Joseph A . Knezetic, PhD

Director, Research Compliance Office

Professor

J Knezetic

Contact

School of Medicine
Pathology
Graduate School
Biomedical Sciences (Master of Science)
Biomedical Sciences (Doctorate)
CUMC - Creighton University Medical Center - 1947B

Joseph A . Knezetic, PhD

Director, Research Compliance Office

Professor

Department

Pathology

Position

Professor

Books

  • Maresso Karen Colbert, Prevention and Screening Risk Factors, Screening, and Chemoprevention [Book Chapter] 2014
  • Lynch Jane F., Lynch Syndrome as a Model for Identification of Hereditary High-Risk Patients [Book Chapter] 2013
  • Lynch Jane F., Hereditary Factors in Endometrial Cancer [Book Chapter] 2007

Publications

  • Head & Neck
    Feldman R., Molecular Profiling of Head and Neck Squamous Cell Carcinoma
    38:Supplement 1, p. E1625 - E1638 2016
  • Expert Opinion on Medical Diagnostics
    Lynch Henry T., Diagnosing Lynch Syndrome in Absence of Colorectal Cancer
    6:6, p. 485 - 488 2015
  • Current Treatment Options in Oncology
    Lynch Henry T., Genetics, biomarkers, hereditary cancer syndrome diagnosis, heterogeneity and treatment: a review
    15:3, p. 429 - 442 2014
  • Journal of clinical oncology
    Feldman Rebecca, Molecular profiling of HPV-positive and -negative HNSCC
    32:15_suppl, p. 6080 - 6080 2014
  • Expert Opinion on Medical Diagnostics
    Lynch Henry T., Diagnosing lynch syndrome in absence of colorectal cancer
    6:6, p. 485 - 488 2012
  • Seminars in Oncology
    Adonizio Christian, Thirty-Nine-Year-Old With Familial Colon Cancer, and Variant of Undetermined Significance in MSH6
    39:2, p. 125 - 131 2012
  • Human Pathology
    Gatalica Zoran, Renal medullary carcinomas: histopathologic phenotype associated with diverse genotypes
    42:12, p. 1979 - 1988 2011
  • Applied Immunohistochemistry & Molecular Morphology
    Stevens T. M., Detection of High-Risk HPV in Head and Neck Squamous Cell Carcinomas: Comparison of Chromogenic In Situ Hybridization and a Reverse Line Blot Method
    19:6, p. 1574 - 1578 2011
  • Laboratory Medicine
    Carlos E. F. C., Use of 16s rRNA Gene Sequencing to Identify a Case of Pediococcus parvulus Bacteremia in a Patient with Metastatic Testicular Cancer
    41:2, p. 93 - 95 2010
  • Cancer Genetics and Cytogenetics
    Locker Gershon Y., The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer
    169:1, p. 33 - 38 2006
  • Journal of Steroid Biochemistry and Molecular Biology
    Rapuri Prema B., Association between Vitamin D receptor polymorphisms and the rate of bone loss in elderly women���importance of adjusting for dietary and lifestyle factors
    89-90:5-Jan, p. 503 - 506 2004
  • Molecular and Cellular Endocrinology
    Cluck M. W., Amylin gene expression mediated by cAMP/PKA and transcription factors HNF-1 and NFY
    210:1-2, p. 63 - 75 2003
  • American Journal of Gastroenterology
    Lynch Jane F., Multiple primary cancer, including transitional cell carcinoma of the upper uroepithelial tract in a multigeneration hnpcc family: molecular genetic, diagnostic, and management implications
    98:3, p. 664 - 670 2003
  • Blood
    Staplin William R., BVL-1-like VL30 promoter sustains long-term expression in erythroid progenitor cells
    101:5, p. 1798 - 1800 2003
  • Archives of Insect Biochemistry and Physiology
    Hart S. J., Cloning and tissue distribution of two Na+/H+ exchangers from the Malpighian tubules of Aedes aegypti
    51:3, p. 121 - 135 2002
  • Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
    Tanko Q., A hMLH1 genomic mutation and associated novel mRNA defects in a hereditary non-polyposis colorectal cancer family
    503:1-2, p. 37 - 42 2002
  • Pancreas
    Thomas Deborah L., The role of oxygen-derived free radicals and nitric oxide in cytokine-induced antiproliferation of pancreatic cancer cells
    24:2, p. 161 - 168 2002
  • Blood Cells, Molecules, &Diseases
    Staplin William R., Conserved, erythropoietin-responsive VL30 promoters isolated from erythroid progenitor cells
    28:2, p. 275 - 282 2002
  • Cancer
    Lynch Jane F., Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families - The familial atypical multiple mole melanoma-pancreatic carcinoma syndrome
    94:1, p. 84 - 96 2002
  • Pancreas
    Murphy Leon O., Receptors and ligands for autocrine growth pathways are up-regulated when pancreatic cancer cells are adapted to serum-free culture
    22:3, p. 293 - 298 2001
  • British Journal of Cancer
    Murphy Richard F., Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions
    84:7, p. 926 - 935 2001
  • Journal of Clinical Endocrinology and Metabolism
    Liu Jian, The intracellular mechanism of insulin resistance in pancreatic cancer patients
    85:3, p. 1232 - 1238 2000
  • Biochemical and biophysical research communications
    Ding Xian-Zhong, Lipoxygenase Inhibitors Abolish Proliferation of Human Pancreatic Cancer Cells
    261:1, p. 218 - 223 1999
  • Cancer Genetics and Cytogenetics
    Ichikawa Yoshihito, Microsatellite Instability and Expression of MLH1 and MSH2 in Normal and Malignant Endometrial and Ovarian Epithelium in Hereditary Nonpolyposis Colorectal Cancer Family Members
    112:1, p. 2 - 8 1999
  • Diseases of the Colon and Rectum
    Thorson Alan G., A Century of Progress in Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome)
    42:1, p. 1 - 9 1999
  • Calcified Tissue International
    Kinyamu H. K., Effect of vitamin D receptor genotypes on calcium absorption, duodenal vitamin D receptor concentration, and serum 1,25 dihydroxyvitamin D levels in normal women
    60:6, p. 491 - 495 1997
  • Clinical nutrition (Edinburgh, Scotland)
    Skullman S., Malnutrition increases m-RNA expression of EGF and EGF-receptor in liver tissue
    13, p. 6 - 7 1994
  • Molecular and cellular biology
    Knezetic Joseph A., Mechanism of Developmental Regulation of απ, the Chicken Embryonic α-Globin Gene
    13:8, p. 4632 - 4639 1993
  • Felsenfeld G, DEVELOPMENTAL REGULATION OF CHICKEN GLOBIN GENE-EXPRESSION 1991
  • Molecular and cellular biology
    Knezetic Joseph A., Identification and Characterization of a Chicken α-Globin Enhancer
    9:3, p. 893 - 901 1989
  • Progress in clinical and biological research
    Felsenfeld G, Regulatory protein action in the neighborhood of chicken globin genes during development
    316A, p. 73 - 87 1989
  • Cell
    Knezetic Joseph A., The presence of nucleosomes on a DNA template prevents initiation by RNA polymerase II in vitro
    45:1, p. 95 - 104 1986

Presentations

  • Grand Rounds titled What's Up with the Rae Family, Omaha, NE 2017
  • CP Lecture - Cytogenetics (H68; C7) (CUMC-OMA) 2016
  • CP Lecture Series - Pearls - Micro-Mol Cavalieri, Knezetic (CUMC-OMA) 2016
  • Pathology Grand Rounds 2008
  • American Cancer Society Colossal Colon Exhibit Presentation 2005
  • Department of Pathology Grand Rounds 2005
  • Red Cell Gordon Conference 2001
  • Fourth Annual Meeting of The American Society of Gene Therapy "Assessment of VL30 Erythropoietin Responsive Promoters for Erythroid Gene Therapy". 2001
  • American Society for Microbiology, Missouri Valley Branch "Assessment of VL30 Erythropoietin Responsive Promoters for Erythroid Gene Therapy. 2001
  • Creighton Cardiac Fellows - Cellular and Molecular Biology of Cardiovascular Disease Lecture Series "Cloning" 2001
  • Creighton Cardiac Fellows - Cellular and Molecular Biology of Cardiovascular Disease Lecture Series & Regulation of Transcription and Translation. 2001
  • Second Midwest Regional Meeting of The American Association for The Advancement of Science "Assessment of VL30 Erythropoietin Responsive Promoters for Erythroid Gene Therapy." 2000
  • Second Midwest Regional Meeting of The American Association for The Advancement of Science & Nucleosome Positioning at The Developmentally Regulated Alpha-Pi Globin Promoter 2000
  • 11th Conference on Hemoglobin Switching 1999
  • Red Cell Gordon Conference 1999
  • 2nd Annual Meeting of the American Society of Gene Therapy 1999
  • Seminar at the Omaha VA Research Center 1999

Foundation/Association

  • Health Future Foundation - Development Regulation of Hemoglobin Genes

  • Health Futures Foundation Grant - Erythroid VL30: Gene Therapy for Globin Expression

Federal

  • Biomedical Research Support Grant - Mutagenesis of a Hemoglobin Enhancer

  • National Institute of Health Supplemental Grant - Treatment for Osteoporosis of the Hip-Supplement

  • National Institutes of Health - EDRN: The Hereditary Cancer Clinical Center

  • National Institutes of Health - Phenotypic and Psychosocial Study of the I1307K Mutation

  • National Institutes of Health - Intracellular pH Homeostasis in Malpighian Tubles

State

  • American Heart Association (NE Affiliate) Manipulating the Development Control of Hemoglobin Gene Regulation

  • State of Nebraska Cancer and Smoking - Related Disease Grant - Shared Instrumentation for Molecular Biology in Cancer Research

  • State of Nebraska Cancer and Smoking - Related Disease Grant - Abnormal Beta-Cell Gene Regulation in Pancreatic Cancer

  • State of Nebraska Cancer and Smoking Related-Disease Grant - Gastrin and Colonic Cancer

  • State of Nebraska Cancer and Smoking Related-Desease Grant - Autocrine Growth Factors in Pancreatic Cancer

  • State of Nebraska Cancer and Smoking Related-Disease Grant

  • State of Nebraska Cancer and Smoking Related-Disease Grant - Peptide Biosynthesis in Tumor Cells

  • State of Nebraska Cancer and Smoking Related-Disease Grant - Hereditary Cancer Program Grant

  • State of Nebraska Cancer and Smoking Related-Disease Grant - Cancer Research Molecular Biology Core Facility

  • State of Nebraska Cancer and Smoking Related-Disease Grant - Metabolic Interactions of Pancreatic Cancer Cells: Implication for Cachexia

  • State of Nebraska Cancer and Smoking Related-Disease Grant - Tobacco Smoke Exposure and Tachykinin Expression

  • State of Nebraska LB 692 Grant - Clinical Translation of the American Founder Mutation

  • State of Nebraska LB 595 Grant - MTHFR Polymorphisms and Cancer in Barret's Esophogus

Awards

  • 25 year service recognition award
    Received 25 year service recognition from Creighton University.
    Creighton University
  • Dedicated Teacher Award, School of Medicine, Creighton University, Omaha, Nebraska.
    Dedicated Teacher Award, School of Medicine, Creighton University, Omaha, Nebraska.
  • Successful inspection led for Creighton University’s full accreditation for five years by the Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP)
    Successful inspection led for Creighton University’s full accreditation for five years by the Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP).