Venkatesh Govindarajan, PhD

Department

Medical Education

Position

Professor

Books

• Kuracha Murali, Govindarajan Venkatesh, Loggie Brian W., Thomas Peter, Carcinoembryonic antigen (CEA) expression is regulated by mutant KAS in mucinous colon cancers 2018
• Kuracha Murali R., Thomas Peter, Loggie Brian W., Govindarajan Venkatesh, FOXO proteins mediate adaptive resistance to PI3K inhibition in mucinous colorectal cancers 2017
• Advances in the Management of Peritoneal Carcinomatosis
  Shetty Shreya J., Sharma Poonam, Sirineni Gopi, Loggie Brian W., Govindarajan Venkatesh, Thomas Peter, Pseudomyxoma Peritonei as a Special Subset of Peritoneal Carcinomatosis [Book Chapter] 2014

Publications

• Plos One
  Kuracha Murali R., Thomas Peter, Loggie Brian W., Govindarajan Venkatesh, Bilateral Blockade of MEK- and PI3K-Mediated Pathways Downstream of Mutant KRAS as a Treatment Approach for Peritoneal Mucinous Malignancies
  12:6, p. e0179510 - e0179510 2017
• Annals of Surgical Oncology
  Judge Sean, Sharma Poonam, Loggie Brian W., Thomas Peter, Govindarajan Venkatesh, Malignant Peritoneal Mesothelioma: Characterization of the Inflammatory Response in the Tumor Microenvironment
  23:5, p. 1496 - 1500 2016
• Cancer Medicine
  Kuracha Murali R., Thomas Peter, Loggie Brian W., Govindarajan Venkatesh, Patient-Derived Xenograft Mouse Models of Pseudomyxoma Peritonei Recapitulate the Human Inflammatory Tumor Microenvironment
  5:4, p. 711 - 719 2016
• Developmental Biology
  Arya P., Rainey M. A., Bhattacharyya S., Mohapatra B., George M., Kuracha Murali R., Storck M. D., Band H., Govindarajan Venkatesh, The endocytic recycling regulatory protein EHD1 Is required for ocular lens development
  408:1, p. 41 - 55 2015
• Annals of Surgical Oncology
  Lohani Kush R., Shetty Shreya J., Sharma Poonam, Govindarajan Venkatesh, Thomas Peter, Loggie Brian W., Pseudomyxoma peritonei: inflammatory responses in the peritoneal microenvironment
  21:5, p. 1441 - 1447 2014
• American Surgeon
  Shetty Shreya J., Bathla Lokesh, Govindarajan Venkatesh, Thomas Peter, Loggie Brian W., Comparison of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with mitomycin or carboplatin for diffuse malignant peritoneal mesothelioma
  80:4, p. 348 - 352 2014
• Nucleic Acids Research
  Wolf L., Harrison W., Huang Jifan, Xie Qingmei, Xiao N., Sun J., Kong L., Lachke S. A., Kuracha M. R., Beebe D. C., Govindarajan Venkatesh, Brindle P. K., Ashery-Padan R., Overbeek P. A., Cvekl A., Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300
  41:22, p. 10199 - 10214 2013
• American Surgeon
  Shetty Shreya, Natarajan Bala, Thomas Peter, Govindarajan Venkatesh, Sharma Poonam, Loggie Brian, Proposed classification of pseudomyxoma peritonei
  79:11, p. 1171 - 1176 2013
• Journal of Surgical Research
  Shetty Shreya J., Thomas Peter, Ramanan Bala, Sharma Poonam, Govindarajan Venkatesh, Loggie Brian W., Kras mutations and p53 overexpression in pseudomyxoma peritonei: association with phenotype and prognosis
  180:1, p. 97 - 103 2013
• Developmental Biology
  Kuracha Murali R., Siefker Ed, Licht Jonathan D., Govindarajan Venkatesh, Spry1 and Spry2 are necessary for eyelid closure
  383:2, p. 227 - 238 2013
• Investigative Ophthalmology & Visual Science
  Kuracha M. R., Cooper J. T., Licht J. D., Robinson M. L., Govindarajan Venkatesh, Siefker E., Burgess D., Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation
  52:9, p. 6887 - 6897 2011
• World Journal of Surgical Oncology
  Foster Jason M., Radhakrishna Uppala, Govindarajan Venkatesh, Carreau Joseph H., Gatalica Zoran, Sharma Poonam, Nath Swapan K., Loggie Brian W., Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma
  8 2010
• BMC Developmental Biology
  Burgess Daniel, Zhang Yan, Siefker Ed, Vaca Ryan, Kuracha Murali R., Reneker Lixing, Overbeek Paul A., Govindarajan Venkatesh, Activated Ras alters lens and corneal development through induction of distinct downstream targets
  10, p. 13 - 13 2010
• BMC Developmental Biology
  Rainey Mark A., George Manju, Ying Guoguang, Akakura Reiko, Burgess Daniel J., Siefker Ed, Bargar Tom, Doglio Lynn, Crawford Susan E., Todd Gordon L., Govindarajan Venkatesh, Band Hamid, Hess Rex A., Band Vimla, Naramura Mayumi, The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in mice
  10 2010
• Developmental Biology
  Zhang Yan, Burgess Daniel, Overbeek Paul A., Govindarajan Venkatesh, Dominant inhibition of lens placode formation in mice
  323:1, p. 53 - 63 2008
• Methods and Findings in Experimental and Clinical Pharmacology
  Zhao Min, Destache Christopher J., Zhan Guilin, Liu Hong, Zhang Yan, Govindarajan Venkatesh, Opere Catherine A., Regulation of retinal morphology and posterior segment amino acids by 8-isoprostaglandin E2 in bovine eyes ex vivo
  30:8, p. 615 - 626 2008
• Molecular Vision
  Zhang Yan, Govindarajan Venkatesh, Overbeek Paul A., Perinatal ablation of the mouse lens causes multiple anterior chamber defects
  13, p. 2289 - 2300 2007
• BMC developmental biology
  Govindarajan Venkatesh, Overbeek Paul A, FGF9 can induce endochondral ossification in cranial mesenchyme
  6:1, p. 7 - 7 2006
• Molecular Vision
  Govindarajan Venkatesh, Harrison Wilbur R., Xiao Ningna, Liang Dongcai, Overbeek Paul A., Intracorneal positioning of the lens in Pax6-GAL4/VP16 transgenic mice
  11, p. 876 - 886 2005
• International Journal of Developmental Biology
  Reneker Lixing W., Xie Leike, Xu Li, Govindarajan Venkatesh, Overbeek Paul A., Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation
  48:8-9, p. 879 - 888 2004
• Development
  Govindarajan V., Overbeek P. A., Secreted FGFR3, but not FGFR1, inhibits lens fiber differentiation
  128:9, p. 1617 - 1627 2001
• Developmental Biology
  Govindarajan Venkatesh, Ito Masataka, Makarenkova Helen P., Lang Richard A., Overbeek Paul A., Endogenous and ectopic gland induction by FGF-10
  225:1, p. 188 - 200 2000
• Development
  Makarenkova Helen P., Ito Masataka, Govindarajan Venkatesh, Faber Sonya C., Li Sun, McMahon Gerald, Overbeek Paul A., Lang Richard A., FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development
  127:12, p. 2563 - 2572 2000
• Nucleic Acids Research
  Seid Christopher A., Tomlinson Craig R., Ramachandran Ravi K., George Jenny M., Flytzanis Constantin N., Govindarajan Venkatesh, González-Rimbau Maria F., An extracellular matrix response element in the promoter of the LpS1 genes of the sea urchin Lytechinus pictus
  25:15, p. 3175 - 3182 1997
• Development
  Ramachandran Ravi K., Wikramanayake Athula H., Uzman J. Akif, Govindarajan Venkatesh, Tomlinson Craig R., Disruption of gastrulation and oral-aboral ectoderm differentiation in the Lytechinus pictus embryo by a dominant/negative PDGF receptor
  124:12, p. 2355 - 2364 1997
• Journal of Molecular Biology
  Seid Christopher A., George Jenny M., Sater Amy K., Kozlowski Mark T., Lee Haemin, Govindarajan Venkatesh, Ramachandran Ravi K., Tomlinson Craig R., USF in the Lytechinus sea urchin embryo may act as a transcriptional repressor in non-aboral ectoderm cells for the cell lineage-specific expression of the LpS1 genes
  264:1, p. 7 - 19 1996
• Developmental Biology
  Govindarajan Venkatesh, Ramachandran Ravi K., George Jenny M., Shakes Diane C., Tomlinson Craig R., An ECM-bound, PDGF-like growth factor and a TGF-α-like growth factor are required for gastrulation and spiculogenesis in the Lytechinus embryo
  172:2, p. 541 - 551 1995
• Developmental Dynamics
  Ramachandran Ravi K., Govindarajan Venkatesh, Seid Christopher A., Patil Sonali, Tomlinson Craig R., Role for platelet‐derived growth factor‐like and epidermal growth factor‐like signaling pathways in gastrulation and spiculogenesis in the Lytechinus sea urchin embryo
  204:1, p. 77 - 88 1995

Presentations

• Thomas, P., Kuracha, M., Govindarajan, V. and Loggie B. A potential role for Carcinoembryonic Antigen in mediating Inflammation and Angiogenesis in Pseudomyxoma Peritonei. 2018, 35th Annual Meeting, The Society for Thermal Medicine, Tucson Arizona 2018
• Kuracha M., Govindarajan, V., Loggie, B. and Thomas, P. Carcinoembryonic antigen (CEA) expression is regulated by mutant KAS in mucinous colon cancers. 2018, American Association for Cancer Research (AACR) Annual Meeting. 2018
• FOXO proteins mediate adaptive resistance to PI3K inhibition in mucinous colorectal cancersMurali R. Kuracha1, Peter Thomas1, Brian W. Loggie1, Venkatesh Govindarajan2Department of Surgery1; Department of Biomedical Sciences2; Creighton University School of Medicine, Omaha, NE-68178.American Association for Cancer Research (Poster) 2017
• ACQUIRED RESISTANCE TO PI3K INHIBITION IN MUCINOUS COLORECTAL CANCERSMurali R. Kuracha1, Peter Thomas1, Brian W. Loggie1, Venkatesh Govindarajan2 Department of Surgery1; Department of Biomedical Sciences2Creighton University School of Medicine, Omaha, NESt. Albert's day Research Symposium (Poster) 2017
• 'Targeted Therapies for Mucinous Peritoneal Malignancies'Surgery Grand Rounds 2016
• 'Pathobiology of Mucinous Peritoneal Malignancies'Department of Biomedical Sciences Seminar 2015
• Priyanka Arya, Mark A Rainey, Sohinee Bhattacharyya, Murali R Kuracha, Vimla Band, Govindarajan V., Hamid Band Association for Research in Vision and Ophthalmology (poster) 05/2015 2015
• Kuracha, M. R., Thomas, P., Loggie, B. W. and Govindarajan, V. Bilateral blockade of MEK- and PI3K-driven pathways is effective in the treatment of KRAS-mutant mucinous colorectal cancer cells American Association for Cancer Research, Philadelphia (Poster) 04/2015 2015
• Kuracha, M. R., Thomas, P., Loggie, B. W. and Govindarajan, V. Targeted therapy for KRAS-mutant mucinous colorectal cancers. Creighton St. Alberts day Research Symposium (Poster) 04/2015 2015
• Judge, S., Shetty, S., Thomas, P., Govindarajan, V., Sharma, P., Loggie, B., Factors associated with survival in patients with Pseudomyxoma Peritonei: influence of signet ring cells. Society of Surgical Oncology Annual Cancer Symposium, Houston (Oral) 03/2015 2015
• Nelson, B.Q Kuracha, M. Govindarajan, V. Loggie, B and Thomas, P Carcinoembryonic Antigen (CEA) Induced Proliferation and Angiogenesis in Pseudomyxoma Peritonei 46th Annual Midwest Student Biomedical Research Forum (poster) 02/2015 2015
• Priyanka Arya, Mark A Rainey, Sohinee Bhattacharyya, Murali R Kuracha, Vimla Band, Govindarajan, V., Hamid Band The endocytic recycling regulator EHD1 is required for ocular lens development 46th Annual Midwest Student Biomedical Research Forum (MSBRF) (poster) 02/2015 2015
• Judge, S. Shetty, S. Thomas, P. Govindarajan, V. Sharma, P. and Loggie, B. Factors associated with survival in patients with Pseudomyxoma peritonei: Influence of signet ring cells. American College of Surgeons Clinical Congress (Oral) 09/2014 2014
• Pathobiology of Mucinous Peritoneal Carcinomatosis Grand Rounds, Department of Surgery Creighton Medical School 2014
• Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City 2006
• Department of Ophthalmology, University of Nebraska Medical Center, Omaha 2005
• Abstract titled: Lens and Corneal Epithelial Cells Are Sensitive to GAL4VP16 Expression. Presented at the Associciation for Research in Vision & Ophthalmology (ARVO) Annual Meeting in Ft Lauderdale, FL. 2005

Awards

• Golden Apple Award for Excellence in Teaching, Creighton University School of Medicine
  Medical students (M1-M4) choose one faculty member for excellence in teaching.
  SOM M1 students