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Lynne Margaret Dieckman, MS, PhD

Associate Professor

Lynne Dieckman

Contact

College of Arts and Sciences
Chemistry
Chemistry Faculty
RGSB - Rigge Science Building

Lynne Margaret Dieckman, MS, PhD

Associate Professor

Research Focus


Research in the Dieckman lab focuses on the mechanisms by which errors in DNA replication and repair and chromatin organization lead to genome instability and disease.  Specifically, our main goal is to characterize the interactions of key factors that are essential for the interplay between genomic and epigenetic stability.  Two of these factors include the proteins PCNA (the processivity factor that stimulates DNA polymerases during DNA replication and repair) and CAF-1 (the main histone chaperone that is necessary for packaging DNA into nucleosomes following replication and repair).  The interaction between PCNA and CAF-1 is crucial for proper DNA synthesis, assembly of nucleosomes, and preservation of epigenetic marks.  Students will learn biochemical techniques used in modern biomedical research in order to determine the mechanistic basis of the network of interactions between CAF-1, PCNA, DNA, and other factors during replication-dependent nucleosome assembly and to work towards an understanding of proper DNA maintenance.

Department

Chemistry and Biochemistry

Position

Associate Professor

Articles

  • Progress in Biophysics and Molecular Biology
    Something’s gotta give: How PCNA alters its structure in response to mutations and the implications on cellular processes 2020
  • Journal of Biological Chemistry
    Salmonella enterica serovar Typhimurium has three transketolase enzymes contributing to the pentose phosphate pathway 
    293 (29), p. 11271-11282 2018
  • PLoS One
    Crystal structures of PCNA mutant proteins defective in gene silencing suggest a novel interaction site on the front face of the PCNA ring 
    13(3), p. e0193333 2018
  • McGraw Hill
    Aspirin
    055900 2017
  • PLoS One
    Identification of New Mutations at the PCNA Subunit Interface that Block Translesion Synthesis
    11(6), p. e0157023 2016
  • Nucleic Acids Research
    Eukaryotic Y-Family Polymerases: A Biochemical and Structural Perspective
    30, p. 85-108 2014
  • Biochemistry
    Distinct Structural Alterations in PCNA Block DNA Mismatch Repair
    52 (33), p. 5611-5619 2013
  • DNA Repair
    PCNA Trimer Instability Inhibits Translesion Synthesis by DNA Polymerase Eta and by DNA Polymerase Delta
    12 (5), p. 367-376 2013
  • Springer Science+Business Media LLC
    PCNA Structure and Function: Insights from Structures of PCNA Complexes and Post-translationally Modified PCNA
    62, p. 281-299 2012
  • Biochemistry
    Pre-steady State Kinetic Studies of the Fidelity of Nucleotide Incorporation by Yeast DNA Polymerase Delta
    49 (34), p. 7344-7350 2010

Other

  • Dr. George F. Haddix President’s Faculty Research Fund, Creighton University

  • National Institutes of Health INBRE Program, DRPP

  • National Science Foundation Nebraska EPSCoR FIRST Award