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Derek David Smith, PhD

Professor

Biomedical Sciences

Derek Smith

Contact

School of Medicine
Biomedical Sciences
Graduate School
Biomedical Sciences (Doctorate)
Biomedical Sciences (Master of Science)
Pharmaceutical Sciences (Master of Science)
CRISS I - Criss 1

Derek David Smith, PhD

Professor

Biomedical Sciences

The overall goal of my research is to exploit the chemical synthesis of peptides to understand normal and abnormal processes in biology and medicine. My interests lie both in the development of new methods for the facile chemical synthesis of peptides, and the application of these methods to prepare pharmacologically and therapeutically interesting synthetic peptides. State-of-the-art techniques in use in the laboratory include the use of automated solid-phase synthesizers, ultra-high-performance liquid chromatography, amino acid analysis, matrix assisted laser desorption ionization-time of flight (MALDI-TOF) and electrospray-quadrupole-orbitrap mass spectrometry.

Department

Biomedical Sciences

Position

Professor

Articles

  • ACS Infectious Diseases
    Alshammari, A.M., Smith, D.D, Parriott, J., Stewart, J.P., Curran, S.M., McCulloh, R.J., Barry, P.A., Iyer, S.S., Palermo, N., Phillips, J.A., Dong, Y., Ronning, D.R.,  Vennerstrom, J.L., Sanderson, S.D, Vetro, J.A. "Targeted Amino Acid Slubstitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67" ACS Infect. Dis. 2020, 6(5), 1169-1181
    6(5), p. 1169-1181 2020
  • Journal of Drug Delivery Science and Technology
    Meerovich, I., Smith, D.D., Dash, A.K. “Direct solid-phase peptide synthesis on chitosan microparticles for targeting tumor cells” J. Drug Delivery Sci. Technol. 2019
    54, p. 101288 2019
  • International Journal of Pharmaceutics
    Tallapaka, S.B., Karuturi, B.V.K., Yeapuri, P., Curran, S.M., Sonawane, Y.A., Phillips, J.A., Smith, D.D., Sanderson, S.D., Vetro, J. “Surface conjugation of EP67 to biodegradable nanoparticles increases the generation of long-lived mucosal and systemic memory T-cells by encapsulated protein vaccine after respiratory immunization and subsequent T-cell-mediated protection against respiratory infection” Int. J. Pharm. 2019, 565, 242-257. 
    2019, 565, p. 242-257 2019
  • Reference Module in Biomedical Sciences
    Smith, D. D., Calcitonin Receptor Agents, Reference Module in Biomedical Sciences. Elsevier. 16-Mar-2017 doi:10.1016/B978-0-12-801238-3.96809-0 2017
  • Reference Module in Biomedical Sciences
    Smith D. D., AC187, Reference Module in Biomedical Sciences, Elsevier. 22-Jul-2016 doi:10.1016/B978-0-12-801238-3.92835-6 2016
  • Synthesis
    D. David Smith; Audrey T. Gallagher; Vincent M. Crowley; Wayne M. Gergens; Peter W. Abel; Martin Hulce ”An Efficient Synthesis of 4(5)-Benzyl-L-histidines Employing Catalytic Transfer Hydrogenolysis at Elevated Temperatures”
    46, p. 515-521 2013
  • Not Applicable
    Synthesis of 4-arylmethyl-L-histidine analogues for structure-activity studies of position 10 of CGRP. D.D.Smith, M.Mao, H.Young, M.Hulce 2007
  • Not Applicable
    Pharmacological characterization of novel alpha-calcitonin gene-related peptide (CGRP) receptor peptide antagonists that are selective for human CGRP receptors. C.K. Taylor, D.D. Smith, M. Hulce, P.W. Abel
    319 2006
  • J. Cell Science
    Vent J, Wyatt TA, Smith DD, Banerjee A, Luduena RF, Sisson JH, Hallworth R. Direct involvement of the isotype-specific C-terminus of beta tubulin in ciliary beating.
    118, p. 4333-4341 2005
  • Xpharm (web based)
    Smith, DD, Abel, PW, AC187 2005
  • Journal of Peptide Research
    Taylor, CK, Abel, PW, Hulce, M, Smith, DD, Solvent eggects on coupling yields during repid solid-phase synthesis of CGRP(8-37) employing in situ neutralization
    65, p. 84-89 2005
  • Xpharm (web based)
    Smith, DD, Abel, PW, Calcitonin Gene-Related Peptide 2004
  • Biochem. Biophys. Res. Commun.
    Conlon, J.M., A. Sonnevend, C. Davidson, D.D. Smith, P.F. Nielsen The ascaphins: a family of antimicrobial
    320 (1), p. 170-175 2004
  • American Journal of Physiology-Regulatory Integrative and Comparative Physiology
    Reidelberger, R.D., A.C. Haver, U. Arnelo, D.D. Smith, C.S. Schaffert, J. Permert Amylin Receptor Blockade Stimulates Food Intake in Rats
    287, p. R568-R574 2004
  • Journal of Medicinal Chemistry
    Smith, DD, S.Saha, G.Fang, C.Schaffert, D.J.J.Waugh, W.Zeng, G.Toth, M.Hulce, P.W.Abel. Modifications to the N-terminus but not the C-terminus of calcitonin gene-related peptide(8-37) produces antagonists with increased affinity
    46, p. 2427-2435 2003
  • Journal of Pharmacology and Experimental Therapeutics
    Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand and reverse transcription-polymerase chain reaction. Boyd R. Rorabaugh, Margaret A. Scofield, D. David Smith, William B. Jeffries, Peter W. Abel
    299 (3), p. 1086-1094 2001
  • Journal of Pharmaceutical Sciences
    Stratton, L.Pl; Kelly, R.M.; Rowe, J.; Shively, J.E.; Smith, D.D.; Carpenter, J.F.; Manning, M.C. Controlling deamidation rates in a model peptide: Effects of temperature, peptide concentration, and additives
    Volume 90, issue 12, p. 2141 to 2148 2001
  • Proceedings of the European Peptide Symposium
    DD Smith, LA Bachle, DH Petzel ”Isolation and characterization of insulin from the Brockmann body of Dissostichus mawsoni, an Antarctic teleost.”, p. 739-740 2001
  • Proceedings of the European Peptide Symposium
    DD Smith, S Saha, DJJ Waugh, PW Abel ”Blocking the N-terminus of Calcitonin Gene-Related Peptide(8-37) produces high affinity antagonists., p. 741-742 2001
  • MDIBL Bulletin
    E Wren, S Guynn, K Karnaky, DD Smith, D Petzel ”The effects of Antarctic head extracts on short circuit current across the epithelium of the killifish”
    39, p. 25 2000
  • J. Peptide Res.
    LA Bachle, DD Smith, D Petzel ”Isolation and characterization of insulin from the Brockmann body of Dissostichus mawsoni, an Antarctic teleost fish
    56(1), p. 47 - 54 2000
  • Not Applicable
    J. Pharmacol. Exp. Ther. 1999, 289, 1419-1426. 1999
  • Not Applicable
    Proceedings of the 15th American Peptide Symposium, pp597-598. 1999
  • Not Applicable
    Proceedings of the 15th American Peptide Symposium, pp416-417. 1999

Publications

  • FASEB Journal
    Taylor CK, Smith DD, Abel PW. Pharmacological characterization of novel high affinity CGRP receptor antagonists that are selective for human CGRP receptors.
    20, p. A665 2006
  • FASEB Journal
    Taylor, CK, Smith, DD, Abel, PW, Pharmacological characterization of irreversible antagonists of calcitonin gene-related peptide receptors.
    19, p. A105 2005
  • FASEB Journal
    Taylor, CK, Abel, PW, Smith, DD, Synthesis and pharmacological characterization of CGRP8-37 analogues containing N-terminal(bis(2-chloroethyl)-amino) and p-(fluorosulfonyl)- alkylating moeities.
    18, p. A597 2004
  • FASEB Journal
    Rorabaugh, B.R.; Abel, P.W.; Smith, D.D.; Scofield, M.A. Putatuve CGRP2 receptors are identified as adrenomedullin receptors in SV40LT-SMC cells
    Volume 16, Number 4, p. A576 2002
  • FASEB Journal
    Taylor, C.T.; Abel, P.W.; Smith, D.D. Synthesis and Pharmacological Characterization of a novel high affinity CGRP receptor antagonist
    Volume 16, Number 4, p. A189 2002
  • FASEB Journal
    BR Rorabaugh, PW Abel, DD Smith, MA Scofield ”CGRP receptor signaling pathways in SK-N-MC and HEK293 cells”, p. A931 2001
  • Not Applicable
    FASEB Journal & Gastroenterology 1999

Presentations

  • Eric Steele; D. David Smith "Preparation of 4(5)-benzyl-L-histidine methyl ester". Oral presentation at the 2017 Nebraska Academy of Sciences Annual Meeting, Nebraska Wesylean University, Lincoln, NE. April 21, 2017. 2017
  • Nick Mason; Martin Hulce; David Smith  "Synthesis of Truncated Calcitonin Gene-Related Peptide (8-11) by Fmoc coupling with Modified Hisitidne". Poster #31 presentation, 2017 St. Albert's Day Student Research Forum, Creighton University, Omaha, NE March 30, 2017. 2017
  • D. David Smith; Eric Steele; Paul Lievens; Martin R. Hulce "Preparation of 4(5)-benzyl-L-histidine methyl ester and its DiBoc derivative". Poster  #32 presentation 2017 St. Albert's Day Student Research Forum, Creighton University, Omaha, NE March 30, 2017. 2017
  • D. David Smith, Eric Steele, Paul Lievens, Martin R. Hulce "Preparation of 4(5)-benzyl-L-histidine methyl ester". Poster #380 presentation at the 51st Midwest Regional Meeting American Chemical Society, Kansas State University, Manhatten, KS. October 26-28, 2016. 2016
  • N.J. Mason; M.R. Hulce; D.D. Smith "Synthesis of trncated calcitonin gene-related peptide analogues by Fmoc coupling with modified histidines". Poster #191 presentation at the 51st Midwest Regional Meeting American Chemical Society, Kansas State University, Manhattan, KS. October 26-28, 2016. 2016
  • B.M. Cokington, K.P. Cokington, M. Hulce, R.T. Ishihara, D.D. Smith, E.M. Villa Sterically Directed Imidazole Side Chain Protection Strategies for Preparation of 4(5)-Benzyl-L-histidine Peptide Synthesis Reagents, poster presentation at St. Albert's Day/University Research Day, Creighton University, Omaha, NE April 14, 2015. 2015
  • I. Meerovich, A.K. Dash, D.D. Smith, M.Hulce Direct Solid Phase Peptide Synthesis on Chitosan Microparticles for Tumor Targeting, poster presentation at St. Albert's Day/University Research Day, Creighton University, Omaha, NE April 14, 2015 2015
  • D.D. Smith, H. Roundtree, T. Simeone, K. Simeone Use of Reversed-Phase High Performance Liquid Chromatography to Measure Adenosine Amounts in Mouse Brain, poster presentation at the 2014 American Chemical Society Midwest Regional Meeting, University of Missouri, Columbia, MO November 12-15, 2014. 2014
  • B.M. Cokington, K.P. Cokington, R.T. Ishihara, M. Hulce, D.D. Smith, Sterically Directed Imidazole Side Chain Protection Strategies for Preparation of 4(5)-Benzyl-L-histidines Suitable for Solid Phase Peptide Synthesis, poster presentation at the 2014 American Chemical Society Midwest Regional Meeting, University of Missouri, Columbia, MO November 12-15, 2014 2014
  • I. Meerovich, A.K. Dash, D.D. Smith, M. Hulce Direct Solid Phase Peptide Synthesis on Chitosan Microparticles for Tumor Targeting, poster presentation at 2014 AAPS Annual Meeting and Exposition, San Diego Convention Center, San Diego, CA November 2-6, 2014. 2014
  • D.D. Smith, C. Griggs, B. Mitchell, H. Mekada, M. Hulce Preparation of Protected Derivatives of 4(5)-Benzyl-L-Histidines, 2nd All University Research Fair, Creighton University, Omaha, NE September 25, 2014 2014
  • D.D. Smith, C. Griggs, B. Mitchell, H. Mekada, M. Hulce Preparation of Protected Derivatives of 4(5)-Benzyl-L-Histidine, poster presentation at 248th Fall American Chemical Society National Meeting and Exposition, San Francisco, CA August 10-14, 2014 2014
  • Benjamin Mitchell; D. David Smith; Martin Hulce 'Preparation of Nalpha,Ntau-bis(t-butoxycarbonyl)-4(5)-benzyl-L-histidine Methyl Ester'. Oral presentation, 124th Nebraska Academy of Sciences, Lincoln, NE April, 4, 2014. 2014
  • Connor Griggs; Martin Hulce; D. David Smith 'Studies Towards the Synthesis of N-methyl-L-beta-hydroxvaline using the Schollkopf Chiral Auxiliary'. Oral presentation, 124th nebraska Academy of Sciences, Lincoln NE April 4, 2014. 2014
  • Benjamin Mitchell; D. David Smith; Martin Hulce 'Preparation of Nalpha,Ntau-bis(t-butoxycarbonyl)-4(5)-benzyl-L-histidine Methyl Ester'. Poster presentation, 124th Nebraska Academy of Sciences, Lincoln, NE April, 1, 2014. 2014
  • Connor Griggs; Martin Hulce; D. David Smith 'Studies Towards the Synthesis of N-methyl-L-beta-hydroxvaline using the Schollkopf Chiral Auxiliary'. Poster presentation, 124th Nebraska Academy of Sciences, Lincoln NE April 4, 2014. 2014
  • The benzylation of histidyl residues during peptide synthesis, Invited speaker, Department of Chemistry weekly seminar, University of Nebraska Omaha, Omaha NE November 11, 2013. 2013
  • D. David Smith; Connor N. Griggs; Martin Hulce 'Synthesis of N-Methyl-L-beta-hydroxyvaline Using The Schollkopf Chiral Auxiliary'. Poster presentation, 48th Midwest Regional Meeting of the American Chemical Society, Springfield, MO October 16-19, 2013. 2013
  • Hideaki Mekada; Martin Hulce; D. David Smith 'Synthesis of a 4(5)-L-histidinyl Peptide Using Fmoc-based Solid-phase Peptide Synthesis'. Poster presentation, 48th Midwest Regional Meeting of the American Chemical Society, Springfield, MO October 16 - 19, 2013. 2013
  • Connor Griggs; Martin Hulce; D. David Smith 'Studies Towards the Synthesis of N-methyl-L-beta-hydroxvaline using the Schollkopf Chiral Auxiliary'. Oral presentation, 12th NE-INBRE Conference, Grand Island, NE August 4-6, 2013. 2013
  • Poster presentation at the 20th American Peptide Symposium in Montreal, Canada. 2007
  • Poster. Smith DD, Taylor CK, Abel PW, Hulce MR, Competitive and irreversible antagonists of CGRP. 30th National Medicinal Chemistry Symposium, Seattle, WA. 2006
  • Oral Presentation: Smith DD, Taylor CK, Abel PW, Hulce MR, Competitive and irreversible antagonists of calcitonin gene-related peptide. 116th Nebraska Academy of Sciences Meeting, Lincoln, NE. 2006
  • Poster Presentation: Taylor CK, Smith DD, Abel, PW. Pharmacological characterization of novel high affinity CGRP receptor antagonists that are selectice for human CGRP receptors. Experimental Biology, ASPET section, San Francisco, CA. 2006
  • Poster Presentation: Taylor CK, Smith DD, Abel, PW. Pharmacological characterization of novel high affinity CGRP receptor antagonists that are selectice for human CGRP receptors. Experimental Biology, Drug Discovery, Drug Development and Regulatory Affairs Young Investigator Section, San Francisco, CA. 2006
  • Oral Presentation: Taylor CK, Smith DD, Abel PW. Pharmacological characterization novel high affinity CGRP receptor antagonists that are selective for human CGRP receptors. 37th Midwest Student Biomedical Research Forum, Omaha, NE. 2006
  • Poster D31. Smith, DD, Taylor, CK, Abel, PW, Hulce, M Synthesis of Irreversible antagonists of CGRP receptors. National Organic Chemistry Symposium, 2005, Salt Lake City, UT. 2005
  • Poster. Taylor, CK, Smith, DD, Abel, PW Characterization of irreversible antagonists of calcitonin gene-related peptide receptors. Nebraska EpSCOR meeting, 2005, Omaha, NE. 2005
  • Taylor, CK, Smith, DD, Abel, PW Pharmacological Characterization of calcitonin gene-related peptide receptors. St. Albert's Day symposium, 2005, Omaha, NE. 2005
  • Poster. Taylor, CK, Smith, DD, Abel, PW, Pharmacological characterization of irreversible antagonists of calcitonin gene-related peptide receptors. Experimental Biology, 2005, San Diego, CA. 2005
  • Lecture. Taylor, CK, Abel, PW, Smith, DD, Synthesis and pharmacological characterization of novel irreversible antagonists of CGRP receptors. 36th Midwest Student Biomedical Research Conference, 2005, Omaha, NE. 2005
  • Poster. Taylor, CK, Abel, PW, Smith, DD, Synthesis and pharmacological characterization of novel irreversivle antagonists of CGRP receptors. Neuroscience meeting, 2004, Omaha, NE. 2004
  • Synthesis and Pharmacological Characterization of CGRP8-37 Analogues Containing N-'Terminal (bis(2- chloroethyl)-amino) and p-(fluorosulfonyl) Alkylating Moieties' poster presentation at Experimental Biology 2004 meeting in Washington DC, April 17-21, 2004. 2004
  • 'SYNTHESIS OF PUTATIVE IRREVERSIBLE ANTAGONISTS OF CGRP RECEPTORS CONTAINING N-TERMINAL (BIS-(2-CHLOROETHYL)-AMINO) AND P-(FLUOROSULFONYL) GROUPS' Lecture presentation at the 114th Annual Meeting of the Nebraska Academy of Sciences, Nebraska Wesleyan University, Lincoln NE 2004
  • 'SYNTHESIS OF PUTATIVE IRREVERSIBLE ANTAGONISTS OF CGRP RECEPTORS CONTAINING N-TERMINAL (BIS-(2-CHLOROETHYL)-AMINO) AND P-(FLUOROSULFONYL) GROUPS' poster presentation at the Peptides, Chemistry & Biology of, Gordon Research conference, Ventura, CA February 15-20, 2004. 2004
  • Taylor CK, Abel PW, Smith DD, NMP is unsuitable as a solvent for the rapid solid phase synthesis of CGRP8-37 using in situ neutralization. Poster presentation at the American Peptide symposium, Boston ME. July 19-24, 2003. 2003
  • Taylor CK, Abel PW, Smith DD NMP is unsuitable as a solvent for the rapid solid phase synthesis of CGRP(837) using in situ neutralization. An oral presentation at the Nebraska Academy of Sciences, Nebraska Wesleyan University, Lincoln, NE. 2003
  • Taylor, C.K.; Abel, P.W.; Smith, D.D. Synthesis and pharmacological characterization of a novel high affinity CGRP receptor antagonist. Poster presentation at Experimental Biology 2002, New Orleans, LA April 20-24, 2002. 2002
  • Rorabaugh, B.R.; Abel, P.W.; Smith, D.D.; Scofield, M.A. Putative CGRP2 receptors are identified as adrenomedullin receptors in SV40LT-SMC cells. Poster presentation at Experimental Biology 2002, New Orleans, LA April 20-24, 2002. 2002
  • Use of Calcitonin Gene-Related Peptide (CGRP) antagonists to Characterize CGRP receptors, D. David Smith, Boyd R. Rorabaugh, Margaret A. Scofield, Peter W. Abel Poster Presentation at Gordon Research Conference, Chemistry & Biology of Peptides, Ventura Beach, CA February 17 - 22, 2002. 2002
  • 'Development of CGRP antagonists and their use.' Invited seminar speaker, Dept. of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO. 2002
  • 'Benzylation of the Amino Terminus of the Peptide Antagonist CGRP(8-37) Leads to Formation of a Dibenzylated Byproduct' D. David Smith, Martin R. Hulce, David J.J. Waugh, Peter W. Abel, 36th Midwest Regional Meeting of the American Chemical Society, Lincoln, NE. 2001 2001
  • Structural characterization of a dibenzylated-CGRP(8-37), a byproduct from n-alpha-benzylation of CGRP(8-37), 2nd International Peptide Symposium/ 17th American Peptide Symposium, San Diego, CA. Poster presentation. 2001
  • CGRP receptor signaling in SK-N-MC and HEK293 cells. 4th Nebraska Physiological Society meeting, Omaha, NE. Poster presentation. 2001
  • CGRP receptor signaling pathway in SK-N-MC and HEK293 cells, FASEB2001, Orlando, FL. Poster presentation 2001
  • Pharmacological Comparison of Porcine CGRP receptors, Midwest Student Biomedical Research Forum, Omaha, NE. Poster presentation. 2001
  • Isolation and characterization of insulin from the Brockmann Body of dissostichus Mawsoni, an Antarctic teleost, 26th European Peptide Symposium, Montpellier, France. Poster presentation. 2000
  • Blocking the N-terminus of Calcitonin Gene-Related Peptide(8-37) produces high affinity antagonists. 26th European Peptide Symposium, Montpellier, Fance. Poster presentation 2000
  • FASEB & Gastroenterology meetings 1999
  • Rosehill Elementary School, Omaha. 1999

Awards

  • Intramural Research Award
    Recipient of a CURAS Faculty Research Fund Award for undergraduate research, $4,500, June 1, 2014 through April 30th, 2015.
  • The Welcome Trust, United Kingdom.