Yaping Tu, PhD

Department

Pharmacology and Neuroscience

Position

Professor

Book, Chapter/Section

• Pharmacology and Therapeutics for Dentistry
  Tu Yaping, Abel Peter W., Piascik M. T., Adrenergic Agonists [Book Chapter] 2010

Publications

• Cell death & disease
  Zhang Jialing, Zhang Yu, Wei Peng, Tu Yaping, Wei Taotao, Hua Chaoju, Correction: KAP1-associated transcriptional inhibitory complex regulates C2C12 myoblasts differentiation and mitochondrial biogenesis via miR-133a repression
  17:1, p. 563 2026
• The Journal of pharmacology and experimental therapeutics
  Xing Tianzhou, Tu Yaping, Abel Peter, Panettieri Reynold A, Molecule Mechanisms of Cigarette Smoke-Induced Glucocorticoid Resistance in Asthmatic Airway Smooth Muscle Cells (Abstract ID: 226722)
  393:5, p. 103930 2026
• American journal of respiratory cell and molecular biology
  Xie Yan, Abel Peter W, Xing Tianzhou, Zhong Na, Jiang Haihong, An Steven S, Tu Yaping, Panettieri Reynold A, Casale Thomas B, Pirfenidone and its Derivative: Novel Bronchodilators and Leukocyte Airway Inflammation Inhibitors 2026
• The Journal of pharmacology and experimental therapeutics
  Xie Yan, Huang Yapei, Xing Tianzhou, Huang Steven K., Chettiar Venkatlaxmi, Moore Bethany B., Asahara Hiroshi, Abel Peter W., Tu Yaping, miR-146b disrupts the EGFR/TGFβR profibrotic feedforward loop to inhibit lung fibroblast proliferation and differentiation, p. 103672 2025
• The Journal of pharmacology and experimental therapeutics
  Xing Tianzhou, Abel Peter, Tu Yaping, Xie Yan, Jiang Haihong, Zhong Na, Aberrantly Upregulated P-Rex1 Confers Chemoresistance in Colorectal Cancer (Abstract ID: 169537)
  392:3 2025
• The Journal of pharmacology and experimental therapeutics
  Afolabi Daniel, Abel Peter, Stessman Holly AF, Tu Yaping, P-Rex1 Modulates Polarization and Functions of Tumor-Associated Macrophages (Abstract ID: 158664)
  392:3 2025
• The Journal of pharmacology and experimental therapeutics
  Xing Tianzhou, Tu Yaping, Casale Thomas B, Xie Yan, Panettieri Reynold A, Abel Peter, Cigarette Smoke Exposure and Glucocorticoid Insensitivity of Airway Smooth Muscle Cells
  389, p. 548 2024
• Journal of Allergy and Clinical Immunology
  Xie Yan, Abel Peter W., Casale Thomas B., Tu Yaping, TH17 cells and corticosteroid insensitivity in severe asthma
  149:2, p. 467 - 479 2022
• ACS Applied Bio Materials
  Zhang Tianbao, Wang Rongrong, Li Zihui, Gao Zonglin, Tu Yaping, Cao Xuni, Wang Liang, Anti-EGFR Single-Chain Fv Antibody Fragment Displayed on the Surface of Ferritin H-Chain Protein Nanoparticle for Asthma Therapy
  4:9, p. 6690 - 6702 2021
• European Journal of Pharmacology
  Zhang Jialing, Yan Liang, Wei Peng, Zhou Ruyi, Hua Chaoju, Xiao Min, Tu Yaping, Gu Zhanjun, Wei Taotao, PEG-GO@XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to-mesenchymal transition
  895 2021
• Biochemical Pharmacology
  Huang Yapei, Xie Yan, Abel Peter W., Wei Peng, Plowman Jocelyn, Toews Myron L., Strah Heather, Siddique Aleem, Bailey Kristina L., Tu Yaping, TGF-β1-induced miR-424 promotes pulmonary myofibroblast differentiation by targeting Slit2 protein expression
  180 2020
• Cell Death and Disease
  Zhang Jialing, Hua Chaoju, Zhang Yu, Wei Peng, Tu Yaping, Wei Taotao, KAP1-associated transcriptional inhibitory complex regulates C2C12 myoblasts differentiation and mitochondrial biogenesis via miR-133a repression
  11:9 2020
• Cell Death and Disease
  Wei Peng, Ma Qin, Li Linghai, Hao Junfeng, Xie Yan, Wolff Dennis W., Abel Peter W., Huang Yapei, Wei Taotao, Tu Yaping, Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis
  10:9 2019
• Journal of Allergy and Clinical Immunology
  Huang Yapei, Xie Yan, Jiang Haihong, Abel Peter W., Panettieri Reynold A., Casale Thomas B., Tu Yaping, Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma
  143:2, p. 778 - 781.e5 2019
• Cellular Signalling
  Ingersoll Matthew A., Yuan Ta Chun, Chou Yu Wei, Lin Jamie S., Miller Dannah R., Xie Yan, Lin Ming Fong, Tu Yaping, Oberley-Deegan Rebecca E., Batra Surinder K., p66Shc regulates migration of castration-resistant prostate cancer cells
  46, p. 1 - 14 2018
• Journal of Cellular Physiology
  Caggia Silvia, Chunduri Hima Bindu, Millena Ana C., Perkins Jonathan N., Venugopal Smrruthi V., Vo Bao Han T., Li Chunliang, Tu Yaping, Khan Shafiq A., Novel role of Giα2 in cell migration
  234:1, p. 802 - 815 2018
• BMC Cancer
  Chen Linjie, Lin M. F., Wolff D. W., Xie Yan, Tu Yaping, Cyproterone Acetate Enhances TRAIL-Induced Androgen-Independent Prostate Cancer Cell Apoptosis Via Up-Regulation of Death Receptor 5
  17:1, p. 179 2017
• Respiratory Research
  Xie Yan, Mehrotra Suneet, Abel Peter W., Toews M. L., Panettieri R. A.,Jr, Casale T. B., Jiang Haihong, Zhang Qian, Wolff D. W., Rennard S., Tu Yaping, Upregulation of RGS2: A New Mechanism for Pirfenidone Amelioration of Pulmonary Fibrosis
  17:1, p. 103 2016
• Protein & Cell
  Wong Chuu-Yun A., Jiang Haihong, Abel Peter W., Scofield Margaret A., Xie Yan, Wei Taotao, Tu Yaping, Phorbol Myristate Acetate Suppresses Breast Cancer Cell Growth Via Down-Regulation of P-Rex1 Expression
  7:6, p. 445 - 449 2016
• Journal of Biological Chemistry
  Huang K., Tu Yaping, Zhang J., O'Neill K. L., Gurumurthy C. B., Quadros R. M., Luo X., Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-Only Protein Bid during TRAIL-Induced Apoptosis
  291:22, p. 11843 - 11851 2016
• Oncotarget
  Zhang F., Zhao L., Wang J., Huang Z., Wei T., Liu Y., Hao J., Tu Yaping, Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer
  6:42, p. 44495 - 44508 2015
• The FASEB Journal
  Jiang Haihong, Panettieri Reynold, Casale Thomas, Tu Yaping, Wolff Dennis, Toews Myron, Xie Yan, Abel Peter, RGS2 Repression Exacerbates Airway Hyperresponsiveness and Remodeling in Asthma
  29:S1, p. 775.10 - 775.10 2015
• Biomaterials
  Zhou Hejiang, Du Yipeng, Zhang Wendi, Wei Taotao, Yu Meifang, Yan Liang, Nie Guangjun, Chen Chunying, Tu Yaping, Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets
  35:37, p. 9833 - 9843 2014
• Advanced Functional Materials
  Zhou Hejiang, Wang Liming, Yu Meifang, Zhang Bo, Wu Xiaochun, Du Yipeng, Hao Junfeng, Tu Yaping, Chen Chunying, Wei Taotao, Inhibition of Cancer Cell Migration by Gold Nanorods: Molecular Mechanisms and Implications for Cancer Therapy
  24:44, p. 6922 - 6932 2014
• American Journal of Respiratory Cell and Molecular Biology
  Jiang Haihong, Xie Yan, Abel Peter W., Wolff Dennis W., Toews Myron L., Panettieri Jr Reynold,A., Casale Thomas B., Tu Yaping, RGS2 Repression Exacerbates Airway Hyperresponsiveness and Remodeling in Asthma
  Article in Press, p. 31 pages 2014
• Breast Cancer Research
  Barrio-Real Laura, Sukumar Saraswati, Kazanietz Marcelo G., Cho Soonweng, Benedetti Lorena G., Engel Nora, Tu Yaping, Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation
  16:5, p. Article 441 (13 pages) 2014
• Oncogene
  Zhao Jian, Huang Y., Wolff Dennis W., Abel Peter W., Tu Yaping, Zhang J., Yu M., Xie Yan, Mitochondrial dynamics regulates migration and invasion of breast cancer cells
  32:40, p. 4814 - 4824 2013
• The FASEB Journal
  Xie Yan, Tu Yaping, Jiang Haihong, Abel Peter W., Casale Thomas B., Panettieri Reynold A., RGS2 repression increases susceptibility of mice to interleukin- 13-induced airway hyperresponsiveness
  27:S1, p. 1095.8 - 1095.8 2013
• The FASEB Journal
  Wong Chuu‐Yun A., Wolff Dennis W., Abel Peter W., Tu Yaping, Xie Yan, PKC-mediated P-Rex1 downregulation suppresses breast cancer cell proliferation
  27:S1, p. 1096.10 - 1096.10 2013
• Journal of Allergy and Clinical Immunology
  DelasAlas Harold C., Casale Thomas B., Tu Yaping, Zhu Ningxi, Relationship of Airway Hyperresponsiveness and RGS2 Expression in Smokers
  131:2, Supplement, p. AB12 2013
• Journal of Allergy and Clinical Immunology
  Zhu Zhihao, Berro Abdo, Stokes Carl, Tu Yaping, Casale Thomas B., Effects of Cigarette Smoke Exposure On RGS2 Expression and Airway Hyperresponsiveness
  131:2, Supplement, p. AB61 2013
• Biochemical Pharmacology
  Xie Yan, Abel Peter W., Deng Cai-Shu, Sharma Poonam, Wolff Dennis W., Toews Myron L., Tu Yaping, Kirui Joseph K., Identification of upregulated phosphoinositide 3-kinase ? as a target to suppress breast cancer cell migration and invasion
  85:10, p. 1454 - 1462 2013
• Journal of Lipid Research
  Zhao Kai, Wolff Dennis W., Zhou Hejiang, Zhao Xingyu, Tu Yaping, Liu Huili, Wei Taotao, Yang Fuyu, Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis
  53:10, p. 2102 - 2114 2012
• Journal of Allergy and Clinical Immunology
  Xie Yan, Abel Peter W., Casale Thomas B., Tu Yaping, Panettieri Jr Reynold A., Jiang Haihong, Nguyen Hoai, Jia Shuping, Berro Abdo, Wolff Dennis W., Regulator of G protein signaling 2 is a key modulator of airway hyperresponsiveness
  130:4, p. 968 - 976.e3 2012
• Small
  Li Xu, Qiu Lihui, Zhu Pei, Tao Xinyi, Imanaka Tadayuki, Zhao Jing, Huang Youguo, Tu Yaping, Cao Xuni, Epidermal growth factor-ferritin H-chain protein nanoparticles for tumor active targeting
  8:16, p. 2505 - 2514 2012
• The FASEB Journal
  Jain Neha, Tu Yaping, Abel Peter W, Regulator of G Protein Signaling 2 (RGS2) regulates pulmonary vasoconstriction
  26:S1 2012
• International Journal of Cancer
  Wolff Dennis W., Xie Yan, Deng Caishu, Gatalica Zoran, Yang Mingjie, Wang Bo, Wang Jincheng, Lin Ming Fong, Abel Peter W., Tu Yaping, Epigenetic repression of regulator of G-protein signaling 2 promotes androgen-independent prostate cancer cell growth
  130:7, p. 1521 - 1531 2012
• Journal of Pharmacology and Experimental Therapeutics
  Jiang Haihong, Tu Yaping, Xie Yan, Abel Peter W., Casale Thomas B., Toews M. L., Townley Robert G., Targeting phosphoinositide 3-kinase gamma in airway smooth muscle cells to suppress interleukin-13-induced mouse airway hyperresponsiveness
  342:2, p. 305 - 311 2012
• Journal of Biological Chemistry
  Wong Chuu-Yun A., Wuriyanghan Hada, Xie Yan, Lin M. F., Abel Peter W., Tu Yaping, Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex1) gene expression in prostate cancer cells
  286:29, p. 25813 - 25822 2011
• The FASEB Journal
  Wong Chuu‐Yun A, Ha Da, Xie Yan, Wolff Dennis W, Abel Peter W, Tu Yaping, Protein kinase C (PKC) regulates phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 (P-Rex1) gene expression through a histone deacetylase interaction with Sp1 in prostate cancer
  25:S1, p. 1090 - 1090 2011
• The FASEB Journal
  Wolff Dennis W., Gatalica Zoran, Xie Yan, Yang Mingjie, Wang Bo, Wang Jincheng, Lin Ming‐Fong, Abel Peter W., Tu Yaping, 5-aza-2-deoxycytidine suppresses androgen independent prostate cancer growth by restoring RGS2 expression
  25:S1, p. 802 - 802 2011
• Journal of Pharmacology and Experimental Therapeutics
  Jiang H., Tu Yaping, Deng C., Casale Thomas B., Xie Y., Abel Peter W., Toews M. L., Phosphoinositide 3-kinase {gamma} regulates airway smooth muscle contraction by modulating calcium oscillations
  334:3, p. 703 - 709 2010
• Cellular and Molecular Life Sciences
  Zhao Kai, Duan Wenjuan, Zhao Xingyu, Tu Yaping, Miao Qi, Cao Dongxu, Sun Yang, Wang Jincheng, Wei Taotao, Yang Fuyu, Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid
  67:15, p. 2665 - 2678 2010
• Journal of Biological Chemistry
  Chuang Tsai Der, Kumar Satyendra, Batra Surinder K., Tu Yaping, Lin Ming Fong, Veeramani Suresh, Chen Siu Ju, Lin Fen Fen, Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth
  285:31, p. 23598 - 23606 2010
• Journal of Pharmacology and Experimental Therapeutics
  Kirui J. K., Xie Y., Wolff Dennis W., Jiang H., Abel Peter W., Tu Yaping, G{beta}{gamma} signaling promotes breast cancer cell migration and invasion
  333:2, p. 393 - 403 2010
• The FASEB Journal
  Wong Chuu‐Yun Anny, Ha Da, Xie Yan, Wolff Dennis W., Abel Peter W., Tu Yaping, Histone Acetylation Up-regulates Phosphatidylinositol-3,4,5-triphosphate-dependent Rac Exchange Factor 1 (P-Rex1) Expression to Promote Prostate Cancer Metastasis
  24:S1, p. 964.7 - 964.7 2010
• Molecular Endocrinology
  Kang Lianguo, Zhang X., Xie Y., Tu Yaping, Wang Zhao-Yi, Liu Z., Involvement of Estrogen Receptor Variant ER-{alpha}36, Not GPR30, in Nongenomic Estrogen Signaling
  24:4, p. 709 - 721 2010
• Oncogene
  Qin J., Lin M. -., Tu Yaping, Hoshino M., Xie Y., Wang B., Wolff Dennis W., Zhao J., Scofield Margaret A., Dowd F. J., Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis
  28:16, p. 1853 - 1863 2009
• Cancer Research
  Xie Yan, Wolff Dennis W., Wei Taotao, Wang Bo, Deng Caishu, Kirui Joseph K., Jiang Haihong, Qin Jianbing, Abel Peter W., Tu Yaping, Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4
  69:14, p. 5743 - 5751 2009
• Molecular Pharmacology
  Xie Yan, Wolff Dennis W., Lin Ming Fong, Tu Yaping, Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells
  72:1, p. 73 - 85 2007
• FASEB Journal
  Xie Y., Wolff Dennis W., Lin M. F., Tu Yaping, Vasoactive intestinal peptide transactivates the androgen receptor through a PKA-dependent extracellular signal-regulated kinase pathway in prostate cancer cells
  21:5, p. A428 2007
• Oncogene
  Cao X., Khan O., Qin J., Xie Y., Dowd F., Scofield M., Lin M. F., Tu Y., Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells
  25:26, p. 3719 - 3734 2006
• Molecular Endocrinology
  Khan Obaid Y., Fu Guilian, Ismail Ayesha, Srinivasan Sathish, Cao Xuni, Tu Yaping, Lu Shan, Nawaz Zafar, Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland
  20:3, p. 544 - 559 2006
• Methods in Enzymology
  Tu Yaping, Wilkie Thomas M., Allosteric regulation of GAP activity by phospholipids in regulators of G-protein signaling
  389, p. 89 - 1005 2004
• Journal of Biological Chemistry
  Tu Yaping, Woodson Jimmy, Ross Elliott M., Nayak Surendra K., Phosphorylation-regulated Inhibition of the Gz GTPase-activating Protein Activity of RGS Proteins by Synapsin I
  278:52, p. 52273 - 52281 2003
• Journal of Biological Chemistry
  Ouyang Ying Shi, Barker Sheryll A., Yang Fuyu, Tu Yaping, Regulators of G-protein signaling (RGS) 4, insertion into model membranes and inhibition of activity by phosphatidic acid
  278:13, p. 11115 - 11122 2003
• Journal of Biological Chemistry
  Tu Yaping, Popov Sergei, Slaughter Clive, Ross Elliott M., Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10
  274:53, p. 38260 - 38267 1999
• Journal of Biological Chemistry
  Wang Jun, Ducret Axel, Tu Yaping, Kozasa Tohru, Aebersold Ruedi, Ross Elliott M., RGSZ1, a G(z)-selective rgs protein in brain
  273:40, p. 26014 - 26025 1998
• Progress in Biochemistry and Biophysics
  Wang Lihua, Yang Xiaoyi, Tu Yaping, Cui Zhaochun, Incorporation of GM3 into the lipid bilayer of sarcoplasmic reticulum and its regulation on Ca2+-ATPase
  24:3, p. 277 - 280 1997
• Science
  Tu Yaping, Wang Jun, Ross Elliott M., Inhibition of brain G(z) GAP and other RGS proteins by palmitoylation of G protein α subunits
  278:5340, p. 1132 - 1135 1997
• Biophysical Chemistry
  Yang F. Y., Yang X. Y., Tsui Z. C., Tu Y. P., Wang L. H., The role of ganglioside GM3 in the modulation of conformation and activity of sarcoplasmic reticulum CA2+-ATPase
  68:1-3, p. 137 - 146 1997
• Advances in Pharmacology
  Ross Elliott M., Biddlecome Gloria H., Wang Jun, Tu Yaping, Guanosine Triphosphatase-Activating Proteins for Heterotrimeric G-Proteins
  42:C, p. 458 - 461 1997
• Science in China, Series C: Life Sciences
  Wang Lihua, Gui Zhaochun, Yang Xiaoyi, Tu Yaping, Yang Fuyu, Ganglioside GM3 modulates conformation of reconstituted Ca2+-ATPase
  40:4, p. 422 - 429 1997
• FEBS Letters
  Wang L. H., Tsui Z. C., Tu Y. P., Yang X. Y., Yang F. Y., Effect of ganglioside GM3 on the activity and conformation of reconstituted Ca2+-ATPase
  388:2-3, p. 128 - 130 1996
• Biochemistry and Molecular Biology International
  Xie W. S., Yue J. C., Tu Y. P., Fluorescence study on ligand induced conformational changes of human erythrocyte glucose transporter
  39:2, p. 279 - 284 1996
• Bioscience Reports
  Tu Y. P., Xu H., Feng C., Guang Z. Y., Lu Q. W., Yang F. Y., Transmembrane Ca2+ gradient is essential for high anion transport activity of human erythrocytes
  16:4, p. 299 - 311 1996
• Biological Trace Element Research
  Yang F. Y., Fen C., Tu Y. P., Se-mediated domain-domain communication in band 3 of human erythrocytes
  55:3, p. 279 - 295 1996
• Biochemistry and Molecular Biology International
  Tu Y. P., Su X. F., Yang F. Y., Xiao L., Cytoplasmic Ca2+ inhibits the glucose transporter of human erythrocytes
  36:2, p. 383 - 391 1995
• Bioscience Reports
  Yang F. Y., Huang Y. G., Tu Y. P., Transmembrane Ca2+ gradient and function of membrane proteins
  15:5, p. 351 - 364 1995
• Journal of Biochemistry
  Tu Y. P., Yang F. Y., Zn2+-mediated domain-domain communication in human erythrocyte band 3
  118:1, p. 161 - 167 1995
• Science in China (Scientia Sinica) Series B
  Tu Yaping, Xu Hong, Yang Fuyu, Transmembrane Ca2+ gradient-mediated phosphatidylcholine modulating sarcoplasmic reticulum Ca2+-ATPase
  38:6, p. 713 - 721 1995
• Bioscience Reports
  Tu Y. P., Yang F. Y., Fluorescence study on transmembrane Ca2+ gradient-mediated conformation changes of sarcoplasmic reticulum Ca2+-ATPase
  14:6, p. 309 - 317 1994
• Bioscience Reports
  Tu Y. P., Xu H., Zn2+ inhibits the anion transport activity of Band 3 by binding to its cytoplasmic tail
  14:4, p. 159 - 169 1994
• Biochemistry and Molecular Biology International
  Tu Y. P., Xu H., Yang F. Y., Transmembrane Ca2+ gradient-mediated change of fluidity in the inner layer of phospholipids modulates Ca2+-ATPase of sarcoplasmic reticulum
  33:3, p. 597 - 605 1994
• Shi yan sheng wu xue bao
  Tu Y. P., Xu H., Yang F. Y., The specificity of modulation of sarcoplasmic reticulum Ca(2+)-ATPase by transmembrane Ca2+ gradient
  26:4, p. 441 - 447 1993
• Biochemical and Biophysical Research Communications
  Tu Y. P., Yang F. Y., Transmembrane Ca2+ Gradient-Mediated Modulation of Sarcoplasmic Reticulum Ca2+-ATPase
  196:2, p. 561 - 568 1993
• Bioscience Reports
  Yang F. Y., Huang Y. G., Tu Y. P., Divalent cation and lipid-protein interactions of biomembranes
  13:3, p. 143 - 157 1993
• Science in China. Series B, Chemistry, life sciences & earth sciences
  Tu Y. P., Yang F. Y., Effect of transmembrane Ca2+ gradient on conformation and enzyme activity of reconstituted adenylate cyclase.
  35:1, p. 67 - 75 1992
• Biochemical and Biophysical Research Communications
  Yang F. Y., Tu Y. P., A proper transmembrane Ca2+ gradient is essential for the higher enzymatic activity of adenylate cyclase
  175:2, p. 366 - 371 1991