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Peter Stephen Steyger, PhD


Biomedical Sciences

P Steyger


School of Medicine
Biomedical Sciences
Graduate School
Biomedical Sciences (Master of Science)
Biomedical Sciences (Doctorate)
Translational Hearing
CRISS I - Criss 1 - 431

Peter Stephen Steyger, PhD


Biomedical Sciences

My unique expertise in mechanisms of iatrogenic hearing loss originates from acquiring hearing loss via treatment with the life-saving aminoglycosides when afflicted with bacterial meningitis as an infant. I recognize how critical it is to translate our now wide-ranging collective knowledge in the etiologies of hearing loss and vestibular disorders into efficacious strategies that preserve or restore optimal hearing and vestibular function to maximize the personal goals, familial relationships, friendships and career trajectories of those afflicted with these sensory disorders.  

Research Focus

Aminoglycoside-induced toxicity
Cisplatin-induced toxicity
Mechanisms of neuro- and cytotoxicity
Physiology of Blood-Labyrinth Barrier
Trafficking of drugs and nutrients across blood barriers
Hearing Loss


Biomedical Sciences




  • Springer Publishing
    Steyger PS. Inflammation Potentiates Cochlear Uptake of Ototoxins and Drug-Induced Hearing Loss . In: Inflammatory Mechanisms in Mediating Hearing Loss. Ramkumar V, Rybak LP, editors. Cham: Springer; 2018. Chapter 7; p.133-147. 237p.  2018


  • Pharmaceuticals
    Shreshtha Dash, Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials. Dash, S.; Zuo, J.; Steyger, P.S. Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials. Pharmaceuticals 2022, 15, 1115. 2022
  • Perspectives in Medicine
    Kros CJ, Steyger PS. Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies. Cold Spring Harb Perspect Med. 2019 Nov 1;9(11). Review. PubMed PMID: 30559254; PubMed Central PMCID: PMC6579718. 
    9(11) 2019
  • Science Advances
    Jiang M, , Jiang M, Li H, Johnson A, Karasawa T, Zhang Y, Meier WB, Taghizadeh F, Kachelmeier A, Steyger PS. Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss. Sci Adv. 2019 Jul 17;5(7):eaaw1836. doi: 10.1126/sciadv.aaw1836. PMID: 31328162; PMCID: PMC6636990. 2019
  • Science Advances
    Jiang M, Li H, Johnson A, Karasawa T, Zhang Y, Meier WB, Taghizadeh F, Kachelmeier A, Steyger PS. Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss. Sci Adv. 2019 Jul;5(7):eaaw1836. doi:10.1126/sciadv.aaw1836. eCollection 2019 Jul. PubMed PMID: 31328162; PubMed Central PMCID: PMC6636990. 
    Jul;5(7) 2019
  • Science Translational Medicine
    Nyberg S, Abbott NJ, Shi X, Steyger PS, Dabdoub A. Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier. Sci Transl Med. 2019 Mar 6;11(482). doi:10.1126/scitranslmed.aao0935. Review. PubMed PMID: 30842313; PubMed Central PMCID: PMC6488020.
    11, p. 482 2019
  • Acoustics Today
    Adler HJ, Ratnanather JT, Steyger PS, Buran BN. Scientists with Hearing Loss Changing Perspectives in STEMM. Acoust Today. 2019 Spring;15(1):66-70. PubMed PMID: 31423114; PubMed Central PMCID: PMC6697183. 
    15(1), p. 66-70 2019
  • PLoS One
    Kachelmeier A, Shola T, Meier WB, Johnson A, Jiang M, Steyger PS. Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells. PLoS One. 2018;13(11):e0206628. doi: 10.1371/journal.pone.0206628. eCollection 2018. PubMed PMID: 30383813; PubMed Central PMCID: PMC6211712. 
    13(11) 2018
  • Garinis AC, Kemph A, Tharpe AM, Weitkamp JH, McEvoy C, Steyger PS. Monitoring neonates for ototoxicity. Int J Audiol. 2018 Sep;57(sup4):S41-S48. doi: 10.1080/14992027.2017.1339130. Epub 2017 Jun 22. Review. PubMed PMID: 28949262; PubMed Central PMCID: PMC5741535. 
    57(sup4), p. S41-S48 2018
  • International Journal of Pediatric Otorhinolaryngology
    Garinis AC,, Garinis AC, Liao S, Cross CP, Galati J, Middaugh JL, Mace JC, Wood AM, McEvoy L, Moneta L, Lubianski T, Coopersmith N, Vigo N, Hart C, Riddle A, Ettinger O, Nold C, Durham H, MacArthur C, McEvoy C, Steyger PS. Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit: A pilot study. Int J Pediatr Otorhinolaryngol. 2017 Jun;97:42-50. doi: 10.1016/j.ijporl.2017.03.025. Epub 2017 Mar 21. PMID: 28483249; PMCID: PMC5439527. 2017
  • Journal of Cystic Fibrosis
    Garinis AC,, Garinis AC, Cross CP, Srikanth P, Carroll K, Feeney MP, Keefe DH, Hunter LL, Putterman DB, Cohen DM, Gold JA, Steyger PS. The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis. J Cyst Fibros. 2017 May;16(3):401-409. doi: 10.1016/j.jcf.2017.01.006. Epub 2017 Feb 24. PMID: 28238634; PMCID: PMC5591745. 2017
  • International Journal of Pediatric Otorhinolaryngology
    Cross CP,, Cross CP, Liao S, Urdang ZD, Srikanth P, Garinis AC, Steyger PS. Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure. Int J Pediatr Otorhinolaryngol. 2015 Nov;79(11):1915-9. doi: 10.1016/j.ijporl.2015.09.004. Epub 2015 Sep 9. PMID: 26384832; PMCID: PMC4593761. 2015
  • Science Translational Medicine
    Koo JW,, Koo JW, Quintanilla-Dieck L, Jiang M, Liu J, Urdang ZD, Allensworth JJ, Cross CP, Li H, Steyger PS. Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity. Sci Transl Med. 2015 Jul 29;7(298):298ra118. doi: 10.1126/scitranslmed.aac5546. PMID: 26223301; PMCID: PMC4534720. 2015
  • PLoS One
    Jiang M, , Jiang M, Wang Q, Karasawa T, Koo JW, Li H, Steyger PS. Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides. PLoS One. 2014 Sep 30;9(9):e108941. doi: 10.1371/journal.pone.0108941. PMID: 25268124; PMCID: PMC4182564. 2014
  • J Clinical Oncology
    Brock PR,, Brock PR, Knight KR, Freyer DR, Campbell KC, Steyger PS, Blakley BW, Rassekh SR, Chang KW, Fligor BJ, Rajput K, Sullivan M, Neuwelt EA. Platinum-induced ototoxicity in children: a consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale. J Clin Oncol. 2012 Jul 1;30(19):2408-17. doi: 10.1200/JCO.2011.39.1110. Epub 2012 Apr 30. PMID: 22547603; PMCID: PMC3675696. 2012
  • Toxicological sciences
    Karasawa T,, Karasawa T, Wang Q, David LL, Steyger PS. Calreticulin binds to gentamicin and reduces drug-induced ototoxicity. Toxicol Sci. 2011 Dec;124(2):378-87. doi: 10.1093/toxsci/kfr196. Epub 2011 Jul 23. PMID: 21785162; PMCID: PMC3216409. 2011
  • Sci Rep
    Li H, , Li H, Steyger PS. Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells. Sci Rep. 2011;1:159. doi: 10.1038/srep00159. Epub 2011 Nov 16. PMID: 22355674; PMCID: PMC3240991. 2011
  • JARO
    Stepanyan RS, , Stepanyan RS, Indzhykulian AA, Vélez-Ortega AC, Boger ET, Steyger PS, Friedman TB, Frolenkov GI. TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells. J Assoc Res Otolaryngol. 2011 Dec;12(6):729-40. doi: 10.1007/s10162-011-0288-x. Epub 2011 Aug 31. PMID: 21879401; PMCID: PMC3214240. 2011
  • PLoS One
    Alharazneh A,, Alharazneh A, Luk L, Huth M, Monfared A, Steyger PS, Cheng AG, Ricci AJ. Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity. PLoS One. 2011;6(7):e22347. doi: 10.1371/journal.pone.0022347. Epub 2011 Jul 26. PMID: 21818312; PMCID: PMC3144223. 2011
  • Cell Death & Disease
    Karasawa T,, Karasawa T, Wang Q, David LL, Steyger PS. CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity. Cell Death Dis. 2010 Nov 18;1(11):e102. doi: 10.1038/cddis.2010.80. PMID: 21368867; PMCID: PMC3032319. 2010
  • JARO
    Wang Q, , Wang Q, Steyger PS. Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells. J Assoc Res Otolaryngol. 2009 Jun;10(2):205-19. doi: 10.1007/s10162-009-0160-4. Epub 2009 Mar 3. PMID: 19255807; PMCID: PMC2674203. 2009
  • Journal of Cell Science
    Karasawa T,, Karasawa T, Wang Q, Fu Y, Cohen DM, Steyger PS. TRPV4 enhances the cellular uptake of aminoglycoside antibiotics. J Cell Sci. 2008 Sep 1;121(Pt 17):2871-9. doi: 10.1242/jcs.023705. Epub 2008 Aug 5. PMID: 18682499; PMCID: PMC2736053. 2008
  • Hearing Research
    Dai CF,, Dai CF, Steyger PS. A systemic gentamicin pathway across the stria vascularis. Hear Res. 2008 Jan;235(1-2):114-24. doi: 10.1016/j.heares.2007.10.010. Epub 2007 Nov 17. PMID: 18082985; PMCID: PMC2703593. 2008
  • Hearing Research
    Myrdal SE,, Myrdal SE, Steyger PS. TRPV1 regulators mediate gentamicin penetration of cultured kidney cells. Hear Res. 2005 Jun;204(1-2):170-82. doi: 10.1016/j.heares.2005.02.005. PMID: 15925202; PMCID: PMC2736064. 2005
  • Hearing Research
    Myrdal SE, , Myrdal SE, Johnson KC, Steyger PS. Cytoplasmic and intra-nuclear binding of gentamicin does not require endocytosis. Hear Res. 2005 Jun;204(1-2):156-69. doi: 10.1016/j.heares.2005.02.002. PMID: 15925201; PMCID: PMC2736065. 2005

Editing and Reviews

  • Frontiers in Cellular Neuroscience
    Steyger PS, Cunningham L, Esquivel C, Watts K and Zuo J (2018). Editorial: Cellular Mechanisms of Ototoxicity. Front. Cell. Neurosci. 12:75. PMID: 29636663 PMCID: PMC5881100.  2018


  • Hospital medication-induced hearing loss presented during ENT Fall Education Series at the Department of Otolaryngology-Head and Neck Surgery at University Hospitals Cleveland Medical Center 2022
  • Mechanisms of Drug-induced Hearing Loss during Research Brainstorming virtual meeting 2022
  • Poster Presentation: F Taghizadeh, M Jiang, W Meier, P Steyger. TLR4 and MyD88 Activation of TRPV1 Modulates Cellular Uptake of Aminoglycosides. 45th Annual Mid-Winter Meeting of the Association for Research in Otolaryngology, San Jose, CA, 1/2020 2020
  • Podium Presentation: F Taghizadeh, M Jiang, W Meier, P Steyger TLR4 and MyD88 activation of TRPV1 modulates cellular uptake of aminoglycosides. 2nd International Society for Inner Ear Therapeutics, Hannover, Germany, 11/2019 2019
  • Keynote speaker: Otopathology of ototoxicity and noise exposure: From animal models to audiological management, NCRAR biennial conference, Portland VA, OR, Sept 2019 2019


  • University Research Award
    Creighton University
  • Keynote Speaker
    Keynote speaker: Otopathology of ototoxicity and noise exposure: From animal models to audiological management, NCRAR biennial conference, Portland VA, OR, Sept 2019.
    NCRAR biennial conference
  • Guest Editor
    Research topic: Cellular Mechanisms of Ototoxicity.
    Frontiers in Celluar Neuroscience
  • Guest Editor
    Research topic: Drug delivery to the inner ear.
    Frontiers in Celluar Neuroscience
  • Lead Discussant
    Ototoxicity Sub-committee for Pharmaceutical Interventions for Hearing Loss (PIHL), Hearing Center of Excellence, US Department of Defense
    Hearing Center of Excellence (DOD)
  • Associate Editor
    Frontiers in Medicine - Translational Medicine