Gwendalyn King, PhD

Department

Biology

Position

Assistant Professor

Articles

• Journal of Molecular Cell Biology
  A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells.
  12, p. 4-16 2020
• JCI: Insight
  FGF23 expression is stimulated in transgenic -Klotho longevity mouse model
  4 2019
• Am J Physiol Lung Cell Mol Physiol
  Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis
  217, p. L141-L154 2019
• Molecular and Cellular Neuroscience
  Klotho deficiency affects the spine morphology and network synchronization of neurons.
  98, p. 1-11 2019
• Eneuro
  FGF-23 Deficiency Impairs Hippocampal-Dependent Cognitive Function
  6 2019
• Brain Plasticity
  Klotho, the Key to Healthy Brain Aging?
  3, p. 183-194 2018
• European Respiratory Journal
  Fibroblast growth factor 23 and Klotho contribute to airway inflammation.
  52 2018
• J Am Soc Nephrol
  Cardiovascular Effects of Renal Distal Tubule Deletion of the FGF Receptor 1 Gene.
  29, p. 69-80 2018
• Neurobiology of Aging
  Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss.
  59, p. 41-54 2017
• Sci Rep
  Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia.
  7 2017
• Neuroscience
  Klotho regulates CA1 hippocampal synaptic plasticity.
  347, p. 123-133 2017
• Elife
  Adult-born neurons modify excitatory synaptic transmission to existing neurons
  6 2017
• Am J Hypertension
  Differential Regulatory Role of Soluble Klothos on Cardiac Fibrogenesis in Hypertension.
  29, p. 1140-47 2016
• PLoS One
  Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport. 2016
• FEBS Lett.
  Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2 D in macrophages.
  590, p. 53-67 2016
• PLoS Genetics
  Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS.
  11 2015
• Mol Neurodegener
  Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction.
  10 2015
• Monoclon Antib Immunodiagn Immunother
  Development and characterization of monoclonal antibodies to detect klotho.
  33, p. 420-7 2014
• Age
  MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro.
  36, p. 141-9 2014
• J. Biol. Chem.
  Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk. 2013
• Investigative Ophthalmology Visual Science
  The age-regulating protein klotho is vital to sustain retinal function.
  51, p. 6675-85 2013
• Brain Res
  Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood.
  1527, p. 1-14 2013
• Age
  Promoter methylation and age-related downregulation of Klotho in rhesus monkey.
  36, p. 1405-19 2012
• Neoplasia
  Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics. 2012
• Identification of novel small molecules that elevate Klotho expression.
  441, p. 453-61 2012
• Am J Neurodegener Dis
  Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization. 2012
• Molecular Therapy
  Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen.
  19, p. 1793-801 2011
• Clin Cancer Res
  Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design 2011
• Current Gene Therapy
  Gene therapy and targeted toxins for glioma.
  44, p. 155-80 2011
• Clin Cancer Res
  Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression. 2009
• Clin Cancer Res
  Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity. 2009
• J. Virol.
  High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity.
  82, p. 4680-4 2008
• Molecular Therapy
  Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.
  16, p. 682-90 2008
• Neuro-Oncology
  Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model.
  10, p. 19-31 2008
• Molecular Therapy
  One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications. 2007
• J Neurooncol
  Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression. 2007
• J Exp Med
  In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain. 2006
• J Immunol
  Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain. 2006
• J Virol
  Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses. 2006
• Current Gene Therapy
  Gene therapy and targeted toxins for glioma.
  5, p. 535-57 2005
• Cancer Research
  Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.
  65, p. 7194-204 2005
• Molecular Therapy
  Regulatable gene expression systems for gene therapy applications: progress and future challenges. 2005
• Curr Top Med Chem
  Combining cytotoxic and immune-mediated gene therapy to treat brain tumors. 2005
• Molecular Therapy
  Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression. 2004
• J Neurochem
  X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.
  88, p. 971-82 2004
• Experimental Neurology
  Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk? 2004
• Neuroscience
  X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence.
  120, p. 143-54 2003

Other

• CURAS Director’s Summer Undergraduate Research Fellowship - student Tavian Sanchez