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Peter Stephen Steyger, PhD


Biomedical Sciences

P Steyger


School of Medicine
Biomedical Sciences
Graduate School
Biomedical Sciences (Master of Science)
Biomedical Sciences (Doctorate)
Translational Hearing
CRISS I - Criss 1 - 431

Peter Stephen Steyger, PhD


Biomedical Sciences

My unique expertise in mechanisms of iatrogenic hearing loss originates from acquiring hearing loss via treatment with the life-saving aminoglycosides when afflicted with bacterial meningitis as an infant. I recognize how critical it is to translate our now wide-ranging collective knowledge in the etiologies of hearing loss and vestibular disorders into efficacious strategies that preserve or restore optimal hearing and vestibular function to maximize the personal goals, familial relationships, friendships and career trajectories of those afflicted with these sensory disorders.  

Research Focus

Aminoglycoside-induced toxicity
Cisplatin-induced toxicity
Mechanisms of neuro- and cytotoxicity
Physiology of Blood-Labyrinth Barrier
Trafficking of drugs and nutrients across blood barriers
Hearing Loss


Biomedical Sciences




  • Borse Vikrant, Ototoxic Hearing Loss and Balance Disorders: Challenges and Treatment 2022
  • Inflammatory Mechanisms in Mediating Hearing Loss
    Steyger Peter S., Inflammation potentiates cochlear uptake of ototoxins and drug-induced hearing loss [Book Chapter] 2018


  • Steyger Peter S., Reader response 2020
  • Steyger Peter, From Screen to Trial 2018
  • Steyger Peter, Translating in vitro data into auditory protection 2014


  • American journal of audiology
    Janky Kristen, Mechanisms and Impact of Aminoglycoside-Induced Vestibular Deficits, p. 1 - 15 2023
  • Pharmaceuticals
    Dash Shreshtha, Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials
    15:9 2022
  • Clinical Pharmacology and Therapeutics
    McDermott John Henry, Clinical Pharmacogenetics Implementation Consortium Guideline for the Use of Aminoglycosides Based on MT-RNR1 Genotype
    111:2, p. 366 - 372 2022
  • Journal of Neuroinflammation
    Mathy Nicholas W., A novel long intergenic non-coding RNA, Nostrill, regulates iNOS gene transcription and neurotoxicity in microglia
    18:1 2021
  • Otolaryngologic Clinics of North America
    Steyger Peter S., Mechanisms of Ototoxicity and Otoprotection
    54:6, p. 1101 - 1115 2021
  • Journal of cystic fibrosis
    Garinis A., 105: Ototoxicity management for patients with cystic fibrosis
    20, p. S53 2021
  • Frontiers in Education
    Huyck Julia Jones, Supporting Equity and Inclusion of Deaf and Hard-of-Hearing Individuals in Professional Organizations
    6 2021
  • American Journal of Audiology
    Steyger Peter S., Mechanisms of aminoglycoside-and cisplatin-induced ototoxicity
    30:3S, p. 887 - 900 2021
  • American Journal of Audiology
    Garinis Angela C., Clinical considerations for routine auditory and vestibular monitoring in patients with cystic fibrosis
    30:3S, p. 800 - 809 2021
  • Hearing Research
    Tian Cong, CACHD1-deficient mice exhibit hearing and balance deficits associated with a disruption of calcium homeostasis in the inner ear
    409 2021
  • Frontiers in Neurology
    Coffin Allison B., Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings
    12 2021
  • Frontiers in Neuroscience
    Prayuenyong Pattarawadee, Preferential Cochleotoxicity of Cisplatin
    15 2021
  • Cold Spring Harbor Perspectives in Medicine
    Kros Corné J., Aminoglycoside- and cisplatin-induced ototoxicity
    9:11 2019
  • Science Advances
    Jiang Meiyan, Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss
    5:7 2019
  • Hearing Journal
    Steyger Peter S., Genetic Contributions to Age-Related Hearing Loss
    72:5, p. 10 - 13 2019
  • Science Translational Medicine
    Nyberg Sophie, Delivery of therapeutics to the inner ear
    11:482 2019
  • PloS one
    Kachelmeier Allan, Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells
    13:11 2018
  • International Journal of Audiology
    Garinis Angela C., Monitoring neonates for ototoxicity
    57:sup4, p. S41 - S48 2018
  • Steyger Peter S., Editorial 2018
  • Frontiers in Cellular Neuroscience
    Jiang Meiyan, Potential mechanisms underlying inflammation-enhanced aminoglycoside-induced cochleotoxicity
    11 2017
  • Frontiers in Cellular Neuroscience
    Jiang Meiyan, Aminoglycoside-induced cochleotoxicity
    11 2017
  • International Journal of Pediatric Otorhinolaryngology
    Garinis Angela C., Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit
    97, p. 42 - 50 2017
  • Journal of Cystic Fibrosis
    Garinis Angela C., The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis
    16:3, p. 401 - 409 2017
  • Adler Henry J., Community network for deaf scientists 2017
  • Hearing Journal
    Steyger Peter S., Is Auditory Synaptopathy a Result of Drug-Induced Hearing Loss?
    70:4, p. 8 - 9 2017
  • Toxicology Letters
    Karasawa Takatoshi, An integrated view of cisplatin-induced nephrotoxicity and ototoxicity
    237:3, p. 219 - 227 2015
  • Expert Opinion on Therapeutic Patents
    Jiang Meiyan, An evaluation of US patent 2015065565 (A1) for a new class of SGLT2 inhibitors for treatment 1 of type II diabetes mellitus
    25:11, p. 1349 - 1352 2015
  • Science Translational Medicine
    Koo Ja Won, Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity
    7:298 2015
  • Hearing Journal
    Steyger Peter S., Novel Aminoglycoside Antibiotics Show Reduced Ototoxicity Risk
    68:4, p. 32 - 35 2015
  • Hearing Journal
    Steyger Peter S., Hearing Loss Risk Factors for Cystic Fibrosis Patients
    69:4, p. 8 - 9 2015
  • PloS one
    Yang Yuqin, Diverse Kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles
    10:5 2015
  • Frontiers in Cellular Neuroscience
    Li Hongzhe, Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells
    9:APR 2015
  • PloS one
    Liu Jianping, Uptake of fluorescent gentamicin by peripheral vestibular cells after systemic administration
    10:3 2015
  • International Journal of Pediatric Otorhinolaryngology
    Cross Campbell P., Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure
    79:11, p. 1915 - 1919 2015
  • PloS one
    Jiang Meiyan, Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides
    9:9 2014
  • Otolaryngology-head and neck surgery
    Luk Lauren J., Perilymphatic Gentamicin Trafficking through Basolateral Channels May Underlie Enhanced Ototoxicity by Noise-Induced Threshold Shifts
    151:1_suppl, p. P222 - P222 2014
  • Otolaryngology-head and neck surgery
    Liao Selena, Noise Exposure in the Neonatal Intensive Care Unit: A Prospective Study
    149:2_suppl, p. P249 - P249 2013
  • Otolaryngology-head and neck surgery
    Liao Selena, Differences in DPOAE and AABR in Noise-Exposed Infants in the Neonatal Intensive Care Unit
    149:2_suppl, p. P244 - P244 2013
  • Otolaryngology - Head and Neck Surgery
    Quintanilla-Dieck Lourdes, Effect of systemic lipopolysaccharide-induced inflammation on cytokine levels in the murine cochlea
    149:2, p. 301 - 303 2013
  • PloS one
    Karasawa Takatoshi, Identification of Cisplatin-Binding Proteins Using Agarose Conjugates of Platinum Compounds
    8:6 2013
  • Hearing Journal
    Steyger Peter S., Ototoxic antibiotics
    66:4, p. 24 - 26 2013
  • Hearing Research
    Zhang Ru, Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs
    298, p. 49 - 59 2013
  • Cell Biochemistry and Biophysics
    Wang Tian, Bumetanide Hyperpolarizes Madin-Darby Canine Kidney Cells and Enhances Cellular Gentamicin Uptake by Elevating Cytosolic Ca2+ Thus Facilitating Intermediate Conductance Ca2+-Activated Potassium Channels
    65:3, p. 381 - 398 2013
  • PloS one
    Uribe Phillip M., Aminoglycoside-Induced Hair Cell Death of Inner Ear Organs Causes Functional Deficits in Adult Zebrafish (Danio rerio)
    8:3 2013
  • PloS one
    Uribe Phillip M., Dimethyl Sulfoxide (DMSO) Exacerbates Cisplatin-induced Sensory Hair Cell Death in Zebrafish (Danio rerio)
    8:2 2013
  • Otolaryngology-head and neck surgery
    Quintanilla-Dieck Lourdes, Cytokines Induced by Gentamicin and Sepsis in the Cochlea
    147:2_suppl, p. P84 - P84 2012
  • Journal of Clinical Oncology
    Brock Penelope R., Platinum-induced ototoxicity in children
    30:19, p. 2408 - 2417 2012
  • Hearing Journal
    Steyger Peter S., Journal club
    65:4, p. 18 - 20 2012
  • Hearing Research
    Zhang Yi Bo, Uptake of gentamicin by vestibular efferent neurons and superior olivary complex after transtympanic administration in guinea pigs
    283:1-2, p. 169 - 179 2012
  • Natural Product Communications
    Escobedo Jorge O., Live cell imaging of a fluorescent gentamicin conjugate
    7:3, p. 317 - 320 2012
  • JARO - Journal of the Association for Research in Otolaryngology
    Stepanyan Ruben S., TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells
    12:6, p. 729 - 740 2011
  • Toxicological Sciences
    Karasawa Takatoshi, Calreticulin binds to gentamicin and reduces drug-induced ototoxicity
    124:2, p. 378 - 387 2011
  • Integrative Biology
    Karasawa Takatoshi, Intracellular mechanisms of aminoglycoside-induced cytotoxicity
    3:9, p. 879 - 886 2011
  • Audiology and Neuro-Otology
    Koo Ja Won, Infection-mediated vasoactive peptides modulate cochlear uptake of fluorescent gentamicin
    16:6, p. 347 - 358 2011
  • Seminars in hearing
    Steyger Peter S., Mechanisms Involved in Ototoxicity
    32:3, p. 217 - 228 2011
  • Scientific Reports
    Li Hongzhe, Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells
    1 2011
  • PloS one
    Alharazneh Abdelrahman, Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity
    6:7 2011
  • PloS one
    Li Hongzhe, Acoustic trauma increases cochlear and hair cell uptake of gentamicin
    6:4 2011
  • Cell Death and Disease
    Karasawa T., CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity
    1:11 2010
  • Laryngoscope
    Zhang Yiliang, Comparison of gentamicin distribution in the inner ear following administration via the endolymphatic sac or round window
    120:10, p. 2054 - 2060 2010
  • Hearing Research
    Wang Qi, Competitive antagonism of fluorescent gentamicin uptake in the cochlea
    268:1-2, p. 250 - 259 2010
  • Otology and Neurotology
    Zhai Feng, Evidence-Based modification of intratympanic gentamicin injections in patients with intractable vertigo
    31:4, p. 642 - 648 2010
  • The FASEB journal
    Wang Tian, Ionic mechanisms for bumetanide enhancement on aminoglycoside ototoxicity: a study with MDCK cells
    24:S1, p. lb486 - lb486 2010
  • Brain Research
    Tiede LeAnn, Metabolic imaging of the organ of corti — A window on cochlea bioenergetics
    1277, p. 37 - 41 2009
  • JARO - Journal of the Association for Research in Otolaryngology
    Wang Qi, Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells
    10:2, p. 205 - 219 2009
  • The FASEB journal
    Ma Ke‐tao, Possible gentamicin trafficking channels in guinea pig cochlear stria vascularis cells
    23:S1 2009
  • Seminars in Hearing
    Steyger Peter S., Potentiation of chemical ototoxicity by noise
    30:1, p. 38 - 46 2009
  • Noise and Health
    Li Hongzhe, Synergistic ototoxicity due to noise exposure and aminoglycoside antibiotics
    11:42, p. 26 - 32 2009
  • Perspectives on hearing and hearing disorders. Research and diagnostics
    Steyger Peter S., Synergistic Ototoxicity of Noise and Chemical Ototoxins
    12:2, p. 48 2008
  • Journal of Cell Science
    Karasawa Takatoshi, TRPV4 enhances the cellular uptake of aminoglycoside antibiotics
    121:17, p. 2871 - 2879 2008
  • Hearing Research
    Dai Chun Fu, A systemic gentamicin pathway across the stria vascularis
    235:1-2, p. 114 - 124 2008
  • Hearing Research
    Hordichok Andrew J., Closure of supporting cell scar formations requires dynamic actin mechanisms
    232:1-2, p. 1 - 19 2007
  • Hearing Research
    Dai C. F., Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo
    213:1-2, p. 64 - 78 2006
  • Hearing Research
    Myrdal Sigrid E., TRPV1 regulators mediate gentamicin penetration of cultured kidney cells
    204:1-2, p. 170 - 182 2005
  • Hearing Research
    Dai C. F., Expression of Trk A receptors in the mammalian inner ear
    187:1-2, p. 1 - 11 2004
  • Neuroscience
    Vass Z., Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries
    124:4, p. 919 - 927 2004
  • JARO - Journal of the Association for Research in Otolaryngology
    Steyger P. S., Uptake of Gentamicin by Bullfrog Saccular Hair Cells in vitro
    4:4, p. 565 - 578 2003
  • Journal of Neurophysiology
    Zheng Jiefu, Vanilloid receptors in hearing
    90:1, p. 444 - 455 2003
  • Journal of Neurocytology
    Jensen-Smith Heather C., Cell type-specific reduction of β tubulin isotypes synthesized in the developing gerbil organ of Corti
    32:2, p. 185 - 197 2003
  • Journal of Neurocytology
    Jensen-Smith H. C., Cell type-specific reduction of β tubulin isotypes synthesized in the developing gerbil organ of Corti
    32:2, p. 185 - 197 2003
  • Hearing Research
    Qiu Jian Hua, Co-existence of tyrosine hydroxylase and calcitonin gene-related peptide in cochlear spiral modiolar artery of guinea pigs
    155:1-2, p. 152 - 160 2001
  • Journal of Biological Chemistry
    Silberbach Michael, Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes
    274:35, p. 24858 - 24864 1999
  • ImmunoMethods
    Steyger Peter, Assessing confocal microscopy systems for purchase
    18:4, p. 435 - 446 1999
  • Journal of Neuroscience
    Steyger Peter S., Myosin Iβ is located at tip link anchors in vestibular hair bundles
    18:12, p. 4603 - 4615 1998
  • Adler H. J., Early education of the deaf [10] 1998
  • Hearing Research
    Baird R. A., Intracellular distributions and putative functions of calcium-binding proteins in the bullfrog vestibular otolith organs
    103:1-2, p. 85 - 100 1997
  • Journal of Controlled Release
    Steyger P. S., Intratumoural
    39:1, p. 35 - 46 1996
  • Hearing Research
    Steyger P. S., Visualization of newt aragonitic otoconial matrices using transmission electron microscopy
    92:1-2, p. 184 - 191 1995
  • Hearing Research
    Hallworth Richard J., Atomic force microscope observations of otoconia in the newt
    85:1-2, p. 115 - 121 1995
  • Hearing Research
    Steyger Peter S., The morphogenic features of otoconia during larval development of Cynops pyrrhogaster, the Japanese red-bellied newt
    84:1-2, p. 61 - 71 1995
  • British Journal of Cancer
    Seymour L. W., Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma
    70:4, p. 636 - 641 1994
  • Journal of Electron Microscopy Technique
    Furness David N., Organization of microtubules in cochlear hair cells
    15:3, p. 261 - 279 1990
  • Hearing Research
    Steyger P. S., Tubulin and microtubules in cochlear hair cells
    42:1, p. 1 - 16 1989
  • British Journal of Audiology
    Steyger P. S., Immunocytochemistry of cytoskeletal proteins in the guinea pig cochleaa comparison of staining patterns with different commercially available antibodies and ultrastructure
    23:2, p. 143 - 174 1989


  • Hospital medication-induced hearing loss presented during ENT Fall Education Series at the Department of Otolaryngology-Head and Neck Surgery at University Hospitals Cleveland Medical Center 2022
  • Mechanisms of Drug-induced Hearing Loss during Research Brainstorming virtual meeting 2022
  • Poster Presentation: F Taghizadeh, M Jiang, W Meier, P Steyger. TLR4 and MyD88 Activation of TRPV1 Modulates Cellular Uptake of Aminoglycosides. 45th Annual Mid-Winter Meeting of the Association for Research in Otolaryngology, San Jose, CA, 1/2020 2020
  • Podium Presentation: F Taghizadeh, M Jiang, W Meier, P Steyger TLR4 and MyD88 activation of TRPV1 modulates cellular uptake of aminoglycosides. 2nd International Society for Inner Ear Therapeutics, Hannover, Germany, 11/2019 2019
  • Keynote speaker: Otopathology of ototoxicity and noise exposure: From animal models to audiological management, NCRAR biennial conference, Portland VA, OR, Sept 2019 2019


  • University Research Award
    Creighton University
  • Keynote Speaker
    Keynote speaker: Otopathology of ototoxicity and noise exposure: From animal models to audiological management, NCRAR biennial conference, Portland VA, OR, Sept 2019.
    NCRAR biennial conference
  • Guest Editor
    Research topic: Cellular Mechanisms of Ototoxicity.
    Frontiers in Celluar Neuroscience
  • Guest Editor
    Research topic: Drug delivery to the inner ear.
    Frontiers in Celluar Neuroscience
  • Lead Discussant
    Ototoxicity Sub-committee for Pharmaceutical Interventions for Hearing Loss (PIHL), Hearing Center of Excellence, US Department of Defense
    Hearing Center of Excellence (DOD)
  • Associate Editor
    Frontiers in Medicine - Translational Medicine