Joseph A . Knezetic, PhD

Department

Pathology

Position

Professor

Articles

• Journal of Head and Neck
  Feldman R, Gatalica Z, Knezetic J, Reddy S, Nathan CA, Javadi N, Teknos, T. Molecular Profiling of Head and Neck Squamous Cell Carcinoma. 2016
• Current Treatment Options in Oncology
  Lynch HT, Drescher K, Knezetic J, Lanspa S. Genetics, Biomarkers, Hereditary Cancer Syndrome Diagnosis, Heterogeneity and Treatment: A Review.
  15 2014
• Seminars in Oncology
  Adonizio C, Gazzillo M, Knezetic J, Snyder C, Lynch HT, Rybak C, Hall MJ, Lowstuter K, Eggington J, Morris GJ. Thirty-Nine-Year-Old With Familial Colon Cancer, and Variant of Undetermined Significance in MSH6.
  39(2), p. 125-31 2012
• Genetic Testing
  A Common 1317TC polymorphism in MTHFR can lead to erroneous 1298AC genotyping by PCR-RE and TaqMan probe assays.
  11(2), p. 167-173 2007
• Journal of Steroid Biochemistry and Molecular Biology
  Rapuri, P.B., Gallagher, J.C., Knezetic, J.A., Kinyamu, H.K. and Ryschon, K.L. Association between vitamin D receptor polymorphisms and the rate of bone loss in elderly women-importance of adjusting for dietary and lifestyle factors.
  89-90(1-5), p. 503-506 2004
• Molecular and Cellular Endocrinology
  Cluck, M.W., Murphy, L.O., Olson, J., Knezetic, J.A. and Adrian, T.E. Amylin gene expression mediated by cAMP/PKA and transcription factors HNF-1 and NFY.
  210(1-2), p. 63-75 2003
• Blood
  Staplin, W.R. and Knezetic, J.A. BVL-1 like VL30 Promoter Sustains Long Term Expression in Erythroid Progenitor Cells
  101(5), p. 1798-1800 2003
• Am J Gastroenterol
  Lynch, H.T., Taylor,R.T., Lynch, J.F., Knezetic, J.A., Barrows, A., Fodde, R., Wijnen, J. and Wagner, A. Multiple Primary Cancer, Including Transitional Cell Carcinoma of the Upper Uroepityhelial Tract in a Multigeneration HNPCC Family: Molecular Genetic, Diagnostic, and Management Implications
  98(3), p. 664-670 2003
• Arch. Insect Biochem. Physiol.
  Hart, S.J., Knezetic, J.A. and Petzel, D.H. Cloning and Tissue Distribution of two Na+/H+ Exchangers from the Malpighian Tubules of Aedes Aegypti
  51(3), p. 121-135 2002
• Mutation Research
  A hMLH1 Genomic Mutation and Associated Novel mRNA Defects in a Hereditary Non-polyposis Colorectal Cancer Family. Tanko, Q.; Franklin, B; Lynch, H. and Knezetic, J.
  503(1-2), p. 37-42 2002
• Blood Cells Molecules and Diseases
  Conserved, Erythropoietin-Responsive VL30 Pro,moters Isolated from Erythroid Progenitor Cells. Staplin, William R., Hodgson, Clague P. and Knezetic, Joseph A.
  28(2), p. 275-282 2002
• Pancreas
  The Role of Oxygen-Derived Free Radicals and Nitric Oxide in Cytokine-Induced Antiproliferation of Pancreatic Cancer Cells. Thomas, Wiliiam, J.; Thomas, Deborah, L.; Knezetic, Joseph, A. and Adrian, Thomas, E.
  24(2), p. 161-168 2002
• Cancer
  Phenotypic Variation in Eight Extended CDKN2A Germline Mutation Familial Atypical Multiple Mole Melanoma-Pancreatic Carcinoma-Prone Families: The Familial Atypical Mole Melanoma-Pancreatic Carcinoma Syndrome. Lynch, Henry T; Brand, Randall E; Hogg, David; Deters, Carolyn A; Fusaro, Ramon M; Lynch, Jane F; Liu, Ling; Knezetic, Joseph; Lassam, Norman J; Goggins, Michael; Kern, Scott.
  94(1), p. 84-96 2002
• Pancreas
  ”Receptors and Ligands for Autocrine Growth Pathways are Up-regulated When Pancreatic Cancer Cells are Adapted to Serum-free Culture.” Murphy, L.O., Abdel-Wahab, Y.H., Wang, Q.J., Knezetic, J.A., Permert, J., Larsson, J., Hollingsworth, A.M. and Adrian, T.E.
  22(3), p. 293-298 2001
• British Journal of Cancer
  ”Pancreatic Cancer Cells Require an EGF Receptor-Mediated Autocrine Pathway for Proliferation in Serum-free Conditions.” Murphy,L.O., Cluck,M.W., Lovas,S., Otvos, F., Murphy, R.F., Schally, A.V., Permert, J., Larsson, J., Knezetic, J.A., and Adrian, T.E.
  84(7), p. 926-935 2001
• Journal of Clinical Endocrinology and Metabolism
  Liu, J., Knezetic, J.A., Strommer, L., Permert, J., Larsson, J., and Adrian, T.E. The Intracellular Mechanism of Insulin Resistance in Pancreatic Cancer Patients. Journal of Clinical Endocrinology Metabolism, Vol 85(3), pages 1232-1238
  Vol 85(3), p. 1232-1238 2000
• Disease of the Colon and Rectum
  Alan G. Thorson, Joseph A. Knezetic and Henry Lynch. A Century of Progress in Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome).
  42, p. 1-9 1999
• Biochem. Biophys. Res. Commun.
  Ding, X., Iverson, P., Cluck, M.W., Knezetic, J.A., Adrian, T.E. Lipooxygenease Inhibitors Abolish Proliferation of Human Pancreatic Cancer Cells.
  261(1), p. 218-223 1999
• Cancer Genetics and Cytogenetics
  Y. Ichikawa, S.J. Lemon, S. Wang, B. Franklin, P. Watson, J.A. Knezetic, C. Bewtra, and H.T. Lynch. Microsatellite Instability and Expression of MLH1 and MSH2 in Normal and Malignant Endometrial and Ovarian Epithelium in Hereditary Nonpolyposis Colorectal Cancer Family Members.
  112(1), p. 2-8 1999

Publications

• Molecular Therapy
  ”Isolation of Epo Responsive VL30 Promoters for Erythroid Gene Therapy.” Staplin, W.R., Zink, M.A., Hodgson, C.P. and Knezetic, J.A.
  5:S, p. 191 2000
• FASEB Journal
  ”Sodium/Hydrogen Isoform 3 Specific Inhibitors Decrease Fluid Secretion in Mosquito Malpigian Tubules.” Petzel, D., Knezetic, J.A. and Lang, H.J.
  14, p. A45 2000
• Not Applicable
  Petzel, Melvin and Knezetic, FASEB Journal
  11, p. A1025 1999
• Not Applicable
  Staplin, Zink, Hodgson and Knezetic, Blood Cells, Molecules and Disease, 1998 Vol 24:498; 1999
• Not Applicable
  Tanko, Petzel and Knezetic, FASEB Journal,
  13, p. A395 1999
• Not Applicable
  Thomas, Thomas, Knezetic and Adrian, Proceeding AACR 39:113, 1998; 1999
• Not Applicable
  Cluck, Murphy Knezetic and Adrian, Dig. Dis. Sci. 43: 1864, 1998; 1999
• Digest Dis Scien
  Murphy, Cluck, Knezetic and Adrian Dig.
  43, p. 1858 1999

General

• Current Treatment Options in Oncology
  Lynch HT, Drescher K, Knezetic J, Lanspa S. Genetics, Biomarkers, Hereditary Cabcer Syndrome Diagnosis, Heterogeneity and Treatment: A Review. Curr. Treat. Options Oncol. : Vol 15  2012
• Expert Opinion on Medical Diagnostics
  Lynch HT, Knezetic J, Lanspa S. Diagnosing Lynch Syndrome in Absence of Colorectal Cancer.
  6(6), p. 475-8

Presentations

• Grand Rounds titled What's Up with the Rae Family, Omaha, NE 2017
• CP Lecture - Cytogenetics (H68; C7) (CUMC-OMA) 2016
• CP Lecture Series - Pearls - Micro-Mol Cavalieri, Knezetic (CUMC-OMA) 2016
• Pathology Grand Rounds 2008
• American Cancer Society Colossal Colon Exhibit Presentation 2005
• Department of Pathology Grand Rounds 2005
• Red Cell Gordon Conference 2001
• Fourth Annual Meeting of The American Society of Gene Therapy "Assessment of VL30 Erythropoietin Responsive Promoters for Erythroid Gene Therapy". 2001
• American Society for Microbiology, Missouri Valley Branch "Assessment of VL30 Erythropoietin Responsive Promoters for Erythroid Gene Therapy. 2001
• Creighton Cardiac Fellows - Cellular and Molecular Biology of Cardiovascular Disease Lecture Series "Cloning" 2001
• Creighton Cardiac Fellows - Cellular and Molecular Biology of Cardiovascular Disease Lecture Series & Regulation of Transcription and Translation. 2001
• Second Midwest Regional Meeting of The American Association for The Advancement of Science "Assessment of VL30 Erythropoietin Responsive Promoters for Erythroid Gene Therapy." 2000
• Second Midwest Regional Meeting of The American Association for The Advancement of Science & Nucleosome Positioning at The Developmentally Regulated Alpha-Pi Globin Promoter 2000
• 11th Conference on Hemoglobin Switching 1999
• Red Cell Gordon Conference 1999
• 2nd Annual Meeting of the American Society of Gene Therapy 1999
• Seminar at the Omaha VA Research Center 1999

Awards

• 25 year service recognition award
  Received 25 year service recognition from Creighton University.
  Creighton University
• Dedicated Teacher Award, School of Medicine, Creighton University, Omaha, Nebraska.
  Dedicated Teacher Award, School of Medicine, Creighton University, Omaha, Nebraska.
• Successful inspection led for Creighton University’s full accreditation for five years by the Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP)
  Successful inspection led for Creighton University’s full accreditation for five years by the Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP).