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Sudhanva S. Kashyap, PhD

Assistant Professor

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CRISS II - Criss 2 - 514B

Sudhanva S. Kashyap, PhD

Assistant Professor

Research Focus

Our research is focused on nematode parasitology, studying anthelmintic resistance in tropical parasitic nematode infections of humans. With the effects of climate change, these diseases are closer to the United States than ever before. My lab is particularly interested in filarial nematode infections, like lymphatic filariasis and onchocerciasis. Due to the lack of anthelmintic drugs that kill the adult worm, these diseases can never be ‘cured’. Overuse, misuse, and underdosing of anthelmintic drugs have resulted in several reports of resistance, highlighting the need for new targets, drugs and synergistic drug-interactions.
 
In our lab, we use the free-living nematode C. elegans and the parasitic nematode – Brugia malayi as models to study human filarial infections. We use electrophysiology, pharmacology, and behavioral analysis to characterize nematode ligand gated ion channels as novel anthelmintic drug targets and improve the efficacy of existing anthelmintics.
 
Currently, we are investigating the mode of action of the potassium channel agonist, emodepside and ways to increase its potency. We are also interested in the heterogeneity of large conductance potassium channels in free-living and parasitic nematodes. We are also exploring the role of the nematode nuclear hormone receptor – DAF-12 and macrocyclic lactones like ivermectin, in potentiating the effects of the cholinergic agonist, levamisole. My lab aims to characterize novel anthelmintic drug targets, bridge the gap in knowledge between the in vitro and in vivo pharmacology of these targets and increase the potency of anthelmintics by providing a rational basis for combination therapy.

Department

Med. Microbiology & Immunology

Position

Assistant Professor

Books

  • Advances in Parasitology
    Adrian J Wolstenholme, Andersen, Erik C; Choudhary, Shivani; Ebner, Friederike; Hartmann, Susanne; Holden-Dye, Lindy; Kashyap, Sudhanva S; Krcken, Jrgen; Martin, Richard J; Midha, Ankur; Nejsum, Peter; Neveu, Cedric; Robertson, Alan P; von Samson-Himmelstjerna, Georg; Walker, Robert; Wang, Jianbin; Whitehead, Bradley J; Williams, Paul DE Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids 2024

Articles

  • Antimicrobial Agents and Chemotherapy
    Paul D. E. Williams, Sudhanva S Kashyap, Alan P Robertson, Richard J Martin Diethylcarbamazine elicits Ca2+ signals through TRP-2 channels that are potentiated by emodepside in Brugia malayi muscles 2023
  • Sci Rep
    Paul D. E. Williams, Sudhanva S Kashyap, Mark A McHugh, Matthew T Brewer, Alan P Robertson, Richard J Martin Diethylcarbamazine, TRP channels and Ca2+ signaling in cells of the Ascaris intestine 2022
  • Int J Parasitol
    Sudhanva S Kashyap, Mark A McHugh, Alan P Robertson, Richard J Martin Diethylcarbamazine mediated potentiation of emodepside induced paralysis requires TRP-2 in adult Brugia malayi 2022
  • Proc Natl Acad Sci U S A
    Shivani Choudhary, Melanie Abongwa, Sudhanva S. Kashyap, Saurabh Verma, Gunnar R. Mair, Daniel Kulke, Richard J. Martin, and Alan P. Robertson Nodulisporic acid produces direct activation and positive allosteric modulation of AVR-14B, a glutamate-gated chloride channel from adult Brugia malayi 2022
  • Micropublication Biology
    Real Datta, Alan P Robertson, Richard J Martin, Sudhanva S Kashyap High concentrations of the anthelmintic diethylcarbamazine paralyze C. elegans independently of TRP-2 2022
  • Int J Parasitol
    Shivani Choudhary, Sudhanva S Kashyap, Alan P Robertson, Richard J Martin Advances in our understanding of nematode ion channels as potential anthelmintic targets 2021
  • Scientific Reports
    Sudhanva S Kashyap, Alan P Robertson, Richard J Martin Anthelmintic resistance and homeostatic plasticity (Brugia malayi) 2021
  • Communications Biology
    Saurabh Verma, Sudhanva S Kashyap, Alan P Robertson, Richard J Martin Diethylcarbamazine activates TRP channels including TRP-2 in filaria, Brugia malayi 2020
  • PLoS Pathogens
    Sudhanva S Kashyap, Saurabh Verma, Denis Voronin, Sara Lustigman, Daniel Kulke, Alan P Robertson, Richard J Martin Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channel 2019
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