Tal Teitz, PhD

Associate Professor

Pharmacology & Neuroscience

T Teitz

Contact

School of Medicine
Pharmacology and Neuroscience
Graduate School
Neuroscience (Master of Science)
CRISS III - Criss 3 - OFFICE 558B

Tal Teitz, PhD

Associate Professor

Pharmacology & Neuroscience

Cancer Research Focus

Our lab works on identifying and testing drugs for protection from chemotherapy-induced hearing loss. We utilize cell-based screens, cochlear explant cultures, and mouse models.

Cancer Research Area(s)
  • Chemotherapy-Induced Toxicities


Curriculum Vitae

Research Focus

- Therapeutic intervention for chemotherapy-induced, noise-induced and age-related hearing
   loss.
- Function and protection of sensory cells in the mouse cochlea.
- Repurposing FDA-approved drugs for hearing loss and acute kidney injury caused by 
  cisplatin chemotherapy.

Department

Pharmacology and Neuroscience

Position

Associate Professor

Books

  • Methods in Molecular Biology
    Teitz Tal, Goktug Asli N., Chen Taosheng, Zuo Jian, Development of cell-based high-throughput chemical screens for protection against cisplatin-induced ototoxicity [Book Chapter] 2016

Articles

  • Xu Heng, Broniscer Alberto, Zhang Hui, Bass Johnnie K., Robinson Giles W., Hassall Tim, Huang Jie, Lim Joshua Yew Suang, Chintagumpala Murali, Bartels Ute, Gururangan Sri, Fisher Michael, Cohn Richard, Yamashita Tetsuji, Teitz Tal, Zuo Jian, Onar-Thomas Arzu, Gajjar Amar, Stewart Clinton F., Yang Jun J., Erratum 2015

Publications

  • Clinical and translational medicine
    Sailor-Longsworth Emma J., Lutze Richard D., Ingersoll Matthew A., Kelmann Regina G., Ly Kristina, Currier Duane, Chen Taosheng, Zuo Jian, Teitz Tal, Oseltamivir (Tamiflu), a commonly prescribed antiviral drug, mitigates hearing loss in mice
    14:8, p. e1803 2024
  • International journal of molecular sciences
    Lutze Richard D., Ingersoll Matthew A., Thotam Alena, Joseph Anjali, Fernandes Joshua, Teitz Tal, ERK1/2 Inhibition via the Oral Administration of Tizaterkib Alleviates Noise-Induced Hearing Loss While Tempering down the Immune Response
    25:12, p. 6305 2024
  • Pharmaceuticals (Basel, Switzerland)
    Lutze Richard D., Ingersoll Matthew A., Teitz Tal, Kelmann Regina G., Trametinib, a MEK1/2 Inhibitor, Protects Mice from Cisplatin- and Noise-Induced Hearing Loss
    17:6, p. 735 2024
  • Journal of the American Society of Nephrology
    Pushpan Chithra K., Kresock Daniel F., Ingersoll Matthew A., Lutze Richard D., Keirns Darby L., Bashir Khalid, Hunter William J., Teitz Tal, Repurposing AZD5438 and Dabrafenib for Cisplatin-Induced Acute Kidney Injury 2023
  • JCI insight
    Ingersoll Matthew A, Lutze Richard D, Pushpan Chithra K, Hunter William J, He David Zz, Teitz Tal, Kelmann Regina G, Liu Huizhan, May Mark T, Dabrafenib protects from cisplatin-induced hearing loss in a clinically relevant mouse model 2023
  • Journal of Medicinal Chemistry
    Hazlitt Robert A., Diao Shiyong, Iconaru Luigi, Yang Lei, Goktug Asli N., Currier Duane G., Chen Taosheng, Rankovic Zoran, Min Jaeki, Teitz Tal, Bonga Justine D., Fang Jie, Zuo Jian, Development of Second-Generation CDK2 Inhibitors for the Prevention of Cisplatin-Induced Hearing Loss
    61:17, p. 7700 - 7709 2018
  • Journal of Experimental Medicine
    Teitz Tal, Kriwacki Richard, Kiplin Guy R., Chen Taosheng, Zuo Jian, Diao Shiyong, Fang Jie, Goktug Asli N., Bonga Justine D., Hazlitt Robert A., Iconaru Luigi, Umans Robyn A., Morfouace Marie, Currier Duane, Zhou Yinmei, Taylor Michael R., Cheng Cheng, Min Jaeki, Freeman Burgess, Peng Junmin, Roussel Martine F., CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss
    215:4, p. 1187 - 1203 2018
  • Nature genetics
    Xu Heng, Robinson Giles W., Huang Jie, Lim Joshua Yew Suang, Zhang Hui, Bass Johnnie K., Broniscer Alberto, Chintagumpala Murali, Bartels Ute, Gururangan Sri, Hassall Tim, Fisher Michael, Cohn Richard, Yamashita Tetsuji, Teitz Tal, Zuo Jian, Onar-Thomas Arzu, Gajjar Amar, Stewart Clinton F., Yang Jun J., Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss
    47:3, p. 263 - 266 2015
  • Cancer Research
    Teitz Tal, Inoue Madoka, Valentine Marcus B., Zhu Kejin, Rehg Jerold E., Zhao Wei, Finkelstein David, Wang Yong Dong, Johnson Melissa D., Calabrese Christopher, Rubinstein Marcelo, Hakem Razqallah, Weiss William A., Lahti Jill M., Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis
    73:13, p. 4086 - 4097 2013
  • PloS one
    Teitz Tal, Johnson Melissa D., Sedlacik Jan, Inoue Madoka, Zhang Ziwei M., Dyer Michael A., Brennan Rachel, Stanke Jennifer J., Federico Sara, Bradley Cori L., Zhang Jiakun, Finkelstein David, Frase Sharon, Rehg Jerold E., Hillenbrand Claudia M., Calabrese Christopher, Lahti Jill M., Preclinical models for Neuroblastoma
    6:4 2011
  • Cancer Research
    Barbero Simone, Mielgo Ainhoa, Torres Vicente, Teitz Tal, Shields David J., Mikolon David, Bogyo Matthew, Barilà Daniela, Lahti Jill M., Schlaepfer David, Stupack Dwayne G., Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis
    69:9, p. 3755 - 3763 2009
  • Cancer Research
    Lahti Jill M., Teitz Tal, Stupack Dwayne G., Does integrin-mediated cell death confer tissue tropism in metastasis?
    66:12, p. 5981 - 5984 2006
  • Cell Cycle
    Teitz Tal, Stupack Dwayne G., Lahti Jill M., Halting neuroblastoma metastasis by controlling integrin-mediated death
    5:7, p. 681 - 685 2006
  • Nature
    Stupack Dwayne G., Kidd Vincent J., Lahti Jill M., Cheresh David A., Teitz Tal, Potter Matthew D., Mikolon David, Houghton Peter J., Potentiation of neuroblastoma metastasis by loss of caspase-8
    439:7072, p. 95 - 99 2006
  • Nature medicine
    Kidd Vincent J, Lahti Jill M, Teitz Tal, Reply to 'Expression and methylation of CASP8 in neuroblastoma: Identification of a promoter region'
    8:12, p. 1335 - 1335 2002
  • Banelli Barbara, Casciano Ida, Croce Michela, Di Vinci Angela, Gelvi Ilaria, Pagnan Gabriella, Brignole Chiara, Allemanni Giorgio, Ferrini Silvano, Ponzon Mirco, Romani Massimo, Teitz Tal, Lahti Jill M., Kidd Vincent J., Expression and methylation of CASP8 in neuroblastoma 2002
  • Oncogene
    Teitz Tal, Wei Tie, Liu Dong, Valentine Virginia, Valentine Marcus, Grenet Jose, Lahti Jill M., Kidd Vincent J., Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN
    21:12, p. 1848 - 1858 2002
  • Oncogene
    Takita Junko, Yang Hong Wei, Chen Yu Yan, Hanada Ryoji, Yamamoto Keiko, Teitz Tal, Kidd Vincent, Hayashi Yasuhide, Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma
    20:32, p. 4424 - 4432 2001
  • Journal of Molecular Medicine
    Teitz Tal, Lahti Jill M., Kidd Vincent J., Aggressive childhood neuroblastomas do not express caspase-8
    79:8, p. 428 - 436 2001
  • Nature Medicine
    Teitz Tal, Wei Tie, Valentine Marcus B., Vanin Elio F., Grenet Jose, Lahti Jill M., Valentine Virginia A., Behm Frederick G., Look A. Thomas, Kidd Vincent J., Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
    6:5, p. 529 - 535 2000
  • Seminars in Cell and Developmental Biology
    Kidd Vincent J., Lahti Jill M., Teitz Tal, Proteolytic regulation of apoptosis
    11:3, p. 191 - 201 2000
  • Medical and Pediatric Oncology
    Takita Junko, Yang Hong Wei, Bessho Fumio, Hanada Ryoji, Yamamoto Keiko, Kidd Vincent, Teitz Tal, Wei Tie, Hayashi Yasuhide, Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma
    35:6, p. 541 - 543 2000
  • Gene
    Grenet Jose, Teitz Tal, Wei Tie, Valentine Virginia, Kidd Vincent J., Structure and chromosome localization of the human CASP8 gene
    226:2, p. 225 - 232 1999
  • Proceedings of the National Academy of Sciences of the United States of America
    Siegel D. S., Zhang X., Feinman R., Teitz T., Zelenetz A., Richon V. M., Rifkind R. A., Marks P. A., Michaeli J., Hexamethylene bisacetamide induces programmed cell death (apoptosis) and down-regulates BCL-2 expression in human myeloma cells
    95:1, p. 162 - 166 1998
  • Investigative and Cell Pathology
    Teitz Tal, Chang Judy C., Kan Yuet Wai, Yen T. S.Benedict, Thymic epithelial neoplasms in transgenic mice expressing SV40 T antigen under the control of an erythroid‐specific enhancer
    177:3, p. 309 - 315 1995
  • Carcinogenesis
    Teitz T., Yen T. S.B., Kan Y. W., Amplification of a sv40 t antigen transgene is associated with sarcomagenesis in mice
    15:9, p. 2049 - 2051 1994
  • DNA and Cell Biology
    Teitz Tal, Yen T. s.Benedict, Chang Judy C., Kan Yuet Wai, SV40 T Antigen Directed by a Powerful Erythroid Enhancer–Promoter Produced Sarcomas and Pancreatic Tumors But Not Erythroid-Specific Tumors in Transgenic Mice
    13:7, p. 705 - 710 1994
  • Proceedings of the National Academy of Sciences of the United States of America
    Teitz T., Chang J. C., Kitamura M., Yen T. S.B., Yuet Wai Kan Wai Kan, Rhabdomyosarcoma arising in transgenic mice harboring the β-globin locus control region fused with simian virus 40 large T antigen gene
    90:7, p. 2910 - 2914 1993
  • Genomics
    Yang-Feng Teresa L., Teitz Tal, Cheung Mei Chi, Kan Yuet Wai, Canaani Dan, Assignment of the human casein kinase II β-subunit gene to 6p12→p21
    8:4, p. 741 - 742 1990
  • Mutation Research - DNA Repair
    Teitz Tal, Eli Dalia, Penner Michal, Bakhanashvili Mary, Naiman Tova, Timme Terry L., Wood Cada M., Moses Robb E., Canaani Dan, Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells
    236:1, p. 85 - 97 1990
  • Gene
    Teitz Tal, Penner Michal, Eli Dalia, Stark Merav, Bakhanashvili Mary, Naiman Tova, Canaani Dan, Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells
    87:2, p. 295 - 298 1990
  • Proceedings of the National Academy of Sciences of the United States of America
    Teitz T., Naiman T., Avissar S. S., Bar S., Okayama H., Canaani D., Complementation of the UV-sensitive phenotype of a xeroderma pigmentosum human cell line by transfection with a cDNA clone library.
    84:24, p. 8801 - 8804 1987
  • Somatic Cell and Molecular Genetics
    Canaani Dan, Teitz Tal, Berg Paul, Naiman Tova, Immortalization of xeroderma pigmentosum cells by simian virus 40 DNA having a defective origin of DNA replication
    12:1, p. 13 - 20 1986

Presentations

  • "Chemotherapy Drugs and Ototoxicity"- PIHL Group Meeting 2023
  • Dual Effect: Kinase inhibitors AZD5438 and Dabrafenib Alleviate Cisplatin-Induced Acute Kidney Injury and Hearing Loss. Brainstorm Presentation at Creighton University, School of Medicine. 2022
  • Bellucci 2022 Symposium on Aging and Age-related Hearing Loss-Dabrafenib, a BRAF Inhibitor Protects Against Cisplatin-Induced Kidney Injury and Hearing Loss. 2022
  • Bellucci Symposia 2022- Repurposing Oseltamivir to Prevent Noise-induced hearing Loss. Regina Kelmann and Emma Sailor First co-authors. 2022
  • Bellucci Symposium 2022- Repurposing FDA-approved MEK Inhibitor Trametanib for Protection from Cisplatin Induced Hearing Loss. 2022
  • Bellucci Symposia 2022- Aging and Age-related Hearing Loss. ERK 1/2 Inhibitor Protects from Noise-induced Hearing Loss. 2022
  • Tamiflu as a Therapeutic Candidate for Noise-Induced Hearing Loss- ARO Meeting 2022. 2022
  • Development of New Pharmacologic Agents for Hearing Loss and Vestibular Pathology. Center for Comparative Evolutionary Biology of Hearing, Translational Research Day, University of Maryland, College Park, School of Medicine, Baltimore, MD, Dec 9, 2021. 2021
  • Gave a presentation in the 5th Chinese Hearing Research Conference on our research studies , Beijing, China 2019, titled "Drug Development for Cisplatin- and Noise- induced Hearing Loss." 2019
  • Research Rounds and Seminars at Department of Pharmacology and Neuroscience 2019
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