David Zhi-Zhou He, MD, PhD

Department

Biomedical Sciences

Position

Professor

Books

• Walters Brad, Hair Cells: From Molecules to Function, Volume II 2022
• Audition
  Beisel K. W., Genetics of Mechanoreceptor Evolution and Development [Book Chapter] 2008

Publications

• Proceedings of the National Academy of Sciences - PNAS
  Xie Zhifang, ZBTB20 is essential for cochlear maturation and hearing in mice
  120:24, p. e2220867120 - e2220867120 2023
• iScience
  Li Xiaofen, Apicosome: Newly identified cell-type-specific organelle in mouse cochlear and vestibular hair cells
  26:4, p. 106535 - 106535 2023
• Frontiers in cellular neuroscience
  Cheatham Mary Ann, Editorial: Hair cells: From molecules to function, volume II
  16, p. 1046646 - 1046646 2022
• Frontiers in neurology
  Wang Tianying, Occlusion of two semicircular canals does not disrupt normal hearing in adult mice
  13, p. 997367 - 997367 2022
• Frontiers in cellular neuroscience
  Xu Zhenhang, Profiling mouse cochlear cell maturation using 10x Genomics single-cell transcriptomics
  16 2022
• Liu Ke, Editorial 2022
• Cell Reports
  Liu Huizhan, Molecular and cytological profiling of biological aging of mouse cochlear inner and outer hair cells
  39:2 2022
• Science Advances
  Giffen Kimberlee P., Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction
  8:14 2022
• BMC Neuroscience
  Zu Mian, SCN11A gene deletion causes sensorineural hearing loss by impairing the ribbon synapses and auditory nerves
  22:1 2021
• Frontiers in Cellular Neuroscience
  Qi Yue, Deletion of C1ql1 Causes Hearing Loss and Abnormal Auditory Nerve Fibers in the Mouse Cochlea
  15 2021
• Frontiers in Cellular Neuroscience
  Li Yi, Endolymphatic Potential Measured From Developing and Adult Mouse Inner Ear
  14 2020
• Cell and Tissue Research
  Nichols David H., Interaction with ectopic cochlear crista sensory epithelium disrupts basal cochlear sensory epithelium development in Lmx1a mutant mice
  380:3, p. 435 - 448 2020
• Frontiers in Neuroscience
  Giffen Kimberlee P., Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells
  13 2019
• Scientific reports
  Rocha-Sanchez Sonia M., Quinoxaline protects zebrafish lateral line hair cells from cisplatin and aminoglycosides damage (vol 8, 15119, 2018)
  9 2019
• The FASEB Journal
  Giffen Kimberlee, Characterizing the Role of Kcnq5a in Zebrafish Inner Ear Hair Cells
  33:S1 2019
• The FASEB journal
  Morrill Seth, The Effects of Bcl6 KO in Mouse Cochlear Hair Cells
  33:S1, p. 610.14 - 610.14 2019
• Cell Reports
  Ranum Paul T., Insights into the Biology of Hearing and Deafness Revealed by Single-Cell RNA Sequencing
  26:11, p. 3160 - 3171.e3 2019
• Frontiers in Molecular Neuroscience
  Hu Qun, Deletion of Kncn Does Not Affect Kinocilium and Stereocilia Bundle Morphogenesis and Mechanotransduction in Cochlear Hair Cells
  11 2018
• Frontiers in Cellular Neuroscience
  Li Yi, Characterization of hair cell-like cells converted from supporting cells after notch inhibition in cultures of the organ of corti from neonatal gerbils
  12 2018
• Scientific Data
  Barta Cody L., RNA-seq transcriptomic analysis of adult zebrafish inner ear hair cells
  5 2018
• Scientific Data
  Li Yi, Transcriptomes of cochlear inner and outer hair cells from adult mice
  5 2018
• Journal of Otology
  Morrill Seth, Apoptosis in inner ear sensory hair cells
  12:4, p. 151 - 164 2017
• Reproduction Fertility and Development
  Guo Weiwei, The Morphological and Functional Development of the Stria Vascularis in Miniature Pigs
  29:3, p. 585 - 593 2017
• PloS One
  Liu Huizhan, Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival?
  11:12 2016
• Plos One
  Li Yi, Transcription Factors Expressed in Mouse Cochlear Inner and Outer Hair Cells
  11:3, p. e0151291 - e0151291 2016
• Journal of Biological Chemistry
  Lovas Sandor, Glutamate Transporter Homolog-based Model Predicts That Anion-pi Interaction Is the Mechanism for the Voltage-dependent Response of Prestin
  290:40, p. 24326 - 24339 2015
• Nature Communications
  Ren An-Jing, ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons
  5, p. Article number 4984 2014
• PLoS One
  Zhang Qian, Identifying microRNAs involved in aging of the lateral wall of the cochlear duct
  9:11, p. e112857 - e112857 2014
• Journal of Neuroscience
  Liu H., Characterization of transcriptomes of cochlear inner and outer hair cells
  34:33, p. 11085 - 11095 2014
• Journal of Neuroscience
  Liu Heping, Characterization of Transcriptomes of Cochlear Inner and Outer Hair Cells
  34:33, p. 11085 - 11095 2014
• PLoS One
  Li Jun, Morphology and Ciliary Motion of Mucosa in the Eustachian Tube of Neonatal and Adult Gerbils
  9:6, p. e99840 2014
• Hearing Research
  He David Z. Z., Prestin at year 14: progress and prospect
  311, p. 25 - 35 2014
• PloS one
  Mao Zhongping, How Well Can Centenarians Hear?
  8:6, p. - 2013
• PloS one
  Zhang Qian, Identifying MicroRNAs Involved in Degeneration of the Organ of Corti during Age-Related Hearing Loss
  8:4 2013
• PloS one
  Tang Jie, Lizard and Frog Prestin
  8:1 2013
• PLoS One
  Mao Zhongping, How Well Can Centenarians Hear?
  8:6, p. 1 - 7 2013
• PloS one
  Yuan Yongyi, Molecular Epidemiology and Functional Assessment of Novel Allelic Variants of SLC26A4 in Non-Syndromic Hearing Loss Patients with Enlarged Vestibular Aqueduct in China
  7:11, p. - 2012
• Journal of Physiology
  Ren Anjing, Regulation of hippocampus-dependent memory by the zinc finger protein Zbtb20 in mature CA1 neurons
  590:19, p. 4917 - 4932 2012
• PloS one
  Yang Shi Ming, Regeneration of Stereocilia of Hair Cells by Forced Atoh1 Expression in the Adult Mammalian Cochlea
  7:9, p. - 2012
• Acta Oto-Laryngologica
  Xu Jin Cao, Type I hair cell regeneration induced by Math1 gene transfer following neomycin ototoxicity in rat vestibular sensory epithelium
  132:8, p. 819 - 828 2012
• PLoS One
  Yuan Yongyi, Molecular Epidemiology and Functional Assessment of Novel Allelic Variants of SLC26A4 in Non-Syndromic Hearing Loss Patients with Enlarged Vestibular Aqueduct in China
  7:11, p. e49984 - e49984 2012
• Journal of Cell Science
  Tan Xiaodong, A motif of eleven amino acids is a structural adaptation that facilitates motor capability of eutherian prestin
  125:4, p. 1039 - 1047 2012
• International Journal of Developmental Neuroscience
  Yang Shi Ming, The role of Smad4 in vestibular development in mice
  29:1, p. 15 - 23 2011
• International Journal of Developmental Neuroscience
  Yang Xiao, The role of Smad4 in vestibular development in mice
  29:1, p. 15 - 23 2011
• International Journal of Developmental Neuroscience
  Yang Xiao, Corrigendum to “The role of Smad4 in vestibular development in mice” [Int. J. Dev. Neurosci. 29 (2011) 15–23]
  29:7, p. 783 2011
• Journal of Neurophysiology
  Xiaodong Tan, From Zebrafish to Mammal: Functional Evolution of Prestin, the Motor Protein of Cochlear Outer Hair Cells
  105:1, p. 36 - 44 2011
• American Journal of Respiratory Cell and Molecular Biology
  Jia Shuping, Expression and Function of a Novel Variant of Estrogen Receptor-ER-{alpha}36 in Mouse Airway
  45:5, p. 1084 - 1089 2011
• Journal of Biological Chemistry
  Tang Jie, Engineered pendrin: An anion transporter and molecular motor
  286:35, p. 31014 - 31021 2011
• Brain Research
  Wang Xiang, Prestin forms oligomer with four mechanically independent subunits
  1333, p. 28 - 35 2010
• Cytoskeleton
  He David Z.Z., Changes in plasma membrane structure and electromotile properties in prestin deficient outer hair cells
  67:1, p. 43 - 55 2010
• Journal of Neuroscience
  Jia S., Fate of mammalian cochlear hair cells and stereocilia after loss of the stereocilia
  29:48, p. 15277 - 15285 2009
• Biochemical and Biophysical Research Communications
  Kumano Shun, Mutation-induced reinforcement of prestin-expressing cells
  389:4, p. 569 - 574 2009
• Developmental Dynamics
  Yang Xiao, Chondrocyte-Specific Smad4 Gene Conditional Knockout Results in Hearing Loss and Inner Ear Malformation in Mice
  238:8, p. 1897 - 1908 2009
• Developmental neurobiology (Hoboken, N.J.)
  Yang Shi-Ming, Smad5 Haploinsufficiency Leads to Hair Cell and Hearing Loss
  69:2-3, p. 153 - 161 2009
• Journal of Neuroscience
  Jia Shuping, Fate of Mammalian Cochlear Hair Cells and Stereocilia after Loss of the Stereocilia
  29:48, p. 15277 - 15285 2009
• Developmental Dynamics
  Yang Shi Ming, Chondrocyte-specific Smad4 gene conditional knockout results in hearing loss and inner ear malformation in mice
  238:8, p. 1897 - 1908 2008
• Brain Research
  Wu Xudong, Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification
  1210, p. 20 - 28 2008
• Neuron
  Dallos Peter, Prestin-Based Outer Hair Cell Motility Is Necessary for Mammalian Cochlear Amplification
  58:3, p. 333 - 339 2008
• Brain Research
  Wu Xudong, Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification
  1210, p. 20 - 28 2008
• Hearing Research
  Wang Xiang, Streptomycin and gentamicin have no immediate effect on outer hair cell electromotility
  234:1-2, p. 52 - 58 2007
• Proceedings of the National Academy of Sciences of the United States of America
  Gao Jiangang, Prestin-based outer hair cell electromotility in knockin mice does not appear to adjust the operating point of a cilia-based amplifier
  104:30, p. 12542 - 12547 2007
• Journal of Physiology
  Albert Jörg T., Voltage-sensitive prestin orthologue expressed in zebrafish hair cells
  580:2, p. 451 - 461 2007
• Journal of Physiology
  Albert J. T., Voltage-sensitive prestin orthologue expressed in zebrafish hair cells
  580:Pt. 2, p. 451 - 461 2007
• Journal of Neuroscience
  Jia S., Mechanoelectric transduction of adult inner hair cells
  27:5, p. 1006 - 1014 2007
• Journal of Neuroscience
  Jia Shuping, Mechanoelectric transduction of adult inner hair cells
  27:5, p. 1006 - 1014 2007
• The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME
  Murakoshi Michio, 109 Atomic Force Microscopic Observation of the Conformational Changes in the Voltage-dependent Motor Protein Prestin
  2005.18, p. 25 - 26 2006
• Journal of Membrane Biology
  He David Z. Z., Tuning in to the amazing outer hair cell: Membrane wizardry with a twist and shout
  209:2/3, p. 119 - 134 2006
• Nature Neuroscience
  Jia Shuping, Motility-associated hair-bundle motion in mammalian outer hair cells
  8:8, p. 1028 - 1034 2005
• Nature
  He David Z.Z., Mechanoelectrical transduction of adult outer hair cells studied in a gerbil hemicochlea
  429:6993, p. 766 - 770 2004
• Developmental Brain Research
  He David Z.Z., Mouse outer hair cells lacking the α9 ACh receptor are motile
  148:1, p. 19 - 25 2004
• Journal of Neuroscience
  He David Z.Z., Prestin and the dynamic stiffness of cochlear outer hair cells
  23:27, p. 9089 - 9096 2003
• Journal of Physiology
  He David Z.Z., Chick hair cells do not exhibit voltage-dependent somatic motility
  546:2, p. 511 - 520 2003
• Journal of Physiology
  He D. Z. Z., Chick hair cells do not exhibit voltage-dependent somatic motility
  546:2, p. 511 - 520 2003
• Nature
  Liberman M. Charles, Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier
  419:6904, p. 300 - 304 2002
• Audiology and Neuro-Otology
  Zheng Jing, Identification of differentially expressed cDNA clones from gerbil cochlear outer hair cells
  7:5, p. 277 - 288 2002
• Brain Research
  Szönyi Magdolna, Intracellular calcium and outer hair cell electromotility
  922:1, p. 65 - 70 2001
• Science
  Oliver D., Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein
  292:5525, p. 2340 - 2343 2001
• Hearing Research
  He David Z.Z., Development of acetylcholine receptors in cultured outer hair cells
  162:1-2, p. 113 - 125 2001
• Nature
  Zheng Jing, Prestin is the motor protein of cochlear outer hair cells
  405:6783, p. 149 - 155 2000
• JARO - Journal of the Association for Research in Otolaryngology
  Richter C. P., Development of the gerbil inner ear observed in the hemicochlea
  1:3, p. 195 - 210 2000
• JARO - Journal of the Association for Research in Otolaryngology
  He D. Z.Z., Properties of voltage-dependent somatic stiffness of cochlear outer hair cells
  1:1, p. 64 - 81 2000
• JARO - Journal of the Association for Research in Otolaryngology
  Dallos Peter, Two models of outer hair cell stiffness and motility
  1:4, p. 283 - 291 2000
• Hearing Research
  He David Z.Z., Isolation of cochlear inner hair cells
  145:1-2, p. 156 - 160 2000
• Hearing Research
  Szönyi Magdolna, Cyclic GMP and outer hair cell electromotility
  137:1-2, p. 29 - 42 1999
• Proceedings of the National Academy of Sciences of the United States of America
  He D. Z.Z., Somatic stiffness of cochlear outer hair cells is voltage-dependent
  96:14, p. 8223 - 8228 1999
• Journal of Neurophysiology
  He David Z.Z., Development of acetylcholine-induced responses in neonatal gerbil outer hair cells
  81:3, p. 1162 - 1170 1999
• Developmental Brain Research
  He David Z.Z., Expression of potassium channels in gerbil outer hair cells during development does not require neural induction
  103:1, p. 95 - 97 1997
• Journal of Neuroscience
  Dallos Peter, Acetylcholine, outer hair cell electromotility, and the cochlear amplifier
  17:6, p. 2212 - 2226 1997
• ORL
  Liu Tien Chen, A novel, simple organotypic culture method to study the organ of corti from the neonatal gerbil
  59:5, p. 243 - 247 1997
• Journal of Neuroscience
  He David Z.Z., Relationship between the development of outer hair cell electromotility and efferent innervation
  17:10, p. 3634 - 3643 1997
• Hearing Research
  Sziklai István, Effect of acetylcholine and GABA on the transfer function of electromotility in isolated outer hair cells
  95:1-2, p. 87 - 99 1996
• Hearing Research
  He David Z.Z., First appearance and development of electromotility in neonatal gerbil outer hair cells
  78:1, p. 77 - 90 1994

Presentations

• ARO Meeting 2023
• Poster presentation at Annual meeting of association for research in otolarynogology at San Joe 2020
• Four Poster presentations at Annual Meeting of Association for Research in Otolaryngology in San Joe 2020
• Poster presentation at Annual Meeting of Association for Research in Otolaryngology at San Joe 2020
• Podium presentation at 5th International meeting on hearing loss, Beijing, China 2019
• Presentation on 5th International meeing on hearing loss, Beijing, China 2019
• Seminar given at Biology Department of University of Iowa 2015
• Poster presentation at 48th ARO meeting in Baltimore 2015
• Podium presentation at 48th ARO meeting in Baltimore 2015
• Poster presentation at Inner Ear Biology Meeting in Japan 2014
• Podium presentation at Inner Ear Biology Meeting in Japan 2014
• Poster Presentation at annual ARO meeting 2014
• Poster presentation at annual Meeting 2014
• Seminar speaker at Boys Town National Research Hospital 2010
• Seminar Speaker at Qinghua University 2010
• Poster Presentation, ARO meeting 2010
• Oral Presentation ARO Meeting 2010
• Poster Presentation at ARO meeting 2010
• Seminar Speaker at Tohoko University 2010
• Invited Seminar Speaker, Medical University of South Carolina 2010
• 46th Inner Ear Biology Meeting 2009
• Seminar speaker at Johns Hopkins University 2009
• departmental seminar 2009
• ARO poster 2009
• ARO annual meeting 2009
• ARO poster presentation 2009
• Seminar speaker at University of Michigan 2008
• invited seminar at boys town national research hospital 2008
• 5th International Conference on Nanotechnology in Biomedical Research 2008
• invited seminar at NIDCD, NIH 2008
• Poster, Annual meeting of the Association for research of otolaryngology 2008
• Poster, Annual Meeting of the Association for research of otolaryngology 2008
• Podium presentation at Annual meeting of the Association for Research in Otolaryngology 2008
• Department Seminar 2008
• Keynote speaker, 30th international conference on comparative physiology, Brazil 2007
• Invited Seminar Speaker at UC Irvine 2007
• Feature Presentation at 4th International Conference on Hearing Sciences, Beijing, China 2007
• Invited Seminar at NIDCD/NIH, Bethesda 2007
• Poster Presentation at ARO Annual Meeting, Denver 2007
• Podium Presentation at ARO Annual Meeting, Denver 2007
• Seminar speaker at University of North Dakota 2006
• Seminar speaker at University of Washington 2006
• Prsentation at ARO, Baltimore 2006
• ARO Annual Meeting at Baltimore 2006
• Seminar speaker at Depts of Otolaryngology, and Physiology and Biophysics, University of Colorado 2005
• 2nd Swiss-Japan conference on biomechanics, Kyoto, Japan 2005
• Invited lecture at Koyto University, Japan 2005
• Auditory Mechanisms: Processes and Models. Oregon, Portland, USA 2005
• Invited seminar speaker at NIDCD (NIH) 2005
• XXXI International conference of Physiology 2005
• Poster presentation at aro annual meeting 2005
• Assoc. Res. Otolaryngology mid winter meeting. 2005
• Gordon research conference on neurobiology of the sensory system in Hong Kong 2004
• Gordon Research Conference in Hong Kong 2004
• ARO Annual Meeting in Florida. 2004
• ARO Meeting in Florida 2004
• ARO Meeting in florida 2004
• The 2nd International Symposium on Future Medical Engineering Based on Bio-Nanotechnology, Japan. 2003
• ARO Meeting 2003
• ARO Meeting 2003
• ARO Meeting 2003
• ARO Meeting 2003
• ARO Meeting 2003
• Presentations at the Annual Meeting of the Association for Research on Otolaryngology in Florida 2003
• ARO mid-winter meeting in Florida 2003
• Seminar speaker at UNMC 2002
• Presentation at the Meeting of Biophysics of the Cochlea in Germany 2002

Awards

• Intramural Research Award
  Receiving Award from Health Future Foundation of CUSOM

Consulting

• ZRG1 IFCN-E Study Section
  Panel Member
  The panel of which Dr. He was a member reviewed grants for NIH.
  NIH
  2021 - 2021