My unique expertise in mechanisms of iatrogenic hearing loss originates from acquiring hearing loss via treatment with the life-saving aminoglycosides when afflicted with bacterial meningitis as an infant. I recognize how critical it is to translate our now wide-ranging collective knowledge in the etiologies of hearing loss and vestibular disorders into efficacious strategies that preserve or restore optimal hearing and vestibular function to maximize the personal goals, familial relationships, friendships and career trajectories of those afflicted with these sensory disorders.
Research Focus
Ototoxicity Cochleotoxicity Vestibulotoxicity Aminoglycoside-induced toxicity Cisplatin-induced toxicity Mechanisms of neuro- and cytotoxicity Physiology of Blood-Labyrinth Barrier Trafficking of drugs and nutrients across blood barriers Hearing Loss Inflammation
Borse Vikrant, Ototoxic Hearing Loss and Balance Disorders: Challenges and Treatment 2022
Inflammatory Mechanisms in Mediating Hearing Loss Steyger Peter S., Inflammation potentiates cochlear uptake of ototoxins and drug-induced hearing loss [Book Chapter] 2018
Articles
Steyger Peter S., Reader response 2020
Steyger Peter, From Screen to Trial 2018
Steyger Peter, Translating in vitro data into auditory protection 2014
Publications
American journal of audiology Janky Kristen, Mechanisms and Impact of Aminoglycoside-Induced Vestibular Deficits, p. 1 - 15 2023
Pharmaceuticals Dash Shreshtha, Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials 15:9 2022
Clinical Pharmacology and Therapeutics McDermott John Henry, Clinical Pharmacogenetics Implementation Consortium Guideline for the Use of Aminoglycosides Based on MT-RNR1 Genotype 111:2, p. 366 - 372 2022
Otolaryngologic Clinics of North America Steyger Peter S., Mechanisms of Ototoxicity and Otoprotection 54:6, p. 1101 - 1115 2021
Journal of Neuroinflammation Mathy Nicholas W., A novel long intergenic non-coding RNA, Nostrill, regulates iNOS gene transcription and neurotoxicity in microglia 18:1 2021
Journal of cystic fibrosis Garinis A., 105: Ototoxicity management for patients with cystic fibrosis 20, p. S53 2021
Frontiers in Education Huyck Julia Jones, Supporting Equity and Inclusion of Deaf and Hard-of-Hearing Individuals in Professional Organizations 6 2021
American Journal of Audiology Garinis Angela C., Clinical considerations for routine auditory and vestibular monitoring in patients with cystic fibrosis 30:3S, p. 800 - 809 2021
American Journal of Audiology Steyger Peter S., Mechanisms of aminoglycoside-and cisplatin-induced ototoxicity 30:3S, p. 887 - 900 2021
Hearing Research Tian Cong, CACHD1-deficient mice exhibit hearing and balance deficits associated with a disruption of calcium homeostasis in the inner ear 409 2021
Frontiers in Neurology Coffin Allison B., Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings 12 2021
Frontiers in Neuroscience Prayuenyong Pattarawadee, Preferential Cochleotoxicity of Cisplatin 15 2021
Cold Spring Harbor Perspectives in Medicine Kros Corné J., Aminoglycoside- and cisplatin-induced ototoxicity 9:11 2019
Science Advances Jiang Meiyan, Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss 5:7 2019
Hearing Journal Steyger Peter S., Genetic Contributions to Age-Related Hearing Loss 72:5, p. 10 - 13 2019
Science Translational Medicine Nyberg Sophie, Delivery of therapeutics to the inner ear 11:482 2019
PloS one Kachelmeier Allan, Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells 13:11 2018
International Journal of Audiology Garinis Angela C., Monitoring neonates for ototoxicity 57:sup4, p. S41 - S48 2018
Frontiers in Cellular Neuroscience Jiang Meiyan, Aminoglycoside-induced cochleotoxicity 11 2017
International Journal of Pediatric Otorhinolaryngology Garinis Angela C., Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit 97, p. 42 - 50 2017
Adler Henry J., Community network for deaf scientists 2017
Hearing Journal Steyger Peter S., Is Auditory Synaptopathy a Result of Drug-Induced Hearing Loss? 70:4, p. 8 - 9 2017
Toxicology Letters Karasawa Takatoshi, An integrated view of cisplatin-induced nephrotoxicity and ototoxicity 237:3, p. 219 - 227 2015
Expert Opinion on Therapeutic Patents Jiang Meiyan, An evaluation of US patent 2015065565 (A1) for a new class of SGLT2 inhibitors for treatment 1 of type II diabetes mellitus 25:11, p. 1349 - 1352 2015
Science Translational Medicine Koo Ja Won, Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity 7:298 2015
Hearing Journal Steyger Peter S., Novel Aminoglycoside Antibiotics Show Reduced Ototoxicity Risk 68:4, p. 32 - 35 2015
Hearing Journal Steyger Peter S., Hearing Loss Risk Factors for Cystic Fibrosis Patients 69:4, p. 8 - 9 2015
PloS one Yang Yuqin, Diverse Kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles 10:5 2015
Frontiers in Cellular Neuroscience Li Hongzhe, Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells 9:APR 2015
PloS one Liu Jianping, Uptake of fluorescent gentamicin by peripheral vestibular cells after systemic administration 10:3 2015
International Journal of Pediatric Otorhinolaryngology Cross Campbell P., Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure 79:11, p. 1915 - 1919 2015
PloS one Jiang Meiyan, Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides 9:9 2014
Otolaryngology-head and neck surgery Luk Lauren J., Perilymphatic Gentamicin Trafficking through Basolateral Channels May Underlie Enhanced Ototoxicity by Noise-Induced Threshold Shifts 151:1_suppl, p. P222 - P222 2014
Otolaryngology-head and neck surgery Liao Selena, Noise Exposure in the Neonatal Intensive Care Unit: A Prospective Study 149:2_suppl, p. P249 - P249 2013
Otolaryngology-head and neck surgery Liao Selena, Differences in DPOAE and AABR in Noise-Exposed Infants in the Neonatal Intensive Care Unit 149:2_suppl, p. P244 - P244 2013
Otolaryngology - Head and Neck Surgery Quintanilla-Dieck Lourdes, Effect of systemic lipopolysaccharide-induced inflammation on cytokine levels in the murine cochlea 149:2, p. 301 - 303 2013
PloS one Karasawa Takatoshi, Identification of Cisplatin-Binding Proteins Using Agarose Conjugates of Platinum Compounds 8:6 2013
Hearing Journal Steyger Peter S., Ototoxic antibiotics 66:4, p. 24 - 26 2013
Hearing Research Zhang Ru, Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs 298, p. 49 - 59 2013
Cell Biochemistry and Biophysics Wang Tian, Bumetanide Hyperpolarizes Madin-Darby Canine Kidney Cells and Enhances Cellular Gentamicin Uptake by Elevating Cytosolic Ca2+ Thus Facilitating Intermediate Conductance Ca2+-Activated Potassium Channels 65:3, p. 381 - 398 2013
PloS one Uribe Phillip M., Aminoglycoside-Induced Hair Cell Death of Inner Ear Organs Causes Functional Deficits in Adult Zebrafish (Danio rerio) 8:3 2013
PloS one Uribe Phillip M., Dimethyl Sulfoxide (DMSO) Exacerbates Cisplatin-induced Sensory Hair Cell Death in Zebrafish (Danio rerio) 8:2 2013
Otolaryngology-head and neck surgery Quintanilla-Dieck Lourdes, Cytokines Induced by Gentamicin and Sepsis in the Cochlea 147:2_suppl, p. P84 - P84 2012
Journal of Clinical Oncology Brock Penelope R., Platinum-induced ototoxicity in children 30:19, p. 2408 - 2417 2012
Hearing Journal Steyger Peter S., Journal club 65:4, p. 18 - 20 2012
Natural Product Communications Escobedo Jorge O., Live cell imaging of a fluorescent gentamicin conjugate 7:3, p. 317 - 320 2012
Hearing Research Zhang Yi Bo, Uptake of gentamicin by vestibular efferent neurons and superior olivary complex after transtympanic administration in guinea pigs 283:1-2, p. 169 - 179 2012
JARO - Journal of the Association for Research in Otolaryngology Stepanyan Ruben S., TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells 12:6, p. 729 - 740 2011
Toxicological Sciences Karasawa Takatoshi, Calreticulin binds to gentamicin and reduces drug-induced ototoxicity 124:2, p. 378 - 387 2011
Audiology and Neuro-Otology Koo Ja Won, Infection-mediated vasoactive peptides modulate cochlear uptake of fluorescent gentamicin 16:6, p. 347 - 358 2011
Integrative Biology Karasawa Takatoshi, Intracellular mechanisms of aminoglycoside-induced cytotoxicity 3:9, p. 879 - 886 2011
Seminars in hearing Steyger Peter S., Mechanisms Involved in Ototoxicity 32:3, p. 217 - 228 2011
PloS one Li Hongzhe, Acoustic trauma increases cochlear and hair cell uptake of gentamicin 6:4 2011
Scientific Reports Li Hongzhe, Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells 1 2011
PloS one Alharazneh Abdelrahman, Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity 6:7 2011
Cell Death and Disease Karasawa T., CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity 1:11 2010
Laryngoscope Zhang Yiliang, Comparison of gentamicin distribution in the inner ear following administration via the endolymphatic sac or round window 120:10, p. 2054 - 2060 2010
Hearing Research Wang Qi, Competitive antagonism of fluorescent gentamicin uptake in the cochlea 268:1-2, p. 250 - 259 2010
Otology and Neurotology Zhai Feng, Evidence-Based modification of intratympanic gentamicin injections in patients with intractable vertigo 31:4, p. 642 - 648 2010
The FASEB journal Wang Tian, Ionic mechanisms for bumetanide enhancement on aminoglycoside ototoxicity: a study with MDCK cells 24:S1, p. lb486 - lb486 2010
JARO - Journal of the Association for Research in Otolaryngology Wang Qi, Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells 10:2, p. 205 - 219 2009
Brain Research Tiede LeAnn, Metabolic imaging of the organ of corti — A window on cochlea bioenergetics 1277, p. 37 - 41 2009
The FASEB journal Ma Ke‐tao, Possible gentamicin trafficking channels in guinea pig cochlear stria vascularis cells 23:S1 2009
Seminars in Hearing Steyger Peter S., Potentiation of chemical ototoxicity by noise 30:1, p. 38 - 46 2009
Noise and Health Li Hongzhe, Synergistic ototoxicity due to noise exposure and aminoglycoside antibiotics 11:42, p. 26 - 32 2009
Perspectives on hearing and hearing disorders. Research and diagnostics Steyger Peter S., Synergistic Ototoxicity of Noise and Chemical Ototoxins 12:2, p. 48 2008
Journal of Cell Science Karasawa Takatoshi, TRPV4 enhances the cellular uptake of aminoglycoside antibiotics 121:17, p. 2871 - 2879 2008
Hearing Research Dai Chun Fu, A systemic gentamicin pathway across the stria vascularis 235:1-2, p. 114 - 124 2008
Hearing Research Hordichok Andrew J., Closure of supporting cell scar formations requires dynamic actin mechanisms 232:1-2, p. 1 - 19 2007
Hearing Research Dai C. F., Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo 213:1-2, p. 64 - 78 2006
Hearing Research Myrdal Sigrid E., TRPV1 regulators mediate gentamicin penetration of cultured kidney cells 204:1-2, p. 170 - 182 2005
Neuroscience Vass Z., Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries 124:4, p. 919 - 927 2004
Hearing Research Dai C. F., Expression of Trk A receptors in the mammalian inner ear 187:1-2, p. 1 - 11 2004
JARO - Journal of the Association for Research in Otolaryngology Steyger P. S., Uptake of Gentamicin by Bullfrog Saccular Hair Cells in vitro 4:4, p. 565 - 578 2003
Journal of Neurophysiology Zheng Jiefu, Vanilloid receptors in hearing 90:1, p. 444 - 455 2003
Journal of Neurocytology Jensen-Smith Heather C., Cell type-specific reduction of β tubulin isotypes synthesized in the developing gerbil organ of Corti 32:2, p. 185 - 197 2003
Journal of Neurocytology Jensen-Smith H. C., Cell type-specific reduction of β tubulin isotypes synthesized in the developing gerbil organ of Corti 32:2, p. 185 - 197 2003
Hearing Research Qiu Jian Hua, Co-existence of tyrosine hydroxylase and calcitonin gene-related peptide in cochlear spiral modiolar artery of guinea pigs 155:1-2, p. 152 - 160 2001
Journal of Biological Chemistry Silberbach Michael, Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes 274:35, p. 24858 - 24864 1999
ImmunoMethods Steyger Peter, Assessing confocal microscopy systems for purchase 18:4, p. 435 - 446 1999
Journal of Neuroscience Steyger Peter S., Myosin Iβ is located at tip link anchors in vestibular hair bundles 18:12, p. 4603 - 4615 1998
Adler H. J., Early education of the deaf [10] 1998
Hearing Research Baird R. A., Intracellular distributions and putative functions of calcium-binding proteins in the bullfrog vestibular otolith organs 103:1-2, p. 85 - 100 1997
Journal of Controlled Release Steyger P. S., Intratumoural 39:1, p. 35 - 46 1996
Hearing Research Steyger P. S., Visualization of newt aragonitic otoconial matrices using transmission electron microscopy 92:1-2, p. 184 - 191 1995
Hearing Research Hallworth Richard J., Atomic force microscope observations of otoconia in the newt 85:1-2, p. 115 - 121 1995
Hearing Research Steyger Peter S., The morphogenic features of otoconia during larval development of Cynops pyrrhogaster, the Japanese red-bellied newt 84:1-2, p. 61 - 71 1995
British Journal of Cancer Seymour L. W., Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma 70:4, p. 636 - 641 1994
Journal of Electron Microscopy Technique Furness David N., Organization of microtubules in cochlear hair cells 15:3, p. 261 - 279 1990
Hearing Research Steyger P. S., Tubulin and microtubules in cochlear hair cells 42:1, p. 1 - 16 1989
British Journal of Audiology Steyger P. S., Immunocytochemistry of cytoskeletal proteins in the guinea pig cochleaa comparison of staining patterns with different commercially available antibodies and ultrastructure 23:2, p. 143 - 174 1989
Presentations
Hospital medication-induced hearing loss presented during ENT Fall Education Series at the Department of Otolaryngology-Head and Neck Surgery at University Hospitals Cleveland Medical Center 2022
Mechanisms of Drug-induced Hearing Loss during Research Brainstorming virtual meeting 2022
Poster Presentation: F Taghizadeh, M Jiang, W Meier, P Steyger. TLR4 and MyD88 Activation of TRPV1 Modulates Cellular Uptake of Aminoglycosides. 45th Annual Mid-Winter Meeting of the Association for Research in Otolaryngology, San Jose, CA, 1/2020 2020
Podium Presentation: F Taghizadeh, M Jiang, W Meier, P Steyger TLR4 and MyD88 activation of TRPV1 modulates cellular uptake of aminoglycosides. 2nd International Society for Inner Ear Therapeutics, Hannover, Germany, 11/2019 2019
Keynote speaker: Otopathology of ototoxicity and noise exposure: From animal models to audiological management, NCRAR biennial conference, Portland VA, OR, Sept 2019 2019
Keynote Speaker Keynote speaker: Otopathology of ototoxicity and noise exposure: From animal models to audiological management, NCRAR biennial conference, Portland VA, OR, Sept 2019. NCRAR biennial conference
Guest Editor Research topic: Cellular Mechanisms of Ototoxicity. Frontiers in Celluar Neuroscience
Guest Editor Research topic: Drug delivery to the inner ear. Frontiers in Celluar Neuroscience
Lead Discussant Ototoxicity Sub-committee for Pharmaceutical Interventions for Hearing Loss (PIHL), Hearing Center of Excellence, US Department of Defense Hearing Center of Excellence (DOD)
Associate Editor Frontiers in Medicine - Translational Medicine