Close MenuClose
Close Menu
Gwendalyn King, PhD

Assistant Professor

Gwendalyn King

Contact

College of Arts and Sciences
Graduate School
Neuroscience (Master of Science)
Biology
HLSB - Hixson Lied Science Building

Gwendalyn King, PhD

Assistant Professor

Teaching Interests

  • Neuroscience

Research Focus

I am interested in changes that occur in the brain as a result of the normal aging process.  Understanding the breakpoints between normal aging and development of neurodegenerative disease is crucial to developing new therapies to treat and prevent neurodegeneration.

Department

Biology

Position

Assistant Professor

Articles

  • Journal of Molecular Cell Biology
    A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells.
    12, p. 4-16 2020
  • JCI: Insight
    FGF23 expression is stimulated in transgenic -Klotho longevity mouse model
    4 2019
  • Am J Physiol Lung Cell Mol Physiol
    Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis
    217, p. L141-L154 2019
  • Molecular and Cellular Neuroscience
    Klotho deficiency affects the spine morphology and network synchronization of neurons.
    98, p. 1-11 2019
  • Eneuro
    FGF-23 Deficiency Impairs Hippocampal-Dependent Cognitive Function
    6 2019
  • Brain Plasticity
    Klotho, the Key to Healthy Brain Aging?
    3, p. 183-194 2018
  • European Respiratory Journal
    Fibroblast growth factor 23 and Klotho contribute to airway inflammation.
    52 2018
  • J Am Soc Nephrol
    Cardiovascular Effects of Renal Distal Tubule Deletion of the FGF Receptor 1 Gene.
    29, p. 69-80 2018
  • Neurobiology of Aging
    Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss.
    59, p. 41-54 2017
  • Sci Rep
    Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia.
    7 2017
  • Neuroscience
    Klotho regulates CA1 hippocampal synaptic plasticity.
    347, p. 123-133 2017
  • Elife
    Adult-born neurons modify excitatory synaptic transmission to existing neurons
    6 2017
  • Am J Hypertension
    Differential Regulatory Role of Soluble Klothos on Cardiac Fibrogenesis in Hypertension.
    29, p. 1140-47 2016
  • PLoS One
    Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport. 2016
  • FEBS Lett.
    Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2 D in macrophages.
    590, p. 53-67 2016
  • PLoS Genetics
    Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS.
    11 2015
  • Mol Neurodegener
    Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction.
    10 2015
  • Monoclon Antib Immunodiagn Immunother
    Development and characterization of monoclonal antibodies to detect klotho.
    33, p. 420-7 2014
  • Age
    MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro.
    36, p. 141-9 2014
  • J. Biol. Chem.
    Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk. 2013
  • Investigative Ophthalmology Visual Science
    The age-regulating protein klotho is vital to sustain retinal function.
    51, p. 6675-85 2013
  • Brain Res
    Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood.
    1527, p. 1-14 2013
  • Age
    Promoter methylation and age-related downregulation of Klotho in rhesus monkey.
    36, p. 1405-19 2012
  • Neoplasia
    Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics. 2012
  • Identification of novel small molecules that elevate Klotho expression.
    441, p. 453-61 2012
  • Am J Neurodegener Dis
    Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization. 2012
  • Molecular Therapy
    Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen.
    19, p. 1793-801 2011
  • Clin Cancer Res
    Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design 2011
  • Current Gene Therapy
    Gene therapy and targeted toxins for glioma.
    44, p. 155-80 2011
  • Clin Cancer Res
    Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression. 2009
  • Clin Cancer Res
    Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity. 2009
  • J. Virol.
    High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity.
    82, p. 4680-4 2008
  • Molecular Therapy
    Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.
    16, p. 682-90 2008
  • Neuro-Oncology
    Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model.
    10, p. 19-31 2008
  • Molecular Therapy
    One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications. 2007
  • J Neurooncol
    Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression. 2007
  • J Exp Med
    In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain. 2006
  • J Immunol
    Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain. 2006
  • J Virol
    Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses. 2006
  • Current Gene Therapy
    Gene therapy and targeted toxins for glioma.
    5, p. 535-57 2005
  • Cancer Research
    Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.
    65, p. 7194-204 2005
  • Molecular Therapy
    Regulatable gene expression systems for gene therapy applications: progress and future challenges. 2005
  • Curr Top Med Chem
    Combining cytotoxic and immune-mediated gene therapy to treat brain tumors. 2005
  • Molecular Therapy
    Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression. 2004
  • J Neurochem
    X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.
    88, p. 971-82 2004
  • Experimental Neurology
    Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk? 2004
  • Neuroscience
    X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence.
    120, p. 143-54 2003

Other

  • CURAS Director’s Summer Undergraduate Research Fellowship - student Tavian Sanchez