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Yaping Tu, PhD

Professor

Yaping Tu

Contact

School of Medicine
Pharmacology and Neuroscience
CRISS III - Criss 3

Yaping Tu, PhD

Professor

Dr. Tu’s laboratory focuses on understanding the role of dysregulation of G protein-coupled receptor signal transduction in human diseases including cancer and asthma using various cellular and murine models. Learn more about Dr. Tu’s research.

Department

Pharmacology and Neuroscience

Position

Professor

Books

  • Not Applicable
    1. Tu, Y. Abel, P.W. and Piascik, M.T. (2010) Adrenergic Agonists. Pharmacology and Therapeutics for Dentistry. Sixth Edition, J.A. Yagiela, F.J. Dowd and E.A. Neidle, eds. pp. 91-105, Elsevier Mosby, Inc.
    Sixth Edition 2010
  • Not Applicable
    Tu, Y. Abel, P.W. and Piascik, M.T. (2010) Adrenergic Agonists. Pharmacology and Therapeutics for Dentistry. Sixth Edition, J.A. Yagiela, F.J. Dowd and E.A. Neidle, eds. Elsevier Mosby, Inc.
    91-105 2010

Articles

  • Cell Death & Disease
    Wei P, Xie Y, Abel PW, Huang Y, Ma Q, Li L, Hao J, Wolff DW, Wei T, Tu Y. (2019) Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis.
    10(9):, p. 670 2019
  • J Allergy Clin Immun
    Huang Y, Xie Y, Jiang H, Abel PW, Panettieri RA Jr, Casale TB, Tu Y. (2019) Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma
    143(2):, p. 778-781 2019
  • Scientific Reports
    Chen L, He X, Xie Y, Huang Y, Wolff DW, Abel PW, Tu Y. (2018) Up-regulated miR-133a orchestrates epithelial-mesenchymal transition of airway epithelial cells
    8(1):, p. 15543. 2018
  • Cell Signal
    Ingersoll MA, Chou YW, Lin JS, Yuan TC, Miller DR, Xie Y, Tu Y, Oberley-Deegan RE, Batra SK, Lin MF. (2018) p66Shc regulates migration of castration-resistant prostate cancer cells
    46:, p. 1-14. 2018
  • J Cell Physiol
    Caggia S, Chunduri H, Millena AC, Perkins JN, Venugopal SV, Vo BT, Li C, Tu Y, Khan SA. (2018)  Novel role of Giα2 in cell migration: Downstream of PI3-kinase-AKT and Rac1 in prostate cancer cells.
    234(1):, p. 802-815 2018
  • BMC Cancer
    Chen L, Wolff DW, Xie Y, Lin MF, Tu Y. (2017) Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5.
    17(1):, p. 179. 2017
  • Biomaterials
    Zhou T, Zhang B, Wei P, Du Y, Zhou H, Yu M, Yan L, Zhang W, Nie G, Chen C, Tu Y, Wei T. (2014) Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets.
    35, p. 9833-9843 2014
  • American Journal of Respiratory Cell Molecular Biology
    Jiang H, Xie Y, Abel PW, Wolff DW, Toews ML, Panettieri Jr RA, Casale TB, Tu Y. RGS2 Repression Exacerbates Airway Hyperresponsiveness and Remodeling in Asthma
    51, p. DOI: 10.1165/rcmb.2014-0319OC 2014
  • Breast Cancer Research
    Barrio-Real L, Benedetti LG, Engel N, Tu Y, Cho S, Sukumar S, Kazanietz MG. (2014) Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation.
    16, p. 441 2014
  • Advanced Functional Materials
    Zhou T, Yu M, Zhang B, Wang L, Wu X, Zhou H, Du Y, Hao J, Tu Y, Chen C,Wei T (2014) Inhibition of Cancer Cell Migration by Gold Nanorods: Molecular Mechanisms and Implications for Cancer Therapy.
    24, p. 6922–6932 2014
  • Oncogene
    Zhao, J., Zhang, J., Yu, M., Xie, Y., Huang, Y., Wolff, D.W., Abel, P.W., Tu, Y. Mitochondrial dynamics regulates migration and invasion of breast cancer cells.
    32, p. 4814-4824 2013
  • Biochem Pharmacol
    Xie Y, Abel PW, Kirui JK, Deng C, Sharma P, Wolff DW, Toews ML, Tu Y. (2013) Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion.
    85:, p. 1454-62 2013
  • Journal of Allergy and Clinical Immunology
    Xie, Y., Jiang, H., Nguyen, H., Jia, S., Berro, A., Panettieri, R.A., Wolff, D.W., Abel, P.W., Casale, T.B., and Tu, Y. (2012) Regulator of G-protein Signaling 2 is a key modulator of airway hyperresponsiveness.
    130, p. 968-976 2012
  • J Lipid Res
    Zhao K, Zhou H, Zhao X, Wolff DW, Tu Y, Liu H, Wei T, Yang F. (2012) Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis.
    53:, p. 2102-14 2012
  • Journal of Pharmacology and Experimental Therapeutics
    Jiang H, Xie Y, Abel PW, Toews ML, Townley RG, Casale TB, Tu Y. (2012) Targeting phosphoinositide 3-kinase γ in airway smooth muscle cells to suppress interleukin-13-induced mouse airway hyperresponsiveness.
    342, p. 305-11. 2012
  • Small
    Li X, Qiu L, Zhu P, Tao X, Imanaka T, Zhao J, Huang Y, Tu Y, Cao X. (2012) Epidermal growth factor-ferritin H-chain protein nanoparticles for tumor active targeting.
    8:, p. 2505-14 2012
  • Eur J Med Chem
    Sinha SH, Owens EA, Feng Y, Yang Y, Xie Y, Tu Y, Henary M, Zheng YG. (2012) Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents.
    54:, p. 647-59 2012
  • Free Radic Biol Med
    Veeramani S, Chou YW, Lin FC, Muniyan S, Lin FF, Kumar S, Xie Y, Lele SM, Tu Y, Lin MF. (2012) Reactive oxygen species induced by p66Shc longevity protein mediate nongenomic androgen action via tyrosine phosphorylation signaling to enhance tumorigenicity of prostate cancer cells.
    53:, p. 95-108 2012
  • Int. J. Cancer
    Wolff, D.W., Xie, Y., Deng, C., Gatalica, Z.., Yang, M., Wang, B., Wang, J., Lin, M.F., Abel, P.W., Tu, Y. (2012) Epigenetic repression of RGS2 promotes androgen-independent prostate cancer cell growth.
    130, p. 1521-1531 2012
  • Journal of Pharmacology and Experimental Therapeutics
    Jiang, H., Xie, Y., Abel, P.W., Toews, M.L., Townley, R.G., Casale, T.B., and Tu, Y. (2012) Targeting phosphoinositide 3-kinase in airway smooth muscle cells to suppress interleukin-13-induced mouse airway hyperresponsiveness.
    342, p. 305-311 2012
  • J Biol Chem
    Wong, C.Y., Wuriyanghan, H., Xie, Y., Lin, M.F., Abel, P.W. and Tu, Y. (2011) Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex1) gene expression in prostate cancer cells.
    286, p. 25813-25822 2011
  • FEBS Lett.
    3. Wang J, Xie Y, Wolff DW, Abel PW and Tu Y. (2010) DHHC protein-dependent palmitoylation protects regulator of G-protein signaling 4 from proteasome degradation.
    584, p. 4570-4574 2010
  • Journal of Pharmacology and Experimental Therapeutics
    5. Jiang, H., Abel, P.W., Toews, M.L., Deng, C., Casale, T.B., Xie, Y., and Tu, Y. (2010) Phosphoinositide 3-kinase ¦Ã regulates airway smooth muscle contraction by modulating calcium oscillations.
    334, p. 703-709 2010
  • Cellular and Molecular Life Sciences
    6. Zhao, K., Zhao, X., Tu, Y., Miao,Q., Cao,X., Duan, W., Sun, Y., Wang, J., Wei, T., Yang, F. (2010) Lysosomal chymotrypsin B Potentiates apoptosis via cleavage of BID.
    67, p. 2665-2678 2010
  • J Biol Chem
    Chuang, T.D, Chen, S.J, Lin, F.F., Veeramani, S., Kumar S, Batra, S.K. Tu, Y. Lin MF (2010). Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.
    285 2010
  • Journal of Pharmacology and Experimental Therapeutics
    Kirui, J., Xie, Y., Wolff, D.W., Jiang, H., Abel, P.W. and Tu, Y. (2010) G¦Â¦Ã signaling promotes breast cancer cell migration and invasion
    333, p. 393-403. 2010
  • Molecular Endocrinology
    Kang, L., Zhang, X., Xie, Y., Tu, Y., Wang, D., Liu, Z. and Wang. Z.Y. (2010) Involvement of Estrogen Receptor Variant ER-¦Á36, not GPR30, in Non-Genomic Estrogen Signaling.
    24, p. 709-721 2010
  • Cellular and Molecular Life Sciences
    Zhao, K., Zhao, X., Tu, Y., Miao,Q., Cao,X., Duan, W., Sun, Y., Wang, J., Wei, T., Yang, F. (2010) Lysosomal chymotrypsin B Potentiates apoptosis via cleavage of BID.
    67, p. 2665-2678 2010
  • Cancer Research
    Xie, Y., Wolff, D.W., Wei, T., Wang, B., Deng, C., Kirui, J., Jiang, H., Qin, J., Abel, P.W. and Tu, Y. (2009) Breast cancer migration and invasion depends on proteasome degradation of regulator of G protein signaling 4 (RGS4).
    69, p. 5743-5751 2009
  • Cancer Research
    Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4
    69, p. 5743-51 2009
  • Oncogene
    Upregulation of PIP3-dependent Rac exchanger 1 promote prostate cancer metastasis
    28, p. 1853-1863 2009
  • Molecular Pharmacology
    Xie, Y., Wolff, D.W., Lin, M.F., and Tu, Y. Vasoactive intestinal peptide transactivates the androgen receptor through a PKA- dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells.
    72, p. 73-85 2007
  • Oncogene
    Cao X, Qin J, Xie Y, Khan O, Dowd F, Scofield M, Lin MF, Tu Y. Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells.
    25, p. 3719-34 2006
  • Molecular Endocrinology
    Khan OY, Fu G, Ismail A, Srinivasan S, Cao X, Tu Y, Lu S and Nawaz Z. Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland.
    20, p. 544-59 2006
  • J. Biol. Chem.
    Tang W, Tu Y, Nayak SK, Woodson J, Jehl M and Ross EM. Gbetagamma inhibits Galpha GTPase-activating proteins by inhibition of Galpha-GTP binding during stimulation by receptor.
    281, p. 4746-4753 2006
  • Methods Enzymol.
    Tu, Y. and Wilkie, T.M. (2004) Allosteric Regulation of RGS Domain GAP Activity
    389, p. 89-105 2004
  • Not Applicable
    Tu, Y., Nayak, S. K., Woodson, J. and Ross, E. M. Phosphorylation-Regulated Inhibition of the Gz GAP Activity of RGS Proteins by Synapsin Ia
    278 2003
  • BioScience Reports
    Ouyang, Y.S. Tu, Y. and Yang, F.Y. (2003) The mutation in the N-terminal domain of RGS4 disrupts PA-conferred inhibitory effect on GAP activity
    23, p. 213-224 2003
  • Cell Death & Disease
    Wei P, Xie Y, Abel PW, Huang Y, Ma Q, Li L, Hao J, Wolff DW, Wei T, Tu Y. (2019) Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis.
    10(9), p. 670

Publications

  • FASEB Journal
    Breast Cancer Metastasis Depends on Proteasome Degradation of Regulator of G-protein Signaling 4
    23, p. 584.3 2009
  • FASEB Journal
    Histone deacetylases inhibit PIP3-dependent Rac exchange factor 1 (P-Rex1) expression in prostate cancer cells via SP1 binding site
    23, p. 585.6 2009
  • FASEB Journal
    Qin, J., Scofield, M.A., Dowd, F.J., Hoshino, M., Tu, Y. PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer cell migration.
    21, p. 554.23 2008
  • FASEB Journal
    Xie, Y., Wolff, D.W., Lin, M.F., and Tu, Y. Vasoactive intestinal peptide transactivates the androgen receptor through a PKA-dependent extracellular signal-regulated kinase pathway in prostate cancer cells.
    21, p. 569.13 2008

Presentations

  • Invited speaker: Airway Relaxation Mechanisms and Structural Basis of Osthole to Improve Lung Function in Asthma,Kansas City University of Medicine and Biosciences, Kansas City, MO, USA 2019
  • Poster presentation: Inhibition of androgen receptor increases sensitivity of TRAIL-induced apoptosis via up-regulation of death receptor 5 in breast cancer. Experimental Biology Annual Meeting-2019, Orland, Florida, USA 2019
  • Poster presentation: TGF-β1-induced miR-424 mediates pulmonary myofibroblast differentiation via targeting slit2, Experimental Biology Annual Meeting-2019, Orland, Florida, USA 2019
  • Invited speaker, Research Conference of Pulmonary, Critical Care, Sleep & Allergy Division, University of Nebraska Medical Center, Omaha, NE 2019
  • Invited speaker: Molecular studies of osthole as a new bronchodilator to treat drug-resistant asthma, The Second JinLing Forum on Membrane Protein Physiology and Drug Discovery, Nanjing, China 2018
  • The Bioscience Seminar, the Morsani College of Medicine, University of South Florida Topic: 'Regulator of G Protein Signaling Proteins: Targets for Treatment of Asthma' 2015
  • The Nebraska Center for Cellular Signaling Month Meeting Topic: “Targeting the Androgen Receptor and TRAIL Pathways: A Novel Treatment Paradigm for Breast Cancer ” 2015
  • The 4th International Symposium on Membrane Biology. Dali, China Topic: 'Regulator of G Protein Signaling Proteins: Targets for Treatment of Asthma' 2014
  • American Asthma Foundation Annual Meeting-2014 2014
  • Department of Pharmacology, Creighton University 2014
  • Department of Chemistry, University of Nebraska at Omaha, NE 2013
  • American Asthma Foundation Annual Meeting, San Francisco, CA 2013
  • Experimental Biology-2013, Boston 2013
  • Department of Urology, University of Kansas Medical Center, Kansas, KS 2013
  • Annual Meeting of the American Academy of Allergy Asthma and Immunology, San Antonio, TX 2013
  • The Nebraska Center for Cellular Signaling, Omaha, NE 2013
  • Omaha VA Medical Center, Omaha 2012
  • The 2nd International Symposium on Membrane Biology, Zhuhai, China 2012
  • 2012-Annual Meeting of American Asthma Foundation 2012
  • 2012 Experimental Biology 2012
  • 2012-Creighton Faculty Club 2012
  • Invited speaker, Creighton Cancer Research Symposium 2011
  • Featured speaker, Nebraska Center for Cellular Signaling Symposium 2011
  • Invited speaker, 7th Annual National Symposium on Prostate Cancer 2011
  • Invited speaker, Innovative Minds in Prostate Cancer Today Conference 2011
  • The 2nd International Symposium on Membrane Biology in China 2010
  • Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center 2010
  • Invited speaker, 2009 Nebraska Research and Innovation Conference. Omaha 2009
  • Department of Pathology, Creighton University Medical Center 2009
  • The 1st International Symposium on Membrane Biology, CHINA 2009
  • GORDON RESEARCH CONFERENCE: PHOSPHORYLATION & G-PROTEIN MEDIATED SIGNALING 2009
  • AACR 100th Annual Meeting 2009 2009
  • 'Dysregulation of G-Protein Signaling in Cancer' at State Key laboratory of Membrane Biology and Membrane Biotechnology, Chinese Academy of Sciences 2009
  • Prostate Cancer Research Group, University of Nebraska Medical Center 2008
  • 'RGS proteins and cancer' at Peking University, China 2008
  • 'RGS2 and Prostate cancer progression' at National Center for Nanoscience and Technology, China 2008
  • Experimental Biology Meeting-2008 2008
  • 3rd RGS Protein Colloquium 2008
  • Harry and Elsa Jiler-American Cancer Society Professors Meeting 2007
  • Braman Family Breast Cancer Institute 2007
  • The 2007 International Symposium on Biomembranes, Hubei, China 2007
  • Department of Surgery at Evanston Northwestern Healthcare and the Department of Urology at Northwestern University Feinberg School of Medicine 2007
  • The University of Minnesota Cancer Center 2007
  • University of Nebraska Medical Center 2007
  • Vasoactive intestinal peptide transactivates the androgen receptor 2007
  • P-Rex1 promotes prostate cancer cell migration and invasion 2007
  • 97th Annul Meeting of the American Association for Cancer Research, at the meeting in Washington, DC (April 1-5, 2006). 2007
  • Role of RGS Proteins in Prostate Cancer 2007
  • Molecular Studies of RGS2 in Prostate Cancer 2006
  • University of Nebraska at Lincoln 2006
  • Experimental Biology 2006 Meeting. in San Francisco (April 1-5) 2006
  • 97th Annul Meeting of the American Association for Cancer Research, at the meeting in Washington, DC (April 1-5, 2006). 2006
  • American Heart Association Symposium(November 2005)at Dallas, TX 2005
  • Modulation of RGS Proteins 2004