Kristen M. Drescher, PhD
Kristen M. Drescher, PhD

Kristen M. Drescher, PhD

Professor
School of Medicine

Academic Appointments

Department

  • Med. Microbiology & Immunology

Position

  • Professor

Biography

Examples of the most recent publications can be found at this PubMed link.

Education

  • University of New Hampshire,B.S.,1979-1983
  • University of Lowell,M.S.,1/88 - 8/90
  • Johns Hopkins University,Ph.D.,9/90-6/95

Publications and Presentations

Articles

  • Drescher KM, Tracy S. Impfen gegen diabetes (German)., Spektrum de Wissenschaft, August 2018, 2018
  • Riesberg LA, McDonald TL, Wang Y, Chen XM, Holzmer SW, Tracy SM, Drescher KM. Creatinine downregulates TNF-a in macrophage and T cell lines., Cytokine, 110, 29-38, 2018
  • Drescher KM, Tracy S. Vanquishing Diabetes., Scientific American, 318 (2), 54-59, 2018
  • Riesberg LA, Weed SA, McDonald TL, Eckerson JM, Drescher KM. Beyond muscles: the untapped potential of creatine, International Immunopharmacology, 37, 31-42, 2016
  • Hu G, Gong AY, Wang Y, Ma S, Chen X, Chen J, Su CJ, Shibata A, Strauss-Soukup JK, Drescher KM, Chen XM. LincRNA-Cox2 promotes late inflammatory gene transcription in macrophages through modulating SWI/SNF-mediated chromatin remodeling., Journal of Immunology, 196 (6), 2799-2808, 2016
  • Drescher KM, von Herrath M, Tracy S. Enteroviruses, hygiene and type 1 diabetes: toward a preventive vaccine, Rev Med Virol, 25, 19-32, 2015
  • Smithee S, Tracy S, Drescher KM, Pitz LA, McDonald T. A novel, broadly applicable approach to isolation of fungi in diverse growth media, J Microbiol Methods, 105, 155-61, 2014
  • Lynch HT, Drescher K, Knezetic J, Lanspa S. Genetics, biomarkers, hereditary cancer syndrome diagnosis, heterogeneity and treatment: a review, Current Treatment Options in Oncology, 15, 429-442, 2014
  • Lynch HT, Drescher KM, Sharma P, Snyder C., Lynch JF, Knezetic J., Mitchins M, Silberstein P, and Lanspa S. Lynch Syndrome as a Model for Identification of Hereditary High-Risk Patients in Cancers of the Colon and Rectum: A Multidisciplinary Approach to Diagnosis and Management. Benson, A, Chakravarthy A, Hamilton S, Sigurdson E, and Thomas C. (eds)., Cancers of the Colon and Rectum, 2013
  • Hu G, Drescher KM, Chen XM. Exosomal miRNAs: Biological Properties and Therapeutic Potential., Fronters in Genetics, 3, 56, 2012
  • McDonald T, Drescher KM, Weber A, Tracy S. Creatinine inhibits bacterial replication., J Antibiotics, 65 (3), 153-156, 2012
  • Zhou R, Li X, Hu G, Gong AY, Drescher KM, Chen XM. miR-16 Targets Transcriptional Corepressor SMRT and Modulates NF-kappaB-Regulated Transactivation of Interleukin-8 Gene., PLoS One, 7, e30772, 2012
  • Tracy S, Drescher KM, Chapman NM. Enteroviruses and type 1 diabetes., Diabetes/Metabolism Research and Reviews, 27, 820-823, 2011
  • Leland KM, McDonald TL, Drescher KM. Effect of creatine, creatinine, and creatine ethyl ester on TLR expression in macrophages. International Immunopharmacology, International Immunopharmacology, 11, 1341-1347, 2011
  • Drescher KM, Sharma P, Lynch HT. Current hypotheses on how microsatellite instability leads to enhanced survival of Lynch Syndrome patients, Clinical and Developmental Immunology, 170432, 1-13, 2010
  • Tracy SM, Drescher KM, Jackson JD, Kim K, Kono K. Enteroviruses, type 1 diabetes and hygeine: a complex relationship, Reviews in Medical Virology, 20, 106-116, 2010
  • Gong AY, Zhou R, Hu G, Liu J, Sosnowska D, Drescher KM, Dong H, Chen XM. Cryptosporidia parvum induces B7-H1 expression in cholangiocytes by downregulating microRNA 513, Journal of Infectious Diseases, 201, 160-169, 2010
  • Drescher KM, Sharma P, Watson P, Gatalica Z, Thibodeau SN, Lynch HT. Lymphocyte recruitment into the tumor is altered in patients in MSI-H cancer, Familial Cancer, 8, 231-239, 2009
  • Liu J, Drescher KM, Chen XM. MicroRNAs and epithelial immunity, International Reviews in Immunology, 28, 139-154, 2009
  • Zhou R, Hu G, Liu J, Gong AY, Drescher KM, Chen XM. NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses, PLoS Pathogens, 5, e1000681, 2009
  • Drescher KM, Sosnowska D. Being a mouse in a man's world: what TMEV has taught us about human disease, Frontiers in Bioscience, 13, 3775-3785, 2008
  • Chapman NM, Kim KS, Drescher KM, Oka K, Tracy S. 5' terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart, Virology, 375, 480-491, 2008
  • Lynch HT, Drescher KM, de la Chapelle A. Immunology and the Lynch Syndrome, Gastroenterology, 134, 1246-1249, 2008
  • Drescher KM and Tracy S. Establishment of a model to examine the early events involved in the development of virus-induced demyelinating lesions, Annals of New York Academy of Science, 1103, 152-156, 2007
  • Tracy S and Drescher KM. Coxsackievirus infections and NOD mice: Relevant models of protection from, and induction of, Type 1 Diabetes., Annals of New York Academy of Science, 1130, 143-151, 2007
  • Drescher KM and Tracy SM. Injection of the sciatic nerve with TMEV: a new model for peripheral nerve demyelination, Virology, 359, 233-242, 2007
  • Immunology for Medical Students: T Cell Development, Not Applicable, 2006
  • Tracy S, Chapman NM, Drescher KM, Tapprich W. Evolution of virulence in picornaviruses in: Quasispecies: Concepts and Implications for Virology, Current Topics in Microbiology and Immunology, 299, 193-210, 2006
  • Kanno T, Kim K, Kono K, Drescher KM, Chapman NM, Tracy SM. Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency., Journal of Virology, 80, 5637-5643, 2006
  • Drescher, KM and Lynch HT. Tumor infiltrating lymphocytes (TILs): Lessons learned in 30 years of study, Clinical and Applied Immunology Reviews, 5 (3), 149-166, 2005
  • Lee CK, Kono K, Haas E, Kim KS, Drescher KM, Chapman NM, Tracy S. Characterization of an infectious cDNA copy of the genome of a naturally-occurring, avirulent coxsackievirus B3 clinical isolate., Journal of General Virology, 86, 197-210, 2005
  • Drescher KM, Kocakova P, Chapman NM, Tracy SM. CVB-based vaccines alter immune responses to self in virus-infected mice., 12th International Congress of Immunology, 341-344, 2004
  • Drescher KM, Kono K, Bopemagamage S, Carson SD, Tracy S Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection, Virology, 329, 381-394, 2004
  • Pavelko, K.D., C.L. Howe, K.M. Drescher, J.D. Gamez, A.J. Johnson, T. Wei, R.M. Ransohoff, M. Rodriguez. Interleukin-6 protects anterior horn neurons from lethal virus-induced injury., Journal of Neuroscience, 23, 481-492, 2003
  • Drescher, K.M., L.J. Zoecklein, and M. Rodriguez. ICAM-1 is crucial to protection from TMEV-induced neuronal damage but not demyelination., Journal of Neurovirology, 8, 452-458, 2002
  • ”T-Cell ” Immunology for Medical Students. Nairn and Helbert. C.V. Mosby Co, Not Applicable, 2002
  • Tracy, S., K.M. Drescher, N.M. Chapman, K.-S. Kim, S.D. Carson, S. Pirruccello, P.H. Lane, J.R. Romero, and J.S. Leser. Toward testing the hypothesis that Group B coxsackieviruses (CVB) trigger insulin-dependent diabetes: inoculating nonobese diabetic mice with CVB markedly lowers diabetes incidence., Journal of Virology, 76, 12097-12111, 2002
  • Drescher, K.M., Johnston, S.L., Hogancamp, W., David, C.S., Rimm, I.J., Wettstein, P.J., and Rodriguez, M. Vb8+T cells protect from demyelinating disease in a viral model of multiple sclerosis:, International Immunology, 12, 271-280, 2000
  • Drescher KM, Murray, PD, Lin X, Carlino J, Rodriguez M. TGF-b2 reduces demyelination, virus antigen expression, and macrophage recruitment in a viral model of multiple sclerosis, Journal of Immunology, 164, 3207-3213, 2000
  • Drescher, K.M., Zoecklein, L.J., Pavelko, K.D., Rivera-Quinones, C., Hollenbaugh, D. and Rodriguez, M. CD40L is critical for protection from demyelinating disease and development of spontaneous remyelination in a mouse model of multiple sclerosis., Brain Pathology, 10, 1-15, 2000
  • Das, P., Drescher, K.M., Bradley, D.S., Rodriguez, M. and David, C.S. Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis, Human Immunology, 61, 279-289, 2000
  • Pavelko, K.D.*, Drescher, K.M.*, McGavern, D.B., David, C.S., and Rodriguez, M. HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosis. *Both authors contributed equally to this manuscript., Molecular and Cellular Neuroscience, 15, 495-509, 2000
  • Drescher KM, Murray PD, David CS, Pease LR, Rodriguez M. CNS cell populations are protected from virus-induced pathology by distinct arms of the immune system, Brain Pathology, 9, 21-31, 1999
  • McGavern DB, Zoecklin L, Drescher KM, Rodriguez M. Quantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination, Experimental Neurology, 158, 171-181, 1999
  • Njenga MK, Murray PD, McGavern DB, Drescher KM, Rodriguez M. Absence of spontaneous central nervous system remyelination in major histocompatibility complex class II-deficient mice infected with Theiler's virus, Journal of Neuropathology and Experimental Neurology, 58, 78-91, 1999

Publications

  • The effect of creatine and creatinine on myocellular injury in doxorubicin-treated skeletal muscle myoblasts
    Bredahl, Eric1; Najdawi, Wisam1; Hook, Sarah1; Eckerson, Joan, FACSM1; Siedlik, Jake1; Drescher, Kristen2
    American College of Sports Medicine, Medicine & Science in Sports & Exercise, 50 5S, 644, 2018
  • Effect of Resistance Training on Contractile Force Production during Doxorubicin-Treatment:
    Kaufenberg, Mikayla1; Tigner, Allison1; Hook, Sarah1; Twaddell, MacKenzie1; Wagner, Meghan1; Bredahl, Eric1; Siedlik, Jake1; Eckerson, Joan, FACSM1; Drescher, Kristen2
    American College of Sports Medicine, Medicine & Science in Sports & Exercise, 50 5S, 644, 2018
  • THE EFFECT OF CREATINE AND CREATININE ON CREATINE METABOLISM IN DOXORUBICIN-TREATED SKELETAL MUSCLE MYOBLASTS
    Wisam Najdawi, Sarah M. Hook, Joan M. Eckerson FACSM, Jake A. Siedlik, Kristen M. Drescher, and Eric C. Bredahl,, St. Albert's day/Creighton University Research day, 2018, ---, 2018
  • THE EFFECT OF RESISTANCE TRAINING ON CONTRACTILE FORCE PRODUCTION DURING DOXORUBICIN TREATMENT
    Mikayla Kaufenberg, Tigner, A.T., Hook, S.M., Twaddell, M.D., Wagner, M.K., Siedlik, J.A., Eckerson, J.M., Drescher, K.M., Bredahl, E.C.,, St. Albert's day/Creighton University Research day, 2018, ---, 2018
  • THE EFFECT OF CREATINE AND CREATININE TREATMENT ON SHORT-TERM ENERGY METABOLISM IN DOXORUBICIN-TREATED SKELETAL MUSCLE MYOBLASTS Hook, S.M.1, Najdawi, W.O.1, Eckerson, J.M.1, Siedlik, J.A.1, Drescher, K.M.2, Bredahl, E.C.1, Nebraska Physiological Society, 2017, --, 2017
  • EFFECT OF RESISTANCE TRAINING ON CONTRACTILE FORCE PRODUCTION DURING DOXORUBICIN-TREATMENT Tigner, A.T.1, Kaufenberg, M.M.1, Hook, S.M.1, Twaddell, M.D.1, Wagner, M.K.1, Siedlik, J.A.1, Eckerson, J.M.1, Drescher, K.M.2, Bredahl, E.C.1, Nebraska Physiological Society, 2017, ---, 2017
  • The Effect of Creatine Supplementation on Upper Body Strength and Immune Function in Men:
    Eckerson, Joan M. FACSM1; Riesberg, Lisa A.1; Serreyn, Kyle1; Yee, Jennifer1; Moore, Geri A.1; Katsavelis, Dimitrios1; Bredahl, Eric1; Drescher, Kristen1; Fukuda, David2; Kurata, Laura1; Moon, Brittany1
    American College of Sports Medicine, Medicine & Science in Sports & Exercise, 49 5S, 1027, 2017
  • The Effects Of Creatine And Creatinine On Rates Of Apoptosis In Doxorubicin-treated Myoblasts:
    Bredahl, Eric C.; Kottensette, Sarah A.; Marshall, Nathaniel R.; Wagner, Meghan K.; Drescher, Kristen; Eckerson, Joan M.
    American College of Sports Medicine, Medicine & Science in Sports & Exercise, 49 5S, 7, 2017
  • KM Drescher, J Sunde, SM Tracy. Neuregulin-1 is upregulated in the sciatic nerve following infection with TMEV., International Congress of Virology, 11, v212, 2005
  • Tracy S, Drescher KM. Group B coxsackievirus infections in NOD mice: towards clarifying the role of enteroviruses in human type 1 diabetes onset, International Congress of Virology, 11, v173, 2005
  • JSM Yeh, S Tracy, KM Drescher, J Sunde, K Kono, N Chapman, JJ Boyle, T Hussell, C Sennoga, RJ Eckersley, MJ Blomley, DO Haskard, P Nihoyannopouloss; E-selectin is expressed in coxsackievirus B3 myocarditis, J American College of Cardiology, 45, 142A, 2005
  • Kristen M. Drescher, Paulina Kocakova, Nora M. Chapman, and Steven M. Tracy. Use of CVB-based Vaccines to Modify an Immune-Response to Self, Abstract Book, ACTRIMS, 2004
  • Drescher KM, Kocakova P, Chapman NM, Tracy SM. Inhibition of Cellular Immune Response to Self-Epitopes in TMEV-Infected Mice, Abstract Book, Intl. Congress of Immunology, 2004
  • SM Tracy, KM Drescher, K Kono, SD Carson, S Bopegamage; Coxsackievirus replicates in islets of old NOD mice and initiates diabetes, Seventh International Symposium on Positive Stranded RNA Viruses, 1, 2004
  • Kocakova P, Drescher KM; C3 is required for efficient clearance of virus from brains of TMEV-infected mice, FASEB Journal, 18, 2004
  • Steven Tracy, Nora M. Chapman, Kyung-Soo Kim, Kristen M. Drescher, Pascale H. Lane, Samuel Pirruccello, J. Smith Leser. Vaccination of young nonobese diabetic (NOD) mice with group B coxsackievirus lowers type 1 diabetes incidence, 26th International Congress of Internal Medicine, 2002, 2002

Editing and Reviews

  • Lynch HT, Lanspa SJ, Snyder CL, Drescher KM. Microsatellite instability, disease-free survival and role of tumour infiltrating lymphocytes (Invited editorial on 'Predictors of disease-free survival in colorectal cancer with microsatellite instability: An AEGO study), European Journal of Cancer, 51, 922-924, 2015

Presentations

  • Presentation for the Health Sciences Educator Development Program How to Improve Your Teaching: Insight From the Evaluation Committee, 2015
  • Drescher, KM and Tracy, SM Injection of the Sciatic Nerve with Theiler’s Virus: A Model of Virus-Induced Peripheral Demyelination; Positive Strand Meeting; Washington DC (poster), 2007
  • Tracy, SM and Drescher, KM COXSACKIEVIRUS AND NOD MICE: RELEVANT MODELS OF PROTECTION FROM, AND INDUCTION OF, TYPE 1 DIABETES, 2006
  • Drescher, KM and Tracy, SM Establishment of a model to examine the events involved in the development of virus-induced demyelinating lesions. NY Acad Sciences, Animal Models of MS and TID, San Franscisco, 2006
  • National Multiple Sclerosis Society - Nebraska Chapter; TRENDS meeting; Roundtable Discussion on Research, 2006
  • Drescher KM and Tracy S Coxsackie B virus replication in pancreatic islets: virus associates with the four major islet cell types, not merely beta cells American Society of Virology, Madison, WI., 2006
  • 6. Tracy, S.M., Drescher, K.M., Jackson, J.D., Sanderson, S Vaccinating NOD mice against CVB-induced rapid T1D onset: type-specific immunity is not required to lower T1D incidence American Society of Virology, Madison, WI., 2006
  • Neuregulins in the peripheral nervous system in virus infections and autoimmune disease, 2006
  • Role of C3 in a model of virus-induced encephalitis, 2006
  • Impact of C3 deletion in a mouse model of virus induced demyelinating disease UNMC Department of Cell Biology and Genetics, 2006
  • Birth of a successful women in medicine and science program in a private, Jesuit medical school; R.E. Sonnino, M. Gentry-Nielsen, K.M. Drescher, M. Schofield, A. Chatterjee; AAMC Meeting, 2005
  • Neuregulin is upregulated in the sciatic nerve following infection with TMEV; KM Drescher, A Heller, S Tracy; International Congress of Virology, 2005
  • Group B Coxsackievirus infections in NOD mice: Towards clarifying a role of enteroviruses in human type 1 diabetes onset, S, Tracy and K. Drescher, International Congress of Virology, 2005
  • American College of Cardiology, 2005
  • Hounsfield Lecture (Imperial College, London) Developing A Novel Ultrasound Method Of Imaging Molecular Activities Dr J Yeh Dr C Sennoga Prof M Blomley Mr P Muckett Dr R Eckersley Prof S Tracy Dr K Drescher Dr YW Li Dr C Tang Dr J Boyle Dr J Mason8 Dr S Nourshargh Prof J Seddon Prof D Haskard Dr P Nihoyannopoulos, 2005
  • America's Conference on the Treatment and Immunology of Multiple Sclerosis, 2004
  • CVB-induces diabetes in older NOD mice; SM Tracy, KM Drescher, K Kono, S Bopegamage, SD Carson, 2004
  • International Congress on Immunology, 2004
  • Coxsackie B virus replicates in islets of old NOD mice and initiates type 1 diabetes. Steven Tracy, Kristen M. Drescher, Ken Kono, Steven D. Carson, Shubhada Bopegamage; Seventh International Symposium on positive-strand RNA viruses; San Francisco, CA, 2004
  • Paula Kocakova and Kristen M. Drescher C3 is required for efficient clearance of virus from the brains of TMEV-infected mice; Federation of the American Society of Experimental Biology, 2004
  • Cary M. Wolter,Jill R. Fuhrman, and Kristen M. Drescher Localization of matrix metalloproteinases (MMPs) in the brains of TMEV-infected mice Midwest Medical Student Research Forum (poster), 2004
  • Oshunleti, O. and Drescher, K.M. Use of CVB chimeric viruses as vaccine vectors in an animal model of multiple sclerosis - National Medical Fellowship Program, 2004
  • Paula Kocakova and Kristen M. Drescher C3 is required for efficient clearance of virus from the brains of TMEV-infected mice, Midwest Medical Student Research Forum, 2004
  • Immunology Group - Use of CVB chimerae as vaccines in a model of multiple sclerosis, 2002
  • Johnson, T.D., Marsh, L.B., Ray, T., Drescher, K.M. The relative contribution of B cells and complement in protection of the brain from Theiler's murine encephalomyelitis virus. Minority summer student poster session, 2002
  • Tracy et al, X!!th International COngress of Virology, 2002
  • Modulation of activin/inhibin mRNA levels following TMEV infection XIIth International Congress of Virology (Paris, France), 2002
  • Theiler's Virus model of multiple sclerosis, 2002
  • Ukpo,O.C., S.E. Hopkins and K.M. Drescher. Identification of apoptotic cells in the brains and spinal cords of TMEV-infected mice. Minority Summer Student Research Forum (Poster), 2001
  • Hopkins, S.E., O.C. Ukpo, and K.M. Drescher. Apoptosis in the brains of TMEV-infected C57BL6/J and B10.Q mice. Minority High School Student Research Forum (Poster)., 2001
  • Texas A & M University - Neuroscience Seminar Series, 2001
  • University of Nebraska Medical Center - Department of Cell Biology and Anatomy, 2001
  • Cooper, D.M. and Drescher, K.M. - Regional ASM Meeting - oral presentation, 2001
  • University of Nebraska Medical Center - Immunology Interest Group, 2001
  • Cooper, D.C. and Drescher, K.D. Midwest Student Research Forum - poster, 2001
  • Cooper, D.M. and Drescher, K.D. - Regional AAAS Meeting - poster, 2000
  • Flores, N., Cooper, D.M. and Drescher, K.M. - Minority summer student poster session, 2000
  • 10/22/99;VA Hospital;"Expression of the HLA-DR3 Transgene reduces the severity of demyelination in a viral model of multiple sclerosis", 1999

Research and Scholarship

Research and Scholarship Interests

  • Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS) in humans. Patients with MS normally experience a chronic progressive loss of motor and/or sensory functions. The origin of MS is unknown, although some investigators have postulated than an environmental agent (i.e. a virus or bacteria) may trigger the disease. My laboratory utilizes a mouse model of virus-induced demyelination (Theiler's murine encephalomyelitis virus) to study immune factors involved in the development of pathology and clinical disease.

Current Research Projects

Awards and Honors

  • Compositions and methods for treatment of inflammation; US Patent Number 9993452, 2018
  • Provisional - MODIFIED TRIZOL METHODOLOGY FOR RNA ISOLATION FROM RNASE-RICH TISSUES (Patent No: 60/934517), 2007
  • National Award, NY Academy of Sciences, 2006