Kristina A. Simeone, PhD
Kristina A. Simeone, PhD

Kristina A. Simeone, PhD

Associate Professor
School of Medicine

Academic Appointments

Department

  • Pharmacology

Position

  • Associate Professor

Education

  • Regis University,B.S.,1996-2000
  • University of California-Irvine,Ph.D.,2001-2006

Publications and Presentations

Articles

  • Kim DY*, Simeone KA*, Simeone TA, Pandya J, Wilke J, Ahn Y, Geddes J, Sullivan PG, Rho JM (2015). Ketone Bodies Mediate Anti-Seizure Effects Through mPT, Annals of Neurology, doi: 10.1002/ana.24424. , [Epub ahead of print]., 2015
  • In vivo ketogenic diet treatment attenuates pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices from epileptic Kv 1.1α knockout mice. Simeone TA, Samson KK, Matthews SA, Simeone KA, Epilepsia, 55(5), 44-49, 2014
  • Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures. Simeone KA, Matthews SA, Samson KK, Simeone TA., Not Applicable, 251, 2014
  • Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices. Simeone TA, Simeone KA, Samson KK, Kim do Y, Rho JM., Not Applicable, 54, 2013
  • Simeone TA, Simeone KA, Samson KK, Kim DY, Rho JM (2013) Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices., Neurobiology of Disease, 54, 68-81, 2013
  • Hypothalamic hamartomas: neuropathological features with and without prior gamma knife radiosurgery. Kerrigan JF, Parsons A, Rice SG, Simeone KA, Shetter AG, Abla AA, Prenger E, Coons SW., Not Applicable, 91(1), 2013
  • L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue. Simeone KA, Sabesan S, Kim do Y, Kerrigan JF, Rho JM, Simeone TA., Epilepsia, 52, 531-540, 2011
  • Chan YM, K.A. Fenoglio-Simeone, S. Paraschos, L. Muhammad, M.M. Troester, Y.Y. Ng, R.E. Johnsonbaugh, S.W. Coons, E.C. Prenger, J.F. Kerrigan, S.B. Seminara. Central precocious puberty due to hypothalamic hamartomas correlates with anatomic features but not with expression of GnRH, TGFalpha, or KISS1., Hormone Research in Paediatrics, 73, 312-319, 2010
  • Head E, V.N. Nukala, K.A. Fenoglio, B.A. Muggenburg, C.W. Cotman, P.G. Sullivan. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging., Experimental Neurology, 220 (1), 171-6, 2009
  • Fenoglio-Simeone K.A., A. Mazarati, S. Sefidvash-Hockley, D. Shin, J. Wilke, H. Milligan, R. Sankar, J.M. Rho, R. Maganti. Anticonvulsant effects of the selective melatonin receptor agonist ramelteon., Epilepsy and Behavior, 16 (1), 52-7, 2009
  • Fenoglio-Simeone K.A., J.C.Wilke, H.L. Milligan, C.N. Allen, J.M. Rho, R.K. Maganti. Ketogenic Diet Treatment Improves Diurnal Rhythmicity and Abolishes Seizure Periodicity in Epileptic Kcna1-null Mice., Epilepsia, 50 (9), 2027-34, 2009
  • Kim DY, Fenoglio (Simeone) KA, Kerrigan JF, Rho JM. Bicarbonate contributes to GABAA receptor-mediated neuronal excitation in surgically resected human hypothalamic hamartomas., Epilepsy Research, 83 (1), 89-93, 2009
  • Roundtree HM, Simeone TA, Johnson CJ, Matthews SA, Samson KK, Simeone KA (submitted) Orexin receptor antagonism improves sleep and reduces seizures in Kcna1-null mice.
  • Simeone TA, Matthews SA, Samson KK, Simeone KA (submitted) Regulation of brain PPARγ mediates ketogenic diet anti-seizure efficacy.
  • Simeone KA, Johnson CJ, Samson KK, Roundtree HM, Simeone TA, Tarhok LA. (in press). Sleep In Masino & Boison (Eds), Brain Homeostasis. Oxford Press.

Publications

  • Pathologic Mitochondria and Refractory Epilepsy: Carbamazepine (CBZ) Directly Modulates Mitochondrial Function in Wild-Type and Epileptic Mice. KA Simeone, JM Rho, N Jain, TA Simeone., 64th Annual Meeting of the American Epilepsy Society, 2010
  • ‘Creighton Pharmacology Professors Probe Mysteries Surrounding Epilepsy'. Interviewed by CUSOM Newsletter to discuss our latest research of how food can have anti-seizure effects in epilepsy. http://medschool.creighton.edu/medicine/newscurrent/simeones/index.php
  • ‘Exploring Epilepsy’ Onwards and Upwards. Interviewed by International Innovation. 174: 109-111. http://www.internationalinnovation.com/exploring-epilepsy/

Presentations

  • Iyer S, Matthews SA, Smason KK, Simeoen KA, Simeone TA. Antiseizure Effects of Ketogenic Diet Are Mediated Via Regulation of Brain PPAR-Gamma, A Nutritionally Responsive Transcription Factor. Antiseizure Drug Development Symposium: Therapy Development in the Era of Team Science and Big Data: What Will the Future Bring to the Patient with Epilepsy? Salt Lake City, UT., 2015
  • Preliminary evidence of adaptive immune cell infiltration into the brain of a genetic model of chronic epilepsy. Antiseizure Drug Development Symposium: Therapy Development in the Era of Team Science and Big Data: What Will the Future Bring to the Patient with Epilepsy? Salt Lake City, UT., 2015
  • Effects of Dual orexin receptor antagonist treatment improves sleep and reduces seizures in Kv1.1KO mice. Antiseizure Drug Development Symposium: Therapy Development in the Era of Team Science and Big Data: What Will the Future Bring to the Patient with Epilepsy? Salt Lake City, UT., 2015
  • Sleepless and Hyperexcitable,’ Biomedical Science Seminar Series, University of California at Riverside, Riverside, CA., 2015
  • Department Research Rounds, CUSOM. Title: A tale of two tales: mitochondria and the ketogenic diet, 2015
  • Orexinergic activity and seizure propagation to the lateral hypothalamus. St. Albert's Day, 2015
  • ‘Mitochondria as a Novel Anti-Seizure Target,’ Biochemistry Seminar Series,CUSOM, Omaha, NE., 2015
  • Simeone TA, Matthews SA, Samson KK, Simeone KA. PPARgamma mediates ketogenic diet anti-seizure efficacy. American Epilepsy Society, Seattle, WA., 2014
  • Consequences of seizure propagation to the sleep regulating lateral hypothalamus. Society for Neuroscience, Washington D.C., 2014
  • Use of Reversed-Phase High Performance Liquid Chromatography to Measure Adenosine Amounts in Mouse Brain. ACS Midwest Regional Meeting - Columbia, MO., 2014
  • University of Nebraska Medical Center, Department of Neurological Sciences. Current and Future Directions for Translational Epilepsy Research Seminar. Title: Epilepsy, sleep and mitochondria., 2014
  • ‘Seizure Propagation to the Lateral Hypothalamus and Sleep-Wake Triggers’ Oregon Health Science University, Portland, OR, 2014
  • ‘Mitochondria, Neurotransmission and Epilepsy’ Biomedical Science Research Series, Creighton University School of Medicine, Omaha, NE, 2014
  • 'Effects of the dual orexin receptor antagonist almorexant on sleep in the Kcna1-null mouse model of epilepsy'. HM Roundtree, CC Johnson, SA Matthews, TA Simeone, KA Simeone at MSRB, Omaha, NE, 2014
  • 'Effects of the dual orexin receptor antagonist almorexant on sleep in the Kcna1-null mouse model of epilepsy'. HM Roundtree, CC Johnson, SA Matthews, TA Simeone, KA Simeone at St. Albert’s Day, Creighton University, Omaha, NE, 2014
  • Interviewed by Malorie Maddox of WOWT News in a piece titled ‘Food For Thought’ to discuss how what you eat influences your brain, December 5, 2013. http://www.wowt.com/video?videoid=2732523, 2013
  • Simeone KA. A Novel Mitochondria-targeted Anticonvulsant Treatment. 2013 Curing the Epilepsies meeting, NINDS, Bethesda, MD., 2013
  • Simeone KA, Stephanie A. Matthews SA, Samson KK, Simeone TA. A Novel Mitochondria-targeted Anticonvulsant Treatment. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • J. F. Kerrigan, A. Parsons, K. Simeone, J. Wu, J. Beggs, S. Coons.SMALL AND LARGE NEURONS FROM HUMAN EPILEPTIC HYPOTHALAMIC HAMARTOMA: GOLGI ANALYSIS OF SURGICALLY-RESECTED TISSUE.American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Roundtree HM, Samson KK, Simeone TA, Simeone KA. Evidence of Pathology in the Lateral Hypothalamus: A Connection Between Sleep Disorder and Epilepsy in the Kv1.1 Knock-Out Mouse. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Ranade NP, Samson KK, Simeone KA, Simeone TA. Anticonvulsant Effects of Pioglitazone on High Potassium Seizure-Like Events in in vitro Hippocampal Slices. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Samson KK, Simeone KA, Rho JM, Simeone TA. Effects of Ketogenic Diet and Constituents on Pathologic Sharp Waves and High Frequency Oscillations. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Simeone KA, Roundtree HM, Samson KK, Simeone TA. Pathologic Hypocretin Circuitry: A Novel Mechanism of Sleep Disorders Associated with Epilepsy in Kv1.1 Knock-Out Mice. Creighton University, The Faculty Club Research at Center Stage, October, 2012., 2012
  • Sleep Disorder Co-morbidities Associated with Epilepsy: The Role of Adenosine Type 1 Receptor (A1R) in the Hypothalamus, 2012
  • Pathologic Hypocretin Circuitry: A Novel Mechanism of Sleep Disorders Associated with Epilepsy in Kv1.1 Knock-Out Mice, 2011
  • Loss of Kv1.1 alpha Subunit Alters Hippocampal Sharp Wave-Ripple Complexes and Promotes the Emergence of Pathologic Fast Ripples, 2011
  • Medical Student Research Interest Group: Epilepsy and Novel Anticonvulsant Therapies, 2011
  • American Epilepsy Society, San Antonio, TX. “Pathologic Mitochondria and Refractory Epilepsy: Carbamazepine (CBZ) Directly Modulates Mitochondrial Function in Wild-Type and Epileptic Mice.” Poster Presenter. KA Simeone, JM Rho, N Jain, TA Simeone., 2010
  • “Mitochondria, Metabolism and Epilepsy,” University of Nebraska at Lincoln, Department of Biochemistry & Redox Biology Center, 2010
  • Creighton University, The Faculty Club Research at Center Stage. “Normal Network Emergent Properties Hijacked by an Epileptic Brain.” TA Simeone, KA Simeone, KA Samson, JM Rho., 2010
  • Creighton University, The Faculty Club Research at Center Stage. “Pathologic Mitochondria and Refractory Epilepsy: Carbamazepine (CBZ) Directly Modulates Mitochondrial Function in Wild-Type and Epileptic Mice.” Poster Presenter. KA Simeone, JM Rho, N Jain, TA Simeone., 2010
  • “Epilepsy, Sleep Disorders and Adenosine,” Brown University, Chronobiology Conference, 2010
  • Simeone, K.A. Epilepsy and Sleep Disorders, 2010
  • A. Strobel, K.A. Simeone, S.W. Coons, J.F. Kerrigan. Cellular Density of Human Hypothalamic Hamartomas., 2009
  • "Epilepsy and Sleep Disorders" Molecular Biology Faculty Meeting, 2009
  • “Translational research: Human epileptic hypothalamic hamartoma tissue” Pharmacology Department Research Rounds on March 27, 2009., 2009

Awards and Honors

  • Travel award for Curing the Epilepsies: Pathways Forward Conference sponsored by NIH/NINDS, 2013
  • Intramural Research Award, 2012
  • Selected to attend the AAMC “Early Career Women Faculty Professional Development Seminar,” Washington DC., 2010