Weather Alert

EARLY CLOSURE MARCH 4 - Due to the forecast for severe winter weather, Creighton's Omaha campus will close at 7 P.M. this evening. 

All in-person classes, clinics, and events, regardless of start time, are asked to end by 7 P.M. For those needing a shuttle, please visit my.creighton.edu for the most up-to-date maps and schedule. Shuttles will run until 8 P.M. this evening. We encourage you to be mindful of other closures or impacted services across the city as well. 

Employees, including those classified as responsible for “essential operations” should review Creighton's Weather and Emergency-Related Absence Policy and work with your immediate supervisor on expectations for job functions during this curtailment of campus operations. 

Please take proper winter weather precautions throughout the day and contact public safety at 402.280.2911 for any emergencies.

Yaping Tu, PhD

Professor

Contact

School of Medicine
Pharmacology and Neuroscience
CRISS III - Criss 3 - 573

Yaping Tu, PhD

Professor


Cancer Research Focus

The long-term objective of Dr. Tu’s research is to develop new therapies for castration-resistant prostate cancer and drug-resistant colorectal cancer. Current research projects are focused on the pivotal role and mechanisms of signal transduction dysregulation in cancer development and progression using various cellular, tissue and murine models.
  • Breast Cancer
  • Colon Cancer
  • Prostate Cancer
Asthma Research Focus
 
Asthma is a chronic obstructive inflammatory airway disease with substantial morbidity and mortality that affects over 300 million people worldwide. Airway hyperresponsiveness and airway inflammation are hallmarks of asthma clinically managed with β2-agonist bronchodilators and corticosteroids. Refractory asthma manifests with persistent symptoms despite the use of high-dose corticosteroids and long-acting β2-agonists, and poses a major healthcare challenge. Over the past few years has been Dr. Tu’s development of a new research dimension in his laboratory in the field of asthma. He initiated these studies through collaborations with Drs. Reynold A. Panettieri and Thomas Casale. Current research projects are funded by NIH, American Asthma Foundation and State of Nebraska. The long-term objective of Dr. Tu’s research is to understand the molecular mechanisms of therapeutic resistance and to develop new strategies to overcome such resistance in refractory asthma.
 

Department

Pharmacology and Neuroscience

Position

Professor

Books

  • Pharmacology and Therapeutics for Dentistry : Seventh Edition
    Tu Yaping, Piascik Michael T., Abel Peter W., Adrenergic Agonists [Book Chapter] 2017

Publications

  • The Journal of pharmacology and experimental therapeutics
    Xing Tianzhou, Tu Yaping, Casale Thomas B, Xie Yan, Abel Peter, Panettieri Reynold A, Cigarette Smoke Exposure and Glucocorticoid Insensitivity of Airway Smooth Muscle Cells
    389, p. 548 2024
  • European Journal of Pharmacology
    Zhang Jialing, Yan Liang, Wei Peng, Zhou Ruyi, Hua Chaoju, Xiao Min, Tu Yaping, Gu Zhanjun, Wei Taotao, PEG-GO@XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to-mesenchymal transition
    895 2021
  • Science Signaling
    Wang Sheng, Cao Zhengyu, Tu Yaping, Jiao Hai Zhan, Kuang Xiaolin, Wolff Dennis W., Huang You Guo, Casale Thomas B., Panettieri Reynold A., Wei Taotao, Li Yan, Xie Yan, Huo Yan Wu, Abel Peter W., Jiang Haihong, Zou Xiaohan, Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma
    13:659 2020
  • Biochemical Pharmacology
    Huang Yapei, Xie Yan, Abel Peter W., Wei Peng, Plowman Jocelyn, Toews Myron L., Strah Heather, Siddique Aleem, Bailey Kristina L., Tu Yaping, TGF-β1-induced miR-424 promotes pulmonary myofibroblast differentiation by targeting Slit2 protein expression
    180 2020
  • Cell Death and Disease
    Zhang Jialing, Hua Chaoju, Zhang Yu, Wei Peng, Tu Yaping, Wei Taotao, KAP1-associated transcriptional inhibitory complex regulates C2C12 myoblasts differentiation and mitochondrial biogenesis via miR-133a repression
    11:9 2020
  • The FASEB journal
    Tu Yaping, Wang Sheng, Xie Yan, Huo Yan-Wu, Li Yan, Abel Peter W., Jiang Haihong, Zou Xiaohan, Jiao Hai-Zhan, Kuang Xiaolin, Wolff Dennis W., Huang You-Guo, Casale Thomas B., Wei TaoTao, Cao Zhengyu, Airway Relaxation Mechanisms and Structural Basis of Osthole to Improve Lung Function in Asthma
    34:S1, p. 1 - 1 2020
  • Cell Death and Disease
    Wei Peng, Ma Qin, Li Linghai, Hao Junfeng, Wolff Dennis W., Abel Peter W., Huang Yapei, Xie Yan, Wei Taotao, Tu Yaping, Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis
    10:9 2019
  • The FASEB journal
    Jiang Haihong, Meissner Hannah, Abel Peter W., Luo Xu, Tu Yaping, Chen Linjie, Xie Yan, Inhibition of androgen receptor increases sensitivity of TRAIL‐induced apoptosis via upregulation of death receptor 5 in breast cancer
    33:S1, p. 674.7 - 674.7 2019
  • Journal of Allergy and Clinical Immunology
    Huang Yapei, Xie Yan, Jiang Haihong, Abel Peter W., Panettieri Reynold A., Casale Thomas B., Tu Yaping, Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma
    143:2, p. 778 - 781.e5 2019
  • Cellular Signalling
    Ingersoll Matthew A., Chou Yu Wei, Lin Jamie S., Yuan Ta Chun, Miller Dannah R., Xie Yan, Tu Yaping, Oberley-Deegan Rebecca E., Batra Surinder K., Lin Ming Fong, p66Shc regulates migration of castration-resistant prostate cancer cells
    46, p. 1 - 14 2018
  • The FASEB journal
    Xie Yan, Abel Peter W., Wei Taotao, Luo Xu, Tu Yaping, Chen Linjie, Targeting Androgen Receptor and TRAIL: A Novel Treatment Paradigm for Breast Cancer
    32:S1, p. 835.10 - 835.10 2018
  • Journal of Cellular Physiology
    Caggia Silvia, Chunduri Hima Bindu, Millena Ana C., Perkins Jonathan N., Venugopal Smrruthi V., Vo Bao Han T., Li Chunliang, Tu Yaping, Khan Shafiq A., Novel role of Giα2 in cell migration
    234:1, p. 802 - 815 2018
  • Laboratory investigation
    Tu Yaping N, Tong Wei Lue, Fawcett Timothy J, Blanck George, Lung tumor exome files with T-cell receptor recombinations: a mouse model of T-cell infiltrates reflecting mutation burdens
    97:12, p. 1516 - 1520 2017
  • BMC Cancer
    Chen Linjie, Wolff D. W., Xie Yan, Lin M. F., Tu Yaping, Cyproterone Acetate Enhances TRAIL-Induced Androgen-Independent Prostate Cancer Cell Apoptosis Via Up-Regulation of Death Receptor 5
    17:1, p. 179 2017
  • Zhongguo yaolixue yu dulixue zazhi
    Abel Peter, Kieffer Cameron, Tu Ya-ping, Neurotransmitter systems in mouse airways
    31:10, p. 1015 2017
  • Journal of oncology research and therapy
    Miller Dannah R., Wakefield C. Brent, Chou Yu-wei, Ingersoll Matthew A., Tu Yaping, Lin Ming-Fong, Lin Fen-Fen, Chaney William G., Anti-Androgen Abiraterone Acetate Improves the Therapeutic Efficacy of Statins on Castration-Resistant Prostate Cancer Cells
    3:5 2017
  • Respiratory Research
    Xie Yan, Mehrotra Suneet, Abel Peter W., Toews M. L., Jiang Haihong, Zhang Qian, Wolff D. W., Rennard S., Panettieri R. A.,Jr, Casale T. B., Tu Yaping, Upregulation of RGS2: A New Mechanism for Pirfenidone Amelioration of Pulmonary Fibrosis
    17:1, p. 103 2016
  • Protein & Cell
    Wong Chuu-Yun A., Jiang Haihong, Abel Peter W., Scofield Margaret A., Xie Yan, Wei Taotao, Tu Yaping, Phorbol Myristate Acetate Suppresses Breast Cancer Cell Growth Via Down-Regulation of P-Rex1 Expression
    7:6, p. 445 - 449 2016
  • Oncotarget
    Zhang F., Wang J., Huang Z., Wei T., Liu Y., Hao J., Zhao L., Tu Yaping, Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer
    6:42, p. 44495 - 44508 2015
  • The FASEB Journal
    Jiang Haihong, Panettieri Reynold, Casale Thomas, Tu Yaping, Wolff Dennis, Toews Myron, Xie Yan, Abel Peter, RGS2 Repression Exacerbates Airway Hyperresponsiveness and Remodeling in Asthma
    29:S1, p. 775.10 - 775.10 2015
  • Journal of allergy and clinical immunology
    Tabatabaian Farnaz, Casale Thomas, Xie Yan, Tran Kim, Tu Yaping, Tian Zhi, Lockey Richard, Teng Michael, Allen-Gipson Diane, Effects of Cigarette Smoke Extract and Nicotine on Regulator of G Protein Signaling-2 Expression in Human Airway Smooth Muscle and Bronchial Epithelial Cells
    135:2, p. AB227 - AB227 2015
  • Biomaterials
    Zhou Hejiang, Zhang Wendi, Wei Taotao, Du Yipeng, Yu Meifang, Yan Liang, Nie Guangjun, Chen Chunying, Tu Yaping, Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets
    35:37, p. 9833 - 9843 2014
  • Advanced Functional Materials
    Zhou Hejiang, Yu Meifang, Zhang Bo, Wang Liming, Wu Xiaochun, Du Yipeng, Hao Junfeng, Tu Yaping, Chen Chunying, Wei Taotao, Inhibition of Cancer Cell Migration by Gold Nanorods: Molecular Mechanisms and Implications for Cancer Therapy
    24:44, p. 6922 - 6932 2014
  • American Journal of Respiratory Cell and Molecular Biology
    Jiang Haihong, Xie Yan, Abel Peter W., Wolff Dennis W., Toews Myron L., Panettieri Jr Reynold,A., Casale Thomas B., Tu Yaping, RGS2 Repression Exacerbates Airway Hyperresponsiveness and Remodeling in Asthma
    Article in Press, p. 31 pages 2014
  • Breast Cancer Research
    Barrio-Real Laura, Sukumar Saraswati, Kazanietz Marcelo G., Cho Soonweng, Benedetti Lorena G., Engel Nora, Tu Yaping, Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation
    16:5, p. Article 441 (13 pages) 2014
  • The FASEB journal
    Wong Chuu‐Yun, Xie Yan, Abel Peter, Tu Yaping, Scofield Margaret, PMA suppresses breast cancer cell proliferation via PKCε‐mediated P‐Rex1 downregulation (1148.5)
    28:S1, p. - n/a 2014
  • Oncogene
    Zhao Jian, Zhang J., Yu M., Xie Yan, Huang Y., Wolff Dennis W., Abel Peter W., Tu Yaping, Mitochondrial dynamics regulates migration and invasion of breast cancer cells
    32:40, p. 4814 - 4824 2013
  • The FASEB Journal
    Wong Chuu‐Yun A., Wolff Dennis W., Abel Peter W., Tu Yaping, Xie Yan, PKC-mediated P-Rex1 downregulation suppresses breast cancer cell proliferation
    27:S1, p. 1096.10 - 1096.10 2013
  • The FASEB Journal
    Xie Yan, Tu Yaping, Jiang Haihong, Abel Peter W., Panettieri Reynold A., Casale Thomas B., RGS2 repression increases susceptibility of mice to interleukin- 13-induced airway hyperresponsiveness
    27:S1, p. 1095.8 - 1095.8 2013
  • The FASEB journal
    Jain Neha, Tu Yaping, Abel Peter W, Effects of hypoxia on regulators of G‐protein signaling 2 (RGS2) regulation of pulmonary arterial constriction
    27:S1 2013
  • Biochemical Pharmacology
    Xie Yan, Abel Peter W., Deng Cai-Shu, Sharma Poonam, Wolff Dennis W., Toews Myron L., Tu Yaping, Kirui Joseph K., Identification of upregulated phosphoinositide 3-kinase ? as a target to suppress breast cancer cell migration and invasion
    85:10, p. 1454 - 1462 2013
  • Journal of Allergy and Clinical Immunology
    Xie Yan, Abel Peter W., Casale Thomas B., Tu Yaping, Wolff Dennis W., Jiang Haihong, Nguyen Hoai, Jia Shuping, Berro Abdo, Panettieri Jr Reynold A., Regulator of G protein signaling 2 is a key modulator of airway hyperresponsiveness
    130:4, p. 968 - 976.e3 2012
  • Journal of Lipid Research
    Zhao Kai, Zhou Hejiang, Zhao Xingyu, Wolff Dennis W., Tu Yaping, Liu Huili, Wei Taotao, Yang Fuyu, Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis
    53:10, p. 2102 - 2114 2012
  • Small
    Li Xu, Qiu Lihui, Zhu Pei, Tao Xinyi, Imanaka Tadayuki, Zhao Jing, Huang Youguo, Tu Yaping, Cao Xuni, Epidermal growth factor-ferritin H-chain protein nanoparticles for tumor active targeting
    8:16, p. 2505 - 2514 2012
  • European Journal of Medicinal Chemistry
    Sinha Sarmistha Halder, Owens Eric A., Feng You, Yang Yutao, Xie Yan, Tu Yaping, Henary Maged, Zheng Yujun George, Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents
    54, p. 647 - 659 2012
  • Free Radical Biology and Medicine
    Veeramani Suresh, Lin Ming Fong, Lin Fen Fen, Chou Yu Wei, Lin Frank C., Muniyan Sakthivel, Kumar Satyendra, Xie Yan, Lele Subodh M., Tu Yaping, Reactive oxygen species induced by p66Shc longevity protein mediate nongenomic androgen action via tyrosine phosphorylation signaling to enhance tumorigenicity of prostate cancer cells
    53:1, p. 95 - 108 2012
  • Gastroenterology (New York, N.Y. 1943)
    Elahi Abul, Hernandez Jonathan M., Wang Jian, Clark Whalen, Tu Yaping, Shibata David, Humphries Leigh Ann, Su2021 The Tumor Suppressive Effects of HPP1 via Stat Signaling in Colon Cancer are Abrogated by Site-Directed Mutation of Its EGF-Like Domain
    142:5, p. S-1066 - S-1066 2012
  • Cancer research (Chicago, Ill.)
    Tu Yaping, Zhao Jing, Yu Meifang, Wolff Dennis W., Abel Peter W., Zhang Juan, Abstract 467: Mitochondrial dynamics regulates migration and invasion of breast cancer cells
    72:8_Supplement, p. 467 - 467 2012
  • The FASEB Journal
    Jain Neha, Tu Yaping, Abel Peter W, Regulator of G Protein Signaling 2 (RGS2) regulates pulmonary vasoconstriction
    26:S1, p. - 2012
  • The FASEB journal
    Jiang Haihong, Xie Yan, Abel Peter W., Toews Myron L., Tu Yaping, Townley Robert G., Casale Thomas B., Targeting phosphoinositide 3‐kinase γ in airway smooth muscle cells to suppress interleukin‐13‐induced mouse airway hyperresponsiveness
    26:S1 2012
  • International Journal of Cancer
    Wolff Dennis W., Xie Yan, Deng Caishu, Gatalica Zoran, Yang Mingjie, Wang Bo, Wang Jincheng, Lin Ming Fong, Abel Peter W., Tu Yaping, Epigenetic repression of regulator of G-protein signaling 2 promotes androgen-independent prostate cancer cell growth
    130:7, p. 1521 - 1531 2012
  • Journal of Pharmacology and Experimental Therapeutics
    Jiang Haihong, Tu Yaping, Xie Yan, Abel Peter W., Casale Thomas B., Toews M. L., Townley Robert G., Targeting phosphoinositide 3-kinase gamma in airway smooth muscle cells to suppress interleukin-13-induced mouse airway hyperresponsiveness
    342:2, p. 305 - 311 2012
  • Journal of Biological Chemistry
    Wong Chuu-Yun A., Wuriyanghan Hada, Xie Yan, Lin M. F., Abel Peter W., Tu Yaping, Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex1) gene expression in prostate cancer cells
    286:29, p. 25813 - 25822 2011
  • The FASEB Journal
    Wolff Dennis W., Xie Yan, Gatalica Zoran, Yang Mingjie, Wang Bo, Wang Jincheng, Lin Ming‐Fong, Abel Peter W., Tu Yaping, 5-aza-2-deoxycytidine suppresses androgen independent prostate cancer growth by restoring RGS2 expression
    25:S1, p. 802 - 802 2011
  • The FASEB Journal
    Wong Chuu‐Yun A, Ha Da, Xie Yan, Wolff Dennis W, Abel Peter W, Tu Yaping, Protein kinase C (PKC) regulates phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 (P-Rex1) gene expression through a histone deacetylase interaction with Sp1 in prostate cancer
    25:S1, p. 1090 - 1090 2011
  • The FASEB journal
    Xie Yan, Wang Jincheng, Wolff Dennis W., Abel Peter W, Tu Yaping, DHHC protein‐dependent palmitoylation protects regulator of G‐protein signaling 4 from proteasome degradation
    25, p. 802.5 - 802.5 2011
  • FEBS Letters
    Wang Jincheng, Abel Peter W., Tu Yaping, Xie Yan, Wolff Dennis W., DHHC protein-dependent palmitoylation protects regulator of G-protein signaling 4 from proteasome degradation
    584:22, p. 4570 - 4574 2010
  • Journal of Pharmacology and Experimental Therapeutics
    Jiang H., Deng C., Casale Thomas B., Xie Y., Tu Yaping, Abel Peter W., Toews M. L., Phosphoinositide 3-kinase {gamma} regulates airway smooth muscle contraction by modulating calcium oscillations
    334:3, p. 703 - 709 2010
  • Journal of Biological Chemistry
    Chuang Tsai Der, Kumar Satyendra, Batra Surinder K., Tu Yaping, Lin Ming Fong, Veeramani Suresh, Chen Siu Ju, Lin Fen Fen, Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth
    285:31, p. 23598 - 23606 2010
  • Journal of Pharmacology and Experimental Therapeutics
    Kirui J. K., Xie Y., Wolff Dennis W., Jiang H., Abel Peter W., Tu Yaping, G{beta}{gamma} signaling promotes breast cancer cell migration and invasion
    333:2, p. 393 - 403 2010
  • Cancer research (Chicago, Ill.)
    Xie Yan, Tu Yaping, Kirui Joseph K., Jiang Haihong, Deng Caishu, Abstract 5188: Phosphoinositide 3-kinase γ: Implications in breast cancer metastasis
    70:8_Supplement, p. 5188 - 5188 2010
  • Cancer research (Chicago, Ill.)
    Tu Yaping, Wolff Dennis W., Gatalica Zoran, Xie Yan, Abel Peter W., Abstract 1710: Epigenetic repression of regulator of G-protein signaling 2 promotes prostate cancer progression
    70:8_Supplement, p. 1710 - 1710 2010
  • The FASEB Journal
    Wong Chuu‐Yun Anny, Ha Da, Xie Yan, Wolff Dennis W., Abel Peter W., Tu Yaping, Histone Acetylation Up-regulates Phosphatidylinositol-3,4,5-triphosphate-dependent Rac Exchange Factor 1 (P-Rex1) Expression to Promote Prostate Cancer Metastasis
    24:S1, p. 964.7 - 964.7 2010
  • The FASEB journal
    Xie Yan, Kirui Joseph K., Jiang Haihong, Deng Caishu, Tu Yaping, Up‐regulated phosphoinositide 3‐kinase γ (PI3Kγ ) promotes breast cancer metastasis
    24:S1, p. 964.17 - 964.17 2010
  • Molecular Endocrinology
    Kang Lianguo, Zhang X., Xie Y., Tu Yaping, Wang Zhao-Yi, Liu Z., Involvement of Estrogen Receptor Variant ER-{alpha}36, Not GPR30, in Nongenomic Estrogen Signaling
    24:4, p. 709 - 721 2010
  • The FASEB journal
    Ha Da, Tu Yaping, Histone deacetylases inhibit PIP3‐dependent Rac exchange factor 1 (P‐Rex1) expression in prostate cancer cells via SP1 binding site
    23:S1 2009
  • The FASEB journal
    Xie Yan, Wei Taotao, Wang Bo, Abel Peter W., Kirui Joseph K., Jiang Haihong, Qin Jianbing, Tu Yaping, Wolff Dennis W., Breast Cancer Metastasis Depends on Proteasome Degradation of Regulator of G‐protein Signaling 4
    23:S1 2009
  • Oncogene
    Qin J., Lin M. -., Tu Yaping, Xie Y., Wang B., Hoshino M., Wolff Dennis W., Zhao J., Scofield Margaret A., Dowd F. J., Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis
    28:16, p. 1853 - 1863 2009
  • Cancer Research
    Xie Yan, Wolff Dennis W., Wei Taotao, Wang Bo, Deng Caishu, Kirui Joseph K., Jiang Haihong, Qin Jianbing, Abel Peter W., Tu Yaping, Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4
    69:14, p. 5743 - 5751 2009
  • The FASEB journal
    TU Yaping, Xie Yan, Kirui Joseph K, Wolff Dennis W, Regulator of G protein Signaling 4 (RGS4): A Novel Inhibitor of Breast Cancer Metastasis
    22:S1 2008
  • The FASEB journal
    Qin Jianbing, Xie Yan, Wang Bo, Wolff Dennis W., Tu Yaping, Hoshino Mikio, Scofield Margaret A., Dowd Frank J., Upregulation of PIP3‐Dependent Rac Exchanger 1 (P‐Rex1) Promotes Prostate Cancer Metastasis
    22:S1 2008
  • Molecular Pharmacology
    Xie Yan, Wolff Dennis W., Lin Ming Fong, Tu Yaping, Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells
    72:1, p. 73 - 85 2007
  • The FASEB journal
    Qin Jianbing, Dowd Frank J., Scofield Margaret A., Tu Yaping, Hoshino Mikio, PIP3‐dependent Rac exchanger 1 (P‐Rex1) promotes prostate cancer cell migration
    21:5, p. A386 - A386 2007
  • Oncogene
    Cao X., Qin J., Xie Y., Khan O., Dowd F., Scofield M., Lin M. F., Tu Y., Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells
    25:26, p. 3719 - 3734 2006
  • Molecular Endocrinology
    Khan Obaid Y., Fu Guilian, Ismail Ayesha, Srinivasan Sathish, Cao Xuni, Tu Yaping, Lu Shan, Nawaz Zafar, Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland
    20:3, p. 544 - 559 2006
  • Journal of Biological Chemistry
    Tang Wei, Tu Yaping, Nayak Surendra K., Woodson Jimmy, Jehl Markus, Ross Elliott M., Gβγinhibits Gα GTPase-activating proteins by inhibition of Gα-GTP binding during stimulation by receptor
    281:8, p. 4746 - 4753 2006
  • Methods in Enzymology
    Tu Yaping, Wilkie Thomas M., Allosteric regulation of GAP activity by phospholipids in regulators of G-protein signaling
    389, p. 89 - 1005 2004
  • Journal of Biological Chemistry
    Tu Yaping, Ross Elliott M., Nayak Surendra K., Woodson Jimmy, Phosphorylation-regulated Inhibition of the Gz GTPase-activating Protein Activity of RGS Proteins by Synapsin I
    278:52, p. 52273 - 52281 2003
  • Bioscience Reports
    Ou-Yang Ying Shi, Yang Fuyu, Tu Yaping, The Mutation in the N-terminal Domain of RGS4 Disrupts PA-conferred Inhibitory Effect on GAP Activity
    23:4, p. 213 - 224 2003
  • Journal of Biological Chemistry
    Ouyang Ying Shi, Yang Fuyu, Tu Yaping, Barker Sheryll A., Regulators of G-protein signaling (RGS) 4, insertion into model membranes and inhibition of activity by phosphatidic acid
    278:13, p. 11115 - 11122 2003
  • Journal of Biological Chemistry
    Tu Yaping, Woodson Jimmy, Ross Elliott M., Binding of regulator of G protein signaling (RGS) proteins to phospholipid bilayers. Contribution of location and/or orientation to GTPase-activating protein activity
    276:23, p. 20160 - 20166 2001
  • Journal of Biological Chemistry
    Tu Yaping, Popov Sergei, Slaughter Clive, Ross Elliott M., Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10
    274:53, p. 38260 - 38267 1999
  • Journal of Biological Chemistry
    Wang Jun, Ducret Axel, Tu Yaping, Kozasa Tohru, Aebersold Ruedi, Ross Elliott M., RGSZ1, a G(z)-selective rgs protein in brain
    273:40, p. 26014 - 26025 1998
  • Science
    Tu Yaping, Wang Jun, Ross Elliott M., Inhibition of brain G(z) GAP and other RGS proteins by palmitoylation of G protein α subunits
    278:5340, p. 1132 - 1135 1997
  • Biophysical Chemistry
    Yang F. Y., Yang X. Y., Tsui Z. C., Tu Y. P., Wang L. H., The role of ganglioside GM3 in the modulation of conformation and activity of sarcoplasmic reticulum CA2+-ATPase
    68:1-3, p. 137 - 146 1997
  • Journal of Biological Chemistry
    Wang Jun, Tu Yaping, Woodson Jimmy, Song Xiaoling, Ross Elliott M., A GTPase-activating protein for the G protein Gα(z). Identification, purification, and mechanism of action
    272:9, p. 5732 - 5740 1997
  • Advances in Pharmacology
    Ross Elliott M., Wang Jun, Tu Yaping, Biddlecome Gloria H., Guanosine Triphosphatase-Activating Proteins for Heterotrimeric G-Proteins
    42:C, p. 458 - 461 1997
  • FEBS Letters
    Wang L. H., Tu Y. P., Yang X. Y., Tsui Z. C., Yang F. Y., Effect of ganglioside GM3 on the activity and conformation of reconstituted Ca2+-ATPase
    388:2-3, p. 128 - 130 1996
  • Biochemistry and Molecular Biology International
    Xie W. S., Yue J. C., Tu Y. P., Fluorescence study on ligand induced conformational changes of human erythrocyte glucose transporter
    39:2, p. 279 - 284 1996
  • Biological Trace Element Research
    Yang F. Y., Fen C., Tu Y. P., Se-mediated domain-domain communication in band 3 of human erythrocytes
    55:3, p. 279 - 295 1996
  • Bioscience Reports
    Tu Y. P., Feng C., Xu H., Guang Z. Y., Lu Q. W., Yang F. Y., Transmembrane Ca2+ gradient is essential for high anion transport activity of human erythrocytes
    16:4, p. 299 - 311 1996
  • Bioscience Reports
    Yang F. Y., Huang Y. G., Tu Y. P., Transmembrane Ca2+ gradient and function of membrane proteins
    15:5, p. 351 - 364 1995
  • Journal of Biochemistry
    Tu Y. P., Yang F. Y., Zn2+-mediated domain-domain communication in human erythrocyte band 3
    118:1, p. 161 - 167 1995
  • Science in China (Scientia Sinica) Series B
    Tu Yaping, Xu Hong, Yang Fuyu, Transmembrane Ca2+ gradient-mediated phosphatidylcholine modulating sarcoplasmic reticulum Ca2+-ATPase
    38:6, p. 713 - 721 1995
  • Bioscience Reports
    Tu Y. P., Yang F. Y., Fluorescence study on transmembrane Ca2+ gradient-mediated conformation changes of sarcoplasmic reticulum Ca2+-ATPase
    14:6, p. 309 - 317 1994
  • Biochemistry and Molecular Biology International
    Tu Y. P., Xu H., Yang F. Y., Transmembrane Ca2+ gradient-mediated change of fluidity in the inner layer of phospholipids modulates Ca2+-ATPase of sarcoplasmic reticulum
    33:3, p. 597 - 605 1994
  • Shi yan sheng wu xue bao
    Tu Y. P., Xu H., Yang F. Y., The specificity of modulation of sarcoplasmic reticulum Ca(2+)-ATPase by transmembrane Ca2+ gradient
    26:4, p. 441 - 447 1993
  • Biochemical and Biophysical Research Communications
    Tu Y. P., Yang F. Y., Transmembrane Ca2+ Gradient-Mediated Modulation of Sarcoplasmic Reticulum Ca2+-ATPase
    196:2, p. 561 - 568 1993
  • Bioscience Reports
    Yang F. Y., Huang Y. G., Tu Y. P., Divalent cation and lipid-protein interactions of biomembranes
    13:3, p. 143 - 157 1993
  • Science in China. Series B, Chemistry, life sciences & earth sciences
    Tu Y. P., Yang F. Y., Effect of transmembrane Ca2+ gradient on conformation and enzyme activity of reconstituted adenylate cyclase.
    35:1, p. 67 - 75 1992
  • Biochemical and Biophysical Research Communications
    Yang F. Y., Tu Y. P., A proper transmembrane Ca2+ gradient is essential for the higher enzymatic activity of adenylate cyclase
    175:2, p. 366 - 371 1991

Presentations

  • Invited speaker: Airway Relaxation Mechanisms and Structural Basis of Osthole to Improve Lung Function in Asthma,Kansas City University of Medicine and Biosciences, Kansas City, MO, USA 2019
  • Poster presentation: Inhibition of androgen receptor increases sensitivity of TRAIL-induced apoptosis via up-regulation of death receptor 5 in breast cancer. Experimental Biology Annual Meeting-2019, Orland, Florida, USA 2019
  • Poster presentation: TGF-β1-induced miR-424 mediates pulmonary myofibroblast differentiation via targeting slit2, Experimental Biology Annual Meeting-2019, Orland, Florida, USA 2019
  • Invited speaker, Research Conference of Pulmonary, Critical Care, Sleep & Allergy Division, University of Nebraska Medical Center, Omaha, NE 2019
  • Invited speaker: Molecular studies of osthole as a new bronchodilator to treat drug-resistant asthma, The Second JinLing Forum on Membrane Protein Physiology and Drug Discovery, Nanjing, China 2018
  • The Bioscience Seminar, the Morsani College of Medicine, University of South Florida Topic: "Regulator of G Protein Signaling Proteins: Targets for Treatment of Asthma" 2015
  • The Nebraska Center for Cellular Signaling Month Meeting Topic: "Targeting the Androgen Receptor and TRAIL Pathways: A Novel Treatment Paradigm for Breast Cancer " 2015
  • The 4th International Symposium on Membrane Biology. Dali, China Topic: "Regulator of G Protein Signaling Proteins: Targets for Treatment of Asthma" 2014
  • American Asthma Foundation Annual Meeting-2014 2014
  • Department of Pharmacology, Creighton University 2014
  • Department of Chemistry, University of Nebraska at Omaha, NE 2013
  • American Asthma Foundation Annual Meeting, San Francisco, CA 2013
  • Experimental Biology-2013, Boston 2013
  • Department of Urology, University of Kansas Medical Center, Kansas, KS 2013
  • Annual Meeting of the American Academy of Allergy Asthma and Immunology, San Antonio, TX 2013
  • The Nebraska Center for Cellular Signaling, Omaha, NE 2013
  • Omaha VA Medical Center, Omaha 2012
  • The 2nd International Symposium on Membrane Biology, Zhuhai, China 2012
  • 2012-Annual Meeting of American Asthma Foundation 2012
  • 2012 Experimental Biology 2012
  • 2012-Creighton Faculty Club 2012
  • Invited speaker, Creighton Cancer Research Symposium 2011
  • Featured speaker, Nebraska Center for Cellular Signaling Symposium 2011
  • Invited speaker, 7th Annual National Symposium on Prostate Cancer 2011
  • Invited speaker, Innovative Minds in Prostate Cancer Today Conference 2011
  • The 2nd International Symposium on Membrane Biology in China 2010
  • Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center 2010
  • Invited speaker, 2009 Nebraska Research and Innovation Conference. Omaha 2009
  • Department of Pathology, Creighton University Medical Center 2009
  • The 1st International Symposium on Membrane Biology, CHINA 2009
  • GORDON RESEARCH CONFERENCE: PHOSPHORYLATION & G-PROTEIN MEDIATED SIGNALING 2009
  • AACR 100th Annual Meeting 2009 2009
  • "Dysregulation of G-Protein Signaling in Cancer" at State Key laboratory of Membrane Biology and Membrane Biotechnology, Chinese Academy of Sciences 2009
  • Prostate Cancer Research Group, University of Nebraska Medical Center 2008
  • "RGS proteins and cancer" at Peking University, China 2008
  • "RGS2 and Prostate cancer progression" at National Center for Nanoscience and Technology, China 2008
  • Experimental Biology Meeting-2008 2008
  • 3rd RGS Protein Colloquium 2008
  • Harry and Elsa Jiler-American Cancer Society Professors Meeting 2007
  • Braman Family Breast Cancer Institute 2007
  • The 2007 International Symposium on Biomembranes, Hubei, China 2007
  • Department of Surgery at Evanston Northwestern Healthcare and the Department of Urology at Northwestern University Feinberg School of Medicine 2007
  • The University of Minnesota Cancer Center 2007
  • University of Nebraska Medical Center 2007
  • Vasoactive intestinal peptide transactivates the androgen receptor 2007
  • P-Rex1 promotes prostate cancer cell migration and invasion 2007
  • 97th Annul Meeting of the American Association for Cancer Research, at the meeting in Washington, DC (April 1-5, 2006). 2007
  • Role of RGS Proteins in Prostate Cancer 2007
  • Molecular Studies of RGS2 in Prostate Cancer 2006
  • University of Nebraska at Lincoln 2006
  • Experimental Biology 2006 Meeting. in San Francisco (April 1-5) 2006
  • 97th Annul Meeting of the American Association for Cancer Research, at the meeting in Washington, DC (April 1-5, 2006). 2006
  • American Heart Association Symposium(November 2005)at Dallas, TX 2005
  • Modulation of RGS Proteins 2004