Yaping Tu, PhD

Department

Pharmacology and Neuroscience

Position

Professor

Books

• Pharmacology and Therapeutics for Dentistry : Seventh Edition
  Tu Yaping, Adrenergic Agonists [Book Chapter] 2017

Publications

• ACS Applied Bio Materials
  Zhang Tianbao, Anti-EGFR Single-Chain Fv Antibody Fragment Displayed on the Surface of Ferritin H-Chain Protein Nanoparticle for Asthma Therapy
  4:9, p. 6690 - 6702 2021
• European Journal of Pharmacology
  Zhang Jialing, PEG-GO@XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to-mesenchymal transition
  895 2021
• Science Signaling
  Wang Sheng, Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma
  13:659 2020
• Biochemical Pharmacology
  Huang Yapei, TGF-β1-induced miR-424 promotes pulmonary myofibroblast differentiation by targeting Slit2 protein expression
  180 2020
• Cell Death and Disease
  Zhang Jialing, KAP1-associated transcriptional inhibitory complex regulates C2C12 myoblasts differentiation and mitochondrial biogenesis via miR-133a repression
  11:9 2020
• The FASEB journal
  Tu Yaping, Airway Relaxation Mechanisms and Structural Basis of Osthole to Improve Lung Function in Asthma
  34:S1, p. 1 - 1 2020
• Cell Death and Disease
  Wei Peng, Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis
  10:9 2019
• The FASEB journal
  Jiang Haihong, Inhibition of androgen receptor increases sensitivity of TRAIL‐induced apoptosis via upregulation of death receptor 5 in breast cancer
  33:S1, p. 674.7 - 674.7 2019
• Journal of Allergy and Clinical Immunology
  Huang Yapei, Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma
  143:2, p. 778 - 781.e5 2019
• Scientific Reports
  Chen Linjie, Up-regulated miR-133a orchestrates epithelial-mesenchymal transition of airway epithelial cells
  8:1 2018
• Cellular Signalling
  Ingersoll Matthew A., p66Shc regulates migration of castration-resistant prostate cancer cells
  46, p. 1 - 14 2018
• The FASEB journal
  Xie Yan, Targeting Androgen Receptor and TRAIL: A Novel Treatment Paradigm for Breast Cancer
  32:S1, p. 835.10 - 835.10 2018
• Journal of Cellular Physiology
  Caggia Silvia, Novel role of Giα2 in cell migration
  234:1, p. 802 - 815 2018
• Laboratory investigation
  Tu Yaping N, Lung tumor exome files with T-cell receptor recombinations: a mouse model of T-cell infiltrates reflecting mutation burdens
  97:12, p. 1516 - 1520 2017
• BMC Cancer
  Chen Linjie, Cyproterone Acetate Enhances TRAIL-Induced Androgen-Independent Prostate Cancer Cell Apoptosis Via Up-Regulation of Death Receptor 5
  17:1, p. 179 2017
• Zhongguo yaolixue yu dulixue zazhi
  Abel Peter, Neurotransmitter systems in mouse airways
  31:10, p. 1015 2017
• Journal of oncology research and therapy
  Miller Dannah R., Anti-Androgen Abiraterone Acetate Improves the Therapeutic Efficacy of Statins on Castration-Resistant Prostate Cancer Cells
  3:5 2017
• Respiratory Research
  Xie Yan, Upregulation of RGS2: A New Mechanism for Pirfenidone Amelioration of Pulmonary Fibrosis
  17:1, p. 103 2016
• Protein & Cell
  Wong Chuu-Yun A., Phorbol Myristate Acetate Suppresses Breast Cancer Cell Growth Via Down-Regulation of P-Rex1 Expression
  7:6, p. 445 - 449 2016
• Oncotarget
  Zhang F., Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer
  6:42, p. 44495 - 44508 2015
• The FASEB Journal
  Jiang Haihong, RGS2 Repression Exacerbates Airway Hyperresponsiveness and Remodeling in Asthma
  29:S1, p. 775.10 - 775.10 2015
• Journal of allergy and clinical immunology
  Tabatabaian Farnaz, Effects of Cigarette Smoke Extract and Nicotine on Regulator of G Protein Signaling-2 Expression in Human Airway Smooth Muscle and Bronchial Epithelial Cells
  135:2, p. AB227 - AB227 2015
• Biomaterials
  Zhou Hejiang, Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets
  35:37, p. 9833 - 9843 2014
• American Journal of Respiratory Cell and Molecular Biology
  Jiang Haihong, RGS2 Repression Exacerbates Airway Hyperresponsiveness and Remodeling in Asthma
  Article in Press, p. 31 pages 2014
• Advanced Functional Materials
  Zhou Hejiang, Inhibition of Cancer Cell Migration by Gold Nanorods: Molecular Mechanisms and Implications for Cancer Therapy
  24:44, p. 6922 - 6932 2014
• Breast Cancer Research
  Barrio-Real Laura, Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation
  16:5, p. Article 441 (13 pages) 2014
• The FASEB journal
  Wong Chuu‐Yun, PMA suppresses breast cancer cell proliferation via PKCε‐mediated P‐Rex1 downregulation (1148.5)
  28:S1, p. - n/a 2014
• Oncogene
  Zhao Jian, Mitochondrial dynamics regulates migration and invasion of breast cancer cells
  32:40, p. 4814 - 4824 2013
• The FASEB Journal
  Wong Chuu‐Yun A., PKC-mediated P-Rex1 downregulation suppresses breast cancer cell proliferation
  27:S1, p. 1096.10 - 1096.10 2013
• The FASEB Journal
  Xie Yan, RGS2 repression increases susceptibility of mice to interleukin- 13-induced airway hyperresponsiveness
  27:S1, p. 1095.8 - 1095.8 2013
• The FASEB journal
  Jain Neha, Effects of hypoxia on regulators of G‐protein signaling 2 (RGS2) regulation of pulmonary arterial constriction
  27:S1 2013
• Biochemical Pharmacology
  Xie Yan, Identification of upregulated phosphoinositide 3-kinase ? as a target to suppress breast cancer cell migration and invasion
  85:10, p. 1454 - 1462 2013
• Journal of Lipid Research
  Zhao Kai, Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis
  53:10, p. 2102 - 2114 2012
• Journal of Allergy and Clinical Immunology
  Xie Yan, Regulator of G protein signaling 2 is a key modulator of airway hyperresponsiveness
  130:4, p. 968 - 976.e3 2012
• Small
  Li Xu, Epidermal growth factor-ferritin H-chain protein nanoparticles for tumor active targeting
  8:16, p. 2505 - 2514 2012
• European Journal of Medicinal Chemistry
  Sinha Sarmistha Halder, Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents
  54, p. 647 - 659 2012
• Free Radical Biology and Medicine
  Veeramani Suresh, Reactive oxygen species induced by p66Shc longevity protein mediate nongenomic androgen action via tyrosine phosphorylation signaling to enhance tumorigenicity of prostate cancer cells
  53:1, p. 95 - 108 2012
• Gastroenterology (New York, N.Y. 1943)
  Elahi Abul, Su2021 The Tumor Suppressive Effects of HPP1 via Stat Signaling in Colon Cancer are Abrogated by Site-Directed Mutation of Its EGF-Like Domain
  142:5, p. S-1066 - S-1066 2012
• Cancer research (Chicago, Ill.)
  Tu Yaping, Abstract 467: Mitochondrial dynamics regulates migration and invasion of breast cancer cells
  72:8_Supplement, p. 467 - 467 2012
• International Journal of Cancer
  Wolff Dennis W., Epigenetic repression of regulator of G-protein signaling 2 promotes androgen-independent prostate cancer cell growth
  130:7, p. 1521 - 1531 2012
• The FASEB Journal
  Jain Neha, Regulator of G Protein Signaling 2 (RGS2) regulates pulmonary vasoconstriction
  26:S1, p. - 2012
• The FASEB journal
  Jiang Haihong, Targeting phosphoinositide 3‐kinase γ in airway smooth muscle cells to suppress interleukin‐13‐induced mouse airway hyperresponsiveness
  26:S1 2012
• Journal of Pharmacology and Experimental Therapeutics
  Jiang Haihong, Targeting phosphoinositide 3-kinase gamma in airway smooth muscle cells to suppress interleukin-13-induced mouse airway hyperresponsiveness
  342:2, p. 305 - 311 2012
• Journal of Biological Chemistry
  Wong Chuu-Yun A., Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex1) gene expression in prostate cancer cells
  286:29, p. 25813 - 25822 2011
• The FASEB Journal
  Wolff Dennis W., 5-aza-2-deoxycytidine suppresses androgen independent prostate cancer growth by restoring RGS2 expression
  25:S1, p. 802 - 802 2011
• The FASEB Journal
  Wong Chuu‐Yun A, Protein kinase C (PKC) regulates phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 (P-Rex1) gene expression through a histone deacetylase interaction with Sp1 in prostate cancer
  25:S1, p. 1090 - 1090 2011
• The FASEB journal
  Xie Yan, DHHC protein‐dependent palmitoylation protects regulator of G‐protein signaling 4 from proteasome degradation
  25, p. 802.5 - 802.5 2011
• FEBS Letters
  Wang Jincheng, DHHC protein-dependent palmitoylation protects regulator of G-protein signaling 4 from proteasome degradation
  584:22, p. 4570 - 4574 2010
• Journal of Pharmacology and Experimental Therapeutics
  Jiang H., Phosphoinositide 3-kinase {gamma} regulates airway smooth muscle contraction by modulating calcium oscillations
  334:3, p. 703 - 709 2010
• Cellular and Molecular Life Sciences
  Zhao Kai, Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid
  67:15, p. 2665 - 2678 2010
• Journal of Biological Chemistry
  Chuang Tsai Der, Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth
  285:31, p. 23598 - 23606 2010
• Journal of Pharmacology and Experimental Therapeutics
  Kirui J. K., G{beta}{gamma} signaling promotes breast cancer cell migration and invasion
  333:2, p. 393 - 403 2010
• Cancer research (Chicago, Ill.)
  Xie Yan, Abstract 5188: Phosphoinositide 3-kinase γ: Implications in breast cancer metastasis
  70:8_Supplement, p. 5188 - 5188 2010
• Cancer research (Chicago, Ill.)
  Tu Yaping, Abstract 1710: Epigenetic repression of regulator of G-protein signaling 2 promotes prostate cancer progression
  70:8_Supplement, p. 1710 - 1710 2010
• The FASEB Journal
  Wong Chuu‐Yun Anny, Histone Acetylation Up-regulates Phosphatidylinositol-3,4,5-triphosphate-dependent Rac Exchange Factor 1 (P-Rex1) Expression to Promote Prostate Cancer Metastasis
  24:S1, p. 964.7 - 964.7 2010
• The FASEB journal
  Xie Yan, Up‐regulated phosphoinositide 3‐kinase γ (PI3Kγ ) promotes breast cancer metastasis
  24:S1, p. 964.17 - 964.17 2010
• Molecular Endocrinology
  Kang Lianguo, Involvement of Estrogen Receptor Variant ER-{alpha}36, Not GPR30, in Nongenomic Estrogen Signaling
  24:4, p. 709 - 721 2010
• The FASEB journal
  Ha Da, Histone deacetylases inhibit PIP3‐dependent Rac exchange factor 1 (P‐Rex1) expression in prostate cancer cells via SP1 binding site
  23:S1 2009
• The FASEB journal
  Xie Yan, Breast Cancer Metastasis Depends on Proteasome Degradation of Regulator of G‐protein Signaling 4
  23:S1 2009
• Oncogene
  Qin J., Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis
  28:16, p. 1853 - 1863 2009
• Cancer Research
  Xie Yan, Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4
  69:14, p. 5743 - 5751 2009
• The FASEB journal
  TU Yaping, Regulator of G protein Signaling 4 (RGS4): A Novel Inhibitor of Breast Cancer Metastasis
  22:S1 2008
• The FASEB journal
  Qin Jianbing, Upregulation of PIP3‐Dependent Rac Exchanger 1 (P‐Rex1) Promotes Prostate Cancer Metastasis
  22:S1 2008
• Molecular Pharmacology
  Xie Yan, Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells
  72:1, p. 73 - 85 2007
• The FASEB journal
  Qin Jianbing, PIP3‐dependent Rac exchanger 1 (P‐Rex1) promotes prostate cancer cell migration
  21:5, p. A386 - A386 2007
• Oncogene
  Cao X., Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells
  25:26, p. 3719 - 3734 2006
• Molecular Endocrinology
  Khan Obaid Y., Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland
  20:3, p. 544 - 559 2006
• Journal of Biological Chemistry
  Tang Wei, Gβγinhibits Gα GTPase-activating proteins by inhibition of Gα-GTP binding during stimulation by receptor
  281:8, p. 4746 - 4753 2006
• Methods in Enzymology
  Tu Yaping, Allosteric regulation of GAP activity by phospholipids in regulators of G-protein signaling
  389, p. 89 - 1005 2004
• Journal of Biological Chemistry
  Tu Yaping, Phosphorylation-regulated Inhibition of the Gz GTPase-activating Protein Activity of RGS Proteins by Synapsin I
  278:52, p. 52273 - 52281 2003
• Bioscience Reports
  Ou-Yang Ying Shi, The Mutation in the N-terminal Domain of RGS4 Disrupts PA-conferred Inhibitory Effect on GAP Activity
  23:4, p. 213 - 224 2003
• Journal of Biological Chemistry
  Ouyang Ying Shi, Regulators of G-protein signaling (RGS) 4, insertion into model membranes and inhibition of activity by phosphatidic acid
  278:13, p. 11115 - 11122 2003
• Journal of Biological Chemistry
  Tu Yaping, Binding of regulator of G protein signaling (RGS) proteins to phospholipid bilayers. Contribution of location and/or orientation to GTPase-activating protein activity
  276:23, p. 20160 - 20166 2001
• Journal of Biological Chemistry
  Tu Yaping, Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10
  274:53, p. 38260 - 38267 1999
• Journal of Biological Chemistry
  Wang Jun, RGSZ1, a G(z)-selective rgs protein in brain
  273:40, p. 26014 - 26025 1998
• Science
  Tu Yaping, Inhibition of brain G(z) GAP and other RGS proteins by palmitoylation of G protein α subunits
  278:5340, p. 1132 - 1135 1997
• Biophysical Chemistry
  Yang F. Y., The role of ganglioside GM3 in the modulation of conformation and activity of sarcoplasmic reticulum CA2+-ATPase
  68:1-3, p. 137 - 146 1997
• Journal of Biological Chemistry
  Wang Jun, A GTPase-activating protein for the G protein Gα(z). Identification, purification, and mechanism of action
  272:9, p. 5732 - 5740 1997
• Advances in Pharmacology
  Ross Elliott M., Guanosine Triphosphatase-Activating Proteins for Heterotrimeric G-Proteins
  42:C, p. 458 - 461 1997
• FEBS Letters
  Wang L. H., Effect of ganglioside GM3 on the activity and conformation of reconstituted Ca2+-ATPase
  388:2-3, p. 128 - 130 1996
• Biological Trace Element Research
  Yang F. Y., Se-mediated domain-domain communication in band 3 of human erythrocytes
  55:3, p. 279 - 295 1996
• Bioscience Reports
  Tu Y. P., Transmembrane Ca2+ gradient is essential for high anion transport activity of human erythrocytes
  16:4, p. 299 - 311 1996
• Biochemistry and Molecular Biology International
  Xie W. S., Fluorescence study on ligand induced conformational changes of human erythrocyte glucose transporter
  39:2, p. 279 - 284 1996
• Biochemistry and Molecular Biology International
  Tu Y. P., Cytoplasmic Ca2+ inhibits the glucose transporter of human erythrocytes
  36:2, p. 383 - 391 1995
• Bioscience Reports
  Yang F. Y., Transmembrane Ca2+ gradient and function of membrane proteins
  15:5, p. 351 - 364 1995
• Journal of Biochemistry
  Tu Y. P., Zn2+-mediated domain-domain communication in human erythrocyte band 3
  118:1, p. 161 - 167 1995
• Science in China (Scientia Sinica) Series B
  Tu Yaping, Transmembrane Ca2+ gradient-mediated phosphatidylcholine modulating sarcoplasmic reticulum Ca2+-ATPase
  38:6, p. 713 - 721 1995
• Bioscience Reports
  Tu Y. P., Fluorescence study on transmembrane Ca2+ gradient-mediated conformation changes of sarcoplasmic reticulum Ca2+-ATPase
  14:6, p. 309 - 317 1994
• Bioscience Reports
  Tu Y. P., Zn2+ inhibits the anion transport activity of Band 3 by binding to its cytoplasmic tail
  14:4, p. 159 - 169 1994
• Biochemistry and Molecular Biology International
  Tu Y. P., Transmembrane Ca2+ gradient-mediated change of fluidity in the inner layer of phospholipids modulates Ca2+-ATPase of sarcoplasmic reticulum
  33:3, p. 597 - 605 1994
• Shi yan sheng wu xue bao
  Tu Y. P., The specificity of modulation of sarcoplasmic reticulum Ca(2+)-ATPase by transmembrane Ca2+ gradient
  26:4, p. 441 - 447 1993
• Biochemical and Biophysical Research Communications
  Tu Y. P., Transmembrane Ca2+ Gradient-Mediated Modulation of Sarcoplasmic Reticulum Ca2+-ATPase
  196:2, p. 561 - 568 1993
• Bioscience Reports
  Yang F. Y., Divalent cation and lipid-protein interactions of biomembranes
  13:3, p. 143 - 157 1993
• Science in China. Series B, Chemistry, life sciences & earth sciences
  Tu Y. P., Effect of transmembrane Ca2+ gradient on conformation and enzyme activity of reconstituted adenylate cyclase.
  35:1, p. 67 - 75 1992
• Biochemical and Biophysical Research Communications
  Yang F. Y., A proper transmembrane Ca2+ gradient is essential for the higher enzymatic activity of adenylate cyclase
  175:2, p. 366 - 371 1991

Presentations

• Invited speaker: Airway Relaxation Mechanisms and Structural Basis of Osthole to Improve Lung Function in Asthma,Kansas City University of Medicine and Biosciences, Kansas City, MO, USA 2019
• Poster presentation: Inhibition of androgen receptor increases sensitivity of TRAIL-induced apoptosis via up-regulation of death receptor 5 in breast cancer. Experimental Biology Annual Meeting-2019, Orland, Florida, USA 2019
• Poster presentation: TGF-β1-induced miR-424 mediates pulmonary myofibroblast differentiation via targeting slit2, Experimental Biology Annual Meeting-2019, Orland, Florida, USA 2019
• Invited speaker, Research Conference of Pulmonary, Critical Care, Sleep & Allergy Division, University of Nebraska Medical Center, Omaha, NE 2019
• Invited speaker: Molecular studies of osthole as a new bronchodilator to treat drug-resistant asthma, The Second JinLing Forum on Membrane Protein Physiology and Drug Discovery, Nanjing, China 2018
• The Bioscience Seminar, the Morsani College of Medicine, University of South Florida Topic: "Regulator of G Protein Signaling Proteins: Targets for Treatment of Asthma" 2015
• The Nebraska Center for Cellular Signaling Month Meeting Topic: "Targeting the Androgen Receptor and TRAIL Pathways: A Novel Treatment Paradigm for Breast Cancer " 2015
• The 4th International Symposium on Membrane Biology. Dali, China Topic: "Regulator of G Protein Signaling Proteins: Targets for Treatment of Asthma" 2014
• American Asthma Foundation Annual Meeting-2014 2014
• Department of Pharmacology, Creighton University 2014
• Department of Chemistry, University of Nebraska at Omaha, NE 2013
• American Asthma Foundation Annual Meeting, San Francisco, CA 2013
• Experimental Biology-2013, Boston 2013
• Department of Urology, University of Kansas Medical Center, Kansas, KS 2013
• Annual Meeting of the American Academy of Allergy Asthma and Immunology, San Antonio, TX 2013
• The Nebraska Center for Cellular Signaling, Omaha, NE 2013
• Omaha VA Medical Center, Omaha 2012
• The 2nd International Symposium on Membrane Biology, Zhuhai, China 2012
• 2012-Annual Meeting of American Asthma Foundation 2012
• 2012 Experimental Biology 2012
• 2012-Creighton Faculty Club 2012
• Invited speaker, Creighton Cancer Research Symposium 2011
• Featured speaker, Nebraska Center for Cellular Signaling Symposium 2011
• Invited speaker, 7th Annual National Symposium on Prostate Cancer 2011
• Invited speaker, Innovative Minds in Prostate Cancer Today Conference 2011
• The 2nd International Symposium on Membrane Biology in China 2010
• Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center 2010
• Invited speaker, 2009 Nebraska Research and Innovation Conference. Omaha 2009
• Department of Pathology, Creighton University Medical Center 2009
• The 1st International Symposium on Membrane Biology, CHINA 2009
• GORDON RESEARCH CONFERENCE: PHOSPHORYLATION & G-PROTEIN MEDIATED SIGNALING 2009
• AACR 100th Annual Meeting 2009 2009
• "Dysregulation of G-Protein Signaling in Cancer" at State Key laboratory of Membrane Biology and Membrane Biotechnology, Chinese Academy of Sciences 2009
• Prostate Cancer Research Group, University of Nebraska Medical Center 2008
• "RGS proteins and cancer" at Peking University, China 2008
• "RGS2 and Prostate cancer progression" at National Center for Nanoscience and Technology, China 2008
• Experimental Biology Meeting-2008 2008
• 3rd RGS Protein Colloquium 2008
• Harry and Elsa Jiler-American Cancer Society Professors Meeting 2007
• Braman Family Breast Cancer Institute 2007
• The 2007 International Symposium on Biomembranes, Hubei, China 2007
• Department of Surgery at Evanston Northwestern Healthcare and the Department of Urology at Northwestern University Feinberg School of Medicine 2007
• The University of Minnesota Cancer Center 2007
• University of Nebraska Medical Center 2007
• Vasoactive intestinal peptide transactivates the androgen receptor 2007
• P-Rex1 promotes prostate cancer cell migration and invasion 2007
• 97th Annul Meeting of the American Association for Cancer Research, at the meeting in Washington, DC (April 1-5, 2006). 2007
• Role of RGS Proteins in Prostate Cancer 2007
• Molecular Studies of RGS2 in Prostate Cancer 2006
• University of Nebraska at Lincoln 2006
• Experimental Biology 2006 Meeting. in San Francisco (April 1-5) 2006
• 97th Annul Meeting of the American Association for Cancer Research, at the meeting in Washington, DC (April 1-5, 2006). 2006
• American Heart Association Symposium(November 2005)at Dallas, TX 2005
• Modulation of RGS Proteins 2004