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Anthony E . Kincaid, PT, PhD

Professor

Pharmacy

Anthony Kincaid

Contact

Graduate School
Medical Sciences (Master of Science)
Neuroscience (Master of Science)
School of Pharmacy and Health Professions
Pharmacy
Pharmacy Faculty
Pharmacy Sciences
Faculty - Pharmacy, OT, PT
HLSB - Hixson Lied Science Building

Anthony E . Kincaid, PT, PhD

Professor

Pharmacy

View my CV.

Research Focus

Pathogenesis of prion diseases; Drug delivery via nasal cavity. Functional neuroanatomy of the basal ganglia.

Department

Pharmacy Sciences

Position

Professor

Articles

  • mSphere
    Shikiya, R.A., Kincaid, A.E.,Bartz. J.C. and Bourret, T.J. (2020) Failure to detect prion infectivity in ticks following prion-infected blood meal. mSphere 5(5): e00741-20. 2020
  • AAPS PharmSciTech
    Vora, D., Kincaid, A.E., Tolman, J. and Chauhan, H. (2020) Characterization and systemic delivery of dibenzoylmethane via the intranasal route. AAPS PharmSciTech 22:3O; DOI:10.1208?sL2249-020-01904-9. 2020
  • Acta Neuropathologica Communications
    Bett, C., Lawrence, J., Kurt, T.D., Orru, C., Aguilar-Calvo, P., Kincaid, A.E., Surewicz, W.K., Caughey, B., Wu, C. and Sigurdson, C.J. (2017) Enhanced neuroinvasion by smaller soluble prions.
    5 (32), p. doi: 10.1186/s40478-017-0430-z 2017
  • PLoS Pathogens
     Shikiya, R.A., Langenfeld, K.A., Eckland, T.E., Trinh, J., Holec, S.A., Mathiason, C.K., Kincaid, A.E., Bartz, J.C. (2017) PrPSc formation and clearance as determinants of prion tropism.PrPSc formation and clearance as determinants of prion tropism.
    13 (3), p. e1006298 2017
  • Journal of Virology
    Kincaid, A.E., Ayers, J.A. and Bartz, J.C. The specificity, size and frequency of spaces that characterize the mechanism of bulk transepithelial transport of prions in the nasal cavity of hamsters and mice.
    90, p. 8293-8301 2016
  • Journal of Virology
    Langenfeld, K.A., Shikiya, R.A., Kincaid, A.E., and Bartz, J.C. Incongruity between prion conversion and incubation period following co-infection.
    90, p. 5715-5723 2016
  • Journal of Virology
    Elder, A.M., Henderson, D.M., Nalls, A.V., Hoover, E.A., Kincaid, A.E., Bartz, J.C. and Mathiason, C.K. Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations.
    89, p. 7421-7424 2015
  • PLoS One
    Clouse, M.D., Shikiya, R.A., Bartz, J.C and Kincaid, A.E. Nasal associated lymphoid tissue of the Syrian hamster expresses high levels of PrPC.
    10, p. e0117935 2015
  • PLoS One
    Elder, A.M., Henderson, D.M., Nalls, A.V., Wilham, J.M., Caughey, B.W., Hoover, E.A., Kincaid, A.E., Bartz, J.C. and Mathiason, C.K. In vitro detection of prionemia in TSE-infected cervids and hamsters.
    8, p. e80203 2013
  • Journal of Virology
    Kincaid, A.E., Hudson, K.F., Richey, M.W. and Bartz, J.C. Rapid transepithelial transport of prions following inhalation.
    86, p. 12731-12740 2012
  • PLoS Pathogens
    Ayers, J.I., Schutt, C.R., Shikiya, R.A., Aguzzi, A., Kincaid, A.E., Bartz, J.C. The strain-encoded relationship between PrPSc replication, stability and processing in neurons is predictive of the incubation period of disease.
    7 (3), p. e1001317 2011
  • Journal of Virology
    Shikiya, R. A., Ayers, J.I., Schutt, C.R., Kincaid, A.E., Bartz, J.C. Co-infecting prion strains compete for a limiting cellular resource.
    84 (11), p. 5706-5714 2010
  • Journal of Virology
    Ayers, J. I., Kincaid, A. E. and Bartz, J. C. Prion strain targeting independent of strain-specific neuronal tropism.
    83, p. 81-87 2009
  • Journal of Virology
    Kincaid, A. E. and Bartz, J. C. The nasal cavity is a route for prion infection in hamsters
    81, p. 4482-4491 2007
  • Journal of Virology
    Bartz, J.C., Kramer, M.L., Sheehan, M.H., Hutter, J.A.L., Ayers, J.I., Bessen, R.A. and Kincaid, A.E. Prion interference is due to a reduction in strain-specific PrPSc levels.
    81 (2), p. 689-697 2007
  • Journal of inorganic biochemistry
    Shara, Michael, Kincaid, Anthony E., Limpach, Aimee L., Sandstrom, Robert, Barrett, Laura, Norton, Neil, Bramble, J. D., Yasmin, Taharat, Tran, Janet, Chatterjee, Archana, Bagchi, Manashi, Bagchi, Debasis Long-term safety evaluation of a novel oxygen-coordinated niacin-bound chromium (III) complex
    101, p. 1059-1069 2007
  • Journal of inorganic biochemistry
    Shara, M., Yasmin, T., Kincaid, A. E., Limpach, A. L., Bartz, J., Brenneman, K. A., Chatterjee, A., Bagchi, M., Stohs, S. J., Bagchi, D. Safety and toxicological evaluation of a novel niacin-bound chromium(III) complex
    99, p. 2161-2183 2005
  • Journal of Virology
    Marsh, R.F., Kincaid, A.E., Bessen, R.A. and Bartz, J.C. Interpsecies transmission of chronic wasting disease prions to squirrel monkeys.
    79 (21), p. 13794-13796 2005
  • Journal of Virology
    Bartz, J.C., DeJoia, C, Tucker, T., Kincaid, A.E. and Bessen, R.A. Extraneural prion neuroinvasion without lymphoreticular system infection.
    79 (18), p. 11858-11863 2005
  • Perceptual and Motor Skills
    Robinson, B. S. and Kincaid, A. E. Repetitive motion in perception of tactile sensation in the fingers of string players
    99, p. 1171-1183 2004
  • Journal of Virology
    Mulcahy, E.R., Bartz, J.C., Kincaid, A.E. and Bessen, R.A. Prion infection of skeletal muscle cells and papillae in the tongue.
    78 (13), p. 6792-6798 2004
  • Journal of Virology
    Bartz, J.C., Kincaid, A.E. and Bessen, R.A. Rapid prion neuroinvasion following tongue infection.
    77 (1), p. 583-591 2003
  • Perceptual and Motor Skills
    Kincaid, A. E., Duncan, S. and Scott, S. A. Assessment of fine motor skill in musicians and nonmusicians: Differences in timing versus sequence accuracy in a bimanual fingering task
    95, p. 245-257 2002
  • Journal of Virology
    Bartz, J.C., Kincaid, A.E. and Bessen, R.A. Retrograde transport of transmissible mink encephalopathy within descending motor tracts.
    76 (11), p. 5759-5768 2002
  • Neuroscience
    Kincaid, A. E. Spontaneous circling behavior and dopamine neuron loss in a genetically hypothyroid mouse
    105, p. 891-898 2001

Presentations

  • Recent Developments in the Pathogenesis of Animal Prion Diseases. Neuroscience Graduation Reception, Creighton University 2019
  • Prions for the Masses. Research Roundtable, Creighton University 2017
  • Characteristics of Prion Entry and Spread Following Inhalation into the Nasal Cavity. Department of Biomedical Sciences, School of Veterinary Medicine, Iowa State University, Ames, Iowa 2015
  • Characteristics of Prion Entry and Spread Following Inhalation into Nasal Cavity. NeuroPrion 2015, Human Prion Workshop, Fort Collins, CO. 2015
  • Rapid Transepithelial Transport of Prions Following Inhalation. Biomedical Sciences Department Seminar, Creighton University 2011
  • Prions, Prion Diseases and Misfolded Proteins.  Cornell College, Mt. Vernon, Iowa 2011
  • The Nasal Cavity as a Route of Prion Infection.  South Dakota State University, Brookings, South Dakota 2009
  • Prion Disease Pathogenesis: The Role of the Nasal Cavity. St. Olaf College, Northfield, Minnesota 2009
  • Prion Infection Following Exposure to the Nasal Cavity. Brain Research Centre, University of British Columbia, Vancouver, Canada.  2007
  • The Nasal Cavity as a Route for Prion Infection. United States Department of Agriculture, National Animal Disease Center, Ames, Iowa 2007
  • The Nasal Cavity as a Route for the Entry and Neuroinvasion of Prions.  Creighton University Medical Center Department of Neurology Grand Rounds 2006
  • Prion Neuroinvasion and Disease Following Extranasal Exposure.  Biomedical Sciences Department Seminar, Creighton University 2005
  • The Nasal Cavity as a Route of Prion Pathogenesis.  Nebraska Center for Virology, University of Nebraska at Lincoln 2005
  • Prion Neuroinvasion and Disease Following Extranasal Exposure.  Great Plains Infectious Disease Meeting, University of Kansas, Lawrence, Kansas 2005
  • Prion Diseases and the Evidence for an Intranasal Route of Entry.  Creighton University Medical Center Department of Neurology Grand Rounds 2005
  • The Transmissible Spongiform Encephalopathies and the Entry and Spread of Prions in the Nervous System.  Creighton University School of Pharmacy and Health Professions Research Forum 2004

Federal

  • Mechanisms of prion strain selection

  • Characteristics of prion entry and neuroinvasion following nasal cavity infection

  • Prion strain selection in the central nervous system

  • Routes of prion neuroinvasion following oral infection

  • Prion strain targeting and competition in the central nervous system

  • The role of glial cells in prion disease

State

  • Determination of prion transport via intranasal routes

Other

  • Prion transmission via Dermacentor andersoni

Awards

  • Scholarly Achievement Award
    School of Pharmacy and Health Professions Faculty
  • Robert F. Kennedy Excellence in Teaching Award
    Creighton University Student's Union
  • Teacher of the Year
    School of Pharmacy and Health Professions Faculty
  • Educator of the Year: 1996, 1997, 1999, 2000, 2002, 2005, 2006, 2007, 2009, 2012
    First year Physical Therapy students