I am interested in the factors that guide cell and tissue movements during embryonic development since his undergraduate days at the University of Kansas. Much of my work has focused on a population of cells called neural crest cells and the mechanisms they use to follow the correct path as they migrate extensively throughout the early embryo. More recently, I have been using avian embryos as a model system for studying the mechanisms behind nicotine-induced birth defects. I joined the Creighton faculty in 2001 and became department chair in 2009. Prior to that, I was a postdoctoral research fellow at The M.D. Anderson Cancer Center, and earned my Ph.D. from the University of California at Davis.
Research Focus
cell and tissue differentiation and morphogenesis during vertebrate development
Prentice Hall R.J. Grebenok, T. Leustek, H. Nickla, G.J. Podgorski, M. Reedy and D.L. Welker. Student Handbook for Genes VIII: Questions, Problems, and Solutions. 2004
Articles
Anatomical Record Patterson, R. A.; Cavanaugh, A. M.; Cantemir, V.; Brauer, P. R.; Reedy, M. V. MT2-MMP Expression During Early Avian Morphogenesis. Anatomical record. 296, p. 64-70 2013
Development Dynamics Heidenreich, D. J., Reedy, M. V., Brauer, P. R. Homocysteine enhances cardiac neural crest cell attachment in vitro by increasing intracellular calcim levels 237, p. 2117-2128 2008
Molecular and Cellular Biology D. B. Gould, M.V. Reedy, L.A. Wilson, R.A. Smith, R.L Johnson and S. W. M. John. Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma. 26, p. 8427-8436 2006
Oxford University Press D.M. Parichy, M.V. Reedy, and C.A. Erickson. Regulation of Melanoblast Migration and Differentiation. Chapter 5 in The Pigmentary System: Physiology and Pathophysiology, 2nd ed. J.J. Nordlund et al., eds., p. 108-139 2006
Developmental Dynamics Cantemir, V., Cai, D. H., Reedy, M. V., Brauer, P. R. Tissue inhibitor of metalloproteinase-2 (TIMP-2) expression during cardiac neural crest cell migration and its role in proMMP-2 activation 231, p. 709-719 2004
Development Dynamics B. J. Tierney, T. Ho, M.V. Reedy, and P. R. Brauer. Homocysteine inhibits neural crest cell formation and morphogenesis in vivo. 229, p. 63-73 2004
Current Biology Cole, DG and Reedy, MV. Algal morphogenesis: How Volvox turns itself inside-out. 13, p. R770-R772 2003
Gene Expression Patterns Reedy, MV; Johnson, RL; Erickson, CA. The expression patterns of c-kit and Sl in chicken embryos suggest unexpected roles for these genes in somite and limb development. Gene Expression Patterns. 3, p. 53-58 2003
Molecular and Cellular Biology B.S. Kim, O.V. Savinova, M.V.Reedy, Y. Lun, L. Gan, S.I Tomarev, S.W.M. John, and R.L. Johnson. Targeted disruption of myocilin (MYOC) suggests that glaucoma-causing mutations of myocilin in humans are gain of function mutations. 21, p. 7707-7713 2001
Development R. Kos, M.V. Reedy, R. Johnson, and C.A. Erickson. The winged helix transcription factor cFoxD3 is important for establishing the neural crest lineage and repressing melanogenesis. 128, p. 1467-1479 2001
Developmental Dynamics M.V. Reedy, C. D. Faraco, and C. A. Erickson. Specification and migration of melanoblasts at the vagal level and in hyperpigmented Silkie chickens. 213, p. 476-485 1998
Developmental Biology M.V. Reedy, C. D. Faraco, and C. A. Erickson. The delayed entry of thoracic neural crest cells into the dorsolateral path is a consequence of the late emigration of melanogenic neural crest cells from the neural tube. 200, p. 234-246 1998
Current Topics in Developmental Biology C.A. Erickson and M.V. Reedy. Neural crest development: the interplay between morphogenesis and cell differentiation. 40, p. 178-209 1998