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Gwendalyn King, PhD

Assistant Professor

Gwendalyn King


College of Arts and Sciences
Graduate School
Neuroscience (Master of Science)
HLSB - Hixson Lied Science Building

Gwendalyn King, PhD

Assistant Professor

Teaching Interests

  • Neuroscience

Research Focus

I am interested in changes that occur in the brain as a result of the normal aging process.  Understanding the breakpoints between normal aging and development of neurodegenerative disease is crucial to developing new therapies to treat and prevent neurodegeneration.




Assistant Professor


  • Journal of Molecular Cell Biology
    Shah/Jiang, A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells.
    12, p. 4-16 2020
  • JCI: Insight
    Xiao/Quarles, FGF23 expression is stimulated in transgenic -Klotho longevity mouse model
    4 2019
  • Am J Physiol Lung Cell Mol Physiol
    Barnes/Krick, Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis
    217, p. L141-L154 2019
  • Molecular and Cellular Neuroscience
    Vo/King, Klotho deficiency affects the spine morphology and network synchronization of neurons.
    98, p. 1-11 2019
  • Eneuro
    Laszczyk/King, FGF-23 Deficiency Impairs Hippocampal-Dependent Cognitive Function
    6 2019
  • Brain Plasticity
    Vo/King, Klotho, the Key to Healthy Brain Aging?
    3, p. 183-194 2018
  • European Respiratory Journal
    Krick/Salathe, Fibroblast growth factor 23 and Klotho contribute to airway inflammation.
    52 2018
  • J Am Soc Nephrol
    Han/Quarles, Cardiovascular Effects of Renal Distal Tubule Deletion of the FGF Receptor 1 Gene.
    29, p. 69-80 2018
  • Neurobiology of Aging
    Laszczyk/King, Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss.
    59, p. 41-54 2017
  • Sci Rep
    KrickSalathe, Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia.
    7 2017
  • Neuroscience
    Laszczyk/King, Klotho regulates CA1 hippocampal synaptic plasticity.
    347, p. 123-133 2017
  • Elife
    Adlaf/Overstreet-Wadiche, Adult-born neurons modify excitatory synaptic transmission to existing neurons
    6 2017
  • Am J Hypertension
    Liu/Sun, Differential Regulatory Role of Soluble Klothos on Cardiac Fibrogenesis in Hypertension.
    29, p. 1140-47 2016
  • PLoS One
    Han/Quarles, Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport. 2016
  • FEBS Lett.
    Han/Quarles, Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2 D in macrophages.
    590, p. 53-67 2016
  • PLoS Genetics
    Watson/Wilson, Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS.
    11 2015
  • Mol Neurodegener
    Vaden/Wilson, Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction.
    10 2015
  • Monoclon Antib Immunodiagn Immunother
    Maltare/King, Development and characterization of monoclonal antibodies to detect klotho.
    33, p. 420-7 2014
  • Age
    Mehi/King, MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro.
    36, p. 141-9 2014
  • J. Biol. Chem.
    Tucker/Abraham, Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk. 2013
  • Investigative Ophthalmology Visual Science
    Reish/King, The age-regulating protein klotho is vital to sustain retinal function.
    51, p. 6675-85 2013
  • Brain Res
    Clinton/King, Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood.
    1527, p. 1-14 2013
  • Age
    King/Abraham, Promoter methylation and age-related downregulation of Klotho in rhesus monkey.
    36, p. 1405-19 2012
  • Neoplasia
    Candolfi/Castro, Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics. 2012
  • King/Abraham, Identification of novel small molecules that elevate Klotho expression.
    441, p. 453-61 2012
  • Am J Neurodegener Dis
    So/Abraham, Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization. 2012
  • Molecular Therapy
    King/Lowenstein, Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen.
    19, p. 1793-801 2011
  • Clin Cancer Res
    Mineharu/Castro, Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design 2011
  • Current Gene Therapy
    Castro/Lowenstein, Gene therapy and targeted toxins for glioma.
    44, p. 155-80 2011
  • Clin Cancer Res
    Muhammad/Castro, Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression. 2009
  • Clin Cancer Res
    Candolfi/Castro, Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity. 2009
  • J. Virol.
    King/Castro, High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity.
    82, p. 4680-4 2008
  • Molecular Therapy
    King/Castro, Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.
    16, p. 682-90 2008
  • Neuro-Oncology
    King/Castro, Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model.
    10, p. 19-31 2008
  • Molecular Therapy
    Barcia/Lowenstein, One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications. 2007
  • J Neurooncol
    Candolfi/Castro, Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression. 2007
  • J Exp Med
    Barcia/Lowenstein, In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain. 2006
  • J Immunol
    Curtin/Castro, Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain. 2006
  • J Virol
    Xiong/Castro, Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses. 2006
  • Current Gene Therapy
    King/Castro, Gene therapy and targeted toxins for glioma.
    5, p. 535-57 2005
  • Cancer Research
    Ali/Castro, Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.
    65, p. 7194-204 2005
  • Molecular Therapy
    Goverdhana/Castro, Regulatable gene expression systems for gene therapy applications: progress and future challenges. 2005
  • Curr Top Med Chem
    Curtin/Castro, Combining cytotoxic and immune-mediated gene therapy to treat brain tumors. 2005
  • Molecular Therapy
    Ali/Castro, Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression. 2004
  • J Neurochem
    King/Turner, X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.
    88, p. 971-82 2004
  • Experimental Neurology
    King/Turner, Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk? 2004
  • Neuroscience
    King/Turner, X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence.
    120, p. 143-54 2003


  • CURAS Director’s Summer Undergraduate Research Fellowship - student Tavian Sanchez