Joseph A . Knezetic, PhD

Department

Pathology

Position

Professor

Books

• Maresso Karen Colbert, Bishehsari Faraz, Jung Barbara H., Lynch Henry T., Drescher Kristen, Sharma Poonam, Snyder Carrie, Lynch Jane F., Knezetic Joseph, Hitchins Megan, Silberstein Peter, Lanspa Stephen, Bownik Hiliary, Chiorean Michael V., Yun Laura, Patterson Sherri, Vilar Eduardo, Hawk Ernest, Prevention and Screening Risk Factors, Screening, and Chemoprevention [Book Chapter] 2014
• Lynch Jane F., Drescher Kristen M., Sharma Poonam, Snyder Carrie L., Knezetic Joseph A., Hitchins M., Silberstein Peter T., Lanspa Stephen J., Lynch Syndrome as a Model for Identification of Hereditary High-Risk Patients [Book Chapter] 2013
• Lynch Jane F., Casey Murray J., Knezetic Joseph A., Shaw Trudy G., Bewtra Chhanda, Hereditary Factors in Endometrial Cancer [Book Chapter] 2007

Publications

• Archives of pathology & laboratory medicine (1976)
  Le Patricia, Hanson Mary, Perez Marcos, Eladely Ahmed, Walters Ryan, Ng Ian, Knezetic Joseph, Difference in Clinical Presentation for Individuals with R485K Polymorphism Compared to Those with Factor V Leiden Mutation: A Single-Institution Study
  148:9, p. E269 - E270 2024
• Head & Neck
  Feldman R., Gatalica Z., Knezetic Joseph A., Reddy S., Nathan C. -A, Javadi N., Teknos T., Molecular Profiling of Head and Neck Squamous Cell Carcinoma
  38:Supplement 1, p. E1625 - E1638 2016
• Expert Opinion on Medical Diagnostics
  Lynch Henry T., Knezetic Joseph A., Lanspa Stephen J., Diagnosing Lynch Syndrome in Absence of Colorectal Cancer
  6:6, p. 485 - 488 2015
• Current Treatment Options in Oncology
  Lynch Henry T., Drescher Kristen M., Knezetic Joseph A., Lanspa Stephen J., Genetics, biomarkers, hereditary cancer syndrome diagnosis, heterogeneity and treatment: a review
  15:3, p. 429 - 442 2014
• Journal of clinical oncology
  Feldman Rebecca, Ghazalpour Anatole, Knezetic Joseph, Gatalica Zoran, Savvides Panayiotis, Teknos Theodoros Nicholas, Molecular profiling of HPV-positive and -negative HNSCC
  32:15_suppl, p. 6080 - 6080 2014
• Expert Opinion on Medical Diagnostics
  Lynch Henry T., Knezetic Joseph A., Lanspa Stephen J., Diagnosing lynch syndrome in absence of colorectal cancer
  6:6, p. 485 - 488 2012
• Seminars in Oncology
  Adonizio Christian, Gazzillo Michelle, Knezetic Joseph A., Snyder Carrie L., Lynch Henry T., Rybak Christina, Hall Michael J., Lowstuter Kristina, Eggington Julie, Morris Gloria J., Thirty-Nine-Year-Old With Familial Colon Cancer, and Variant of Undetermined Significance in MSH6
  39:2, p. 125 - 131 2012
• Human Pathology
  Gatalica Zoran, Sharma Poonam, Lilleberg S. L., McCue P. A., Koul M. S., Knezetic Joseph A., Legendre B., Bridge J. A., Monzon F. A., Renal medullary carcinomas: histopathologic phenotype associated with diverse genotypes
  42:12, p. 1979 - 1988 2011
• Applied Immunohistochemistry & Molecular Morphology
  Stevens T. M., Caughron S. K., Dunn S. T., Knezetic Joseph A., Gatalica Zoran, Detection of High-Risk HPV in Head and Neck Squamous Cell Carcinomas: Comparison of Chromogenic In Situ Hybridization and a Reverse Line Blot Method
  19:6, p. 1574 - 1578 2011
• Laboratory Medicine
  Carlos E. F. C., Knezetic Joseph A., Cavalieri Stephen J., Use of 16s rRNA Gene Sequencing to Identify a Case of Pediococcus parvulus Bacteremia in a Patient with Metastatic Testicular Cancer
  41:2, p. 93 - 95 2010
• Cancer Genetics and Cytogenetics
  Locker Gershon Y., Kaul Karen, Weinberg David S., Gatalica Zoran, Gong Gordon, Peterman Amy, Lynch Jane, Klatzco Lucy, Olopade Olufunmilayo I., Bomzer Charles A., Newlin Anna, Keenan Eileen, Tajuddin Mohammed, Knezetic Joseph, Coronel Stephanie, Lynch Henry T., The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer
  169:1, p. 33 - 38 2006
• Journal of Steroid Biochemistry and Molecular Biology
  Rapuri Prema B., Kinyamu H. K., Gallagher J. Christopher, Knezetic Joseph A., Ryschon K. L., Association between Vitamin D receptor polymorphisms and the rate of bone loss in elderly women���importance of adjusting for dietary and lifestyle factors
  89-90:5-Jan, p. 503 - 506 2004
• Molecular and Cellular Endocrinology
  Cluck M. W., Murphy L. O., Olson Jody, Knezetic Joseph A., Adrian Thomas E., Amylin gene expression mediated by cAMP/PKA and transcription factors HNF-1 and NFY
  210:1-2, p. 63 - 75 2003
• American Journal of Gastroenterology
  Lynch Jane F., Taylor Rodney J., Knezetic Joseph A., Barrows Alicia, Fodde Riccardo, Wijnen Juul, Wagner Anja, Multiple primary cancer, including transitional cell carcinoma of the upper uroepithelial tract in a multigeneration hnpcc family: molecular genetic, diagnostic, and management implications
  98:3, p. 664 - 670 2003
• Blood
  Staplin William R., Knezetic Joseph A., BVL-1-like VL30 promoter sustains long-term expression in erythroid progenitor cells
  101:5, p. 1798 - 1800 2003
• Archives of Insect Biochemistry and Physiology
  Hart S. J., Knezetic Joseph A., Petzel David H., Cloning and tissue distribution of two Na+/H+ exchangers from the Malpighian tubules of Aedes aegypti
  51:3, p. 121 - 135 2002
• Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
  Tanko Q., Knezetic J., Lynch H., Franklin B., A hMLH1 genomic mutation and associated novel mRNA defects in a hereditary non-polyposis colorectal cancer family
  503:1-2, p. 37 - 42 2002
• Pancreas
  Thomas Deborah L., Adrian Thomas E., Knezetic Joseph A., The role of oxygen-derived free radicals and nitric oxide in cytokine-induced antiproliferation of pancreatic cancer cells
  24:2, p. 161 - 168 2002
• Blood Cells, Molecules, &Diseases
  Staplin William R., Knezetic Joseph A., Hodgson Clague P., Conserved, erythropoietin-responsive VL30 promoters isolated from erythroid progenitor cells
  28:2, p. 275 - 282 2002
• Cancer
  Lynch Jane F., Brand R. E., Hogg D., Deters Carolyn A., Fusaro Ramon M., Liu L., Knezetic Joseph A., Lassam N. J., Goggins M., Kern S., Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families - The familial atypical multiple mole melanoma-pancreatic carcinoma syndrome
  94:1, p. 84 - 96 2002
• Pancreas
  Murphy Leon O., Larsson J., Hollingsworth A. M., Adrian Thomas E., Permert J., Abdel-Wahab Yasser H. A., Wang Qiming J., Knezetic Joseph A., Receptors and ligands for autocrine growth pathways are up-regulated when pancreatic cancer cells are adapted to serum-free culture
  22:3, p. 293 - 298 2001
• British Journal of Cancer
  Murphy Richard F., Cluck Michael W., Lovas Sandor, Otvös F., Schally A. V., Permert J., Larsson J., Knezetic Joseph A., Adrian Thomas E., Otvos Ferenc, Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions
  84:7, p. 926 - 935 2001
• Journal of Clinical Endocrinology and Metabolism
  Liu Jian, Strommer L., Permert J., Larsson J., Adrian Thomas E., Knezetic Joseph A., The intracellular mechanism of insulin resistance in pancreatic cancer patients
  85:3, p. 1232 - 1238 2000
• Biochemical and biophysical research communications
  Ding Xian-Zhong, Iversen Patrick, Cluck Michael W., Knezetic Joseph A., Adrian Thomas E., Lipoxygenase Inhibitors Abolish Proliferation of Human Pancreatic Cancer Cells
  261:1, p. 218 - 223 1999
• Cancer Genetics and Cytogenetics
  Ichikawa Yoshihito, Lemon Stephen J., Wang Shuhe, Franklin Barbara A., Watson Patrice, Knezetic Joseph A., Bewtra Chhanda, Lynch Henry T., Microsatellite Instability and Expression of MLH1 and MSH2 in Normal and Malignant Endometrial and Ovarian Epithelium in Hereditary Nonpolyposis Colorectal Cancer Family Members
  112:1, p. 2 - 8 1999
• Diseases of the Colon and Rectum
  Thorson Alan G., Knezetic Joseph A., Lynch Henry T., A Century of Progress in Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome)
  42:1, p. 1 - 9 1999
• Calcified Tissue International
  Kinyamu H. K., Gallagher J. C., Knezetic J. A., DeLuca H. F., Prahl J. M., Lanspa S. J., Effect of vitamin D receptor genotypes on calcium absorption, duodenal vitamin D receptor concentration, and serum 1,25 dihydroxyvitamin D levels in normal women
  60:6, p. 491 - 495 1997
• Clinical nutrition (Edinburgh, Scotland)
  Skullman S., Adrian T.E., Knezetic J., Permert J., Wirén M., Larsson J., Malnutrition increases m-RNA expression of EGF and EGF-receptor in liver tissue
  13, p. 6 - 7 1994
• Molecular and cellular biology
  Knezetic Joseph A., Felsenfeld Gary, Mechanism of Developmental Regulation of απ, the Chicken Embryonic α-Globin Gene
  13:8, p. 4632 - 4639 1993
• Felsenfeld G, Clark D, Clark S, Evans T, Gibney G, Jackson P D, Knezetic J, Lewis C, Minie M, Reitman M, Trainor C, DEVELOPMENTAL REGULATION OF CHICKEN GLOBIN GENE-EXPRESSION 1991
• Molecular and cellular biology
  Knezetic Joseph A., Felsenfeld Gary, Identification and Characterization of a Chicken α-Globin Enhancer
  9:3, p. 893 - 901 1989
• Progress in clinical and biological research
  Felsenfeld G, Evans T, Jackson P D, Knezetic J, Lewis C, Nickol J, Reitman M, Regulatory protein action in the neighborhood of chicken globin genes during development
  316A, p. 73 - 87 1989
• Cell
  Knezetic Joseph A., Luse Donal S., The presence of nucleosomes on a DNA template prevents initiation by RNA polymerase II in vitro
  45:1, p. 95 - 104 1986

Presentations

• Grand Rounds titled What's Up with the Rae Family, Omaha, NE 2017
• CP Lecture - Cytogenetics (H68; C7) (CUMC-OMA) 2016
• CP Lecture Series - Pearls - Micro-Mol Cavalieri, Knezetic (CUMC-OMA) 2016
• Pathology Grand Rounds 2008
• American Cancer Society Colossal Colon Exhibit Presentation 2005
• Department of Pathology Grand Rounds 2005
• Red Cell Gordon Conference 2001
• Fourth Annual Meeting of The American Society of Gene Therapy "Assessment of VL30 Erythropoietin Responsive Promoters for Erythroid Gene Therapy". 2001
• American Society for Microbiology, Missouri Valley Branch "Assessment of VL30 Erythropoietin Responsive Promoters for Erythroid Gene Therapy. 2001
• Creighton Cardiac Fellows - Cellular and Molecular Biology of Cardiovascular Disease Lecture Series "Cloning" 2001
• Creighton Cardiac Fellows - Cellular and Molecular Biology of Cardiovascular Disease Lecture Series & Regulation of Transcription and Translation. 2001
• Second Midwest Regional Meeting of The American Association for The Advancement of Science "Assessment of VL30 Erythropoietin Responsive Promoters for Erythroid Gene Therapy." 2000
• Second Midwest Regional Meeting of The American Association for The Advancement of Science & Nucleosome Positioning at The Developmentally Regulated Alpha-Pi Globin Promoter 2000
• 11th Conference on Hemoglobin Switching 1999
• Red Cell Gordon Conference 1999
• 2nd Annual Meeting of the American Society of Gene Therapy 1999
• Seminar at the Omaha VA Research Center 1999

Foundation/Association

• Health Future Foundation - Development Regulation of Hemoglobin Genes

• Health Futures Foundation Grant - Erythroid VL30: Gene Therapy for Globin Expression

Federal

• Biomedical Research Support Grant - Mutagenesis of a Hemoglobin Enhancer

• National Institute of Health Supplemental Grant - Treatment for Osteoporosis of the Hip-Supplement

• National Institutes of Health - EDRN: The Hereditary Cancer Clinical Center

• National Institutes of Health - Phenotypic and Psychosocial Study of the I1307K Mutation

• National Institutes of Health - Intracellular pH Homeostasis in Malpighian Tubles

State

• American Heart Association (NE Affiliate) Manipulating the Development Control of Hemoglobin Gene Regulation

• State of Nebraska Cancer and Smoking - Related Disease Grant - Shared Instrumentation for Molecular Biology in Cancer Research

• State of Nebraska Cancer and Smoking - Related Disease Grant - Abnormal Beta-Cell Gene Regulation in Pancreatic Cancer

• State of Nebraska Cancer and Smoking Related-Disease Grant - Gastrin and Colonic Cancer

• State of Nebraska Cancer and Smoking Related-Desease Grant - Autocrine Growth Factors in Pancreatic Cancer

• State of Nebraska Cancer and Smoking Related-Disease Grant

• State of Nebraska Cancer and Smoking Related-Disease Grant - Peptide Biosynthesis in Tumor Cells

• State of Nebraska Cancer and Smoking Related-Disease Grant - Hereditary Cancer Program Grant

• State of Nebraska Cancer and Smoking Related-Disease Grant - Cancer Research Molecular Biology Core Facility

• State of Nebraska Cancer and Smoking Related-Disease Grant - Metabolic Interactions of Pancreatic Cancer Cells: Implication for Cachexia

• State of Nebraska Cancer and Smoking Related-Disease Grant - Tobacco Smoke Exposure and Tachykinin Expression

• State of Nebraska LB 692 Grant - Clinical Translation of the American Founder Mutation

• State of Nebraska LB 595 Grant - MTHFR Polymorphisms and Cancer in Barret's Esophogus

Awards

• 25 year service recognition award
  Received 25 year service recognition from Creighton University.
  Creighton University
• Dedicated Teacher Award, School of Medicine, Creighton University, Omaha, Nebraska.
  Dedicated Teacher Award, School of Medicine, Creighton University, Omaha, Nebraska.
• Successful inspection led for Creighton University’s full accreditation for five years by the Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP)
  Successful inspection led for Creighton University’s full accreditation for five years by the Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP).