Andrew E . Ekpenyong, MS, PhD
Associate Professor
Physics
Contact
College of Arts and Sciences
Graduate School
Medical Physics (Master of Science)
Physics (Master of Science)
Physics
African Studies
HLSB - Hixson Lied Science Building - G71
Andrew E . Ekpenyong, MS, PhD
Associate Professor
Physics
Teaching Interests
- Medical Physics (didactic and research)
Research Focus
Almost all the vital signs are biophysical properties: blood pressure, pulse rate, body temperature, etc. With collaborators from the Departments of Chemistry, Physics and Mathematics, the School of Medicine, Creighton University, as well as international collaborators in the UK and Germany, I develop and use novel biophysical tools to discover new biomarkers that provide diagnostic information and new therapeutic options. I address the physician’s wish list in order to improve disease diagnosis, patient monitoring, drug development and testing, etc. While these efforts seek to improve biomedicine using principles and tools of physics, I also aim at advancing the physics of complex systems such as living matter. In particular, I seek to understand how biological cells function as mechanical units, with material properties.Department
Physics
Position
Associate Professor
Books
- Ekpenyong Andrew E., Mathematical physics for nuclear experiments 2022
- Mathematical Physics for Nuclear Experiments
Ekpenyong Andrew E, Probability and Statistics for Nuclear Experimental Data [Book Chapter] 2022 - Mathematical Physics for Nuclear Experiments
Ekpenyong Andrew E, Radioactivity and Decay Law [Book Chapter] 2022 - Mathematical Physics for Nuclear Experiments
Ekpenyong Andrew E, Energy Loss of Electrons and Positrons through Matter [Book Chapter] 2022 - Mathematical Physics for Nuclear Experiments
Ekpenyong Andrew E, Energy Loss of Heavy Charged Particles through Matter [Book Chapter] 2022 - Mathematical Physics for Nuclear Experiments
Ekpenyong Andrew E, Interactions of Photons in Matter [Book Chapter] 2022 - Methods in Molecular Biology
Djam Kimal Honour, Quantum Dots for Assessment of Reactive Oxygen Species Accumulation During Chemotherapy and Radiotherapy [Book Chapter] 2020 - Methods in Cell Biology
Schurmann M., Refractive index measurements of single, spherical cells using digital holographic microscopy [Book Chapter] 2015
Publications
- Micromachines (Basel)
Abraham Ashley, Microfluidic Microcirculation Mimetic for Exploring Biophysical Mechanisms of Chemotherapy-Induced Metastasis
14:9, p. 1653 2023 - Life (Basel, Switzerland)
McKinley Spencer, Simulated Microgravity-Induced Changes to Drug Response in Cancer Cells Quantified Using Fluorescence Morphometry
13:8, p. 1683 2023 - Biomedicines
Walter Yohan, Development of In Vitro Assays for Advancing Radioimmunotherapy against Brain Tumors
10:8 2022 - Applied Sciences (Switzerland)
Asuquo Marcus Inyama, Microfluidic Microcirculation Mimetic as a Tool for the Study of Rheological Characteristics of Red Blood Cells in Patients with Sickle Cell Anemia
12:9 2022 - Biophysical journal
Virdi Sukhman, The role of cell mechanics in chemotherapy-induced metastasis
121:3, p. 266a - 266a 2022 - Biochemistry and Biophysics Reports
Merrick Michael, In vitro radiotherapy and chemotherapy alter migration of brain cancer cells before cell death
27 2021 - Pharmaceutical Research
Palliyage Gayathri Heenatigala, Novel Curcumin-Resveratrol Solid Nanoparticles Synergistically Inhibit Proliferation of Melanoma Cells
38:5, p. 851 - 871 2021 - Biophysical journal
Abraham Ashley, Which Chemotherapy Drugs Alter Cell Mechanical Properties with Impact on Metastasis?
120:3, p. 66a - 66a 2021 - Pan African Medical Journal
Otu Akaninyene, Private sector initiatives to tackle the burden of covid-19
38 2021 - Life
Prasanth Devika, Microgravity modulates effects of chemotherapeutic drugs on cancer cell migration
10:9, p. 1 - 11 2020 - Lee Bong H., Fluorescence intensity modulation of CdSe/ZnS quantum dots assesses reactive oxygen species during chemotherapy and radiotherapy for cancer cells 2019
- Nature Methods
Wu Pei Hsun, A comparison of methods to assess cell mechanical properties
15:7, p. 491 - 498 2018 - Biophysical journal
Ekpenyong Andrew E., Effects of Ionizing Radiation on the Mechanosensitivity of Single Cells
114:3, p. 514 - 514a 2018 - Open Access Macedonian Journal of Medical Sciences
Ikpeme Anthonia, The value of mobile ultrasound services in rural communities in South-South Nigeria
5:7, p. 1011 - 1015 2017 - Science Advances
Ekpenyong Andrew E., Mechanical Deformation Induces Depolarization of Neutrophils
3:6, p. e1602536 - e1602536 2017 - Biophysical journal
Prasanth Devika, Microgravity Modulates Drug-Induced Enhancement of Cancer Cell Migration
112:3, p. 311a - 311a 2017 - Biophysical Journal
Prathivadhi-Bhayankaram Sruti V., Chemotherapy impedes in vitro microcirculation and promotes migration of leukemic cells with impact on metastasis
112:3, p. 124a - 124a 2017 - Biophysical journal
Prathivadhi-Bhayankaram Sruti V., Cell Mechanical Properties and Cancer Metastasis: Effects of Cancer Drugs and Radiotherapy
110:3, p. 621a - 621a 2016 - Biochemical and Biophysical Research Communications
Prathivadhi-Bhayankaram Sruti, Chemotherapy Impedes in Vitro Microcirculation and Promotes Migration of Leukemic Cells with Impact on Metastasis
479:4, p. 841 - 846 2016 - Biochimica et Biophysica Acta
Ekpenyong Andrew E., Mechanotransduction in neutrophil activation and deactivation, p. (12 pages) 2015 - Biophysical Journal
Chan Chii J., Myosin II activity softens cells in suspension
108:8, p. 1856 - 1869 2015 - Nature Methods
Otto O., Real-time deformability cytometry: on-the-fly cell mechanical phenotyping
12:3, p. 199 - 202 2015 - Proceedings of the National Academy of Sciences of the United States of America
Man Si Ming, Actin polymerization as a key innate immune effector mechanism to control Salmonella infection
111:49, p. 17588 - 17593 2014 - Interface Focus
Holmes David, Separation of blood cells with differing deformability using deterministic lateral displacement
4:6 2014 - Biophysical journal
Ekpenyong Andrew, The Evolution of Mechanical Properties of Differentiating Stem Cells is Fate- and Function-Dependent
106:2, p. 42a - 42a 2014 - Ekpenyong Andrew E., Bacterial infection of macrophages induces decrease in refractive index 2013
- Acta Mechanica
Boyde Lars, Elastic theory for the deformation of a solid or layered spheroid under axisymmetric loading
224:4, p. 819 - 839 2013 - Biophysical Journal
Chalut Kevin J., Chromatin decondensation and nuclear softening accompany Nanog downregulation in embryonic stem cells
103:10, p. 2060 - 2070 2012 - Applied Optics
Boyde Lars, Comparison of stresses on homogeneous spheroids in the optical stretcher computed with geometrical optics and generalized lorenz–mie theory
51:33, p. 7934 - 7944 2012 - PloS one
Ekpenyong Andrew E., Viscoelastic Properties of Differentiating Blood Cells Are Fate- and Function-Dependent
7:9 2012 - Integrative biology : quantitative biosciences from nano to macro
Chalut Kevin J., Quantifying cellular differentiation by physical phenotype using digital holographic microscopy.
4:3, p. 280 - 284 2012 - Journal of Biophotonics
Jacobs Kenneth M., Diffraction imaging of spheres and melanoma cells with a microscope objective
2:8-9, p. 521 - 527 2009 - Applied Optics
Ekpenyong Andrew E., Determination of cell elasticity through hybrid ray optics and continuum mechanics modeling of cell deformation in the optical stretcher
48:32, p. 6344 - 6354 2009
Presentations
- Sruti Prathivadhi, Carolyn Taylor, Jianhao Ning, Michael Nichols, Andrew Ekpenyong, Effects of chemotherapy-induced alterations in cell mechanical properties on cancer metastasis. Annual Meeting, American Physical Society, Maryland, 2016
- Sruti Prathivadhi, Carolyn Taylor, Jianhao Ning, Michael Nichols, Andrew Ekpenyong. Cell mechanical properties and cancer metastasis: effects of cancer drugs and radiotherapy. Annual Meeting, Biophysical Society of America, Los Angeles 2016
- Carolyn Taylor, Sruti Prathivadhi, Jianhao Ning, Michael Nichols, Andrew Ekpenyong. Microfluidic devices for biomechanical assessment of metastatic effects of cancer drugs. Global Health Conference-Midwest, Omaha, 2016
- Sruti Prathivadhi, Michael Nichols, Nathan Pennington, Andrew Ekpenyong. Mathematically Modeling Cancer Metastasis through Mechanical Properties Detected by a Microfluidic Microcirculation Mimetic Device. National MAA MathFest Conference in Washington D.C., 2015
- Ekpenyong, AE, Whyte, GB, Chalut, KJ, Pagliara, S, Guck, JR, et al. Contributions of actin and myosin to creep compliance of blood stem cells during differentiation. Optical Trapping and Optical Micro- manipulation X, SPIE NanoScience and Engineering. 28 Aug 2013, San Diego, USA. 2013
- Ekpenyong, AE, Schuermann, M, Man, SM, Achouri, S, Guck, J, et al. Monitoring cell differentiation and infection using Digital Holographic Microscopy. European Conferences on Biomedical Optics (ECBO). 12 May, 2013, Munich, Germany. 2013
- Ekpenyong, AE, Whyte, GB, Lautenschlaeger, F, Guck, JR, et al.Viscoelastic properties of differentiating blood stem cells evolve to suit their func- tions. Spring Meeting of the German Physical Society (DPG). 15 March 2013, Regensburg, Germany. 2013
- Ekpenyong, AE, Guck, JR, et al. Viscoelastic properties of differenti- ating cells evolve to meet tissue-specific functions Dynamics of Tissues and Multicellular Systems. 14 Dec 2012, Leipzig, Germany. 2012
- Ekpenyong, AE,Whyte, GB, Chilvers, ER, Guck, JR, et al. Fate- and function-dependent evolution of cellular mechanical properties during myeloid haematopoiesis. 4th International Congress on Stem Cells and Tissue Formation. 20 July 2012, Dresden, Germany. 2012
Other
CytoSMART Omni Instrument
Physics of Cancer: Role of Cell Mechanics in Chemotherapy-Induced Metastasis
CytoSMART Omni Instrument
Physics of Cancer: Role of Cell Mechanics in Chemotherapy-Induced Metastasis