approaches for Treating Autism Spectrum Disorders, Affective Disorders and Cognitive Impairment Comorbid with Epilepsy: A Review of Clinical and Preclinical Evidence
  16:4 2024
• Epilepsy currents
  Simeone Timothy, Simeone Kristina, The Unconventional Effects of the Ketogenic Diet (KD) in Preclinical Epilepsy 2024
• European journal of pharmacology
  Kostansek, 4th Joseph A, Simeone Timothy A, Latona Gavin J, Heruye Segewkal H, Matthews Stephanie, Bockman Charles S, Simeone Kristina A, Orexin receptors regulate hippocampal sharp wave-ripple complexes in ex vivo slices
  950, p. 175763 - 175763 2023
• Frontiers in Neurology
  Hampson Johnson P., Hampson Jaison S., Lacuey Nuria, Rani MRS Sandhya, Lemieux Louis, Simeone Kristina A., Simeone Timothy A., Narayana Ponnada A., Lhatoo Samden D., Functional MRI Correlates of Carbon Dioxide Chemosensing in Persons With Epilepsy
  13 2022
• Nutrients
  Heruye Segewkal H., Warren Ted J., Kostansek Joseph A., Draves Samantha B., Matthews Stephanie A., West Peter J., Simeone Kristina A., Simeone Timothy A., Ascorbic Acid Reduces Neurotransmission, Synaptic Plasticity, and Spontaneous Hippocampal Rhythms in In Vitro Slices
  14:3 2022
• European Journal of Pharmacology
  Deodhar Malavika, Wells Tabitha, Matthews Stephanie A., Thomas Brittany, Adamian Leena, Mattes Sarah, Zieba Brianna, Simeone Kristina A., Simeone Timothy A., Pharmacoresponsiveness of spontaneous recurrent seizures and the comorbid sleep disorder of epileptic Kcna1-null mice
  913 2021
• Epilepsia
  Simeone Kristina A., Wilke Julianne C., Matthews Stephanie A., Simeone Timothy A., Rho Jong M., Ketogenic diet–mediated seizure reduction preserves CA1 cell numbers in epileptic Kcna1-null mice
  62:8, p. e123 - e128 2021
• Brain Sciences
  Simeone Timothy A., Heruye Segewkal H., Kostansek Joseph A., Yeh Mary Y., Matthews Stephanie A., Samson Kaeli K., Simeone Kristina A., Carbamazepine reduces sharp wave-ripple complexes and exerts synapse-specific inhibition of neurotransmission in ex vivo hippocampal slices
  11:6 2021
• Metabolomics
  Johnson Alicia, Grove Ryan A., Madhavan Deepak, Samson Kaeli, Boone Cory H.T., Braga Camila, Kyllo Hannah, Simeone Kristina, Simeone Timothy, Helikar Tomas, Hanson Corrine K., Adamec Jiri, Changes in lipid profiles of epileptic mouse model
  16:10 2020
• Journal of Proteomics
  Grove Ryan A., Simeone Kristina, Papackova Zuzana, Kyllo Hannah, Samson Kaeli, Simeone Timothy, Helikar Tomas, Braga Camila Pereira, Boone Cory H.T., Hanson Corrine K., Adamec Jiri, Madhavan Deepak, Aberrant energy metabolism and redox balance in seizure onset zones of epileptic patients
  223 2020
• Epilepsia
  Iyer Shruthi H., Aggarwal Ankita, Warren Ted J., Hallgren Jodi, Abel Peter W., Simeone Timothy A., Simeone Kristina A., Progressive cardiorespiratory dysfunction in Kv1.1 knockout mice may provide temporal biomarkers of pending sudden unexpected death in epilepsy (SUDEP)
  61:3, p. 572 - 588 2020
• Epilepsy Currents
  Jobst Barbara C., Hirsch Lawrence J., Chapman Kevin E., Fu Aradia, Goldman Alica, Jehi Lara E., Kossoff Eric H., Plueger Madona, Rho Jong M., Simeone Timothy A., Schevon Catherine A., Shinnar Shlomo, Sperling Michael R., Wagner Janelle L., Lado Fred, Ben-Menachem Elinor, Highlights From the Annual Meeting of the American Epilepsy Society 2018
  19:3, p. 152 - 158 2019
• Epilepsy Research
  Knowles Sara, Budney Sarah, Deodhar Malavika, Matthews Stephanie A., Simeone Kristina A., Simeone Timothy A., Ketogenic diet regulates the antioxidant catalase via the transcription factor PPARγ2
  147, p. 71 - 74 2018
• Neurobiology of Disease
  Warren Ted J., Simeone Kristina A., Simeone Timothy A., Smith D. David, Grove Ryan, Adamec Jiri, Samson Kaeli K., Roundtree Harrison M., Madhavan Deepak, Adenosine has two faces
  114, p. 45 - 52 2018
• Neuropharmacology
  Simeone Timothy A., Rho Jong M., Simeone Kristina A., Stafstrom Carl E., Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?
  133, p. 233 - 241 2018
• Epilepsia
  Simeone Kristina A., Hallgren Jodi, Bockman Charles S., Aggarwal Ankita, Kansal Vikash, Netzel Lauren, Iyer Shruthi H., Matthews Stephanie A., Deodhar Malavika, Oldenburg Peter J., Abel Peter W., Simeone Timothy A., Respiratory dysfunction progresses with age in Kcna1-null mice, a model of sudden unexpected death in epilepsy
  59:2, p. 345 - 357 2018
• Epilepsia
  Iyer Shruthi H., Matthews Stephanie A., Simeone Timothy A., Maganti Rama, Simeone Kristina A., Accumulation of rest deficiency precedes sudden death of epileptic Kv1.1 knockout mice, a model of sudden unexpected death in epilepsy
  59:1, p. 92 - 105 2018
• Epilepsia
  Simeone Kristina A., Matthews Stephanie A., Synergistic Protection Against Acute Flurothyl-Induced Seizures by Adjuvant Treatment of the Ketogenic Diet with the Type 2 Diabetes Drug Pioglitazone
  58:8, p. 1440 - 1450 2017
• Neurochemical Research
  Simeone Kristina A., Rho Jong M., Ketone Bodies as Anti-Seizure Agents
  42:7, p. 2011 - 2018 2017
• Experimental Neurology
  Simeone Kristina A., Matthews Stephanie A., Samson Kaeli K., Regulation of Brain PPARgamma2 Contributes to Ketogenic Diet Anti-Seizure Efficacy
  284:Part 1, p. 54 - 64 2017
• Epilepsia
  Simeone Timothy A., Matthews Stephanie A., Rho J. M., Ketogenic Diet Treatment Increases Longevity in Kcna1-Null Mice, a Model of Sudden Unexpected Death in Epilepsy
  57:8, p. e178 - e182 2016
• Sleep
  Roundtree Harrison M., Simeone Kristina A., Johnson Chaz, Matthews Stephanie A., Samson Kaeli K., Orexin Receptor Antagonism Improves Sleep and Reduces Seizures in Kcna1-Null Mice
  39:2, p. 357 - 368 2016
• Annals of Neurology
  Kim do Y., Ahn Y., Geddes J. W., Sullivan P. G., Simeone Timothy A., Wilke J. C., Rho J. M., Pandya J. D., Ketone bodies mediate antiseizure effects through mitochondrial permeability transition
  78:1, p. 77 - 87 2015
• Epilepsia
  Simeone Kristina A., Samson Kaeli K., Matthews Stephanie A., In Vivo Ketogenic Diet Treatment Attenuates Pathologic Sharp Waves and High Frequency Oscillations in in Vitro Hippocampal Slices from Epileptic Kv 1.1α Knockout Mice.
  55:5, p. e44 - e49 2014
• Experimental Neurology
  Simeone Timothy A., Matthews Stephanie A., Samson Kaeli K., Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures
  251, p. 84 - 90 2014
• Neurobiology of Disease
  Simeone Kristina A., Rho Jong M., Samson Kaeli K., Kim Do Y., Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices
  54, p. 68 - 81 2013
• Epilepsy Research
  Simeone Timothy A., Wilcox Karen S., White H. Steve, CAMP-Dependent protein kinase A activity modulates topiramate potentiation of GABA A receptors
  96:1-2, p. 176 - 179 2011
• Pharmacological Research
  Simeone Timothy A., Wilcox Karen S., White H. Steve, Topiramate modulation of β1- and β3- homomeric GABAA receptors
  64:1, p. 44 - 52 2011
• Epilepsia
  Simeone Timothy A., Sabesan S., Kim D. Y., Kerrigan John F., Jr., Rho J. M., Fenoglio-Simeone Kristina A., L-type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue
  52:3, p. 531 - 540 2011
• Epilepsia
  Kim Do Young, Chang Yongchang, Fenoglio Kristina A., Simeone Timothy A., Coons Stephen W., Wu Jie, Kerrigan John F., Rho Jong M., GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas
  49:5, p. 861 - 871 2008
• Neurobiology of Disease
  Richichi Cristina, Simeone Timothy A., Brewster Amy L., Bender Roland A., Zha Qinqin, Yin Hong Z., Weiss John H., Baram Tallie Z., Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels
  29:2, p. 297 - 305 2008
• Seminars in Pediatric Neurology
  Fenoglio Kristina A., Wu Jie, Kim Do Young, Simeone Timothy A., Kerrigan John F., Coons Stephen W., Rekate Harold, Rho Jong M., Hypothalamic Hamartoma
  14:2, p. 51 - 59 2007
• Journal of Neurochemistry
  Kim Do Young, Davis Laurie M., Sullivan Patrick G., Maalouf Marwan, Simeone Timothy A., Van Brederode Johannes, Rho Jong M., Ketone bodies are protective against oxidative stress in neocortical neurons
  101:5, p. 1316 - 1326 2007
• European Journal of Pharmacology
  Simeone Timothy A., Otto James F., Wilcox Karen S., White H. Steve, Felbamate is a subunit selective modulator of recombinant γ-aminobutyric acid type A receptors expressed in Xenopus oocytes
  552:1-3, p. 31 - 35 2006
• Neuropharmacology
  Simeone Timothy A., Wilcox Karen S., White H. Steve, Subunit selectivity of topiramate modulation of heteromeric GABAA receptors
  50:7, p. 845 - 857 2006
• Journal of Physiology
  Simeone T. A., Rho J. M., Baram T. Z., Single channel properties of hyperpolarization-activated cation currents in acutely dissociated rat hippocampal neurones
  568:2, p. 371 - 380 2005
• Richichi C, Simeone T, Bender R A, Brewster A L, Yin H Z, Weiss J H, Baram T Z, Seizures reduce the expression of the hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel I via Ca++/calmodulin dependent protein kinase II activation 2005
• Journal of child neurology
  Simeone Timothy A., Sanchez Russell M., Rho Jong M., Molecular biology and ontogeny of glutamate receptors in the mammalian central nervous system
  19:5, p. 343 - 360 2004
• Neurochemical Research
  Poulsen Claus F., Simeone Timothy A., Maar Thomas E., Smith-Swintosky Virginia, Schousboe Arne, White H. Steven, Modulation by Topiramate of AMPA and Kainate Mediated Calcium Influx in Cultured Cerebral Cortical, Hippocampal and Cerebellar Neurons
  29:1, p. 275 - 282 2004
• Journal of child neurology
  Simeone Timothy A., Donevan Sean D., Rho Jong M., Molecular biology and ontogeny of γ-Aminobutyric acid (GABA) receptors in the mammalian central nervous system
  18:1, p. 39 - 48 2003

Awards

• Intramural Research Award
  Creighton University School of Medicine New Investigator Award