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Venkatesh Govindarajan, PhD

Professor

Medical Education

Venkatesh Govindarajan

Contact

School of Medicine
Medical Education
Graduate School
HLSB - Hixson Lied Science Building

Venkatesh Govindarajan, PhD

Professor

Medical Education

Research Focus

Mucinous colorectal cancers, Pseudomyxoma peritonei, targeted therapy

Department

Medical Education

Position

Professor

Articles

  • Curcumin as a treatment option for inflammation in peritoneal surface malignancies.  Norton, E., Thomas, P., Govindarajan, V. and Loggie, B.  (Manuscript in preparation) 2019
  • PLoS One
    Kuracha, M. R., Thomas, P., Loggie, B., and Govindarajan, V. Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies PLOS One, 2017
    12(6), p. p. e0179510. 2017
  • Medical Research Archives
    Thomas, P., Kuracha, M. R., Loggie, B., and Govindarajan, V. Carcinoembryonic antigen: A multifunctional molecule in colorectal cancer progression and metastasis Medical Research Archives
    3:(3) 2017
  • Cancer Medicine
    Kuracha, M. R., Thomas, P., Loggie, B., and Govindarajan, V. Patient-derived Xenograft Mouse Models of Pseudomyxoma Peritonei Recapitulates the Human Inflammatory Tumor Microenvironment.
    5 (4), p. 711-719 2016
  • Annals of Surgical Oncology
    Judge, S., Thomas, P., Govindarajan, V., Sharma, P., and Loggie, B.  Malignant Peritoneal Mesothelioma: Characterization of the Inflammatory Response in the Tumor Microenvironment.
    23(5), p. 1496-1500. 2015
  • Annals of Surgical Oncology
    3. Lohani K, Shetty S, Sharma P, Govindarajan V, Thomas P, Loggie B. Pseudomyxoma Peritonei: Inflammatory Responses in the Peritoneal Microenvironment. 2014
  • American Surgeon
    4. Shetty S., Bathla, L., Govindarajan V., Thomas P. and Loggie B. W. Comparison of visceral sparing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with mitomycin or carboplatin for diffuse malignant peritoneal mesothelioma. 2014
  • Nucleic Acids Research
    7. Wolf L, Harrison W, Huang J, Xie Q, Xiao N, Sun J, Kong L, Lachke SA, Kuracha MR, Govindarajan V, Brindle PK, Ashery-Padan R, Beebe DC, Overbeek PA, Cvekl A. Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. 2013
  • Developmental Biology
    Kuracha MR, Siefker E, Licht JD, Govindarajan V. Spry1 and Spry2 are necessary for eyelid closure. 2013
  • Not Applicable
    Shetty S, P Thomas, V Govindarajan, P Sharma, G Sirineni, B Loggie. Pseudomyxoma peritonei as a special subset of peritoneal carcinomatosis. Future Medicine 2013
  • J Surg Res
    Shetty S, Thomas P, Ramanan B, Sharma P, Govindarajan V, Loggie B. Kras mutations and p53 overexpression in pseudomyxoma peritonei: association with phenotype and prognosis. 2013
  • BMC Developmental Biology
    Govindarajan, V.,PA.Overbeek. FGF9 can induce endochondral ossification in cranial mesenchyme.
    20, 6, p. 7 2006
  • Molecular Vision
    Govindarajan, V., WR. Harrison, N. Xiao, D. Liang, PA.Overbeek. Intracorneal positioning of the lens in Pax6-GAL4/VP16 transgenic mice.
    11, p. 876-886 2005
  • International Journal of Developmental Biology
    Reneker L.W., Xie L., Xu L., Govidarajan, V, Overveek P.A. Activated Ras Induces Lens Epithelial Cell Hyperplasia but not Premature Differentiation.
    48, p. 879-888 2004
  • Reneker L.W., L. Xie, L. Xu, V. Govindarajan and P.A. Overbeek. Constitutive Activation of Ras in Ocular Lens Results in Lens Epithelial Cell Over-Proliferation but not Premature Differntiation.
  • Priyanka Arya, Mark A Rainey, Sohinee Bhattacharyya, Bhopal Mohapatra, Manju George, Murali R Kuracha, Matthew Storck, Vimla Band, Venkatesh Govindarajan, Hamid Band. The Endocytic Recycling Regulatory Protein EHD1 Is Required for Ocular Lens Development Submitted to Developmental Biology
  • Judge, S., Shetty, S., Thomas, P., Govindarajan, V., Sharma, P., Loggie, B. Factors associated with survival in patients with Pseudomyxoma Peritonei: influence of signet ring cells. Submitted to Annals of Surgical Oncology

Publications

  • Kuracha M., Govindarajan, V., Loggie, B. and Thomas, P. Carcinoembryonic antigen (CEA) expression is regulated by mutant KAS in mucinous colon cancers. 2018, American Association for Cancer Research (AACR) Annual Meeting.
    78(13 Suppl) 2018
  • American Association for Cancer Research
    FOXO proteins mediate adaptive resistance to PI3K inhibition in mucinous colorectal cancers.Murali R. Kuracha1, Peter Thomas1, Brian W. Loggie1, Venkatesh Govindarajan2Department of Surgery1; Department of Biomedical Sciences2; Creighton University School of Medicine, Omaha, NE-68178.
    138 2017
  • Gifford-Truhlesen Conference
    Arya P, M A Rainey, S Bhattacharyya, M R Kuracha, V Band, V Govindarajan, H Band. An essential role for the endocytic recycling regulator EHD1 in ocular lens development. Gifford-Truhlsen Conference, University of Nebraska Medical Center, Omaha 2014
  • Gordon Research Conference
    Arya P, M A Rainey, S Bhattacharyya, M R Kuracha, V Band, V Govindarajan, H Band. An essential role for the endocytic recycling regulator EHD1 in ocular lens development. 2014
  • St. Albert's day/Creighton University Research day
    Kuracha MR, Siefker E, Thomas P, Loggie B, Govindarajan V. Mutant KRAS is necessary for MUC2 production in mucinous peritoneal cancers. 2014
  • Midwest Student Biomedical Research Forum
    Massop, D., C Troika, K Lohani, B Loggie, V Govindarajan, P Thomas. The effect of carcinoembryonic antigen on the peritoneal microenvironment in Pseudomyxoma Peritonei. 45th Annual Midwest Student Biomedical Research Forum, Omaha 2014
  • Midwest Student Biomedical Research Forum
    Smith T, M Kuracha, E Seifker, A Sarawagi, P Thomas, B Loggie, V Govindarajan. SAM-pointed domain-containing ETS-like factor (SPDEF) and Mucin2 (MUC2) in Pseudomyxoma Peritonei. 45th Annual Midwest Student Biomedical Research Forum, Omaha 2014
  • Midwest Student Biomedical Research Forum
    Arya P, M A Rainey, S Bhattacharyya, M R Kuracha, V Band, V Govindarajan, H Band. An essential role for the endocytic recycling regulator EHD1 in ocular lens development. 2014
  • Academic Surgical Congress
    Shah P K, K Lohani, S Shetty, P Thomas, P, V Govindarajan, B Natarajan, P Sharma, B Loggie. Signet Ring Cells In Pseudomyxoma Peritonei is a Marker For Poor Survival Academic Surgical Congress, San Diego, CA 2014
  • Not Applicable
    Arya P, M A Rainey, S Bhattacharyya, M R Kuracha, V Band, V Govindarajan, H Band. An essential role for the endocytic recycling regulator EHD1 in ocular lens development. 2013
  • Association for Research in Vision & Ophthalmology (ARVO) Annual Meeting
    Lens and Corneal Epithelial Cells Are Sensitive to GAL4VP16 Epression. 2005

Presentations

  • Thomas, P., Kuracha, M., Govindarajan, V. and Loggie B. A potential role for Carcinoembryonic Antigen in mediating Inflammation and Angiogenesis in Pseudomyxoma Peritonei. 2018, 35th Annual Meeting, The Society for Thermal Medicine, Tucson Arizona 2018
  • Kuracha M., Govindarajan, V., Loggie, B. and Thomas, P. Carcinoembryonic antigen (CEA) expression is regulated by mutant KAS in mucinous colon cancers. 2018, American Association for Cancer Research (AACR) Annual Meeting. 2018
  • FOXO proteins mediate adaptive resistance to PI3K inhibition in mucinous colorectal cancersMurali R. Kuracha1, Peter Thomas1, Brian W. Loggie1, Venkatesh Govindarajan2Department of Surgery1; Department of Biomedical Sciences2; Creighton University School of Medicine, Omaha, NE-68178.American Association for Cancer Research (Poster) 2017
  • ACQUIRED RESISTANCE TO PI3K INHIBITION IN MUCINOUS COLORECTAL CANCERSMurali R. Kuracha1,  Peter Thomas1, Brian W. Loggie1, Venkatesh Govindarajan2 Department of Surgery1; Department of Biomedical Sciences2Creighton University School of Medicine, Omaha, NESt. Albert's day Research Symposium (Poster) 2017
  • 'Targeted Therapies for Mucinous Peritoneal Malignancies'Surgery Grand Rounds 2016
  • 'Pathobiology of Mucinous Peritoneal Malignancies'Department of Biomedical Sciences Seminar 2015
  • Priyanka Arya, Mark A Rainey, Sohinee Bhattacharyya, Murali R Kuracha, Vimla Band, Govindarajan V., Hamid Band Association for Research in Vision and Ophthalmology (poster) 05/2015 2015
  • Kuracha, M. R., Thomas, P., Loggie, B. W. and Govindarajan, V. Bilateral blockade of MEK- and PI3K-driven pathways is effective in the treatment of KRAS-mutant mucinous colorectal cancer cells American Association for Cancer Research, Philadelphia (Poster) 04/2015 2015
  • Kuracha, M. R., Thomas, P., Loggie, B. W. and Govindarajan, V. Targeted therapy for KRAS-mutant mucinous colorectal cancers. Creighton St. Albert’s day Research Symposium (Poster) 04/2015 2015
  • Judge, S., Shetty, S., Thomas, P., Govindarajan, V., Sharma, P., Loggie, B., Factors associated with survival in patients with Pseudomyxoma Peritonei: influence of signet ring cells. Society of Surgical Oncology Annual Cancer Symposium, Houston (Oral) 03/2015 2015
  • Nelson, B.Q Kuracha, M. Govindarajan, V. Loggie, B and Thomas, P Carcinoembryonic Antigen (CEA) Induced Proliferation and Angiogenesis in Pseudomyxoma Peritonei 46th Annual Midwest Student Biomedical Research Forum (poster) 02/2015 2015
  • Priyanka Arya, Mark A Rainey, Sohinee Bhattacharyya, Murali R Kuracha, Vimla Band, Govindarajan, V., Hamid Band The endocytic recycling regulator EHD1 is required for ocular lens development 46th Annual Midwest Student Biomedical Research Forum (MSBRF) (poster) 02/2015 2015
  • Judge, S. Shetty, S. Thomas, P. Govindarajan, V. Sharma, P. and Loggie, B. Factors associated with survival in patients with Pseudomyxoma peritonei: Influence of signet ring cells. American College of Surgeons Clinical Congress (Oral) 09/2014 2014
  • Pathobiology of Mucinous Peritoneal Carcinomatosis Grand Rounds, Department of Surgery Creighton Medical School 2014
  • Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City 2006
  • Department of Ophthalmology, University of Nebraska Medical Center, Omaha 2005
  • Abstract titled: Lens and Corneal Epithelial Cells Are Sensitive to GAL4VP16 Expression. Presented at the Associciation for Research in Vision & Ophthalmology (ARVO) Annual Meeting in Ft Lauderdale, FL. 2005

Awards

  • Golden Apple Award for Excellence in Teaching, Creighton University School of Medicine
    Medical students (M1-M4) choose one faculty member for excellence in teaching.
    SOM M1 students